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1. 发明申请

WO2018067923A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF COLITIS IN INFANTS 审中-公开
标题翻译：婴幼儿预防和治疗婴儿隐球菌病的组合物和方法
公开(公告)号：WO2018067923A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055528
申请日：2017-10-06
申请人： TALLGRASS THERAPEUTICS, LLC
发明人： HANNA, Adam
IPC分类号： A61K38/44 , C12N9/06 , A23C11/02
CPC分类号： A23L33/40 , A23C9/1216 , A23C9/206 , A23V2002/00 , A23V2200/32 , A61K35/20 , A61K38/44 , C12Y104/03006 , C12Y104/03022
摘要： This disclosure describes compositions and methods for preventing and/or treating necrotizing enterocolitis (NEC) and preventing loss of intestinal integrity and/or improving intestinal integrity in neonatal subjects. Compositions useful in the methods of the disclosure comprise diamine oxidase (DAO) which can be from any source and formulated for systemic administration.
摘要翻译：本公开描述了用于在新生儿受试者中预防和/或治疗坏死性小肠结肠炎（NEC）并预防肠完整性丧失和/或改善肠完整性的组合物和方法。可用于本公开方法的组合物包含二胺氧化酶（DAO），其可以来自任何来源并且配制用于全身性施用。

2. 发明申请

WO2016164402A1 METHODS OF DIAGNOSING AND TREATING AUTOIMMUNE DISEASE 审中-公开
标题翻译：诊断和治疗自发性疾病的方法
公开(公告)号：WO2016164402A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026129
申请日：2016-04-06
申请人： OKLAHOMA MEDICAL RESEARCH FOUNDATION
发明人： GAFFNEY, Patrick , JAMES, Judith
IPC分类号： A61K35/74 , A61K45/06 , C12N1/20
CPC分类号： A61K45/06 , A61K31/7048 , C12Q1/6883 , C12Q1/689 , G01N33/564 , G01N33/56911 , G01N2800/104
摘要： The present disclosure relates to methods of diagnosing and treating Systemic Lupus Erythematosus (SLE) based on microbe population alterations in the oral cavity and intestines. It has been discovered that SLE patients present with the following abnormalities as compared to healthy individuals: (1) decreases in the general microbial diversity in fecal samples; (2) decreases in the microbial phyla Bacteroidetes in fecal samples; (3) decreases in the Faecalibacterium genus in fecal samples; (4) decreased phylogenetic and species diversity in saliva samples; (5) increases in the microbial phyla Bacteroidetes in saliva samples; and (6) increased levels of the Prevotella genus in saliva. Thus, the present disclosure provides methods of diagnosing SLE by exploiting these abnormalities. Furthermore, the present disclosure provides methods of treating SLE by resolving the above microbe abnormalities.
摘要翻译：本公开涉及基于口腔和肠道中的微生物群体改变来诊断和治疗系统性红斑狼疮（SLE）的方法。已经发现与健康个体相比，SLE患者具有以下异常：（1）粪便样品中一般微生物多样性降低; （2）粪便样本中微生物菌类菌的数量减少; （3）粪便样本中粪便杆菌属数量减少; （4）减少唾液样品的系统发育和物种多样性; （5）唾液样本中微生物菌类菌的数量增加; 和（6）唾液中Prevupella属的水平提高。因此，本公开提供了通过利用这些异常来诊断SLE的方法。此外，本公开提供了通过解决上述微生物异常来治疗SLE的方法。

3. 发明申请

WO2014205228A1 TRAMADOL PARTICLE FORMULATIONS AND METHODS 审中-公开
标题翻译： TRAMADOL颗粒制剂和方法
公开(公告)号：WO2014205228A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/043202
申请日：2014-06-19
申请人： ORBIS BIOSCIENCES, INC.
发明人： BERKLAND, Cory , SINGH, Milind , DORMER, Nathan
IPC分类号： A61K9/22
CPC分类号： A61K9/145 , A61K9/0019 , A61K9/10 , A61K9/146 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K31/135 , A61K47/44
摘要： Particles for delivery of tramadol formed from tramadol and a hydrophobic matrix, as well as methods for making and using such particles. Tramadol is an opioid receptor agonist and centrally acting synthetic analgesic used to treat moderate to moderately severe pain. Tramadol has a wide range of applications, including treatment of rheumatoid arthritis, restless legs syndrome, motor neuron disease, and fibromyalgia.
摘要翻译：用于递送由曲马多和疏水基质形成的曲马多的颗粒，以及制备和使用这些颗粒的方法。曲马多是一种阿片受体激动剂和中枢作用的合成镇痛药，用于治疗中度至中度严重的疼痛。曲马多具有广泛的应用，包括治疗类风湿性关节炎，不宁腿综合征，运动神经元疾病和纤维肌痛。

4. 发明申请

WO2012087840A1 DISPERSION INJECTION METHODS FOR BIOSENSING APPLICATIONS 审中-公开
标题翻译：生物传感应用的分散注射方法
公开(公告)号：WO2012087840A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065613
申请日：2011-12-16
申请人： FLIR SYSTEMS, INC. , QUINN, John, Gerard
发明人： QUINN, John, Gerard
IPC分类号： G01N21/05
CPC分类号： G01N33/53 , G01N21/05 , G01N21/272 , G01N21/45 , G01N21/553 , G01N21/7703 , G01N35/00693 , G01N35/08
摘要： I Injection methods for determining biomolecular interaction parameters such in label-free biosensing systems are provided. The methods generally relate to analyte sample injection methods that generate well-defined analyte concentration gradients en route to a sensing region possessing an immobilized binding partner. The injections conditions are generally established according to a set of rules that create a dispersion event that can be accurately modeled by a dispersion term. The dispersion term is incorporated into the desired interaction model to provide a reliable representation of the analyte concentration gradient profile, The resulting interaction model is then fitted to a measured binding response curve in order to calculate the interaction parameters. Thus, the injection methods described herein provide a continuous analyte titration allowing a full analyte dose response to be recorded in a single injection in contrast to the standard multiple injection approach
摘要翻译：提供了用于确定生物分子相互作用参数的注射方法，例如无标记的生物传感系统。所述方法通常涉及分析物样品注射方法，其在通向具有固定化结合配偶体的感测区域途中产生明确定义的分析物浓度梯度。注射条件通常根据创建可以通过色散项精确建模的色散事件的一组规则建立。将分散项合并到所需的相互作用模型中以提供分析物浓度梯度分布的可靠表示。然后将所得的相互作用模型拟合到测量的结合响应曲线上，以计算相互作用参数。因此，本文所述的注射方法提供连续的分析物滴定，与标准多次注射方法相反，允许在单次注射中记录完整的分析物剂量反应

5. 发明申请

WO2018035182A1 STORAGE AND PRESERVATION OF LIVING TISSUE ALLOGRAFTS 审中-公开
标题翻译：活体组织异体移植物的储存和保存
公开(公告)号：WO2018035182A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047059
申请日：2017-08-16
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： VUNJAK-NOVAKOVIC, Gordana , YEAGER, Keith , LIU, David
IPC分类号： C12M1/00 , C12M1/02 , C12M1/04 , C12M1/12 , C12M1/16 , C12M1/18
CPC分类号： C12M1/00 , A01N1/0242 , A01N1/0252 , A01N1/0263 , A01N1/0273 , C12M1/02 , C12M1/04 , C12M1/12 , C12M1/16 , C12M1/18 , C12M21/08 , C12M29/10 , C12M41/14 , C12M45/22
摘要： Provided are devices, systems and methods for storing and preserving living tissue allografts. The systems are simple, robust and yet have multiple functionalities. The purpose is to provide automated and highly controlled maintenance of viable tissues over periods of time sufficient for the evaluation, typing and matching of tissue grafts for transplantation.
摘要翻译：提供用于存储和保存活组织同种异体移植物的装置，系统和方法。该系统简单，强大，但具有多种功能。目的是提供足够的评估，分型和匹配的组织移植用于移植的自动和高度控制的可行组织的维持。

6. 发明申请

WO2017210651A1 A SYMBIONT FOR ENHANCEMENT OF PLANT PERFORMANCE 审中-公开
标题翻译：一个提高植物性能的象征
公开(公告)号：WO2017210651A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035844
申请日：2017-06-02
申请人： NOBLE RESEARCH INSTITUTE, LLC
发明人： CRAVEN, Kelly , RAY, Prasun
IPC分类号： A01N35/02 , A01N35/04 , A01N37/02
摘要： The present disclosure provides a novel endophyte, Serendipita vermifera ssp. bescii (" S. bescii "), uses thereof and methods incorporating the use thereof for enhancement of plant performance. The present disclosure also provides methods for detecting the presence of and identifying S. bescii .
摘要翻译：本公开提供了一种新型内生真菌Serendipita vermifera ssp。（“S。bescii”），其用途以及包含其用于提高植物性能的方法。本公开还提供了用于检测S的存在和鉴定S的方法。 bescii 的

7. 发明申请

WO2017180714A1 ANTIFUNGAL ACTIVITY OF lRON SEQUESTERING POLYMERS 审中-公开
标题翻译：长链聚合物的抗真菌活性
公开(公告)号：WO2017180714A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027158
申请日：2017-04-12
申请人： UNIVERSITY OF KANSAS
发明人： BERKLAND, Cory , QIAN, Jian , SULLIVAN, Bradley, Paul
IPC分类号： A61K31/785 , A61K47/48
摘要： A polymeric metal sequestrant providing antifungal activity is provided. The polymeric metal sequestrant comprises a polyamine polymer covalently coupled to a chelator, wherein the chelator has a benzene ring with more than one hydroxyl group at any position that is free. The polymeric metal sequestrant is effective in inhibiting and preventing fungal infections and displays synergistic effects in combination with traditional antifungal agents.
摘要翻译：提供了提供抗真菌活性的聚合金属螯合剂。该聚合物金属多价螯合剂包含与螯合剂共价偶联的多胺聚合物，其中该螯合剂具有在任何游离的位置具有多于一个羟基的苯环。聚合金属多价螯合剂可有效抑制和预防真菌感染，并与传统的抗真菌药物联合显示协同作用。

8. 发明申请

WO2016154070A1 HYPOTHERMIC 3D BIOPRINTING OF LIVING TISSUES SUPPORTED BY PERFUSABLE VASCULATURE 审中-公开
标题翻译：由可渗透血管支持的生活组织的高效3D生物
公开(公告)号：WO2016154070A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023302
申请日：2016-03-18
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： MILLER, Jordan , TA, Anderson , GRIGORYAN, Bagrat
IPC分类号： B01L3/02 , C12M3/00 , B29C67/00
CPC分类号： C12N5/0062 , B29C64/129 , B29C64/393 , B29K2071/02 , B33Y10/00 , B33Y50/02 , B33Y70/00 , C12M3/00 , C12M21/08 , C12M25/14 , C12N5/0068 , C12N2513/00 , C12N2533/30 , C12N2537/00
摘要： The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.
摘要翻译：本公开提供了用于生产水凝胶基质构建体的组合物和方法。还公开了使用水凝胶基质构建体用于组织修复和再生以及红细胞氧合的方法。

9. 发明申请

WO2016057754A1 ANTIBIOTIC ACTIVITY OF IRON SEQUESTRING POLYMERS 审中-公开
标题翻译：铁离子序列聚合物的抗生物活性
公开(公告)号：WO2016057754A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054627
申请日：2015-10-08
申请人： THE UNIVERSITY OF KANSAS
发明人： BERKLAND, Cory , RIVERA, Mario , ESHELMAN, Kate , QIAN, Jian , EL-GENDY, Nashwa
IPC分类号： A61K31/785 , A61K47/48 , C08G59/50
CPC分类号： A61K31/785 , A61K31/496 , A61K31/7036 , A61K45/06 , A61K2300/00
摘要： A polymeric metal sequestrant providing antibiotic activity is provided. The polymeric metal sequestrant comprises a polyamine polymer covalently coupled to a chelator, wherein the chelator has a benzene ring with more than one hydroxyl group at any position that is free. The polymeric metal sequestrant is effective in inhibiting and preventing bacterial infections and displays synergistic effects in combination with traditional antibiotics.
摘要翻译：提供了提供抗生素活性的聚合物金属螯合剂。聚合金属多价螯合剂包含与螯合剂共价偶联的聚胺聚合物，其中螯合剂在任何自由位置具有多于一个羟基的苯环。聚合金属多价螯合剂有效抑制和预防细菌感染，并与传统抗生素结合显示协同效应。

10. 发明申请

WO2012106654A1 METHODS FOR TREATING BRAIN INJURY 审中-公开
标题翻译：治疗脑损伤的方法
公开(公告)号：WO2012106654A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023855
申请日：2012-02-03
申请人： HOUGH EAR INSTITUTE , OKLAHOMA MEDICAL RESEARCH FOUNDATION , KOPKE, Richard D. , FLOYD, Robert A. , TOWNER, Rheal
发明人： KOPKE, Richard D. , FLOYD, Robert A. , TOWNER, Rheal
IPC分类号： A61K31/195 , A61K31/14
CPC分类号： A61K31/198 , A61K9/0053 , A61K31/15 , A61K31/16 , A61K31/185 , A61K31/205 , A61K31/221 , A61K31/555 , A61K38/063 , A61K38/07 , A61K45/06 , A61K2300/00
摘要： The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprises 2,4-disulfonyl α-phenyl tertiary butyl nitrone and N- acetylcysteine (NAC).
摘要翻译：用于治疗爆发诱发和噪声诱发的创伤性脑损伤和耳鸣的治疗方案是有限的。因此，本发明提供了治疗创伤性脑损伤和耳鸣的方法。所述方法包括施用药学有效量的组合物包含2,4-二磺酰基α-苯基叔丁基硝酮和N-乙酰半胱氨酸（NAC）。

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