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1. 发明申请

WO2009137275A1 FUNCTIONALIZED SUBSTRATES WITH ION-EXCHANGE PROPERTIES 审中-公开
标题翻译：具有离子交换特性的功能化基底
公开(公告)号：WO2009137275A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/041563
申请日：2009-04-23
申请人： DIONEX CORPORATION , LIU, Xiaodong , POHL, Christopher, A. , CHEN, Jinhua , WOODRUFF, L., Andy
发明人： LIU, Xiaodong , POHL, Christopher, A. , CHEN, Jinhua , WOODRUFF, L., Andy
IPC分类号： B01D15/36 , B01J20/287 , B01J43/00
CPC分类号： B01D15/362 , B01D15/325 , B01D15/361 , B01D15/363 , B01D15/3847 , B01J20/28097 , B01J20/3221 , B01J20/3285 , B01J20/3295 , B01J39/26 , B01J43/00 , B01J41/20
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by "interior walls". To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.
摘要翻译：本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。组合物包括具有由“内壁”限定的外表面和孔开口的多孔固体支持物（例如硅胶，二氧化硅整料或合成有机树脂）。固体支持物是共价结合的有机离子交换配体（例如，甲硅烷基配体），其结合至少一个离子交换基团（例如离子或可离子化基团）。组合物还包括结合离子交换基团的微粒（例如胶乳颗粒），其具有与载体上发现的电荷相反的电荷。微粒子结合到支撑体的外表面（例如通过静电力）。微粒具有足以使能够进入载体的孔的颗粒数量最小化的尺寸，从而减少或基本上防止微粒与孔内壁的结合。虽然孔对于微粒基本上太小，但是它们仍然可以通过色谱样品中存在的分析物进行访问。分别位于孔和微粒表面之间的离子交换基团的物理分离防止相反电荷基团之间的反应（例如，形成盐桥），并提供具有阴离子交换和阳离子交换的组合物，交换能力在同一个固定阶段。与固体支持物结合的配体可以任选地包括产生多模态（例如，三峰）固定相的另外的（例如反相）官能团。

2. 发明申请

WO2008060780A2 GLYCEROL LINKED PEGYLATED SUGARS AND GLYCOPEPTIDES 审中-公开
标题翻译：甘油连接的聚乙二醇和糖蛋白
公开(公告)号：WO2008060780A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/080471
申请日：2007-10-04
申请人： NEOSE TECHNOLOGIES, INC. , DEFREES, Shawn , ZENG, Xiao
发明人： DEFREES, Shawn , ZENG, Xiao
IPC分类号： C07K14/00 , C07K14/755 , C07K14/51 , C07K14/745 , C07K14/52 , C07K16/00 , C07K14/54
CPC分类号： C12N9/96 , A61K38/4846 , A61K47/549 , A61K47/60 , C12N9/6437 , C12Y304/21021 , C12Y304/21022
摘要： The present invention provides conjugates between peptides and PEG moieties through glycerol linkers.
摘要翻译：本发明通过甘油接头提供肽和PEG部分之间的缀合物。

3. 发明申请

WO2008036486A1 MEMBRANE SUPPRESSOR WITH AN OUTLET SUBSTANTIALLY NON-RETENTIVE FOR IONIC SPECIES 审中-公开
标题翻译：具有出口的膜抑制剂对于离子物质具有非常重要的作用
公开(公告)号：WO2008036486A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/076211
申请日：2007-08-17
申请人： DIONEX CORPORATION , LIU, Yan , BARRETO, Victor , POHL, Christopher, A.
发明人： LIU, Yan , BARRETO, Victor , POHL, Christopher, A.
IPC分类号： G01N30/02
CPC分类号： G01N30/96 , G01N2030/965
摘要： An apparatus for ion chromatography comprising a suppressor comprising a housing and a liquid conduit segment disposed in the housing, the liquid conduit segment including a membrane, the membrane having an inlet section adjacent the inlet of the conduit segment and an outlet section adjacent the outlet of the conduit segment, the inlet section having ion exchange sites capable of transmitting ions of one charge, positive or negative, and the outlet section being substantially non-retentive electrostatically for charged ionic species. Also, the method of using the apparatus.
摘要翻译：一种用于离子色谱的装置，包括抑制器，其包括壳体和设置在壳体中的液体导管段，液体导管段包括膜，所述膜具有邻近导管段入口的入口部分和邻近出口的出口部分导管部分，入口部分具有能够传输一个电荷的离子的正离子或负离子的离子交换位置，并且对于带电离子物质，出口部分静电地基本上是非保持性的。另外，使用该装置的方法。

4. 发明申请

WO2007134114A2 PRECISION FOLDED STRUCTURAL AND AESTHETIC COMPONENT AND SHEET THEREFOR 审中-公开
标题翻译：精密折叠结构和美观组件及其片
公开(公告)号：WO2007134114A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068578
申请日：2007-05-09
申请人： INDUSTRIAL ORIGAMI, INC. , DURNEY, Max, W.
发明人： DURNEY, Max, W.
IPC分类号： A61B18/04
CPC分类号： B21D11/20 , B62D25/14
摘要： A sheet material is provided for forming a precision folded structural and aesthetic component of a contoured three-dimension. The sheet material may include a forward-panel bend line separating a forward panel and a fold panel, the forward-panel bend line may be curved to impart contour on at least the fold panel upon bending of the sheet material about the forward-panel bend line, and a fold line extending along the fold panel, the fold line may be substantially straight to impart the contour of the fold panel to the upper panel upon bending of the sheet material about the fold line. The sheet material may include an upper panel, a first upper-panel-flange bend line separating a forward upper flange from a warp zone of the upper panel, the first upper-panel-flange bend line may be curved to impart a first contour on one or more of the first upper flange and the warp zone, a second upper-panel-flange bend line separating a second upper flange from the warp zone, the second upper-panel-flange bend line may be curved to impart a second contour on one or more of the second upper flange and the warp zone, and first and second curved warp zone bend lines separating the warp zone from a remainder of the upper panel, the first and second curved warp zone bend lines configured to localize bending along the bend line and substantially isolate warpage within the warp zone. A method of forming the same is also disclosed.
摘要翻译：提供了用于形成轮廓三维的精确折叠结构和美学部件的片材。片材可以包括分离前面板和折叠面板的前面板弯曲线，前面板弯曲线可以弯曲，以在片材围绕前面板弯曲部弯曲时在至少折叠面板上赋予轮廓线和折叠线沿着折叠板延伸，折叠线可以是基本上直的，以便在折叠线周围的片材弯曲时将折叠面板的轮廓赋予上面板。片材可以包括上板，将前上凸缘与上板的经向区域分开的第一上板 - 法兰弯曲线，第一上板 - 法兰弯曲线可以弯曲以赋予第一轮廓所述第一上凸缘和所述经向区域中的一个或多个，将所述第二上凸缘与所述经向区域分隔开的第二上板 - 凸缘弯曲线，所述第二上板 - 凸缘弯曲线可以是弯曲的，以将第二轮廓赋予所述第二上凸缘和所述经向区域中的一个或多个以及将所述经向区域与所述上面板的其余部分分开的第一和第二弯曲经线区域弯曲线，所述第一和第二弯曲经线区域弯曲线被配置为沿着所述弯曲部定位弯曲并且基本上隔离翘曲区域内的翘曲。还公开了一种其形成方法。

5. 发明申请

WO2007115305A3 ORAL DOSAGE FORMS INCLUDING AN ANTIPLATELET AGENT AND AN ACID INHIBITOR 审中-公开
公开(公告)号：WO2007115305A3
公开(公告)日：2007-10-11
申请号：PCT/US2007/065967
申请日：2007-04-04
申请人： COGENTUS PHARMACEUTICALS, INC. , GOLDSMITH, Mark, A. , VADAS, Elizabeth
发明人： GOLDSMITH, Mark, A. , VADAS, Elizabeth
IPC分类号： A61K9/48 , A61K9/20
摘要： The present disclosure provides oral dosage forms comprising an antiplatelet agent and an acid inhibitor, as well as methods of treating subjects with an antiplatelet agent and an acid inhibitor.

6. 发明申请

WO2007056166A3 SEAT ASSEMBLY WITH MOVABLE SEAT AND BACKREST AND METHOD 审中-公开
公开(公告)号：WO2007056166A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/042997
申请日：2006-11-03
申请人： SERBER, Hector
发明人： SERBER, Hector
IPC分类号： B60N2/42
摘要： A seat assembly (21) for a vehicle including a seat (22), a seat mounting assembly (20) mounting the seat (22) for movement along an upwardly concaved arcuate path, a backrest (25) assembly with a backrest member (23) having a lower portion (18) coupled for arcuate motion with the seat (22) and an upper portion (99) mounted for movement in a vertically extending direction. The backrest assembly (25) further includes a recliner mechanism (32, 33). A method of providing a seat assembly also is disclosed including the steps of mounting the seat (22) for movement along an upwardly arcuate path, mounting the backrest (25) proximate the seat, coupling a lower portion (18) of the backrest for movement with the seat (22) and mounting the upper portion (99) of the backrest for vertically extending movement.

7. 发明申请

WO2007035459A1 AGGLOMERATED ION EXCHANGE PARTICLE BED AND METHOD 审中-公开
标题翻译：聚合离子交换粒子和方法
公开(公告)号：WO2007035459A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/035956
申请日：2006-09-14
申请人： DIONEX CORPORATION , POHL, Christopher, A. , CHARANJIT, Saini
发明人： POHL, Christopher, A. , CHARANJIT, Saini
IPC分类号： B01J47/00 , B01D15/36
CPC分类号： B01D15/361 , B01J20/3221 , B01J39/26 , B01J41/20 , B01J47/016
摘要： A liquid chromatography agglomerated bed comprising component A comprising (a) substrate particles and polymer chains (e.g. a condensation polymer) bound to the substrate particles and projecting therefrom, and (b) component B comprising substrate particles having external surfaces of opposite charge to that of the charged polymer chains, components A and B being bound at least in part by electrostatic forces between the component A charged polymer chains and the component B external surfaces to form in composite an agglomerated bed of ion exchange particles packed in a chromatography column.
摘要翻译：包含组分A的液相色谱附聚床包含（a）底物颗粒和与基底颗粒结合并从其中突出的聚合物链（例如缩合聚合物），和（b）组分B，其包含具有与带电聚合物链，组分A和B至少部分地由组分A带电的聚合物链和组分B外表面之间的静电力结合，以形成填充在色谱柱中的离子交换颗粒的聚集床。

8. 发明申请

WO2007035346A1 RECYCLING OF SUPPRESSOR REGENERANTS 审中-公开
标题翻译：抑制剂再生剂的回收
公开(公告)号：WO2007035346A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/035628
申请日：2006-09-13
申请人： DIONEX CORPORATION , LIU, Yan , BARRETO, Victor, Manuel, Berber , POHL, Christopher, A. , RIVIELLO, John, M.
发明人： LIU, Yan , BARRETO, Victor, Manuel, Berber , POHL, Christopher, A. , RIVIELLO, John, M.
IPC分类号： G01N30/96
CPC分类号： G01N30/96 , G01N2030/965
摘要： A suppressed ion chromatographic apparatus using a regenerant recycle loop, comprising (a) an ion separation device (34) , (b) a membrane suppressor (36) , (c) a detector (38) , (d) a container for regenerant solution (40) , (e) a first conduit between the ion separation device and the suppressor, (f) a second conduit between the regenerant solution container and the suppressor, (g) a third conduit between the suppressor and the regenerant solution container, and (h) a regenerant solution recycle loop out of fluid communication with the detector outlet.
摘要翻译：一种使用再生剂循环回路的抑制离子色谱装置，包括（a）离子分离装置（34），（b）膜抑制剂（36），（c）检测器（38），（d）再生剂溶液容器（40），（e）离子分离装置和抑制器之间的第一导管，（f）再生剂溶液容器和抑制器之间的第二导管，（g）抑制器和再生剂溶液容器之间的第三导管，以及（h）与检测器出口流体连通的再生剂溶液循环回路。

9. 发明申请

WO2006110898A2 JOINERY MEMBER AND FASTENER AND PROCESS AND APPARATUS FOR PLACEMENT OF THE FASTENER 审中-公开
标题翻译：联合会员和紧固件及其紧固件的安装和装置
公开(公告)号：WO2006110898A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/014118
申请日：2006-04-12
申请人： CASTLE, INC. , DURNEY, Max W.
发明人： DURNEY, Max W.
IPC分类号： B27D1/00
CPC分类号： B27M1/08 , F16B5/0291 , F16B25/0015 , F16B25/0068 , F16B25/10 , F16B35/041 , F16B35/06 , Y10T408/352 , Y10T409/30756
摘要： A ready-to-use pocket joinery assembly is manufactured by first forming a fastener pocket in a surface of a joinery member near to and spaced from an end of the joinery member. Subsequently, one propels a fastener having a tip or point into the fastener pocket to impact and engage a fastener pocket end, which is opposite the end of the joinery member. In preferred embodiments having a bore, a fastener point does not impact the fastener pocket end. Rather, a shank portion of the fastener impacts a fastener pocket end around the bore. In preferred embodiments without a bore, a fastener point does impact the fastener pocket end because there is no bore opening. Finally, to a greater or lesser extent across a range of embodiments, one drives the fastener to a stable, engaged position wherein the fastener point or tip is intermediate between the fastener pocket and the end of the joinery member. The result, in preferred embodiments having a bore and in preferred embodiments without a bore, is a joinery assembly with a joinery member and an embedded fastener.
摘要翻译：通过首先在细型构件的表面上形成靠近并与细长型构件的端部间隔开的紧固件口袋来制造即用型口袋细木工组件。随后，一个推进具有尖端或尖端的紧固件进入紧固件口袋，以冲击和接合与细长部件的端部相对的紧固件口袋端部。在具有孔的优选实施例中，紧固件点不会冲击紧固件袋端。相反，紧固件的柄部分围绕孔冲击紧固件口袋端部。在没有孔的优选实施例中，由于没有孔开口，紧固件点确实冲击紧固件袋端部。最后，在一系列实施例中，或多或少的程度，将紧固件驱动到稳定的接合位置，其中紧固件口或尖端位于紧固件口袋和细长型件的端部之间。结果，在具有孔的优选实施例中，在没有孔的优选实施例中，是具有细长构件和嵌入式紧固件的细木工装置。

10. 发明申请

WO2006057844A3 CARD GUIDE FOR MOUNTING PRINTED CIRCUIT BOARDS AND THE LIKE TO ELECTRONIC EQUIPMENT HOUSINGS 审中-公开
公开(公告)号：WO2006057844A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/041160
申请日：2005-11-09
申请人： INDUSTRIAL ORIGAMI, LLC , DURNEY, Max, W. , CARDONA, Joseph, C. , LAM, Chien (Ryan) , SHNOEBELEN, William, H.
发明人： DURNEY, Max, W. , CARDONA, Joseph, C. , LAM, Chien (Ryan) , SHNOEBELEN, William, H.
IPC分类号： A47G19/08 , H05K7/14
摘要： A card guide (111) for mounting printed circuit boards, electronic pathway or component carrying cards, or the like, to an electronic equipment housing (fig.11) having a wall (116) with a pair of opening (117) formed to receive mounting feet (118) provided on the card guide (111). The card guide body (111) includes a card-receiving guideway (112) on an inwardly facing side of the body and a card mounting structure (113) on the outwardly facing side of the body. The card mounting structure (113) preferably includes L-shaped posts or feet having longitudinally extending portions which enable the card guide (111) to be inserted through an opening (117) in a housing wall (116) to a position in which the L-shaped feet interlock with the housing wall adjacent to the openings. Most preferably the card guide body (111) is resiliently flexible and can be bowed to allow insertion into pairs of mounting openings and will spring back once inserted to secure the card guide (111) to the housing wall. Embodiments suitable for mounting the card guide (111) to a single housing wall (116) or a sandwich of two abutting housing walls are disclosed.

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