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1. 发明申请

WO2018126000A1 IMPROVEMENT IN LOCOMOTOR ACTIVITY AND INCREASE IN LONGEVITY OF LATE INFANTILE NEURONAL CERIOD LIPOFUSCINOSIS SUBJECTS BY GEMFIBROZIL 审中-公开
公开(公告)号：WO2018126000A1
公开(公告)日：2018-07-05
申请号：PCT/US2017/068699
申请日：2017-12-28
申请人： RUSH UNIVERSITY MEDICAL CENTER
发明人： PAHAN, Kalipada
IPC分类号： A61K31/192 , A61K31/216
摘要： Provided herein are methods for treatment of a neurodegenerative disease, such as Late Infantile Neuronal Ceroid Lipofuscinosis, including administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of an agent comprising a fibrate.

2. 发明申请

WO2017040488A1 PREDICTION OF KIDNEY DISEASE, SEVERITY AND RELATED TREATMENT APPROACHES 审中-公开
标题翻译：儿童疾病预防，严重程度及相关治疗方法
公开(公告)号：WO2017040488A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049421
申请日：2016-08-30
申请人： RUSH UNIVERSITY MEDICAL CENTER , MASSACHUSETTS GENERAL HOSPITAL , EMORY UNIVERSITY SCHOOL OF MEDICINE
发明人： REISER, Jochen , SEVER, Sanja , QUYYUMI, Arshed, A.
IPC分类号： C07K14/705 , G01N33/50 , G01N33/68
CPC分类号： G01N33/50 , G01N33/6893 , G01N2333/972 , G01N2800/347 , G01N2800/50
摘要： Methods of treatment for subjects at risk of developing a chronic kidney disease and methods of identifying subjects at risk of developing a chronic kidney disease are provided.
摘要翻译：提供了处于发展慢性肾脏疾病风险的受试者的治疗方法和识别患有发展为慢性肾脏疾病风险的受试者的方法。

3. 发明申请

WO2016205193A1 BRAIN DERIVED PPARα LIGANDS 审中-公开
标题翻译：脑衍生PPARα配体
公开(公告)号：WO2016205193A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037365
申请日：2016-06-14
申请人： RUSH UNVERSITY MEDICAL CENTER
发明人： PAHAN, Kalipada , ROY, Avik
IPC分类号： B01D15/38 , G01N33/50 , G01N33/566
CPC分类号： G01N33/6896 , G01N33/5058 , G01N2800/2814 , G01N2800/2835
摘要： Methods of modulating peroxisome proliferator-activated receptor α (PPARα) activity in a cell in a subject In need thereof are provided. The methods include administering an effective amount of a PPARα ligand to the subject where the PPARα ligand is selected from 3-hydroxy-2,2-dimethyl butyrate (HMB), hexadecananamide (HEX) and 9-octadecenamide (OCT), Methods of treating dementia, neurodegenerative disorders, lysosomal storage diseases and body weight disorders in a subject in need thereof are provided. The methods include administering an effective amount of a PPARα ligand to the subject.
摘要翻译：在受试者的细胞中调节过氧化物酶体增殖物激活受体α（PPARα）活性的方法提供了需要。所述方法包括向受试者施用有效量的PPARα配体，其中PPARα配体选自3-羟基-2,2-二甲基丁酸酯（HMB），十六烷酰胺（HEX）和9-十八烯酰胺（OCT），治疗方法提供了有需要的受试者中的痴呆，神经变性疾病，溶酶体贮积病和体重紊乱。所述方法包括向受试者施用有效量的PPARα配体。

4. 发明申请

WO2016028986A1 FOOD/BEVERAGE VENDING MACHINE WITH ADJUSTABLE DELIVERY DELAYS 审中-公开
标题翻译：食品/饮料维修机具有可调延迟的延迟
公开(公告)号：WO2016028986A1
公开(公告)日：2016-02-25
申请号：PCT/US2015/046056
申请日：2015-08-20
申请人： RUSH UNIVERSITY MEDICAL CENTER
发明人： APPELHANS, Bradley, M.
IPC分类号： B67D1/08
CPC分类号： G07F17/0021 , G07F9/006 , G07F9/02 , G07F9/023 , G07F11/16 , G07F13/065 , G07F17/0064
摘要： A method and system for encouraging the selection of healthy products with a vending machine are provided. The method includes providing a vending machine that displays an inventory of products. Each product of the inventory of products includes a dispensing countdown time displayed on the vending machine. The method also includes receiving a first customer selection of a first product from the inventory of products, where the first product has a first dispensing countdown time. Additionally, the method includes actuating a countdown timer to count down to zero seconds from the first dispensing countdown time. The method also includes dispensing the first product once the countdown timer reaches zero seconds. The first product is only dispensed if a customer does not select a second product having a second dispensing countdown time before the first dispensing countdown time counts down to zero seconds.
摘要翻译：提供了一种鼓励使用自动售货机选择健康产品的方法和系统。该方法包括提供显示产品库存的自动售货机。产品库存的每个产品包括在自动售货机上显示的分配倒计时时间。该方法还包括从第一产品具有第一分发倒数时间的产品清单中接收第一产品的第一顾客选择。此外，该方法包括启动倒数计时器以从第一分发倒数时间向下计数至零秒。该方法还包括一旦倒数计时器达到零秒就分配第一产品。如果客户在第一个分发倒数时间倒数到零秒之前没有选择具有第二个分配倒计时时间的第二个产品，则仅发放第一个产品。

5. 发明申请

WO2016007338A1 MIGRATION-RESISTANT GASTROINTESTINAL BARRIER WITH ADHESIVE PORTION 审中-公开
标题翻译：具有粘接部分的耐移动气体阻隔器
公开(公告)号：WO2016007338A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/038744
申请日：2015-07-01
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： GITTARD, Shaun, D. , SURTI, Vihar, C.
IPC分类号： A61F2/00 , A61L27/28 , A61F2/04
CPC分类号： A61F2/0077 , A61F2/04 , A61F2/844 , A61F2/848 , A61F2/90 , A61F2002/0086 , A61F2002/044 , A61F2002/045 , A61F2220/0008 , A61F2220/005 , A61F2250/0024 , A61F2250/0025 , A61L31/022 , A61L31/04 , A61L31/12 , A61L31/14 , A61L31/146
摘要： A prosthesis and a method for securing a prosthesis at a treatment site are provided. The prosthesis includes a material portion. The material portion includes a liquid-impermeable material layer (22), a porous material layer (28) having a pore size adapted for promoting tissue ingrowth, and an adhesive portion (60) provided on the porous material layer adapted to secure the material portion to a site for at least 24 hours following implantation of the prosthesis at the site. In some embodiments, the prosthesis further includes a body (18).
摘要翻译：提供了一种用于在治疗部位固定假体的假体和方法。假体包括材料部分。所述材料部分包括液体不可渗透材料层（22），具有适于促进组织向内生长的孔径的多孔材料层（28）和设置在所述多孔材料层上的粘合剂部分（60），其适于固定所述材料部分到现场植入假体至少24小时的位置。在一些实施例中，假体还包括主体（18）。

6. 发明申请

WO2015191364A1 A FLEXIBLE MOMENT CONNECTION DEVICE FOR MAST ARM SIGNAL MOUNTING 审中-公开
标题翻译：一种用于MAST ARM信号安装的灵活连接器件
公开(公告)号：WO2015191364A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/034222
申请日：2015-06-04
申请人： TOWNSEND, Robert E., Jr.
发明人： TOWNSEND, Robert E., Jr.
IPC分类号： F16M13/02 , G08G1/09
CPC分类号： E01F9/658 , E04H12/18 , F16M13/022 , F21S8/085 , F21V21/116 , F21W2111/02 , G08G1/01 , G08G1/095 , Y10T29/49828
摘要： An attachment assembly and a method for mounting a traffic control device to a mast arm are provided. The attachment assembly includes an attachment device. The attachment device includes a first portion operably connect to the mast arm so that a first surface of the first portion is oriented toward the mast arm, a second portion extending substantially parallel to the first portion along at least a portion of a first length, a second surface of the second portion is oriented toward the traffic control device, and a third portion having a third length and extending between the first portion and the second portion so that a gap is formed between a second face of the first portion and a first face of the second portion that allows the attachment device to flex when the traffic control device is mounted to the mast arm.
摘要翻译：提供了一种用于将交通控制装置安装到桅杆臂的附接组件和方法。附件组件包括附接装置。附接装置包括可操作地连接到桅杆臂的第一部分，使得第一部分的第一表面朝向桅杆臂定向;沿着第一长度的至少一部分基本平行于第一部分延伸的第二部分，第二部分的第二表面朝向交通控制装置，并且具有第三长度并在第一部分和第二部分之间延伸的第三部分，使得在第一部分的第二面和第一面之间形成间隙的第二部分，当交通控制装置安装到桅杆臂时允许附接装置弯曲。

7. 发明申请

WO2015108958A1 THERAPEUTIC TARGET FOR MUSCULOSKELETAL INFLAMMATION 审中-公开
标题翻译：用于胶质细胞炎症的治疗目标
公开(公告)号：WO2015108958A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/011380
申请日：2015-01-14
申请人： PLAAS, Anna , WANG, Vincent , SANDY, John , BELL, Rebecca , GALANTE, Jorge , TRELLA, Katie, J.
发明人： PLAAS, Anna , WANG, Vincent , SANDY, John , BELL, Rebecca , GALANTE, Jorge , TRELLA, Katie, J.
IPC分类号： G01N33/68
CPC分类号： C12Q1/6883 , A61K38/1841 , A61K38/43 , C12Q2600/158 , G01N33/6887 , G01N2800/10 , G01N2800/52
摘要： A method for monitoring a treatment of a subject having a musculoskeletal disorder is provided. The method includes measuring a first expression level of at least two biomarkers at a treatment site prior to the treatment and measuring a second expression level of the at least two biomarkers at the treatment site after the treatment begins. The method further includes comparing the first expression level of the at least two biomarkers prior to the treatment to the second expression level of the at least two biomarkers post treatment and continuing the treatment, altering the treatment or stopping the treatment based on the comparison. A method of treating a musculoskeletal disorder in a subject is also provided. The method includes removing a aggrecan-hyaluronan matrix from a treatment site in the subject.
摘要翻译：提供了一种用于监测具有肌肉骨骼疾病的受试者的治疗方法。该方法包括在治疗之前在治疗部位测量至少两种生物标志物的第一表达水平，并且在治疗开始后测量治疗部位的至少两种生物标志物的第二表达水平。该方法还包括将治疗前的至少两种生物标志物的第一表达水平与治疗后的至少两种生物标志物的第二表达水平进行比较，并继续进行治疗，基于比较改变治疗或停止治疗。还提供了治疗受试者的肌肉骨骼疾病的方法。该方法包括从受试者的治疗部位去除聚集蛋白聚糖凝胶透明质酸基质。

8. 发明申请

WO2014066081A1 ANTI-REFLUX PROSTHESIS 审中-公开
标题翻译：防反射机制
公开(公告)号：WO2014066081A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/064780
申请日：2013-10-14
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： MCHUGO, Vincent
IPC分类号： A61F2/04 , A61F2/24
CPC分类号： A61F2/04 , A61F2/2412 , A61F2002/044 , A61F2002/045
摘要： A prosthesis (10) and a method for controlling flow through a bodily lumen in a first direction and a second direction are provided. The prosthesis includes a body (12) having a proximal portion (14), a distal portion (16) and a body lumen (18) extending therethrough. The prosthesis also includes a first valve (24) for controlling flow through the body lumen in a first direction where the first valve forms a first opening (21) in the prosthesis. The prosthesis includes a second valve (28) for controlling flow through the body lumen in a second direction where the second valve includes a portion that contacts the body in a closed configuration and the portion is spaced apart from the body in an open configuration to form a second opening (49). The first opening is positioned apart from the second opening and the second opening opens in response to a higher pressure than the first opening.
摘要翻译：提供了假体（10）和用于控制沿着第一方向和第二方向通过身体腔的流动的方法。假体包括具有近端部分（14），远侧部分（16）和延伸穿过其的体腔（18）的主体（12）。假体还包括第一阀（24），用于在第一方向上控制通过体腔的流动，其中第一阀在假体中形成第一开口（21）。假体包括用于控制在第二方向上流过体腔的第二阀（28），其中第二阀包括以闭合构型接触身体的部分，并且该部分以开放构型与主体间隔开以形成第二开口（49）。第一开口定位成与第二开口分开，第二开口响应于比第一开口更高的压力打开。

9. 发明申请

WO2013163283A2 ANTI-ASPIRATION PROSTHESIS 审中-公开
标题翻译：反兴奋剂
公开(公告)号：WO2013163283A2
公开(公告)日：2013-10-31
申请号：PCT/US2013/037965
申请日：2013-04-24
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： LIDDY, Alison , RYAN, Michael , TREACY, Gerard , HOULIHAN, Ger , LAVELLE, Shay, Joseph , NEILAN, John , MCHUGO, Vincent
IPC分类号： A61F2/24
CPC分类号： A61F2/04 , A61F2/2412 , A61F2/2415 , A61F2/88 , A61F2002/044 , A61F2220/0091 , A61F2230/0013 , A61F2230/0078 , A61F2230/0091
摘要： A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.
摘要翻译：提供了一种假体和制造用于控制通过体腔的流动的假体的方法。假体包括具有近端部分，远侧部分和延伸通过其的内腔的主体。假体还包括可操作地连接到身体的阀。瓣膜具有近端部分，远端部分和延伸穿过瓣膜的内腔，其中阀腔连接到体腔。阀被配置为在没有顺行压力和逆行压力的情况下关闭，逆行压力大于顺行压力。所述阀包括可操作地连接到所述阀的材料部分，所述材料部分相对于所述阀单独地为所述阀提供增加的刚度，其中所述材料部分构造成促进所述阀自动回复到所述关闭构型。

10. 发明申请

WO2013103796A1 ATTACHMENT DEVICE FOR TISSUE APPROXIMATION AND RETRACTION 审中-公开
标题翻译：用于组织近似和退缩的附件装置
公开(公告)号：WO2013103796A1
公开(公告)日：2013-07-11
申请号：PCT/US2013/020258
申请日：2013-01-04
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： CHANG, Kenneth J. , CHMURA, Kevin , DUCHARME, Richard W. , MCLAWHORN, Tyler E.
IPC分类号： A61B17/00 , A61B17/04
CPC分类号： A61B17/0401 , A61B17/0057 , A61B17/0483 , A61B2017/00336 , A61B2017/00477 , A61B2017/00663 , A61B2017/0409 , A61B2017/0441 , A61B2017/0464
摘要： An attachment system for tissue apposition or manipulation and a method of attaching a suture to a tissue for apposition or manipulation of the tissue are provided. The system includes an attachment device (10) including a body (12) having a proximal portion (14) and a distal portion (16). The attachment device further includes a tissue attachment portion (18) operably connected to the distal portion wherein the tissue attachment portion has a shape that is maintained throughout a tissue apposition procedure. The attachment device also includes a suture (22) operably connected to the body and having an unconnected proximal end (25) and a retaining structure (26) at the proximal portion of the body. The retaining structure configured to releasably mate with a complementary retaining structure (32) on a stylet (36).
摘要翻译：提供了用于组织结合或操作的附接系统以及将缝合线附着到组织上用于组织或操纵组织的方法。该系统包括附接装置（10），其包括具有近端部分（14）和远端部分（16）的主体（12）。附接装置还包括可操作地连接到远端部分的组织附接部分（18），其中组织附着部分具有整个组织安置过程中保持的形状。附接装置还包括可操作地连接到主体并且具有在主体的近端部分处的未连接的近端（25）和保持结构（26）的缝合线（22）。所述保持结构构造成可与探针（36）上的互补的保持结构（32）可释放地配合。

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