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    • 8. 发明申请
    • PART-STREAM DISTILLATION
    • WO2016066629A1
    • 2016-05-06
    • PCT/EP2015/074839
    • 2015-10-27
    • BASF SEDOW GLOBAL TECHNOLOGIES LLC
    • RIEDEL, Dominic
    • C07D301/12
    • C07D301/12
    • A continuous process for the preparation of propylene oxide, comprising (a) reacting propene with hydrogen peroxide in a reaction apparatus in the presence of acetonitrile as solvent, obtaining a stream SO containing propylene oxide, acetonitrile, water, at least one further component B wherein the normal boiling point of the at least one component B is higher than the normal boiling point of acetonitrile; (b) separating propylene oxide from SO, obtaining a stream SI containing acetonitrile, water and the at least one further component B; (c) dividing S1 into two streams S2 and S3; (d) subjecting S3 to a vapor-liquid fractionation in a first fractionation unit, obtaining a vapor fraction stream S4 a being depleted, relative to S3, of at least one of the at least one component B and obtaining a liquid bottoms stream S4b, and subjecting at least part of the vapor fraction stream S4 a to a vapor-liquid fractionation in a second fractionation unit, obtaining a vapor fraction stream S4c and a liquid bottoms stream S4 being depleted, relative to S4a, of at least one of the at least one component B; (e) recycling at least a portion of S4, optionally after work-up, to (a).
    • 一种用于制备环氧丙烷的连续方法,包括(a)在乙腈作为溶剂存在下,在反应装置中使丙烯与过氧化氢反应,得到含有环氧丙烷,乙腈,水,至少一种其它组分B的物流SO,其中 至少一种组分B的标准沸点高于乙腈的标准沸点; (b)从SO中分离环氧丙烷,得到含有乙腈,水和至少一种其它组分B的流SI; (c)将S1划分成两个流S2和S3; (d)使S3在第一分馏单元中进行汽 - 液分馏,获得相对于S3耗尽的至少一种组分B中的至少一种的蒸气馏分流S4a,并获得液体底部流S4b, 并且使至少部分蒸汽馏分流S4a在第二分馏单元中进行汽 - 液分馏,获得相对于S4a耗尽的蒸汽馏分流S4c和液体塔底流S4至少一个 至少一个组分B; (e)将至少一部分S4,任选地在后处理之后再循环至(a)。
    • 10. 发明申请
    • PROCESS FOR THE RESOLUTION OF (R,S)-DIAZEPANE AND DIAZEPANONE DERIVATIVES
    • (R,S) - 二氮杂萘和二氮茚酮衍生物的分解方法
    • WO2016020404A1
    • 2016-02-11
    • PCT/EP2015/067994
    • 2015-08-04
    • SANDOZ AG
    • BARTH, RolandKAUFMANN, Marius
    • C07D413/14C07D403/06C07D413/12C07D243/08C07D209/82
    • C07D209/82C07D243/08C07D403/06C07D413/12C07D413/14Y02P20/55
    • The present invention relates to a process for the preparation of an acid salt (T) of a compound of formula (A) (A) as well as to the acid salt (T) and the compound (A) as such,wherein R 1 is selected from the group consisting of H, PG 1 and R A , with R A being or and wherein PG 1 is a suitable protecting group, and wherein n is 0 or 1, wherein the acid salt (T) is the salt of one stereoisomer of a chiral acid, preferably wherein the chiral acid salt is a tartaric acid derivative salt, preferably wherein the tartaric acid derivative salt is selected from the group consisting of 2,3-ditoluoyl tartaric acid salt, 2,3-dibenzoyl tartaric acid salt, 2,3-dianisoyl tartaric acid salt, 2,3-dibenzoyl tartaric acid mono(dimethylamide) salt and a mixture of two or more thereof. Further the present invention relates to use of (T) and/or (A) for the preparation of suvorexant.
    • 本发明涉及制备式(A)(A)化合物的酸式盐(T)以及酸式盐(T)和化合物(A)的方法,其中R1为 选自H,PG1和RA组成的组,其中RA是或其中PG1是合适的保护基,其中n是0或1,其中酸性盐(T)是手性酸的一种立体异构体的盐 优选其中所述手性酸盐是酒石酸衍生物盐,优选其中所述酒石酸衍生物盐选自2,3-二甲酰基酒石酸盐,2,3-二苯甲酰酒石酸盐,2,3-二甲酰基酒石酸盐, 二茴香酰酒石酸盐,2,3-二苯甲酰酒石酸单(二甲基酰胺)盐及其两种或多种的混合物。 此外,本发明还涉及(T)和/或(A)用于制备suvorexant的用途。