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1. 发明申请

WO2021158954A1 NITRIC OXIDE-RELEASING ANTIBACTERIAL COMPOUNDS, FORMULATIONS, AND METHODS PERTAINING THERETO 审中-公开
公开(公告)号：WO2021158954A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/016869
申请日：2021-02-05
申请人： KNOW BIO, LLC
发明人： FOLK, Drew , ANDERSON, Ryan Gerald , SIMONS, John Kelly , AHONEN, Mona Jasmine Rosales , MCDONALD, Rebecca Anthouard
IPC分类号： A01N65/03 , A61K31/734 , A61P11/12
摘要： Methods of treating baldness, fibrotic disease, cancer and other pathological conditions resulting from abnormal cell proliferation, cardiovascular disease, metabolic syndrome, central nervous system disorders, platelet aggregation, platelet adhesion, disease caused by or characterized by low nitric oxide levels, transplantation rejections, autoimmune diseases, inflammation, vascular diseases, restenosis, pain, fever, gastrointestinal disorders, respiratory disorders, and sexual dysfunctions are disclosed. The methods involve administering specific nitric oxide-releasing compounds.

2. 发明申请

WO2021158930A1 NITRIC OXIDE-RELEASING ANTIBACTERIAL COMPOUNDS, FORMULATIONS, AND METHODS PERTAINING THERETO 审中-公开
公开(公告)号：WO2021158930A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/016841
申请日：2021-02-05
申请人： KNOW BIO, LLC
发明人： FOLK, Drew , ANDERSON, Ryan Gerald , SIMONS, John Kelly , AHONEN, Mona Jasmine Rosales , MCDONALD, Rebecca Anthouard
IPC分类号： A01N65/03 , A61K31/734 , A61P11/12
摘要： Methods of sanitizing, disinfecting, decontaminating, and/or sterilizing surfaces with small molecule NO releasing compounds are disclosed. In some embodiments, the compounds are covalently modified to store and release nitric oxide. The compounds may be tailored to release nitric oxide in a controlled manner and can be useful, for example, for preventing the spread of microbial infections, such as nocosomial infections.

3. 发明申请

WO2019213584A1 MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS 审中-公开
公开(公告)号：WO2019213584A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030680
申请日：2019-05-03
申请人： EMORY UNIVERSITY , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
发明人： SCHINAZI, Raymond, F. , COX, Bryan , CHAI, Chofit , GILADI, Hilla , GALUN, Eithan , AMBLARD, Franck
IPC分类号： A61K31/5513
摘要： Compounds, compositions and methods for modulating retinoic acid receptor-like orphan receptors (ROR) and associated diseases. Methods for treatment or prophylaxis of metabolic disorders, liver disorders or diseases, including NASH, immune disorders, central nervous system disorders, or cancer are disclosed.

4. 发明申请

WO2008130459A2 POLYMERIC COMPOSITIONS FOR USE IN PREPARING A BALLISTIC MATERIAL 审中-公开
标题翻译：用于制备弹性材料的聚合物组合物
公开(公告)号：WO2008130459A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/000243
申请日：2008-01-08
申请人： BALLISTICS RESEARCH, INC. , DUKE, Leslie, P. , BARRETT, Wayne
发明人： DUKE, Leslie, P. , BARRETT, Wayne
IPC分类号： F42B30/02
CPC分类号： F41H5/02 , C08G18/7671
摘要： Polymeric compositions for use in preparing a ballistic material and ballistic materials capable of absorbing incoming projectiles prepared from the polymeric material are disclosed. The resulting ballistic materials are also disclosed. The materials have sufficient elasticity so that the polymer or polymer blend does not shatter when stuck with a high- velocity projectile. The polymer blends ideally have one or more of the following physical properties - a) a modulus of elasticity in the range of around 12,500 psi and around 19,000 psi, b) a max stress psi in the range of around 545 and around 985, and c) a tensile strength in the range of around 3.50ft-lbf/in and around 11.00 ft-lbf/in. The thickness of the ballistic material is at least around 3 inches, with a size of around 4-5 inches square or diameter. Objects made of a hardened material, typically between about 1/4 and 1/2 inch, can be interspersed throughout the interior volume of the material.
摘要翻译：公开了用于制备弹道材料的聚合物组合物和能够吸收由聚合物材料制备的入射弹的弹道材料。还公开了所得到的防弹材料。这些材料具有足够的弹性，使得聚合物或聚合物共混物在用高速弹丸粘住时不会破碎。聚合物共混物理想地具有以下物理性质中的一种或多种：a）约12,500psi和约19,000psi范围内的弹性模量，b）约545和约985范围内的最大应力psi，c ）在约3.50ft-lbf / in和约11.00ft-lbf / in的范围内的拉伸强度。弹道材料的厚度至少约为3英寸，尺寸约为4-5英寸或者直径。通常在约1/4和1/2英寸之间的硬化材料制成的物体可以散布在材料的整个内部体积中。

5. 发明申请

WO2008024470A2 CATIONIC LATEX AS A CARRIER FOR BIOACTIVE INGREDIENTS AND ITS USE IN WALLBOARD MANUFACTURE 审中-公开
标题翻译：作为生物活性成分的载体及其在墙板制造中的使用
公开(公告)号：WO2008024470A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/018741
申请日：2007-08-24
申请人： DOW REICHHOLD SPECIALTY LATEX, LLC , MICROBAN INTERNATIONAL LTD. , KRISHNAN, Venkataram , SWOFFORD, Howard, Wayne
发明人： KRISHNAN, Venkataram , SWOFFORD, Howard, Wayne
IPC分类号： A61K9/14
CPC分类号： E04C2/043
摘要： Wallboard, and the gypsum and paper layers that are used to prepare wallboard, can include latex compositions comprising latex particles incorporating bioactive components. Methods for preparing the latex particles, and for forming both wallboard as well as gypsum and paper layers for use in wallboard, are also disclosed. The latex compositions disclosed herein can be prepared, for example, by the emulsion polymerization of the latex component monomers in the presence of one or more of the listed bioactive components.
摘要翻译：墙板以及用于制备墙板的石膏和纸层可以包括胶乳组合物，其包含掺入生物活性组分的胶乳颗粒。还公开了制备胶乳颗粒以及用于形成墙板以及用于墙板的石膏和纸层的方法。本文公开的胶乳组合物可以例如通过乳液组分单体在一种或多种列出的生物活性组分的存在下的乳液聚合来制备。

6. 发明申请

WO2005002337A1 DISINFECTANT COMPOSITIONS AND METHODS 审中-公开
标题翻译：消毒剂组合物和方法
公开(公告)号：WO2005002337A1
公开(公告)日：2005-01-13
申请号：PCT/US2004/010015
申请日：2004-04-02
申请人： VIRTUAL DRUG DEVELOPMENT, INC. , THE UAB RESEARCH FOUNDATION , PORTER, R., Stephen , FERKANY, John , BROUILLETTE, Wayne, J. , BROUILLETTE, Christie , BRADIN, David
发明人： PORTER, R., Stephen , FERKANY, John , BROUILLETTE, Wayne, J. , BROUILLETTE, Christie , BRADIN, David
IPC分类号： A01N37/44
CPC分类号： A01N47/44 , A01N37/44 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N61/00 , A23L3/3526 , A61K31/00 , A61L2/18 , A61L2/22 , A61L2/235 , A61L9/14 , C02F1/50
摘要： Methods for treating or preventing infection by a spore-forming bacterium, killing the spore, germinating spore, and/or vegetative cell of a spore-forming bacterium in an environment, and disinfecting, sterilizing, and decontaminating an object are disclosed. The methods involve the use of an inhibitor of bacterial NAD synthetase, optionally in conjunction with a composition that promotes germination of spore-forming bacteria. Suitable compounds for inhibiting bacterial NAD synthetase are described, for example, in PCT WO 02/07516. The compounds can be applied in a variety of manners, including applying a fog, mist, aerosol, spray, foam, gel, and the like to the environment, object, or other substrate to be treated.
摘要翻译：公开了用于治疗或预防环境中孢子形成细菌感染的方法，杀死孢子形成细菌的孢子，发芽孢子和/或营养细胞，以及对物体进行消毒，消毒和去污。该方法涉及使用细菌NAD合成酶抑制剂，任选与促进孢子形成细菌发芽的组合物结合使用。用于抑制细菌NAD合成酶的合适化合物描述于例如PCT WO 02/07516中。化合物可以以各种方式施用，包括将雾，雾，气溶胶，喷雾，泡沫，凝胶等施用于待处理的环境，物体或其它基底。

7. 发明申请

WO2003053887A1 A METHOD FOR INCREASING THE STABILITY AND INTENSITY OF ODORANT MOLECULES 审中-公开
标题翻译：一种提高气味分子稳定性和强度的方法
公开(公告)号：WO2003053887A1
公开(公告)日：2003-07-03
申请号：PCT/US2002/026438
申请日：2002-08-20
申请人： FLEXITRAL, INC. , TURIN, Luca
发明人： TURIN, Luca
IPC分类号： C07B61/00
CPC分类号： C11B9/003 , A23L27/20 , A23L27/203 , A23L27/2052 , C07C45/69 , C07C47/11 , C07C47/21 , C07C47/225 , C07C47/293 , C07C47/34 , C07C47/45 , C11B9/0076 , C11D3/50
摘要： Methods for determining determinants of an odorant, such as character, intensity and stability, are described. Odorant character is determined based on the vibrational spectra of the odorant, odor intensity is determined based on zinc-binding affinity, and stability is based on an analysis of the odorant in a particular environment. The methods described herein permit one to design novel odorant molecules with increased zinc-binding ability, with all other things such as size volatility and hydrophobicity being equal, to increase the intensity of an odorant derivative relative to a parent odorant from which it is derived. Combinatorial libraries of odorants ("odotopic libraries") to be evaluated for odor character and intensity are also disclosed, as are high throughput methods of evaluating these compounds. Further, methods for identifying an odorant with similar odor character but with improved intensity, stability or other improved physical and/or chemical properties are disclosed.
摘要翻译：描述了用于确定气味剂的决定因素的方法，例如性质，强度和稳定性。基于加臭剂的振动光谱确定气味特性，气味强度基于锌结合亲和力确定，稳定性基于特定环境中加臭剂的分析。本文所述的方法允许设计具有增加的锌结合能力的新型加臭剂分子，其它所有其它物质如尺寸挥发性和疏水性相等，以增加相对于其衍生的母味加味剂的气味衍生物的强度。还公开了要评估气味特征和强度的气味组合组合（“odotopic library”），以及评价这些化合物的高通量方法。此外，公开了用于鉴定具有相似气味特性但具有改进的强度，稳定性或其它改进的物理和/或化学性质的气味剂的方法。

8. 发明申请

WO2022051606A1 NITRIC OXIDE DONORS, COMPOSITIONS, AND METHODS OF USE 审中-公开
公开(公告)号：WO2022051606A1
公开(公告)日：2022-03-10
申请号：PCT/US2021/049036
申请日：2021-09-03
申请人： KNOW BIO, LLC
发明人： SIMONS, John Kelly , KIMBLE, Kyle , STASKO, Nathan , MCDONALD, Rebecca Anthouard , CHAMBERS, Madyson , COCKRELL, Adam
IPC分类号： A01N65/03 , A61K31/734 , A61P11/12
摘要： Disclosed are compositions comprising NO donors formulated for effectively treating disease states, such as microbial infections, including Covid-19 infections. Mucoadhesive agents, chelating agents, and gallium enable highly efficacious formulations for treating infections, particularly when the nature of the pathogenic species is unknown.

9. 发明申请

WO2021163432A1 CO-ADMINISTRATION OF PREDNISOLONE/METHYL PREDNISOLONE AND ZOLEDRONIC ACID TO TREAT AND PREVENT OSTEOARTHRITIS 审中-公开
公开(公告)号：WO2021163432A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/017792
申请日：2021-02-12
申请人： LEVOLTA PHARMACEUTICALS, INC.
发明人： DESAI, Ketan
IPC分类号： A61K9/00 , A61K31/573 , A61K31/663 , A61K31/675 , A61P19/02
摘要： A combination therapy for treating osteoarthritis is disclosed. The combination therapy includes the co-administration, via intravenous delivery, of Zoledronic Acid or a pharmaceuticallyacceptable salt thereof, and prednisone or methylprednisolone, in a dosage range between 10 and about 50 mg. The co-administration of the steroid in this dosage range treats osteoarthritis, and helps to prevent the onset of osteoarthritis in patients at risk for osteoarthritis, while minimizing the post-dosing effects of zoledronic acid administration.

10. 发明申请

WO2010030781A2 AROMATIC CARBOXYLIC ACID DERIVATIVES FOR TREATMENT AND PROPHYLAXIS OF GASTROINTESTINAL DISEASES INCLUDING COLON CANCER 审中-公开
标题翻译：用于治疗和预防胃肠疾病的芳香羧酸衍生物，包括结肠癌
公开(公告)号：WO2010030781A2
公开(公告)日：2010-03-18
申请号：PCT/US2009/056515
申请日：2009-09-10
申请人： NUMED INTERNATIONAL, INC. , EKWURIBE, Nnochiri
发明人： EKWURIBE, Nnochiri
IPC分类号： C07C311/45 , C07C309/26 , C07C245/08 , C07D311/58 , C07D311/36 , A61K31/18 , A61K31/185 , A61P1/04 , A61P35/00
CPC分类号： A61K31/655 , A01N41/04 , A01N41/06 , A01N41/08 , A61K45/06 , C07C245/06 , C07C245/08 , C07C309/15 , C07C309/24 , C07C311/46 , C07C311/49 , C07C311/54 , C07D311/54 , C07D311/68
摘要： Prodrug compounds which metabolize into 5-ASA or analogs thereof, and taurine or analogs thereof, in the colon site are disclosed. Pharmaceutical compositions including the compounds, and methods of treatment using the compounds, are also disclosed. Such compounds have utility for treating or preventing gastrointestinal disorders, including colon cancer, ulcerative colitis and Crohn's disease.
摘要翻译：公开了在结肠部位代谢为5-ASA或其类似物的前体化合物及其牛磺酸或其类似物。还公开了包括该化合物的药物组合物和使用该化合物的治疗方法。这些化合物可用于治疗或预防胃肠道疾病，包括结肠癌，溃疡性结肠炎和克罗恩氏病。

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