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1. 发明申请

WO2015179711A1 MICRONIZED WHARTON'S JELLY 审中-公开
公开(公告)号：WO2015179711A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/032078
申请日：2015-05-21
申请人： MIMEDX GROUP, INC.
发明人： SPENCER, Randall , SITH, Somaly
IPC分类号： C12N5/00
CPC分类号： A61K35/51 , A61K9/0019 , A61K35/50 , A61L27/36 , C12N5/0605 , C12N2509/10
摘要： The present invention provides compositions and formulations of micronized Wharton' s jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste, suitable for delivery into the space adjacent the articular surface cartilage injured region of a subject. The micronized Wharton's jelly when employed at sufficient concentrations can be hydrated into a gel or paste and administered topically, or it can be injected into the body through the use of a needle and syringe.
摘要翻译：本发明提供了具有受控粘度的微粉化沃顿顿果冻的组合物和制剂，使得当被输送到受试者的受损区域时，其保持基本上局部化，几乎或不迁移出受损区域用于修复和/或再生它们。微粉沃顿的果冻可以悬浮在药学上可接受的水性载体中，例如盐水，无菌水或任何合适的缓冲液，以形成悬浮液或凝胶状凝胶组合物，或者可以是糊剂的形式，适于递送到邻近被检体的关节面软骨损伤区域的空间。当使用足够浓度时，微粉化的沃顿的果冻可以水合成凝胶或糊状物，并局部施用，或者可以通过使用针头和注射器将其注入体内。

2. 发明申请

WO2014144525A1 MOLDED PLACENTAL TISSUE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：模制的组合物组合物及其制备和使用方法
公开(公告)号：WO2014144525A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028975
申请日：2014-03-14
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas, J. , DENOZIERE, Guilhem , BROWN, Rebeccah, J.c.
IPC分类号： A61K35/50
CPC分类号： A61L27/3604 , A61L27/3695 , A61L2400/06 , A61L2430/34
摘要： Described arc molded placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein. This invention is directed to molded dehydrated tissue and, in particular, to molded dehydrated placental tissue compositions. Such compositions are prepared from dehydrated micronized placental tissue.
摘要翻译：描述的弧形胎盘组织组合物及其药物组合物。该组合物具有许多医学应用。本文还描述了制备和使用模制的脱水胎盘组织组合物的方法。本发明涉及模制脱水组织，特别是成型脱水胎盘组织。这样的组合物由脱水的微粉化胎盘组织制备。

3. 发明申请

WO2014078080A1 CROSS-LINKED COLLAGEN WITH A BOUND ANTIMICROBIAL AGENT 审中-公开
标题翻译：具有粘合抗菌剂的交联胶原蛋白
公开(公告)号：WO2014078080A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/067618
申请日：2013-10-30
申请人： MIMEDX GROUP, INC. , KOOB, Thomas J.
发明人： KOOB, Thomas J.
IPC分类号： A61P31/00 , A61K9/00 , A61K38/17
CPC分类号： A61K47/48292 , A61K8/19 , A61K8/65 , A61K9/0024 , A61K33/38 , A61K38/39 , A61K47/42 , A61K47/6435 , A61K2800/51 , A61L27/24 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61Q17/005 , A61K2300/00
摘要： The disclosure describes collagen constructs comprising antimicrobial agents and related methods. Also described is a novel vacuum drying device and the use thereof.
摘要翻译：本公开描述了包含抗微生物剂和相关方法的胶原构建体。还描述了一种新颖的真空干燥装置及其用途。

4. 发明申请

WO2014028657A1 REINFORCED PLACENTAL TISSUE GRAFTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：增强的特殊组织织物及其制造和使用方法
公开(公告)号：WO2014028657A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/055003
申请日：2013-08-14
申请人： MIMEDX GROUP, INC
发明人： KOOB, Thomas J. , TOFE, Robert , CHEN, Elizabeth
IPC分类号： A61F2/02 , A61F2/04 , C12N5/071 , A61L27/14
CPC分类号： A61L27/54 , A61L27/14 , A61L27/36 , A61L27/44 , A61L27/56
摘要： Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
摘要翻译：这里描述的是来自胎盘组织的组织移植物，其被用至少一种生物相容性筛网增强。组织移植物对生物组织具有良好的粘附性，并且可用于伤口愈合应用。本文还描述了制造和使用组织移植物的方法。

5. 发明申请

WO2013082158A1 SHREDDED TISSUE GRAFTS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译： SHREDDED TISSUE GRAFTS及其制造和使用方法
公开(公告)号：WO2013082158A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/066862
申请日：2012-11-28
申请人： MIMEDX GROUP INC. , SPENCER, Randall , RAY, Steven
发明人： SPENCER, Randall , RAY, Steven
IPC分类号： A61K35/50
CPC分类号： A61F2/105 , A61F2/02 , A61K35/50 , A61K35/51
摘要： Described herein are shredded tissue grafts composed of one or more placental components. The compositions have numerous medical applications with respect to wound healing and complications associated with wound healing. Methods for making the shredded tissue graft compositions are also described herein.
摘要翻译：这里描述的是由一种或多种胎盘成分组成的切碎的组织移植物。该组合物在伤口愈合和与伤口愈合相关的并发症方面具有许多医学应用。本文还描述了制备切碎的组织移植组合物的方法。

6. 发明申请

WO2012112441A1 LAMINATED TISSUE GRAFTS COMPOSED OF WHARTON'S JELLY AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：组合的糖衣的组合组织及其制造和使用方法
公开(公告)号：WO2012112441A1
公开(公告)日：2012-08-23
申请号：PCT/US2012/024858
申请日：2012-02-13
申请人： MIMEDX GROUP INC. , MORSE, Brenda, S. , SITH, Somaly , SPENCER, Randall , DANIEL, John , TOFE, Robert
发明人： MORSE, Brenda, S. , SITH, Somaly , SPENCER, Randall , DANIEL, John , TOFE, Robert
IPC分类号： A01N63/00
CPC分类号： A61F2/02 , A61L27/3604 , A61L27/3683 , A61L27/50 , A61L2430/40
摘要： Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.
摘要翻译：本文描述了衍生自具有改善的物理和生物学特性的胎盘的组织移植物。在一个方面，组织移植物包括第一膜，其包含层叠有羊膜，绒毛膜或其组合的沃顿顿胶。 Wharton果冻在移植物中的存在增强了同种异体移植羊水来源的，caderivic同种异体移植物，异种移植物或异种移植物软组织替代物的表现。

7. 发明申请

WO2012112417A2 TISSUE GRAFTS MODIFIED WITH A CROSS-LINKING AGENT AND METHOD OF MAKING AND USING THE SAME 审中-公开
标题翻译：用交联剂修饰的组织接头及其制造和使用方法
公开(公告)号：WO2012112417A2
公开(公告)日：2012-08-23
申请号：PCT/US2012/024814
申请日：2012-02-13
申请人： MIMEDX GROUP INC. , MORSE, Brenda, S. , SITH, Somaly , SPENCER, Randall , DANIEL, John
发明人： MORSE, Brenda, S. , SITH, Somaly , SPENCER, Randall , DANIEL, John
IPC分类号： A61K35/50
CPC分类号： A61L27/3891 , A61K35/50 , A61L27/3604 , A61L27/3687 , A61L27/3804 , A61L27/3839 , A61L27/3878 , A61L27/3882 , A61L2400/18 , A61L2430/12 , A61L2430/16 , A61L2430/22 , A61L2430/32 , A61L2430/40
摘要： Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
摘要翻译：本文描述了衍生自胎盘的组织移植物，其对生物组织具有良好的粘附性并且可用于治愈应用。在一个方面，组织移植物包括（1）两层或更多层羊膜，其中至少一层羊膜交联，（2）两层或多层绒毛膜，其中至少一层羊膜是交叉的，连接或（3）一层或多层羊膜和绒毛膜，其中至少一层羊膜和/或绒毛膜交联。另一方面，移植物由彼此交联的羊膜和绒毛膜组成。在另一方面，移植物具有夹在羊膜和绒毛膜之间的一层或多层。羊膜和/或绒毛膜在形成移植物之前用交联剂处理。存在于移植物上的交联剂的存在也增强了对感兴趣的生物组织的粘附。本文还描述了用于制造和使用组织移植物的方法。

8. 发明申请

WO2015109329A1 METHOD FOR INDUCING ANGIOGENESIS 审中-公开
标题翻译：诱导血管生成的方法
公开(公告)号：WO2015109329A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/012087
申请日：2015-01-20
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas J.
IPC分类号： A61K35/50 , C12N5/073
CPC分类号： A61K35/50 , A61L27/3604 , A61L27/3804 , A61L27/54 , A61L2300/414 , A61L2400/06
摘要： Disclosed herewith is a method for inducing angiogenesis using modified placental tissue or an extract thereof to treat conditions other than cardiovascular conditions.
摘要翻译：本文公开了一种使用修饰的胎盘组织或其提取物诱导血管生成以治疗心血管疾病以外的病症的方法。

9. 发明申请

WO2015038477A1 COSMETIC USES OF MOLDED PLACENTAL COMPOSITIONS 审中-公开
标题翻译：成型用途的化妆品成分
公开(公告)号：WO2015038477A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/054603
申请日：2014-09-08
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas J. , BROWN, Rebeccah J.C.
IPC分类号： A61K8/98 , A61K8/72 , A61Q19/08 , A61Q19/00
CPC分类号： A61Q19/08 , A61K8/982
摘要： Described herein are methods of using molded dehydrated placental compositions, and cosmetic compositions thereof. The compositions have numerous cosmetic applications.
摘要翻译：本文描述了使用模制脱水胎盘组合物及其化妆品组合物的方法。组合物具有许多化妆品应用。

10. 发明申请

WO2015031681A1 MICRONIZED PLACENTAL COMPOSITIONS COMPRISING A CHELATOR 审中-公开
标题翻译：包含螯合剂的微粒化胎儿组合物
公开(公告)号：WO2015031681A1
公开(公告)日：2015-03-05
申请号：PCT/US2014/053270
申请日：2014-08-28
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas J.
IPC分类号： A61K35/50 , A61K9/16 , A61K47/30
CPC分类号： A61K35/50 , A61K33/24 , A61K45/06 , A61K47/547 , A61K2300/00
摘要： Provided herein are micronized placental compositions composed of micronized placental tissue component, such as amnion or chorion and/or filler bound to one or more chelating agents, which in turn are optionally bound, reversibly, to pharmacologically active metal ions. Further provided are methods of making and using the placental compositions. The compositions have numerous therapeutic applications.
摘要翻译：本文提供了微粉化的胎盘组合物，其由微粉化的胎盘组织组分组成，例如与一种或多种螯合剂结合的羊膜或绒毛膜和/或填充剂，其又任选地可逆地结合药理活性金属离子。进一步提供了制造和使用胎盘组合物的方法。该组合物具有许多治疗应用。

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