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1. 发明申请

WO2009103941A1 CHEMICAL MODIFICATION OF PROTEINS 审中-公开
标题翻译：蛋白质的化学修饰
公开(公告)号：WO2009103941A1
公开(公告)日：2009-08-27
申请号：PCT/GB2009/000194
申请日：2009-01-23
申请人： ISIS INNOVATION LIMITED , BERNARDES, Goncalo , CHALKER, Justin , DAVIS, Benjamin
发明人： BERNARDES, Goncalo , CHALKER, Justin , DAVIS, Benjamin
IPC分类号： C07K1/02 , C07K1/113
CPC分类号： C07K1/1133 , C07K1/02 , C07K1/026 , C07K1/107 , C07K1/13
摘要： The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which may be converted to any natural or unnatural amino acid residue desired without the alteration of the remainder of the peptide or protein. The invention also allows ligation of a desired peptide at any point rather than at a point where there should be a naturally occurring cysteine, thereby allowing native chemical ligation to be used in the synthesis of peptides that do not contain cysteine. The methodology allows for the synthesis of very large peptides.
摘要翻译：本发明涉及将肽或蛋白质中的半胱氨酸残基选择性转化为脱氢丙氨酸（Dha）残基的方法。该方法还适用于硒代半胱氨酸和取代的半胱氨酸和硒代半胱氨酸残基，导致Dha残基，其可以转化为任何天然或非天然氨基酸残基，而不改变肽或蛋白质的其余部分。本发明还允许在任何点而不是在应当存在天然存在的半胱氨酸的位点连接所需的肽，从而允许天然化学连接用于合成不含半胱氨酸的肽。该方法允许合成非常大的肽。

2. 发明申请

WO2008099198A2 OSTEOGENIC COMPOUNDS 审中-公开
标题翻译：化学成分
公开(公告)号：WO2008099198A2
公开(公告)日：2008-08-21
申请号：PCT/GB2008/000544
申请日：2008-02-15
申请人： INION LIMITED , CHOPRA, Bikramjit , MCKENZIE, Grahame , HARDWICK, Bryn
发明人： CHOPRA, Bikramjit , MCKENZIE, Grahame , HARDWICK, Bryn
IPC分类号： A61K31/45 , A61L27/14 , A61L27/54 , A61P19/08
CPC分类号： A61K31/45 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , C08L67/04
摘要： The invention relates to certain 2- and 4-piperidones and their pharmaceutically acceptable salts and prodrugs, compositions comprising same and the use of these compounds and compositions as a medicament and in the manufacture of compositions for promoting bone regrowth and repair, and to methods of treating damaged or broken bones.
摘要翻译：本发明涉及某些2-和4-哌啶酮及其药学上可接受的盐和前药，包含其的组合物，以及这些化合物和组合物作为药物和用于制备促进骨再生和修复的组合物的用途，以及治疗损坏或破碎的骨头。

3. 发明申请

WO2008099190A2 OSTEOGENIC COMPOUNDS 审中-公开
标题翻译：成骨化合物
公开(公告)号：WO2008099190A2
公开(公告)日：2008-08-21
申请号：PCT/GB2008/000529
申请日：2008-02-15
申请人： INION LIMITED , CHOPRA, Bikramjit , MCKENZIE, Grahame , HARDWICK, Bryn
发明人： CHOPRA, Bikramjit , MCKENZIE, Grahame , HARDWICK, Bryn
IPC分类号： A61K31/16 , A61K38/18 , A61K47/34 , A61K47/36 , A61K47/42 , A61P19/00
CPC分类号： A61K9/0063 , A61K31/16 , A61K38/1875 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61K2300/00 , C08L67/04
摘要： The invention relates to N,N-dimethylacetamide and its pharmaceutically acceptable salts and prodrugs, compositions comprising same and the use of these compounds and compositions as a medicament and in the manufacture of compositions for promoting bone regrowth and repair, and to methods of treating damaged or broken bones.
摘要翻译：本发明涉及N，N-二甲基乙酰胺及其药学上可接受的盐和前药，包含其的组合物以及这些化合物和组合物作为药物和用于促进骨再生的组合物的制备和修复以及治疗受损或骨折的方法。

4. 发明申请

WO2008029136A1 PHARMACEUTICAL COMPOSITION AND METHOD FOR CANCER TREATMENT BASED ON COMBINATIONAL USE OF CONVENTIONAL OR PLANT-DERIVED ANTICANCER AGENTS AND GERANIUM OIL OR COMPOUNDS THEREOF 审中-公开
标题翻译：基于常规或植物衍生的抗原药剂和甘油或其化合物的组合使用的癌症治疗的药物组合物和方法
公开(公告)号：WO2008029136A1
公开(公告)日：2008-03-13
申请号：PCT/GB2007/003351
申请日：2007-09-05
申请人： ULTRA BIOTECH LIMITED , CHU, Kee Hung , XIE, Wei Dong , HO, Cheong Yip
发明人： CHU, Kee Hung , XIE, Wei Dong , HO, Cheong Yip
IPC分类号： A61K36/185 , A61K36/13 , A61K31/045 , A61K31/337 , A61P35/00
CPC分类号： A61K36/185 , A61K36/00 , A61K2300/00
摘要： A cancer treatment composition includes geranium oil or its chemical constituents and a chemotherapeutic agent or plant extract selected from the group consisting of plant-derived bioactive compounds. The cancer is selected from the group consisting of lung, breast, ovary, prostate, colon, liver, gastrointestinal, head-and-neck, cervix, kidney, neuroblastoma, leukemia, lymphoma, and melanoma.
摘要翻译：癌症治疗组合物包括天竺葵油或其化学成分以及选自植物来源的生物活性化合物的化学治疗剂或植物提取物。癌症选自肺癌，乳腺癌，卵巢癌，前列腺癌，结肠癌，肝癌，胃肠道癌，头颈部癌，宫颈癌，肾癌，神经母细胞瘤，白血病，淋巴瘤和黑素瘤。

5. 发明申请

WO2006126008A2 IMPROVED IMMUNOASSAY METHODS 审中-公开
标题翻译：改进的免疫方法
公开(公告)号：WO2006126008A2
公开(公告)日：2006-11-30
申请号：PCT/GB2006/001944
申请日：2006-05-26
申请人： ONC-IMMUNE LTD. , ROBERTSON, John, Forsyth, Russell , BARNES, Tony , MURRAY, Andrea , CHAPMAN, Caroline
发明人： ROBERTSON, John, Forsyth, Russell , BARNES, Tony , MURRAY, Andrea , CHAPMAN, Caroline
IPC分类号： G01N33/564 , G01N33/574
CPC分类号： G01N33/574 , G01N33/564 , G01N2800/102 , G01N2800/52
摘要： The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.
摘要翻译：本发明涉及检测哺乳动物受试者的疾病状态或疾病易感性的方法，其包括检测包含来自所述哺乳动物受试者的体液的测试样品中的抗体，其中所述抗体是疾病状态或疾病易感性的生物标志物，所述方法包括：（a）使所述测试样品与多种不同量的对所述抗体特异的抗原接触，（b）检测所述抗体与所述抗原之间的特异性结合量，（c）绘制或计算所述特异性结合量相对于步骤（a）和（d）中使用的每种抗原量的抗原量，基于所述抗体与所述抗体的特异性结合量，确定所述疾病状态或疾病易感性的存在或不存在抗原在各种不同抗原浓度下使用。

6. 发明申请

WO2006059104A1 HERBAL COMPOSITIONS COMPRISING FRUCTUS CRATAEGI, SEMEN ZIZYPHUS, FRUCTUS SCHIZANDRAE AND PANAX GINSENG 审中-公开
标题翻译：含有木瓜，玻璃，紫杉，茯苓的草本组合物
公开(公告)号：WO2006059104A1
公开(公告)日：2006-06-08
申请号：PCT/GB2005/004597
申请日：2005-11-30
申请人： ULTRA BIOTECH LIMITED , PANG, Shiu Fun , LUK, Sharon , LIU, Shiu Lam, Edgar , XING, Hongtao
发明人： PANG, Shiu Fun , LUK, Sharon , LIU, Shiu Lam, Edgar , XING, Hongtao
IPC分类号： A61K36/258 , A61K36/725 , A61K36/734 , A61K36/79 , A61P35/00 , A61P37/02
CPC分类号： A61K36/258 , A23L33/105 , A23V2002/00 , A61K36/06 , A61K36/254 , A61K36/28 , A61K36/48 , A61K36/725 , A61K36/73 , A61K36/734 , A61K36/79 , A61K36/906 , A61K2300/00 , A23V2200/308 , A23V2250/2124 , A23V2250/21
摘要： A composition containing extracts obtained form Fructus Crataegi, Semen Zizyphus, Fructus Schizandrae, and Panax Ginseng. Also disclosed is a method of treating cancer or modulating an immune response in a subject and a method of inducing a cytokine in a cell with the composition.
摘要翻译：含有由枸杞子，精hus子，五味子和人参提取的提取物的组合物。还公开了治疗癌症或调节受试者的免疫应答的方法以及在具有该组合物的细胞中诱导细胞因子的方法。

7. 发明申请

WO2010149959A1 IMPROVED MASSAGE APPARATUS AND METHOD OF USE 审中-公开
标题翻译：改进的按摩装置和使用方法
公开(公告)号：WO2010149959A1
公开(公告)日：2010-12-29
申请号：PCT/GB2010/001218
申请日：2010-06-22
申请人： INNOVATIVE TREATMENT SOLUTIONS LTD , PARSLOE, Colin
发明人： PARSLOE, Colin
IPC分类号： A61H15/00 , A61H15/02
CPC分类号： A61H15/0092 , A61H7/00 , A61H7/002 , A61H7/003 , A61H7/004 , A61H7/005 , A61H7/007 , A61H15/00 , A61H2015/0007 , A61H2015/0028 , A61H2201/0153 , A61H2201/0157 , A61H2201/0207 , A61H2201/12 , A61H2201/1207 , A61H2201/1215 , A61H2205/024
摘要： The present invention relates to a device for therapeutic and/or prophylactic massage, in particular massage of mammalian eyelids, having a body housing a heater in thermal communication with a massaging bobbin, the bobbin having a plurality of massaging elements extending therefrom. In use, the bobbin heats the eyelid and rotates such that a massaging force is exerted on the eyelid perpendicular to the lash line. This force can be used to express material from blocked sebaceous glands of the mammalian eyelid. As such, also disclosed herein is a method for treating disorders of the mammalian eyelid, such as inflammation, using the device of the invention.
摘要翻译：本发明涉及用于治疗和/或预防性按摩的装置，特别是哺乳动物眼睑的按摩，其具有容纳与按摩线轴热连通的加热器的主体，所述线轴具有从其延伸的多个按摩元件。在使用中，筒管加热眼睑并旋转，使得按摩力垂直于睫毛线施加在眼睑上。该力可用于表达来自哺乳动物眼睑的阻塞皮脂腺的物质。因此，本文还公开了使用本发明的装置治疗哺乳动物眼睑疾病如炎症的方法。

8. 发明申请

WO2010055300A3 POMEGRANATE OIL 审中-公开
公开(公告)号：WO2010055300A3
公开(公告)日：2010-05-20
申请号：PCT/GB2009/002658
申请日：2009-11-13
申请人： ASTON UNIVERSITY , EARTHOIL PLANTATIONS LTD , GRIFFITHS, Gareth , CHANDER, Anuj, Kumar , WALTER; Campbell, Andrew
发明人： GRIFFITHS, Gareth , CHANDER, Anuj, Kumar , WALTER; Campbell, Andrew
IPC分类号： A61K8/92 , A61Q19/00 , A61K8/36
摘要： Use of pomegranate oil or pomegranate oil derivative as a preservative for a lipid or lipid-containing composition.

9. 发明申请

WO2009066077A1 APPARATUS AND METHOD OF MASSAGE 审中-公开
标题翻译：装置和按摩方法
公开(公告)号：WO2009066077A1
公开(公告)日：2009-05-28
申请号：PCT/GB2008/003900
申请日：2008-11-21
申请人： INNOVATIVE TREATMENT SOLUTIONS LIMITED , PARSLOE, Colin
发明人： PARSLOE, Colin
IPC分类号： A61H23/02 , A61H7/00
CPC分类号： A61H7/005 , A61H2201/0153 , A61H2201/0207 , A61H2201/0228 , A61H2201/0242 , A61H2201/0257 , A61H2201/105 , A61H2201/1215 , A61H2201/1604 , A61H2201/1688 , A61H2201/1692 , A61H2205/022 , A61H2205/024
摘要： The invention relates to an apparatus for melting and expressing material from blocked glands in a mammalian eyelid comprising a massager and a deformable eyelid interface having a heater and arranged so that, in use, a massaging nodule causes the eyelid interface to massage the eyelid. The apparatus additionally comprises a scrubbing element and further comprises a reservoir in fluid connection with the eyelid interface for the storage and subsequent application to the eyelid of fluid and or gel which may be for lubrication or may contain pharmaceutical ingredients. Also disclosed is a method for unblocking blocked glands.
摘要翻译：本发明涉及一种用于在哺乳动物眼睑中从封闭的腺体熔化和表达材料的装置，其包括按摩器和具有加热器的可变形的眼睑接口，并且布置成使用中，按摩结节使得眼睑接口按摩眼睑。该装置还包括洗涤元件，并且还包括与眼睑接口流体连接的储存器，用于储存和随后施加到可用于润滑的或可能含有药物成分的流体和/或凝胶眼睑。还公开了一种用于解除堵塞的腺体的方法。

10. 发明申请

WO2009022129A1 A 3' -BASED SEQUENCING APPROACH FOR MICROARRAY MANUFACTURE 审中-公开
标题翻译：一种用于微型制造的3'-BASED测序方法
公开(公告)号：WO2009022129A1
公开(公告)日：2009-02-19
申请号：PCT/GB2008/002735
申请日：2008-08-12
申请人： ALMAC DIAGNOSTICS LIMITED , HARKIN, Paul , MULLIGAN, Karl , TANNEY, Austin , OLIVER, Gavin , FULTON, Ciaran
发明人： HARKIN, Paul , MULLIGAN, Karl , TANNEY, Austin , OLIVER, Gavin , FULTON, Ciaran
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q2525/185 , C12Q2565/501
摘要： Methods are described to derive design sequences for the production of nucleic acid microarrays. The present methods use high throughput 3 ' sequencing of transcripts in a tissue sample or diseased state to design probes for nucleic acid microarrays. Also described are nucleic acid microarrays that possess probes directed to the extreme 3' end of transcripts in a tissue. These microarrays preferably represent alternate polyadenylation sequences that are specific to the tissue from which the transcripts are derived. Also described are methods of using the microarrays directed to the extreme 3 ' end of the transcript for evaluating gene expression in a tissue where there are reduced false positive and false negative results.
摘要翻译：描述了用于衍生用于产生核酸微阵列的设计序列的方法。本方法使用组织样品或病态的转录物的高通量3'测序来设计核酸微阵列的探针。还描述了具有针对组织中转录物的极端3'末端的探针的核酸微阵列。这些微阵列优选代表对衍生转录物的组织特异性的替代聚腺苷酸化序列。还描述了使用指向转录物的极端3'末端的微阵列来评估组织中的基因表达的方法，其中减少了假阳性和假阴性结果。

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