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1. 发明申请

WO2022197770A1 METHODS FOR TAILORING ANALGESIC REGIMEN IN LUNG OR COLON CANCER PATIENTS BASED ON TUMOR GENOMICS 审中-公开
公开(公告)号：WO2022197770A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020502
申请日：2022-03-16
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人： MINCER, Joshua , FISCHER, Gregory , MCCORMICK, Patrick
IPC分类号： C12Q1/6883 , A61K31/485 , A61P35/04 , G01N33/574 , C12Q1/6806 , C12Q1/6851
摘要： The present disclosure relates to methods for determining whether a patient diagnosed with lung or colon cancer and undergoing tumor resection surgery will benefit from treatment with intraoperative opioid analgesics or opioid-free intraoperative analgesics. The present disclosure relates to methods for determining whether a patient diagnosed with lung or colon cancer and undergoing tumor resection surgery will benefit from treatment with intraoperative opioid analgesics or opioid-free intraoperative analgesics. In some embodiments, the methods disclosed herein are based on screening a lung cancer patient for elevated FGA, mutations in CDKN2A and/o mutations in the Wnt or Hippo signaling pathways.

2. 发明申请

WO2022197703A1 WOUND HEALING ENHANCEMENT WITH ANTI-CERAMIDE ANTIBODIES 审中-公开
公开(公告)号：WO2022197703A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020385
申请日：2022-03-15
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人： KOLESNICK, Richard , BUSIK, Julia
IPC分类号： A61P17/02 , C07K16/18 , A61K39/395 , A61K8/30
摘要： The present disclosure provides compositions and methods to improve or accelerate the healing of a wound. In various embodiments, the methods comprise the use of anti-ceramide antibodies and antibody fragments. In some embodiments, the wound is a chronic wound. In some embodiments, the wound is a diabetic wound.

3. 发明申请

WO2022178211A2 MIR200C-EPCAM AXIS REPROGRAMED IMMUNE CELLS FOR ENHANCED ANTI-TUMOR FUNCTION 审中-公开
公开(公告)号：WO2022178211A2
公开(公告)日：2022-08-25
申请号：PCT/US2022/016921
申请日：2022-02-18
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
发明人： HUSE, Morgan , ZHANG, Minggang
IPC分类号： A61K9/51 , A61K35/76 , A61K9/12 , A61K47/69 , C12N15/113 , C12N7/00 , A61P35/00 , A61K39/0012 , C12N15/11
摘要： Provided herein are compositions, kits, and methods for manufacturing cells for adoptive cell therapy comprising engineered immune cells that overexpress miR200c and/or EpCAM.

4. 发明申请

WO2022177989A1 MODELS FOR PREDICTING MUTANT P53 FITNESS AND THEIR IMPLICATIONS IN CANCER THERAPY 审中-公开
公开(公告)号：WO2022177989A1
公开(公告)日：2022-08-25
申请号：PCT/US2022/016594
申请日：2022-02-16
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , INSTITUTE FOR ADVANCED STUDY , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人： GREENBAUM, Benjamin , HOYOS, David , MERGHOUB, Taha , WOLCHOK, Jedd , ZAPPASODI, Roberta , HELLMANN, Matthew D. , SETHNA, Zachary , SCHULZE, Isabell , BALACHANDRAN, Vinod , LEVINE, Arnold , LUKSZA, Marta
IPC分类号： A61K39/00 , A61K35/15 , G01N33/574 , A61K35/17 , C12Q1/68 , G01N33/68 , A61K39/395 , A61P35/00
摘要： The present technology relates to methods, computing devices, and systems for predicting the fitness of mutant p53 based on the loss of transcription factor function and immunogenicity of a particular TP53 mutation. The fitness of mutant p53 may be used to determine whether a patient will benefit from a particular anti-cancer therapy such as immune checkpoint inhibitor therapy, adoptive T-cell therapy, or prophylactic cancer vaccine therapy.

5. 发明申请

WO2022159677A1 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF COMPOUNDS THAT PROTECT AGAINST LIPOFUSCIN CYTOTOXICITY 审中-公开
公开(公告)号：WO2022159677A1
公开(公告)日：2022-07-28
申请号：PCT/US2022/013276
申请日：2022-01-21
申请人： CORNELL UNIVERSITY
发明人： NOCIARI, Marcelo M.
IPC分类号： A61K31/03 , A61K31/18 , A61K31/427 , A61K31/506 , A61P25/00 , A61P27/02
摘要： The present disclosure provides compositions and methods for treating eye diseases ( e.g., retinopathies), and more particularly, eye diseases associated with cytotoxic lipofuscin- associated cytotoxicity in retinal cells.

6. 发明申请

WO2022093770A1 COMBINATION THERAPY WITH PI3K-AKT-MTOR INHIBITORS AND FERROPTOSIS INDUCING AGENTS TO TREAT CANCER 审中-公开
公开(公告)号：WO2022093770A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056583
申请日：2021-10-26
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： JIANG, Xuejun
IPC分类号： A61K31/4439 , A61K45/06 , A61P35/00
摘要： The present technology provides methods for treating cancers using combination therapy with a PI3K-AKT-mTOR pathway inhibitor (e.g., a PI3K inhibitor, an ART inhibitor, an mTOR inhibitor, a SREBP1 inhibitor, or a SCD1 inhibitor) and a ferroptosis inducing agent. Kits for use in practicing the methods are also provided.

7. 发明申请

WO2022026439A2 COMPOSITIONS INCLUDING EX VIVO ARMED T CELLS WITH MULTI-SPECIFIC ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2022026439A2
公开(公告)日：2022-02-03
申请号：PCT/US2021/043270
申请日：2021-07-27
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： PARK, Jeong A. , CHEUNG, Nai-Kong V. , SANTICH, Brian
IPC分类号： A61K39/395 , A61K35/17 , C07K16/30 , C07K16/46 , A61K2039/505 , A61K2039/507 , A61K35/00 , A61K39/0011 , C07K16/2809 , C07K16/2827 , C07K16/3084 , C07K16/32 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/622 , C12N5/00
摘要： The present disclosure provides ex vivo armed T cell (EAT) compositions that comprise multi-specific (e.g., bispecific) antibodies that bind to CDS and at least one additional target antigen (e.g., antigen that is expressed by tumor cells and/or a DOTA label). The EAT compositions of the present technology are useful for adoptive immunotherapy in a subject in need thereof.

8. 发明申请

WO2022015986A1 METHODS FOR TREATING METASTATIC CANCER USING LOW DOSE CARBON MONOXIDE 审中-公开
公开(公告)号：WO2022015986A1
公开(公告)日：2022-01-20
申请号：PCT/US2021/041833
申请日：2021-07-15
申请人： CORNELL UNIVERSITY
发明人： DU, Yi-Chieh , CHOI, Augustine
IPC分类号： A61K9/08 , A61K9/72 , A61K33/00 , A61K33/44 , A61K41/00 , A61K45/06 , A61K47/04
摘要： The present technology relates generally to methods for treating, preventing, and/or ameliorating metastasis in a subject in need thereof comprising administering to the subject a therapeutically effective amount of low dose carbon monoxide.

9. 发明申请

WO2021216997A2 NANOTHERAPY TARGETING RHAMM-POSITIVE TUMORS 审中-公开
公开(公告)号：WO2021216997A2
公开(公告)日：2021-10-28
申请号：PCT/US2021/028834
申请日：2021-04-23
申请人： CORNELL UNIVERSITY
发明人： TUNG, Ching-Hsuan , DU, Yi-Chieh Nancy , LEE, Seung Koo , CHEN, Xiang
IPC分类号： A61P35/04 , C07K14/705 , G01N33/50 , C12N15/113 , A61K31/726 , A61K38/17 , A61K47/36 , A61K48/00
摘要： The present technology is directed to nanoparticle compositions and methods useful in treating RHAMM-positive cancers. Such nanoparticle compositions include a plurality of nanoparticles where each nanoparticle includes (i) a particle core with an outer surface; a first layer coating the outer surface of the particle core, the first layer including one or both of poly-L-lysine and poly-L-arginine and optionally including a fluorescent dye; a second layer coating the first layer, the second layer including one or more siRNA that inhibit expression of Bcl-2, inhibit expression of Bcl-xL (BCL2L1), inhibit expression of MCL1, inhibit expression of Bcl-w (BCL2L2), inhibit expression of Bcl-b (BCL2L10), and/or inhibit expression of BFL1 (BCL2A1); a third layer coating the second layer, the third layer including an apoptotic peptide and optionally including a fluorescent dye; and a fourth layer coating the third layer, the fourth layer including hyaluronic acid or a pharmaceutically acceptable salt thereof (HA); and where the plurality of nanoparticles has an intensity- weighted average diameter as determined by dynamic light scattering from about 100 nm to about 300 nm; or (ii) a particle core with an outer surface; a first layer coating the outer surface of the particle core, the first layer including an apoptotic peptide and optionally including a fluorescent dye; a second layer coating the first layer, the second layer including one or more siRNA that inhibit expression of Bcl-2, inhibit expression of Bcl-xL (BCL2L1), inhibit expression of MCL1, inhibit expression of Bcl-w (BCL2L2), inhibit expression of Bcl-b (BCL2L10), and/or inhibit expression of BFL1 (BCL2A1); a third layer coating the second layer, the third layer including one or both of poly-L-lysine and poly-L-arginine and optionally including a fluorescent dye; and a fourth layer coating the third layer, the fourth layer including hyaluronic acid or a pharmaceutically acceptable salt thereof (HA); and where the plurality of nanoparticles has an intensity-weighted average diameter as determined by dynamic light scattering from about 100 nm to about 300 nm.

10. 发明申请

WO2021202381A2 METHODS AND COMPOSITIONS FOR MODULATING LIPID STORAGE IN ADIPOSE TISSUE 审中-公开
公开(公告)号：WO2021202381A2
公开(公告)日：2021-10-07
申请号：PCT/US2021/024656
申请日：2021-03-29
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： GEISSMANN, Frederic , COX, Nehemiah
IPC分类号： A61K39/395 , A61K51/10 , A61P3/04 , A61P3/06 , A61K2039/507 , A61P35/00 , C07K16/22 , C07K16/2866 , C07K2317/75 , C07K2317/76
摘要： The present technology provides compositions and methods for the treatment of diseases associated with abnormal lipid accumulation. In some embodiments, the present technology also provides methods of treating lipodystrophy, and disorders characterized by abnormal lipid accumulation and/or lipid storage in adipose tissue.

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