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1. 发明申请

WO2012040223A2 METHOD FOR TREATING NON-ALCOHOLIC FATTY LIVER DISEASE AND TYPE-II DIABETES 审中-公开
标题翻译：用于治疗非酒精性脂肪肝和II型糖尿病的方法
公开(公告)号：WO2012040223A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052390
申请日：2011-09-20
申请人： NORTH CAROLINA CENTRAL UNIVERSITY , SEXTON, Jonathan, Z. , BRENMAN, Jay
发明人： SEXTON, Jonathan, Z. , BRENMAN, Jay
IPC分类号： C12Q1/00
CPC分类号： G01N33/92 , C12N5/067 , C12Q1/6897 , G01N33/5067 , G01N2800/042 , G01N2800/08
摘要： This relates generally to compounds that can be used to treat nonalcoholic fatty liver disease and type II diabetes and an assay for identifying the compounds. The invention also relates to an assay that can be used to identify compounds that increase cellular peroxisomal mass.
摘要翻译：这通常涉及可用于治疗非酒精性脂肪肝疾病和II型糖尿病的化合物和用于鉴定化合物的测定法。本发明还涉及可用于鉴定增加细胞过氧化物酶体质量的化合物的测定法。

2. 发明申请

WO2005017079A1 PROCESS FOR THE PURIFICATION OF NON-IONIC SOLVANTS FOR STABILIZED INJECTABLE PHARMACEUTICAL FORMULAITONS 审中-公开
标题翻译：用于稳定的可注射药物制剂的非离子溶剂的纯化方法
公开(公告)号：WO2005017079A1
公开(公告)日：2005-02-24
申请号：PCT/US2003/023243
申请日：2003-07-24
申请人： DABUR RESEARCH FOUNDATION , CORD, Janet, I. , BURMAN, Anand, C. , MUKHERJEE, Rama , KUMAR, Dinesh , KHATTAR, Dhiraj , KHULLER, Praveen , SRINIVASAN, PS , SRIVASTAVA, Rajesh
发明人： BURMAN, Anand, C. , MUKHERJEE, Rama , KUMAR, Dinesh , KHATTAR, Dhiraj , KHULLER, Praveen , SRINIVASAN, PS , SRIVASTAVA, Rajesh
IPC分类号： C11B3/00
CPC分类号： A61K9/0019 , A61K47/44
摘要： A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.
摘要翻译：公开了一种稳定的抗癌药物和溶剂，如聚乙氧基化蓖麻油（cremophor）的药物组合物，其还含有适于人类给药的任何其它合适的增溶剂如脱水醇。使用该纯化的聚乙氧基化蓖麻油制备的组合物增强紫杉醇在这些组合物中的稳定性。

3. 发明申请

WO2004050647A3 POLYMORPHIC FORMS OF DIHYDROCHLORIDE SALTS OF CETIRIZINE AND PROCESSES FOR PREPARATION THEREOF 审中-公开
公开(公告)号：WO2004050647A3
公开(公告)日：2004-06-17
申请号：PCT/US2003/038494
申请日：2003-12-04
申请人： DR. REDDY'S LABORATORIES LIMITED , DR. REDDY'S LABORATORIES, INC. , REDDY, Manne, Satyanarayana , SRINIVASAN, Thirumalai, Rajan , UPPALA, Venkata, Bhaskara, Rao , VADDADI, Pattabhi, Ramayya , JOGA, Rajender
发明人： REDDY, Manne, Satyanarayana , SRINIVASAN, Thirumalai, Rajan , UPPALA, Venkata, Bhaskara, Rao , VADDADI, Pattabhi, Ramayya , JOGA, Rajender
IPC分类号： C07D295/08
摘要： The present invention relates to crystalline and amorphous forms of dextrorotatory dihydrochloride salt of cetirizine, the process for the preparation thereof and compositions containing the same. The invention also relates to the crystalline and amorphous forms of levorotatory dihydrochloride salt of cetirizine, the process for the preparation thereof and compositions containing the same. Both crystalline and amorphous salt forms of cetirizine dihydrochloride are suitable for pharmaceutical purposes in the treatment of allergies, including ailments such as chronic and acute allergic rhinitis, allergic conjunctivitis, pruritus, urticaria and the like.

4. 发明申请

WO2004020436A1 AMORPHOUS HYDRATES OF ESOMEPRAZOLE MAGNESIUM AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：异辛酸镁的非晶态水合物及其制备方法
公开(公告)号：WO2004020436A1
公开(公告)日：2004-03-11
申请号：PCT/US2003/027177
申请日：2003-08-28
申请人： REDDY'S LABORATORIES LIMITED , REDDY'S LABORATORIES, INC. , REDDY, Manne, Satyanarayana , KUMAR, Muppa, Kishore , PURANDHAR, Koilkonda , SREENATH, Keshaboina
发明人： REDDY, Manne, Satyanarayana , KUMAR, Muppa, Kishore , PURANDHAR, Koilkonda , SREENATH, Keshaboina
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , A61K31/44
摘要： A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the form of an amorphous solid are also provided.
摘要翻译：提供了非晶体固体形式的艾美拉唑镁的水合物。还提供了制备和使用含有非晶形固体形式的艾美拉唑镁水合物的方法。

5. 发明申请

WO2004020396A1 CRYSTALLINE FORM OF NATEGLINIDE AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译： N-甲基吡咯烷的结晶形式及其制备方法
公开(公告)号：WO2004020396A1
公开(公告)日：2004-03-11
申请号：PCT/US2003/026880
申请日：2003-08-27
申请人： DR. REDDY'S LABORATORIES LIMITED , DR. REDDY'S LABORATORIES, INC. , REGURI, Buchi, Reddy , KADABOINA, Rajasekhar , POLAVARAPU, Srinivas
发明人： REGURI, Buchi, Reddy , KADABOINA, Rajasekhar , POLAVARAPU, Srinivas
IPC分类号： C07C233/63
CPC分类号： C07C271/34 , C07B2200/13 , C07C2601/14
摘要： A new crystalline form of nateglinide (N-(trans-4-isopropylcyclohexanecarbonyl)D-phenylalanine) is provided. The new crystalline form is described by X-ray owder diffraction. Process for making the new crystalline form of nateglinide a e also provided.
摘要翻译：提供那格列奈（N-（反式-4-异丙基环己烷羰基）D-苯丙氨酸）的新结晶形式。通过X射线衍射描述新的结晶形式。还提供了制备奈格列奈新结晶形式的方法。

6. 发明申请

WO2003104212A1 A NOVEL AMORPHOUS FORM OF [2-[4-[(4-CHLOROPHENYL)-PHENYL METHYL]-1- PIPERAZINYL] ETHOXY] ACETIC ACID DIHYDROCHLORIDE (CETIRIZINE DIHYDROCHLORIDE) 审中-公开
标题翻译： [2- [4 - [（4-氯苯基） - 苯基] -1-哌嗪基]乙氧基]乙酸二氢氯化物（二苯并二恶英）的新型不对称形式
公开(公告)号：WO2003104212A1
公开(公告)日：2003-12-18
申请号：PCT/US2003/017600
申请日：2003-06-04
申请人： DR.REDDY'S LABORATORIES LTD. , DR.REDDY'S LABORATORIES, INC. , REDDY, Manne, Satyanarayana , RAJAN, Srinivasan, Thirumalai , SHANKAR, Ranga, Ravi , VARDHAN, Sunkara, Vishnu
发明人： REDDY, Manne, Satyanarayana , RAJAN, Srinivasan, Thirumalai , SHANKAR, Ranga, Ravi , VARDHAN, Sunkara, Vishnu
IPC分类号： C07D295/08
CPC分类号： C07D295/088
摘要： The present invention relates to a novel amorphous form of [2-[4-[(4-Chlorophenyl)-phenyl methyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride suitable for pharmaceutical formulations and process for the preparation thereof.
摘要翻译：本发明涉及适用于药物制剂的新型无定形形式的[2- [4 - [（4-氯苯基） - 苯基甲基] -1-哌嗪基]乙氧基]乙酸二盐酸盐及其制备方法。

7. 发明申请

WO2003082858A1 CRYSTALLINE FORMS OF RABEPRAZOLE SODIUM 审中-公开
标题翻译：吡虫啉钠的结晶形式
公开(公告)号：WO2003082858A1
公开(公告)日：2003-10-09
申请号：PCT/US2003/009307
申请日：2003-03-25
申请人： DR. REDDY'S LABORATORIES LIMITED , CORD, Janet, I. , REDDY, Manne, Satyanarayana , ESWARAIAH, Sajja , BOLUGODDU, Vijaya, Bhaskar , PINGILI, Ramchandra, Reddy , GANTA, Madhusudhan, Reddy
发明人： REDDY, Manne, Satyanarayana , ESWARAIAH, Sajja , BOLUGODDU, Vijaya, Bhaskar , PINGILI, Ramchandra, Reddy , GANTA, Madhusudhan, Reddy
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention relates to novel polymorphic forms of Rabeprazole sodium. The present invention also relates to methods of making polymorphic forms of Rabeprazole sodium. Achiphex7 (Rabeprazole sodium) is an inhibitor of the gastric proton pump. It causes dose-dependant inhibition of acid secretion and is useful as an antiulcer agent. The chemical designation of Rabeprazole sodium is 2-[[[4-(3-methoxypropoxy)-3 methyl-2-pyridinyl]-methyl] sulfinyl]-1 H -benzimidazole sodium. It may be represented by Formula (1).
摘要翻译：本发明涉及雷贝拉唑钠的新型多晶型物。本发明还涉及制备雷贝拉唑钠的多晶型物的方法。 Achiphex7（雷贝拉唑钠）是胃质子泵的抑制剂。它导致酸分泌的剂量依赖性抑制，并且可用作抗溃疡剂。雷贝拉唑钠的化学名称是2 - [[[4-（3-甲氧基丙氧基）-3-甲基-2-吡啶基] - 甲基]亚磺酰基] -1H-苯并咪唑钠。它可以由公式（1）表示。

8. 发明申请

WO2003002203A1 PEPTIDE COMBINATION FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的肽组合
公开(公告)号：WO2003002203A1
公开(公告)日：2003-01-09
申请号：PCT/US2001/020775
申请日：2001-06-29
申请人： DABUR ONCOLOGY PLC , CORD, Jenet, I. , BURMAN, Anand, C. , MUKHERJEE, Rama , PRASAD, Sudhanand , JAGGI, Manu , SINGH, Anu, T.
发明人： BURMAN, Anand, C. , MUKHERJEE, Rama , PRASAD, Sudhanand , JAGGI, Manu , SINGH, Anu, T.
IPC分类号： A61P35/00
CPC分类号： A61K38/10 , A61K38/08 , A61K2300/00
摘要： The present invention relates to a combination of peptides that may be used for treatment of cancer. The combination of peptides modulates multiple cellular pathways implicated in cell proliferation by altering the levels of key intracellular molecules thereby showing a broad spectrum of anticancer activity. The invention also relates to a pharmaceutical composition containing a combination of such peptide analogs.
摘要翻译：本发明涉及可用于治疗癌症的肽的组合。肽的组合通过改变关键细胞内分子的水平从而显示广谱的抗癌活性来调节与细胞增殖相关的多种细胞途径。本发明还涉及含有这些肽类似物的组合的药物组合物。

9. 发明申请

WO2015073882A1 ELECTRORESPONSIVE TECHNOLOGY 审中-公开
标题翻译：电子科技
公开(公告)号：WO2015073882A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065791
申请日：2014-11-14
申请人： NORTH CAROLINA CENTRAL UNIVERSITY
发明人： TAYLOR, Darlene K. , BALAMI, Uddhav
IPC分类号： C07C309/43 , C07C39/15 , G01N27/10
CPC分类号： C08F12/30 , C07C17/16 , C07C29/147 , C07C43/23 , C07C2603/90 , C08F8/36 , C08F12/22 , C08F12/32 , G01N27/3277 , G01N27/3335 , C07C33/20 , C07C22/04
摘要： A styrene based water soluble polymer containing pendant sulfonated calix[4]arene groups has been synthesized by using free radical polymerization combined with post-polymerization sulfonation chemistry. The monomer 25-(4-vinylbenzyl)-26, 27, 28-hydroxy-calix[4]arene was prepared in 3 steps: (1) reduction of 4-vinyl benzoic acid to the respective alcohol (2) formation of the bromide by the Appel reaction and (3) synthesis of the respective ether by Williamson O-alkylation reaction with calix[4]arene. Polymerization was accomplished by azobisisobutyronitrile (AIBN) initiated free radical polymerization technique. Electro-responsive properties of the sulfonated polymer were studied wherein a response to electrochemical stimulus is observed when guest molecules of methyl viologen are incorporated with polymerized 25-(4-vinylbenzy1)-26, 27, 28-hydroxy-calix[4]arene.
摘要翻译：通过与后聚合磺化化学结合使用自由基聚合，合成了含有侧链磺化杯[4]芳烃基的苯乙烯基水溶性聚合物。单体25-（4-乙烯基苄基）-26,27,28-羟基 - 杯[4]芳烃分三个步骤制备：（1）将4-乙烯基苯甲酸还原成相应的醇（2）溴化物的形成通过Appel反应和（3）通过与杯[4]芳烃的Williamson O-烷基化反应合成各自的醚。聚合由偶氮二异丁腈（AIBN）引发的自由基聚合技术完成。研究了磺化聚合物的电响应性质，其中当甲基紫精的客体分子与聚合的25-（4-乙烯基苯基）-26,27,28-羟基 - 杯[4]芳烃结合时，观察到对电化学刺激的响应。

10. 发明申请

WO2011091209A1 SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 审中-公开
标题翻译： MICRORNA MIR-122的小分子改良剂
公开(公告)号：WO2011091209A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/021976
申请日：2011-01-21
申请人： NORTH CAROLINA STATE UNIVERSITY , DEITERS, Alexander , YOUNG, Douglas, D.
发明人： DEITERS, Alexander , YOUNG, Douglas, D.
IPC分类号： A01N43/00 , A61K31/33
CPC分类号： A61K31/47 , A61K31/04
摘要： MicroRNAs are a class of endogenous regulators of gene function. Aberrant regulation of microRNAs has been linked to various human diseases, most importantly cancer. Small molecule intervention of microRNA misregulation has the potential to provide new therapeutic approaches to such diseases. microRNA miR-122 is the most abundant microRNA in the liver and is involved in hepatocellular carcinoma development and hepatitis C virus (HCV) infection. Small molecule inhibitors and activators of the microRNA miR-122 are described, and methods for their identification are reported. These small molecule inhibitors reduce viral replication in liver cells and thus represent a new approach to the treatment of HCV infections. Moreover, small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, and thus has implications in cancer chemotherapy.
摘要翻译： MicroRNA是一类基因功能的内源性调控因子。微小RNA的异常调节与各种人类疾病有关，最重要的是癌症。小分子干扰microRNA的失调有可能为这些疾病提供新的治疗方法。 microRNA miR-122是肝脏中最丰富的microRNA，涉及肝细胞癌发展和丙型肝炎病毒（HCV）感染。描述了微小RNA miR-122的小分子抑制剂和活化剂，并报道了其鉴定方法。这些小分子抑制剂减少肝细胞中的病毒复制，因此代表了治疗HCV感染的新方法。此外，肝癌细胞中miR-122的小分子激活通过半胱天冬酶活化选择性诱导凋亡，因此在癌症化疗中具有意义。

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