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1. 发明申请

WO2008016995A3 METHODS OF IDENTIFYING MODULATORS OF INSULIN SIGNALLING 审中-公开
公开(公告)号：WO2008016995A3
公开(公告)日：2008-02-07
申请号：PCT/US2007/075001
申请日：2007-08-01
申请人： JOSLIN DIABETES CENTER, INC. , TANIGUCHI, Cullen , UEKI, Koji , KAHN, C. Ronald
发明人： TANIGUCHI, Cullen , UEKI, Koji , KAHN, C. Ronald
IPC分类号： C12Q1/00 , G01N33/00 , G01N33/53
摘要： This invention relates to methods of identifying drugs for the treatment of insulin resistance and diabetes.

2. 发明申请

WO2006138506A3 GENERALIZED 5D DYNAMIC AND SPECTRAL FACTOR ANALYSIS 审中-公开
公开(公告)号：WO2006138506A3
公开(公告)日：2006-12-28
申请号：PCT/US2006/023390
申请日：2006-06-16
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , FAKHRI, Georges, El , SITEK, Arkadiusz
发明人： FAKHRI, Georges, El , SITEK, Arkadiusz
IPC分类号： G06K9/00
摘要： A method for processing image data includes representing the image data as a model having a spatial dimension, a time dimension, and an energy dimension; providing an objective function that is a function of energy factors, time factors, and image coefficients included in the model; and determining values of the energy factors, the time factors, and the image coefficients that minimize a difference between the optimal value of an objective function and a value of the objective function, the values of the energy factors, the time factors, and the image coefficients defining a solution.

3. 发明申请

WO2009006583A1 TREATMENT OF CARDIOVASCULAR DISEASE WITH SALICYLATES 审中-公开
标题翻译：用盐酸处理心血管疾病
公开(公告)号：WO2009006583A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/069177
申请日：2008-07-03
申请人： JOSLIN DIABETES CENTER, INC. , SHOELSON, Steven , GOLDFINE, Allison, B.
发明人： SHOELSON, Steven , GOLDFINE, Allison, B.
IPC分类号： C12Q1/68
CPC分类号： A61K31/185
摘要： This invention relates to methods for the treatment of atherosclerotic cardiovascular disease using a non-acetylated forms of salicylate, e.g., salsalate and/or trilisate.
摘要翻译：本发明涉及使用非乙酰化形式的水杨酸盐，例如硫柳酸盐和/或苦味酸盐治疗动脉粥样硬化心血管疾病的方法。

4. 发明申请

WO2008016996A3 METHODS OF MODULATING METABOLIC MEMORY 审中-公开
公开(公告)号：WO2008016996A3
公开(公告)日：2008-02-07
申请号：PCT/US2007/075004
申请日：2007-08-01
申请人： JOSLIN DIABETES CENTER, INC. , GERALDES, Pedro , KING, George Liang
发明人： GERALDES, Pedro , KING, George Liang
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53 , A61K48/00
摘要： Described are methods of identifying modulators of metabolic memory, for the treatment of microvascular complications of diabetes, as well as methods of use thereof. Also described are methods of treating microvascular complications of diabetes by decreasing expression and/or activity of SHP-1.

5. 发明申请

WO2008098007A1 TISSUE FILLERS AND METHODS OF USING THE SAME 审中-公开
标题翻译：组织填料及其使用方法
公开(公告)号：WO2008098007A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053093
申请日：2008-02-05
申请人： FREEDOM-2, INC. , BERNSTEIN, Eric, F.
发明人： BERNSTEIN, Eric, F.
IPC分类号： A61F2/12
CPC分类号： A61K9/0024 , A61L27/48 , A61L27/50 , A61L2400/06
摘要： The invention relates to tissue filler compositions, including a matrix material and a tissue filler material, that are alterable or removable on demand, including by disrupting at least a portion of a matrix-associated tissue filler material. Also provided are methods for filling or augmenting tissue using the tissue fillers described herein, and correcting such tissue implants as required.
摘要翻译：本发明涉及组织填充剂组合物，包括基质材料和组织填充材料，其可根据需要是可改变的或可移除的，包括通过破坏基质相关组织填充材料的至少一部分。还提供了使用本文所述的组织填充物填充或增加组织的方法，以及根据需要校正这样的组织植入物。

6. 发明申请

WO2006102686A2 HIGH POWER DIODE LASERS 审中-公开
标题翻译：高功率二极管激光器
公开(公告)号：WO2006102686A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/011476
申请日：2006-03-27
申请人： TRUMPF PHOTONICS INC. , CHARACHE, Greg , JIANG, Ching-Long , MENNA, Raymond J.
发明人： CHARACHE, Greg , JIANG, Ching-Long , MENNA, Raymond J.
IPC分类号： H01S5/00
CPC分类号： H01S5/0425 , H01S5/0014 , H01S5/0202 , H01S5/028 , H01S5/0282 , H01S5/1014 , H01S5/16 , H01S5/22 , H01S5/2214 , H01S5/2231 , H01S2301/18
摘要： The invention relates to ridge waveguide semiconductor diode lasers that include a substrate, a first cladding layer near the substrate, a second cladding layer near the first cladding layer, and an active layer between the first cladding layer and the second cladding layer and extending the distance between a first facet and a second facet of the diode laser. The diode laser includes a cap layer located near the second cladding layer, a ridge formed in the cap layer and the second cladding layer, and a contact layer applied at least at the ridge for injecting current into the active layer. The contact layer contacts the cap layer in a contact region having a length that is less than the distance between the first facet and the second facet such that the cap layer includes an unpumped facet region. Methods to make the new lasers are also described.
摘要翻译：本发明涉及脊形波导半导体二极管激光器，其包括衬底，靠近衬底的第一包层，靠近第一包层的第二包层以及在第一包层和第二包层之间的有源层，第二包层并延伸二极管激光器的第一小面和第二小面之间的距离。该二极管激光器包括位于第二覆盖层附近的覆盖层，形成在覆盖层和第二覆盖层中的脊，以及至少施加在脊处用于将电流注入有源层的接触层。接触层在长度小于第一小面与第二小面之间的距离的接触区域中接触盖层，使得盖层包括未抛出的小面积区域。还介绍了制作新激光器的方法。

7. 发明申请

WO2006096710A3 DETECTION, IMAGING, AND DEPLETION OF CHLAMYDIA 审中-公开
公开(公告)号：WO2006096710A3
公开(公告)日：2006-09-14
申请号：PCT/US2006/008065
申请日：2006-03-06
申请人： UNIVERSITY OF MASSACHUSETTS , STUART, Elizabeth, S.
发明人： STUART, Elizabeth, S.
IPC分类号： C12P21/02 , C12N5/06 , C07K16/00 , C07H21/04
摘要： Methods and compositions are disclosed for detecting and depleting cells infected with bacteria of the Chlamydiaceae family from a biological sample. Compositions include, for example, an immunoglobulin constant region polypeptide linked to an imaging moiety or a bactericide. Methods include, for example, contacting a biological sample that includes chlamydia infected cells, with a composition that includes an immunoglobulin constant region polypeptide linked to a detectable moiety, wherein the composition is selectively taken up by chlamydia infected cells and thereby detectably labels them. Methods of depleting chlamydia infected cells include for example, contacting a biological sample that includes chlamydia infected cells with a composition that includes an immunoglobulin constant region polypeptide linked to a bactericide, wherein the composition is selectively taken up by the infected cells and comes into contact with intracellular chlamydial bacteria and can thereby kill them or inhibit their replication.

8. 发明申请

WO2006084019A3 SNARE WITH CAPTURE-AREA ENHANCEMENT 审中-公开
公开(公告)号：WO2006084019A3
公开(公告)日：2006-08-10
申请号：PCT/US2006/003661
申请日：2006-02-01
申请人： PRIMUS MEDICAL GROUP, LLC. , MATHEWS, Eric , DOBSON, Paul, J. , COATS, Jeffry
发明人： MATHEWS, Eric , DOBSON, Paul, J. , COATS, Jeffry
IPC分类号： A61B19/00
摘要： A surgical snare for ensnaring an object in a patient includes a flexible section that selectively switches between an insertion shape and an ensnaring shape; and a capture-area enhancer deployed when the flexible section assumes the ensnaring shape. An actuator coupled to the flexible section causes the flexible section to transition between the insertion shape and the ensnaring shape.

9. 发明申请

WO2014120794A1 MAGNETIC SEPARATION USING NANOPARTICLES 审中-公开
标题翻译：使用纳米颗粒的磁分离
公开(公告)号：WO2014120794A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/013633
申请日：2014-01-29
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CHILDREN'S MEDICAL CENTER CORPORATION
发明人： LEE, Jung-Jae , JEONG, Kyung Jae , KOHANE, Daniel, S.
IPC分类号： B01D35/06
CPC分类号： A61L9/00 , A61L2/00
摘要： Nanoparticles as described herein are configured to bind to bacterial contaminants, such as Gram positive bacteria, Gram negative bacteria, and endotoxins. The nanoparticles include a core comprising a magnetic material; and a plurality of ligands attached to the core. The ligands include, for example, bis(dipicolylamine) ("DPA") coordinated with a metal ion, e.g., Zn 2+ or Cu 2+ , to form, e.g., bis-Zn-DPA or bis-Cu-DPA, which can bind to the bacterial contaminants. The nanoparticles can be included in compositions for use in methods and systems to separate bacterial contaminants from liquids, such as liquids, such as blood, e.g., whole or diluted blood, buffer solutions, albumin solutions, beverages for human and/or animal consumption, e.g., drinking water, liquid medications for humans and/or animals, or other liquids.
摘要翻译：如本文所述的纳米颗粒被配置为结合细菌污染物，例如革兰氏阳性细菌，革兰氏阴性细菌和内毒素。纳米颗粒包括包含磁性材料的芯; 和连接到芯的多个配体。配体包括例如与金属离子（例如Zn 2+或Cu 2+）配位的双（二吲哚胺）（“DPA”），以形成例如双-Zn-DPA或双-Cu-DPA，其可以结合到细菌污染物。纳米颗粒可以包括在方法和系统中用于将细菌污染物与液体例如液体如血液（例如全血或稀释的血液，缓冲溶液，白蛋白溶液，用于人类和/或动物消耗的饮料）分离的方法和系统中，例如饮用水，人类和/或动物的液体药物或其他液体。

10. 发明申请

WO2011153521A2 MULTI-MODAL IMAGING OF BLOOD FLOW 审中-公开
标题翻译：血液流动多模态成像
公开(公告)号：WO2011153521A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/039230
申请日：2011-06-06
申请人： MCLEAN HOSPITAL CORPORATION , FREDERICK, Blaise , TONG, Yunjie
发明人： FREDERICK, Blaise , TONG, Yunjie
IPC分类号： A61B5/055 , A61B5/026 , A61B5/1455
CPC分类号： A61B5/0035 , A61B5/0042 , A61B5/0075 , A61B5/02014 , A61B5/02042 , A61B5/0261 , A61B5/0263 , A61B5/0295 , A61B5/055 , A61B5/14551 , A61B5/4064 , A61B5/4088 , A61B5/4244 , A61B5/4312 , A61B5/4842 , A61B5/4848 , A61B5/7203 , A61B5/7225 , A61B5/7278 , A61B5/742
摘要： The application features methods, devices, and systems for measuring blood flow in a subject. The computer-implemented methods include receiving functional magnetic resonance imaging (fMRI) data that provides information on at least one of volume or oxygenation of blood at one or more locations in a body over a first predetermined length of time. The methods also include receiving near-infrared spectroscopic (NIRS) imaging or measurement data representing at least one of blood concentration or oxygenation at a first portion of the body over a second predetermined length of time. The methods further include deriving, from the fMRI data corresponding to a second portion of the body, a time varying data set representing changes in blood oxygenation or volume or both blood oxygenation and volume at the second portion over the first predetermined length of time and determining, by a computing device, a time delay and a value of a similarity metric corresponding to a part of the spectroscopic imaging data that most closely matches the time varying data set. The time delay represents a difference between a first time in which blood flows from a third portion in the body to the first portion and a second time in which blood flows to the second portion from the third portion. The value of the similarity metric represents an amount of blood at the second portion. An estimate of a characteristic of at least one of blood flow or blood volume in the second portion at a given time is determined based on the time delay and the value of the similarity metric.
摘要翻译：该应用的特征在于测量受试者血液流动的方法，装置和系统。计算机实现的方法包括接收功能性磁共振成像（fMRI）数据，该功能磁共振成像（fMRI）数据在第一预定时间长度上提供关于身体中的一个或多个位置的血液的体积或氧合中的至少一种的信息。所述方法还包括在第二预定时间长度上接收表示身体第一部分的血液浓度或氧合中的至少一种的近红外光谱（NIRS）成像或测量数据。所述方法还包括从对应于身体的第二部分的fMRI数据导出表示在第一预定时间长度上的血氧饱和度或体积变化或第二部分的血氧值和体积变化的时变数据集，并确定通过计算设备，时间延迟和与最接近地匹配时变数据集的分光成像数据的一部分相对应的相似性度量的值。时间延迟表示血液从身体的第三部分流向第一部位的第一次与血液从第三部分流向第二部分的第二次的差。相似性度量的值表示第二部分处的血液量。基于时间延迟和相似性度量的值来确定在给定时间的第二部分中的血流或血液体积中的至少一个的特性的估计。

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