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1. 发明申请

WO2008048468A1 FORMATION OF MEDICALLY USEFUL GELS COMPRISING MICROPOROUS PARTICLES AND METHODS OF USE 审中-公开
标题翻译：形成包含微生物颗粒的医学上有用的凝胶和使用方法
公开(公告)号：WO2008048468A1
公开(公告)日：2008-04-24
申请号：PCT/US2007/021732
申请日：2007-10-11
申请人： MEDAFOR, INCORPORATED , DRAKE, James, F. , GRONDA, Ann
发明人： DRAKE, James, F. , GRONDA, Ann
IPC分类号： A61K9/14 , A61K9/00
CPC分类号： A61L26/008 , A61K9/10 , A61K9/14 , A61K9/7015 , A61L26/0052
摘要： Compositions and methods use the gel-forming properties of microporous particles to create useful formulations combining two free-flowing materials to produce a hydrogel mass. The free-flowing materials preferably provide dry microporous particles (preferably as an aerosol) that may contain additional agents, and a second composition of a fluid material which is an aqueous solution of one or more high molecular weight polymers capable of forming a hydrogel upon further concentration and/or reaction. The hydrogels can be preferably formed on a surface by spraying the two compositions as fluids together in the proper ratio onto the surface.
摘要翻译：组合物和方法使用微孔颗粒的凝胶形成性质来产生组合两种自由流动材料以产生水凝胶团的有用配方。自由流动的材料优选提供可以含有另外的试剂的干燥微孔颗粒（优选为气溶胶）和流体材料的第二组合物，其是一种或多种能够进一步形成水凝胶的高分子量聚合物的水溶液浓度和/或反应。优选通过将两种组合物作为流体以适当的比例喷射到表面上而在表面上形成水凝胶。

2. 发明申请

WO2008048461A3 METHOD AND COMPOSITION FOR CREATING AND/OR ACTIVATING A PLATELET-RICH GEL BY CONTACT WITH A POROUS PARTICULATE MATERIAL, FOR USE IN WOUND CARE, TISSUE ADHESION,OR AS A MATRIX FOR DELIVERY OF THERAPEUTIC COMPONENTS 审中-公开
标题翻译：用于通过与多孔微粒物质接触来创建和/或激活富含血小板的凝胶的方法和组合物，其用于创伤护理，组织粘附或作为用于递送治疗成分的基质
公开(公告)号：WO2008048461A3
公开(公告)日：2008-06-19
申请号：PCT/US2007021707
申请日：2007-10-11
申请人： MEDAFOR INC , DRAKE JAMES F , GRONDA ANN
发明人： DRAKE JAMES F , GRONDA ANN
IPC分类号： A61K35/14
CPC分类号： A61L26/0057 , A61K31/715 , A61K35/14 , A61K35/16 , A61K35/19 , A61L26/0023 , A61K2300/00 , C08L3/00
摘要： A composition, method, and use of microporous particles such as polysaccharide hemostat particle gels activates platelet rich plasma (PRP) or other platelet-containing substances. The composition may contain microporous polysaccharaide hemostats (MPH) mixed with platelet-rich plasma, platelet-poor plasma, blood, or the like. The method may contain mixing the MPH with platelet-rich plasma or other platelet-containing substance either by hand, in a device, or by applying the MPH directly to the wound before or after application of the platelet-containing substance. Alternatively, MPH can by applied directly to the bleeding wound, using the blood as a source of platelets.
摘要翻译：微孔颗粒如多糖止血颗粒凝胶的组合物，方法和用途可活化富含血小板的血浆（PRP）或其它含血小板物质。该组合物可以含有与富血小板血浆，贫血小板血浆，血液等混合的微孔多糖止血剂（MPH）。该方法可以包含将MPH与富含血小板的血浆或其它含血小板物质混合，或者通过手工，装置中，或者通过在施用含血小板物质之前或之后将MPH直接应用于伤口。或者，MPH可以直接应用于出血伤口，使用血液作为血小板来源。

3. 发明申请

WO2007030776A3 METHOD OF SUPPORTING AND/OR APPLYING PARTICULATE MATERIALS 审中-公开
标题翻译：支持和/或应用颗粒材料的方法
公开(公告)号：WO2007030776A3
公开(公告)日：2008-05-02
申请号：PCT/US2006035180
申请日：2006-09-08
申请人： MEDAFOR INC , DRAKE JAMES FRANKLIN , LYNN SKOW R
发明人： DRAKE JAMES FRANKLIN , LYNN SKOW R
IPC分类号： A61K31/715
CPC分类号： B05B11/062 , A61L26/0023 , A61L26/0085 , B05B7/1413 , B05D1/28 , B05D2401/32 , C08L5/02
摘要： Masses of particles are structurally supported by the application of vacuum through a support surface having holes thereon that are smaller than the average diameter of the particle mass that is to be supported. The reduced pressure structurally supports particles on the support surface. The mass of particles tends is so well supported that it tends retain its shape unless additional forces are applied. The system comprises the vacuum applicator (e.g., pump), a vacuum carrying system and the support surface. When a mass of particles is supported on the support surface under vacuum, the particles can be carried to a target surface, the mass of particles pressed against the target surface, the mass conforming to the target surface, and the vacuum reduced or stopped, depositing the particle mass onto the surface in excellent shape compliance with that surface.
摘要翻译：颗粒的质量在结构上通过在其上具有孔的支撑表面施加真空来支撑，该支撑表面小于待支撑的颗粒物质的平均直径。减压结构上支撑在支撑表面上的颗粒。颗粒的质量倾向于非常好的支撑，除非施加额外的力，否则它倾向于保持其形状。该系统包括真空施加器（例如泵），真空承载系统和支撑表面。当颗粒物质在真空下支撑在支撑表面上时，颗粒可以被运送到目标表面，颗粒物质压在目标表面上，质量符合目标表面，真空减少或停止，沉积表面上的颗粒质量与该表面良好的形状一致。

4. 发明申请

WO2007030776A2 METHOD OF SUPPORTING AND/OR APPLYING PARTICULATE MATERIALS 审中-公开
标题翻译：支持和/或应用颗粒材料的方法
公开(公告)号：WO2007030776A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/035180
申请日：2006-09-08
申请人： MEDAFOR, INCORPORATED , DRAKE, James, Franklin , LYNN, Skow, R.
发明人： DRAKE, James, Franklin , LYNN, Skow, R.
IPC分类号： B05D1/12 , A61L33/00 , B05D3/00
CPC分类号： B05B11/062 , A61L26/0023 , A61L26/0085 , B05B7/1413 , B05D1/28 , B05D2401/32 , C08L5/02
摘要： Masses of particles are structurally supported by the application of vacuum through a support surface having holes thereon that are smaller than the average diameter of the particle mass that is to be supported. The reduced pressure structurally supports particles on the support surface. The mass of particles tends is so well supported that it tends retain its shape unless additional forces are applied. The system comprises the vacuum applicator (e.g., pump), a vacuum carrying system and the support surface. When a mass of particles is supported on the support surface under vacuum, the particles can be carried to a target surface, the mass of particles pressed against the target surface, the mass conforming to the target surface, and the vacuum reduced or stopped, depositing the particle mass onto the surface in excellent shape compliance with that surface.
摘要翻译：颗粒的质量在结构上通过在其上具有孔的支撑表面施加真空来支撑，该支撑表面小于待支撑的颗粒物质的平均直径。减压结构上支撑在支撑表面上的颗粒。颗粒的质量倾向于非常好的支撑，除非施加额外的力，否则它倾向于保持其形状。该系统包括真空施加器（例如泵），真空承载系统和支撑表面。当颗粒物质在真空下支撑在支撑表面上时，颗粒可以被运送到目标表面，颗粒物质压在目标表面上，质量符合目标表面，真空减少或停止，沉积表面上的颗粒质量与该表面良好的形状一致。

5. 发明申请

WO9105754A3 DERIVATIVES OF LONG-CHAIN FATTY ALCOHOLS AND THEIR APPLICATIONS, IN PARTICULAR AS CYTOTROPHIC AND CYTOPROTECTIVE MOLECULES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：长链脂肪醇的衍生物及其应用，特别是细胞因子和CYPOPROTECTIVE分子，以及含有其的药物组合物
公开(公告)号：WO9105754A3
公开(公告)日：1991-11-28
申请号：PCT/FR9000742
申请日：1990-10-15
申请人： MEDAFOR
发明人： BORG JACQUES
IPC分类号： A61K31/01 , A61K31/02 , A61K31/045 , A61K31/075 , A61K31/13 , A61K31/23 , A61K31/275 , A61K31/575 , A61K31/66 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/7088 , A61K38/00 , A61P1/04 , A61P1/16 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C31/02 , C07C31/133 , C07C33/02 , C07C33/025 , C07C33/035 , C07C33/14 , C07C45/30 , C07C47/11 , C07C47/225 , C07C49/507 , C07C57/03 , C07C69/145 , C07C237/22 , C07C255/31 , C07C403/00 , C07C403/08 , C07F9/09 , C07F9/6574 , C07H19/04 , C07H19/20 , C07H21/00 , C07J7/00 , C07J9/00 , C07K14/00 , C07K14/575 , C07K14/62
CPC分类号： C07C403/12 , C07C33/02 , C07C33/025 , C07C33/035 , C07C33/14 , C07C45/305 , C07C47/225 , C07C49/507 , C07C255/31 , C07C403/08 , C07C403/20 , C07C403/24 , C07C2601/14 , C07C2601/16 , C07F9/65744 , C07J9/00
摘要： Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, conditions linked to skin ageing, the phenomena of thrombosis and atherosclerosis, and immune deficiencies.

6. 发明申请

WO2008048461A2 METHOD AND COMPOSITION FOR CREATING AND/OR ACTIVATING A PLATELET-RICH GEL BY CONTACT WITH A POROUS PARTICULATE MATERIAL, FOR USE IN WOUND CARE, TISSUE ADHESION,OR AS A MATRIX FOR DELIVERY OF THERAPEUTIC COMPONENTS 审中-公开
标题翻译：通过与多孔颗粒材料接触来制造和/或激活平板玻璃的方法和组合物，用于创伤治疗，组织粘连或作为用于递送治疗组件的矩阵
公开(公告)号：WO2008048461A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/021707
申请日：2007-10-11
申请人： MEDAFOR, INCORPORATED , DRAKE, James, F. , GRONDA, Ann
发明人： DRAKE, James, F. , GRONDA, Ann
IPC分类号： A61K35/14 , A61K31/715
CPC分类号： A61L26/0057 , A61K31/715 , A61K35/14 , A61K35/16 , A61K35/19 , A61L26/0023 , A61K2300/00 , C08L3/00
摘要： A composition, method, and use of microporous particles such as polysaccharide hemostat particle gels activates platelet rich plasma (PRP) or other platelet-containing substances. The composition may contain microporous polysaccharaide hemostats (MPH) mixed with platelet-rich plasma, platelet-poor plasma, blood, or the like. The method may contain mixing the MPH with platelet-rich plasma or other platelet-containing substance either by hand, in a device, or by applying the MPH directly to the wound before or after application of the platelet-containing substance. Alternatively, MPH can by applied directly to the bleeding wound, using the blood as a source of platelets.
摘要翻译：多孔颗粒如多糖止血剂颗粒凝胶的组合物，方法和用途激活富血小板血浆（PRP）或其他含血小板的物质。该组合物可以含有与富血小板血浆，血小板血浆，血液等混合的微孔多糖止血剂（MPH）。该方法可以包括在手部，装置中或通过在施用含血小板的物质之前或之后将MPH直接施加到伤口上来将MPH与富含血小板的血浆或其他含血小板的物质混合。或者，MPH可以直接应用于出血伤口，使用血液作为血小板来源。

7. 发明申请

WO1994011343A1 LONG CHAIN FATTY ALCOHOLS WITH NEUROTROPHIC AND PARAMNESIC ACTIVITY, AND METHOD OF PREPARATION 审中-公开
标题翻译：具有神经营养和参与活性的长链脂肪醇及其制备方法
公开(公告)号：WO1994011343A1
公开(公告)日：1994-05-26
申请号：PCT/FR1993001059
申请日：1993-10-28
申请人： MEDAFOR , LUU, Bang , BORG, Jacques , BECK, Alain , LAABICH, Aicha , CRESTANI, Florence , NEVEUX, Odile
发明人： MEDAFOR
IPC分类号： C07C403/08
CPC分类号： C07C33/14 , C07B2200/09 , C07C31/1355 , C07C403/08 , C07C2601/14 , C07C2601/16
摘要： New long chain fatty alcohol derivatives, characterized by general formulas (I) or (II) whose linear hydrocarbon side chain has from 7 to 25 carbon atoms, is saturated or has a double bond with a configuration cis or trans at beta of the alcohol function, but has no ramification.
摘要翻译：由具有7至25个碳原子的直链烃侧链的通式（I）或（II）表征的新的长链脂肪醇衍生物是饱和的或具有双键结构，其具有在醇官能团上的顺式或反式，但没有分支。

8. 发明申请

WO1991005754A2 DERIVATIVES OF LONG-CHAIN FATTY ALCOHOLS AND THEIR APPLICATIONS, IN PARTICULAR AS CYTOTROPHIC AND CYTOPROTECTIVE MOLECULES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：长链脂肪醇的衍生物及其应用，特别是细胞因子和CYPOPROTECTIVE分子，以及含有其的药物组合物
公开(公告)号：WO1991005754A2
公开(公告)日：1991-05-02
申请号：PCT/FR1990000742
申请日：1990-10-15
申请人： MEDAFOR , BORG, Jacques
发明人： MEDAFOR
IPC分类号： C07C33/02
CPC分类号： C07C403/12 , C07C33/02 , C07C33/025 , C07C33/035 , C07C33/14 , C07C45/305 , C07C47/225 , C07C49/507 , C07C255/31 , C07C403/08 , C07C403/20 , C07C403/24 , C07C2601/14 , C07C2601/16 , C07F9/65744 , C07J9/00
摘要： Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, conditions linked to skin ageing, the phenomena of thrombosis and atherosclerosis, and immune deficiencies.
摘要翻译：提供长链脂肪醇的衍生物及其获得方法，以及含有衍生物及其用途的药物组合物，特别是治疗或预防神经退行性疾病，与皮肤老化有关的病症，血栓形成现象和动脉粥样硬化和免疫缺陷。

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