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1. 发明申请

WO2020142687A1 COMBINATION THERAPY OF PHOSPHATE BINDERS AND VITAMIN K 审中-公开
公开(公告)号：WO2020142687A1
公开(公告)日：2020-07-09
申请号：PCT/US2020/012181
申请日：2020-01-03
申请人： KAYDENCE PHARMA AS , ROSENBAUM, Daniel H. , TECHNER, Lee M.
发明人： ROSENBAUM, Daniel H. , TECHNER, Lee M.
IPC分类号： A61P13/12 , A61P3/14 , A61K31/122 , A61K31/395
摘要： A method of treating chronic kidney disease including administering to a subject in need thereof a combination of a vitamin K and a phosphate binder.

2. 发明申请

WO2019191773A1 RAPIDLY IMPROVING VASCULAR CONDITIONS BY ADMINISTERING VITAMIN K 审中-公开
公开(公告)号：WO2019191773A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/025220
申请日：2019-04-01
申请人： KAYDENCE PHARMA AS
发明人： CHLOPICKI, Stefan , MARESZ, Katarzyna
IPC分类号： A61K31/122 , A61K31/593 , A23L33/15 , A23L33/155
摘要： A method for rapidly improving cardiovascular function, reducing arterial stiffness and reversing calcification of a blood vessel in a mammal comprising administering to the mammal an effective amount of vitamin K for a period of less than 6 months. Also a method for increasing endothelial nitric oxide production in mammals comprising administering to the mammal an effective amount of vitamin K for a period of less than 6 months. The vitamin K can be administered together with additional substances such as vitamin D.

3. 发明申请

WO2019109075A1 METHOD AND DEVICES FOR SIGNIFYING SCRUBBING ACTION 审中-公开
公开(公告)号：WO2019109075A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/063610
申请日：2018-12-03
申请人： CAREFUSION 2200, INC.
发明人： ROTHENBERG, Ashley , SIERACKI, Nathan
IPC分类号： A61M35/00 , A61B90/80 , A61F13/40
CPC分类号： G01D7/005 , A47K7/02 , A47K7/03
摘要： A method for signifying a selected cumulative scrubbing action between a device and a surface, the cumulative scrubbing action being signified by a signaling element, wherein the signaling element is configured to provide an observable signal when the selected cumulative scrubbing action has been provided to the surface. The method may comprise applying scrubbing action to the signaling element to release and/or expose at least a first portion of an indicator, and observing the device and/or surface for the signal. The present disclosure also relates to signaling elements and devices for use according to the methods of the present disclosure, and to methods of preparing the same.

4. 发明申请

WO2019028045A1 PROTECTION AND SELECTIVE RELEASE OF COLORANT 审中-公开
公开(公告)号：WO2019028045A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/044636
申请日：2018-07-31
申请人： CAREFUSION 2200, INC.
发明人： BOROWSKI, Brandon , SIERACKI, Nathan
IPC分类号： C08K5/42 , C08K5/46 , C08K5/47
摘要： Selectively-releasable colorant compositions that allow a controllable release of colorant molecules from resin in response to one or more specific environmental stimuli. The selectively-releasable colorant composition may comprise resin particles having colorant molecules reversibly bound thereto. The compositions of the present disclosure may also provide precise and uniform control of free colorant content in an environment and/or protection of the immobilized (i.e., unreleased) colorant from compromising environmental chemistries. The present disclosure also relates to methods of preparing and methods of using the compositions described herein.

5. 发明申请

WO2017004412A1 SYSTEMS, METHODS, AND DEVICES FOR STERILIZING ANTISEPTIC SOLUTIONS 审中-公开
标题翻译：用于灭菌抗菌药物的系统，方法和装置
公开(公告)号：WO2017004412A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040483
申请日：2016-06-30
申请人： CAREFUSION 2200, INC.
发明人： DEGALA, Satish , MCGINLEY, Christopher Matthew , THURMOND, Kenneth Bruce
IPC分类号： A61L2/04 , A01N47/44 , A61L2/28
CPC分类号： A61L2/28 , A01N47/44 , A61L2/04 , A01N25/02 , A01N31/02
摘要： A method for sterilizing an antiseptic solution includes providing a plurality of containers containing the antiseptic solution, the antiseptic solution having an initial purity, selecting a sterilization temperature from about 85C to about 135C and an sterilization time from about 1 minute to about 19 hours, heating the antiseptic solution in the plurality of containers to the selected sterilization temperature, maintaining the temperature for the selected sterilization time, and terminating the heating of the antiseptic solution when the sterilization time expires. After terminating the heating, the antiseptic solution in the plurality of containers has a post-sterilization purity. The sterilization temperature and the sterilization time are selected such that after terminating the heating, the antiseptic solution is sterile and have a post-sterilization purity of at least about 92% and the percentage point change in purity from the initial purity to the post-sterilization purity is at most about 5%.
摘要翻译：消毒溶液灭菌方法包括提供多个含有防腐溶液的容器，初始纯度的防腐溶液，选择约85℃至约135℃的灭菌温度和约1分钟至约19小时的灭菌时间，加热将所述多个容器中的所述消毒溶液设定为选择的灭菌温度，将所述灭菌时间的温度保持在一定范围内，并且在所述灭菌时间到期时终止所述防腐溶液的加热。在终止加热后，多个容器中的消毒溶液具有消毒后的纯度。选择灭菌温度和灭菌时间，使得在终止加热后，防腐溶液是无菌的，并且具有至少约92％的灭菌后纯度和从初始纯度到灭菌后的纯度百分比变化纯度至多约5％。

6. 发明申请

WO2016196977A1 SYSTEMS AND METHODS FOR ALERTING UNAUTHORIZED ACCESS INTO A CONTAINER 审中-公开
标题翻译：用于将未经授权的进入通知给集装箱的系统和方法
公开(公告)号：WO2016196977A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035793
申请日：2016-06-03
申请人： CEROVENE, INC.
发明人： DIFALCO, Richard J. , SHAH, Manish S.
IPC分类号： B65D50/02 , B65D51/24 , G08B3/10 , G08B13/08 , G08B13/14
CPC分类号： G08B13/08 , B65D1/02 , B65D41/00 , B65D43/02 , B65D55/02 , B65D2101/00 , B65D2203/10 , B65D2203/12 , G08B13/14 , G08B13/1427 , G08B13/1436
摘要： The present disclosure provides devices, systems and methods for monitoring unauthorized access into a container or bottle, and alerting the authorized user, or someone designated by the authorized user, of any unauthorized access.
摘要翻译：本公开提供了用于监视未经授权的进入容器或瓶子的设备，系统和方法，以及警告授权用户或由授权用户指定的某人未经授权的访问。

7. 发明申请

WO2016149028A2 EPINEPHRINE FORMULATIONS 审中-公开
标题翻译： EPINEPHRINE配方
公开(公告)号：WO2016149028A2
公开(公告)日：2016-09-22
申请号：PCT/US2016/021716
申请日：2016-03-10
申请人： PAR PHARMACEUTICAL, INC.
发明人： KANNAN, Vinayagam , IRISH, Patrick , BERGREN, Michael
IPC分类号： A61K47/02 , A61K31/137
CPC分类号： A61K31/137 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0073 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/183
摘要： Pharmaceutical compositions comprising epinephrine, methods of administration, and methods of making the same. Compositions may comprise at least one of an active agent, a pH raising agent, an antioxidant, a transition metal complexing agent, a pH lowering agent, a tonicity regulating agent, optionally a preservative, and optionally a solvent.
摘要翻译：包含肾上腺素的药物组合物，给药方法及其制备方法。组合物可以包含活性剂，pH升高剂，抗氧化剂，过渡金属络合剂，pH降低剂，张力调节剂，任选的防腐剂和任选的溶剂中的至少一种。

8. 发明申请

WO2016094716A1 ANTISEPTIC APPLICATOR 审中-公开
标题翻译：抗辩申请人
公开(公告)号：WO2016094716A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065088
申请日：2015-12-10
申请人： CAREFUSION 2200, INC.
发明人： MINGIONE, Louis P. , BEUCHAT, Charlie
IPC分类号： B05C5/02
CPC分类号： A61M35/006 , A61M35/003
摘要： An applicator assembly includes a plurality of ampoules formed of a frangible material and containing liquid to be applied, a container having a proximal end, a distal end, and an interior portion defining a chamber adapted to receive the plurality of ampoules, an application member attached to the distal end of the container; and at least one actuator projecting from the container, wherein the at least one actuator is actuatable to independently fracture the plurality of ampoules, thereby independently releasing the liquid into the application member. The at least one actuator may be moveable from a first position to a second position, the applicator having a smaller profile when the actuator is in the second position than when the actuator is in the first position.
摘要翻译：施用器组件包括由易碎材料形成并包含要施加的液体的多个安瓿，具有近端，远端和限定适于容纳多个安瓿的室的内部的容器，附着的施用构件到容器的远端; 以及至少一个致动器，其从所述容器突出，其中所述至少一个致动器可致动以独立地破裂所述多个安瓿，从而独立地将所述液体释放到所述施加构件中。所述至少一个致动器可以从第一位置移动到第二位置，当所述致动器处于所述第二位置时，所述施加器具有比当所述致动器处于所述第一位置时更小的轮廓。

9. 发明申请

WO2014151331A1 TINTED ANTISEPTIC SOLUTIONS HAVING IMPROVED STABILITY 审中-公开
标题翻译：具有改进的稳定性的特定抗静电解决方案
公开(公告)号：WO2014151331A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/025484
申请日：2014-03-13
申请人： CAREFUSION 2200, INC.
发明人： DOKKEN, Kenneth M. , BENITEZ, Tenoch , BARDWELL, James
IPC分类号： A61K31/74
CPC分类号： A61K47/32 , A61B46/40 , A61K9/0014 , A61K9/7015 , A61K31/155 , A61K31/444 , A61L26/0014 , A61L26/0066 , A61L2300/404 , C08L33/08
摘要： An antiseptic solution including, a cationic antiseptic agent, a film forming polymer, an anionic tinting agent, and a solvent, wherein the cationic antiseptic agent, the film forming polymer and the anionic tinting agent each remain solubilized within the solution for greater than about 1 hour at 25°C and 60% relative humidity. The antiseptic agent is preferably octenidine dihydrochloride or chlorhexadine gluconate. The film forming polymer is preferably an acrylate polymer. The solvent is preferably ethanol, isopropanol, and n-propanol. When a drape is adhered to a dried surgical film via the antiseptic solution, the force required to peel the drape from the surgical film is at least about 105 g/25 mm.
摘要翻译：包括阳离子防腐剂，成膜聚合物，阴离子着色剂和溶剂的防腐溶液，其中阳离子防腐剂，成膜聚合物和阴离子着色剂各自保持溶解在溶液中大于约1 小时在25°C和60％相对湿度。防腐剂优选为二辛基化二辛胺或葡萄糖酸氯己定。成膜聚合物优选为丙烯酸酯聚合物。溶剂优选为乙醇，异丙醇和正丙醇。当通过防腐溶液将悬垂布贴在干燥的手术膜上时，从手术膜剥离悬垂液所需的力至少约为105g / 25mm。

10. 发明申请

WO2014146093A2 ABUSE DETERRENT COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：阻止组合物和使用方法
公开(公告)号：WO2014146093A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/031052
申请日：2014-03-18
申请人： INSPIRION DELIVERY TECHNOLOGIES, LLC
发明人： SHAH, Manish S. , DIFALCO, Ray J. , AIGNER, Stefan
IPC分类号： C11B3/00
CPC分类号： A61K9/2086 , A61K9/2846 , A61K9/5073 , A61K31/485 , A61K45/06
摘要： Orally administrable pharmaceutical compositions, methods of administration, and methods of making the same are provided. The pharmaceutical compositions provide abuse deterrent properties.
摘要翻译：提供口服给药的药物组合物，给药方法及其制备方法。药物组合物提供滥用威慑性质。

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