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1. 发明申请

WO2010075448A1 SKIN PROTECTION FOR SUBDERMAL CRYOGENIC REMODELING FOR COSMETIC AND OTHER TREATMENTS 审中-公开
标题翻译：皮肤保护用于化妆品和其他处理剂的低温低温重塑
公开(公告)号：WO2010075448A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069304
申请日：2009-12-22
申请人： MYOSCIENCE, INC. , FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron , OLSEN, Phillip
发明人： FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron , OLSEN, Phillip
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/00041 , A61B2018/00452 , A61B2018/0293
摘要： A systems and methods for controlling temperature in a cryogenic device includes providing a device having a probe and a heater element. A distal region of the probe is engaged with the target region. Measuring and recording current temperature of a proximal region of the probe and time of the measurement is used to determine slope of a temperature curve defined by two points. The first point is defined by the current temperature and time of measurement and a second point is defined by a previous measurement of proximal region temperature and time of measurement. When the slope is less than a slope threshold value a treatment flag is activated, treatment start time is recorded and the proximal region is heated with the heater element. Heating is discontinued and the treatment flag is deactivated after elapsed treatment time exceeds a duration threshold value.
摘要翻译：用于控制低温装置中的温度的系统和方法包括提供具有探针和加热器元件的装置。探针的远侧区域与目标区域接合。测量和记录探头近端区域的当前温度和测量时间用于确定由两点定义的温度曲线的斜率。第一点由当前的测量温度和时间定义，第二个点由先前测量的近端区域温度和测量时间定义。当斜率小于斜率阈值时，处理标志被激活，记录处理开始时间，并且用加热器元件加热近端区域。加热停止，经过治疗时间超过持续时间阈值后，治疗标志被禁用。

2. 发明申请

WO2010075438A1 INTEGRATED CRYOSURGICAL SYSTEM WITH REFRIGERANT AND ELECTRICAL POWER SOURCE 审中-公开
标题翻译：具有制冷和电力来源的综合性CRYOSURGICAL系统
公开(公告)号：WO2010075438A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069282
申请日：2009-12-22
申请人： MYOSCIENCE, INC. , FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron
发明人： FOURKAS, Michael , WILLIAMS, Ronald , GOVENJI, Punit , REYNOLDS, Byron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0281 , A61B2018/0293 , A61F2007/0052 , A61F2007/0056
摘要： A system for treating tissue in a patient includes a body having a cooling fluid supply path and a tissue piercing probe in fluid communication with the cooling fluid supply path. The probe extends distally from the body and is insertable into the tissue through the patient's skin. A cooling fluid source is fluidly coupled with the probe such that when cooling is initiated, cooling fluid flows in the probe thereby cooling the probe and any adjacent tissue. A heater element is in thermal engagement with the cooling fluid source and a power source provides power to the heater element thereby heating the cooling fluid. The power source has sufficient power to heat the cooling fluid to at least a desired temperature but has insufficient power to heat the cooling fluid above a critical temperature which results in rupture of the cooling fluid source.
摘要翻译：用于治疗患者组织的系统包括具有冷却流体供应路径和与冷却流体供应路径流体连通的组织刺穿探针的主体。探头从身体向远端延伸，并通过病人的皮肤插入组织。冷却流体源与探针流体耦合，使得当冷却开始时，冷却流体在探针中流动，从而冷却探针和任何相邻组织。加热器元件与冷却流体源热接合，并且电源为加热器元件提供电力，从而加热冷却流体。电源具有足够的功率以将冷却流体加热到至少所需温度，但是具有不足以将冷却流体加热到高于导致冷却流体源破裂的临界温度以上的功率。

3. 发明申请

WO2014146105A3 CRYOGENIC ENHANCEMENT OF JOINT FUNCTION, ALLEVIATION OF JOINT STIFFNESS AND/OR ALLEVIATION OF PAIN ASSOCIATED WITH OSTEOARTHRITIS 审中-公开
标题翻译：关节功能的低温强化，减轻关节僵直和/或与骨关节炎相关的疼痛的缓解
公开(公告)号：WO2014146105A3
公开(公告)日：2014-11-06
申请号：PCT/US2014031079
申请日：2014-03-18
申请人： MYOSCIENCE INC
发明人： KARNIK JWALA , REYNOLDS JASON , ALLISON JOHN , CARNELL CLINT
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/02 , A61B2018/00041 , A61B2018/00434 , A61B2018/0293 , A61B2018/1425 , A61F2007/0042 , A61F2007/0087 , A61F2007/0285 , A61M5/00 , A61M2202/0484 , A61M2210/086 , A61N1/403
摘要： A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.
摘要翻译：一种方法，其中在与疼痛状态相关的感觉神经附近的皮肤上确定位置。将低温装置的至少一根针插入皮肤上的位置，使得针靠近感觉神经。该装置被激活，使得至少一个针在感觉神经周围产生冷却区，从而消除或减轻疼痛状况的严重程度。

4. 发明申请

WO2014146122A1 METHODS AND SYSTEMS FOR TREATMENT OF OCCIPITAL NEURALGIA 审中-公开
标题翻译：治疗神经性神经病的方法和系统
公开(公告)号：WO2014146122A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/031107
申请日：2014-03-18
申请人： MYOSCIENCE, INC.
发明人： CARNELL, Clint , ALLISON, John , KARNIK, Jwala , ROSEN, Jesse
IPC分类号： A61B18/02 , A61F7/12 , A61M5/158 , A61F7/08
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00041 , A61B2018/00321 , A61B2018/00625 , A61B2018/00642 , A61B2018/00839 , A61B2018/0293
摘要： A system for alleviating occipital neuralgia. The system has a needle probe having at least one needle. The at least one needle has a proximal end, a distal end, and a needle lumen therebetween, the needle configured for insertion proximate to a location of the occipital nerve. A cooling fluid supply lumen extends distally within the needle lumen to a distal portion of the needle lumen. A cooling fluid source is coupled to the cooling fluid supply lumen to direct cooling fluid flow into the needle lumen. A controller that has at least one processor configured implements an occipital neuralgia treatment algorithm for controlling the cooling fluid source so that liquid from the cooling flow vaporizes within the needle lumen to provide a treatment phase to location of the occipital nerve such that the occipital neuralgia is mitigated.
摘要翻译：一种缓解枕骨神经痛的系统。该系统具有至少一个针的针头探针。所述至少一个针具有近端，远端和其间的针管腔，所述针被配置为用于插入靠近枕骨神经的位置。冷却液供应腔在针内腔内向远端延伸到针管腔的远端部分。冷却流体源联接到冷却流体供应管腔以将冷却流体引导到针内腔中。具有至少一个处理器配置的控制器实施枕叶神经痛治疗算法来控制冷却流体源，使得来自冷却流的液体在针腔内蒸发以提供治疗阶段到枕骨神经的位置，使得枕骨神经痛是缓解。

5. 发明申请

WO2006127467A3 SUBDERMAL CRYOGENIC REMODELING 审中-公开
标题翻译：低温低温重塑
公开(公告)号：WO2006127467A3
公开(公告)日：2007-04-12
申请号：PCT/US2006019471
申请日：2006-05-18
申请人： MYOSCIENCE INC , ELKINS LISA , WILLIAMS RONALD
发明人： ELKINS LISA , WILLIAMS RONALD
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2017/00792 , A61B2018/00023 , A61B2018/00041 , A61B2018/00452 , A61B2018/00464 , A61B2018/0262 , A61B2018/0293 , A61M5/44 , A61M37/0015 , A61M2037/0023 , A61M2037/003
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
摘要翻译：装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

6. 发明申请

WO2016145452A1 METHODS AND SYSTEMS FOR PREVENTING NEUROMA FORMATIONS 审中-公开
标题翻译：用于预防神经瘤形成的方法和系统
公开(公告)号：WO2016145452A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/022373
申请日：2016-03-14
申请人： MYOSCIENCE, INC.
发明人： ALLISON, John , PRECIADO, Jessica , HSU, Michael
IPC分类号： A61B18/02 , A61B18/14 , A61F7/12
CPC分类号： A61B18/02 , A61B2018/00434 , A61B2018/0293 , A61B2090/3925 , A61B2090/3937
摘要： The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for amputating a limb of a patient are provided. In many embodiments, devices, systems, and methods may provide chronic denervation of one or more nerves of a patient as part of a therapeutic treatment. The methods may employ cold for the prevention of neuromas or fibromas associated with amputation of a limb of a patient. Embodiments of the invention include needles that can be advanced through skin or other tissues to cause axonotmesis of a target nerve of the patient and to repeatedly interrupt a regeneration of the nerve so as to provide therapeutic chronic denervation of the target nerve. The therapeutic chronic denervation may delay the formation of neuromas or fibromas in a patient's residual limb and/or may provide long lasting and permanent pain relief associated with the target nerve.
摘要翻译：本发明一般涉及改进的医疗装置，系统和方法。在许多实施例中，提供了用于截肢患者肢体的装置，系统和方法。在许多实施例中，装置，系统和方法可以作为治疗性治疗的一部分提供患者的一个或多个神经的慢性去神经支配。这些方法可能会用于预防与患者肢体截肢有关的神经瘤或纤维瘤。本发明的实施例包括可以通过皮肤或其他组织推进以引起患者的目标神经的轴突断裂并且重复地中断神经的再生以便提供目标神经的治疗性慢性去神经支配的针。治疗性慢性去神经支配可能延迟患者残肢中的神经瘤或纤维瘤的形成和/或可能提供与目标神经相关的持久和持久的疼痛缓解。

7. 发明申请

WO2014146126A1 CRYOGENIC BLUNT DISSECTION METHODS AND DEVICES 审中-公开
标题翻译：低温脱氮方法和装置
公开(公告)号：WO2014146126A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/031112
申请日：2014-03-18
申请人： MYOSCIENCE, INC.
发明人： ALLISON, John
IPC分类号： A61B18/02 , A61F7/00
CPC分类号： A61B18/02 , A61B2018/00023 , A61B2018/00321 , A61B2018/00434 , A61B2018/00452 , A61B2018/0262 , A61B2018/0293 , A61F7/00
摘要： A point of incision is created within tissue, the tissue having a temporoparietal fasciadeep temporoparietal fascia layer (TPF-sDTF) beneath skin and a temporal branch of a target nerve extending along a portion of the TPF-sDTF, the point of incision being laterally displaced from the target nerve. A cryogenic probe having a distal tip extending from an elongated body is inserted into the point of incision. The TPFsDTF is bluntly dissected using the cryogenic probe such that a treating portion of the cryogenic probe is directly adjacent to a first treatment portion of the target nerve. The cryogenic probe is activated to create a first treatment zone at the first treatment portion of the target nerve to cause a therapeutic effect.
摘要翻译：在组织内产生切口点，组织具有在皮肤下方的颞叶颞下筋膜层（TPF-sDTF）和沿着TPF-sDTF的一部分延伸的靶神经的颞分支，切口点横向移位从目标神经。具有从细长体延伸的远端的低温探针插入切口点。使用低温探针直接解剖TPFsDTF，使得低温探针的处理部分与目标神经的第一处理部分直接相邻。激活低温探针以在目标神经的第一处理部分处产生第一治疗区域以引起治疗效果。

8. 发明申请

WO2014146106A3 METHODS, SYSTEMS, AND DEVICES FOR TREATING NEUROMAS, FIBROMAS, NERVE ENTRAPMENT, AND/OR PAIN ASSOCIATED THEREWITH 审中-公开
公开(公告)号：WO2014146106A3
公开(公告)日：2014-09-18
申请号：PCT/US2014/031081
申请日：2014-03-18
申请人： MYOSCIENCE, INC.
发明人： KARNIK, Jwala , ALLISON, John , CARNELL, Clint
IPC分类号： A61B18/02
摘要： A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.

9. 发明申请

WO2008101027A3 REPLACEABLE AND/OR EASILY REMOVABLE NEEDLE SYSTEMS FOR DERMAL AND TRANSDERMAL CRYOGENIC REMODELING 审中-公开
标题翻译：可更换和/或易用的可拆卸针头系统用于真空和超导低温重构
公开(公告)号：WO2008101027A3
公开(公告)日：2008-10-23
申请号：PCT/US2008053876
申请日：2008-02-13
申请人： MYOSCIENCE INC , BURGER KEITH , ELKINS LISA , WILLIAMS RONALD
发明人： BURGER KEITH , ELKINS LISA , WILLIAMS RONALD
IPC分类号： A61B18/02
CPC分类号： A61B18/0218 , A61B18/02 , A61B2017/00747 , A61B2018/00023 , A61B2018/00458 , A61B2018/0262 , A61B2018/0293
摘要： The present invention provides improved medical devices, systems and methods for treatment of a wide range of target tissues Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar Examplary embodiments make use of replaceable needle probes supported by a probe body handle Careful control over the control of cryogenic cooling fluid into a needle probe can allow the length of the active cooling to be control through depletion of liquid from an evaporating cryogenic cooling flow Some embodiments apply a lubricious coating over the probe to facilitate removal of the probe from the frozen tissue.
摘要翻译：本发明提供用于治疗大范围靶组织的改进的医疗装置，系统和方法本发明的一些实施例用至少一个小的组织穿透性探针施加冷却，所述探针通常包括适合于通过患者皮肤的暴露表面插入，而不会留下可见的疤痕。示例性实施例使用由探针本体把手支撑的可更换的针探针。仔细控制低温冷却流体进入针头探针可以允许活动的长度通过从蒸发的低温冷却流中的液体的消耗来控制冷却。一些实施例在探针上施加润滑涂层，以便于从冷冻组织中去除探针。

10. 发明申请

WO2008079812A3 DERMAL AND TRANSDERMAL CRYOGENIC MICROPROBE SYSTEMS AND METHODS 审中-公开
标题翻译：皮肤和经皮低温微球系统和方法
公开(公告)号：WO2008079812A3
公开(公告)日：2008-08-21
申请号：PCT/US2007087893
申请日：2007-12-18
申请人： MYOSCIENCE INC , BURGER KEITH , WILLIAMS RONALD , ELKINS LISA
发明人： BURGER KEITH , WILLIAMS RONALD , ELKINS LISA
IPC分类号： A61M1/00
CPC分类号： A61B18/02 , A61B2017/00747 , A61B2018/00452 , A61B2018/0262 , A61B2018/0293
摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-tolerated lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.
摘要翻译：医疗装置，系统和方法任选地治疗皮肤病和/或美容缺陷，和/或广泛的额外目标组织。实施例利用至少一个小的穿透组织的探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入而不留下可见疤痕的尺寸的针。可以沿着细长针的大部分或全部可插入长度施加治疗，任选地通过熔融石英流体供应管的小的，紧密容忍的腔将低温冷却流体引入针内腔，其中供应管内腔经常计量冷却液。使用经由有限的总排气体积空间联接到针腔的简单减压阀可以提高治疗温度和/或时间控制。

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