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1. 发明申请

WO2022094193A1 COMPOSITIONS AND METHODS FOR DETECTING INFLUENZA A, INFLUENZA B, AND SARS-COV-2 审中-公开
公开(公告)号：WO2022094193A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/057223
申请日：2021-10-29
申请人： GEN-PROBE INCORPORATED
发明人： CLARK, Craig, Brian , PHAM, Jimmykim , DARBY, Paul, M. , HO, Yi-Hsuan Elisha
IPC分类号： C12Q1/68 , C12Q1/70 , C12Q1/6844 , C12Q1/686
摘要： Disclosed are nucleic acid oligonucleotides, including primers, probes, and target capture oligonucleotides, for detection of SARS-CoV-2, Influenza A, and Influenza B. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligonucleotides. Corresponding formulations, reaction mixtures, and kits and related methods for preparing aqueous reaction mixtures from dried formulations are described.

2. 发明申请

WO2021119124A1 QUANTIFICATION OF POLYNUCLEOTIDE ANALYTES FROM DRIED SAMPLES 审中-公开
公开(公告)号：WO2021119124A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/064004
申请日：2020-12-09
申请人： GEN-PROBE INCORPORATED
发明人： NAIR, Sangeetha Vijaysri , WANG, Xianqun
IPC分类号： C12Q1/6851 , C12Q1/6834
摘要： Presented are methods, systems, and software products useful for determining the concentration of an analyte in a fluid specimen used to produce a dried sample, where the dried sample serves as a source of the analyte in a detection and quantification procedure. Particularly illustrated is the use of dried blood spots for quantifying a polynucleotide analyte.

3. 发明申请

WO2020142347A3 SYSTEMS AND METHODS FOR FILLING MULTI-WELL CARTRIDGES WITH SOLID REAGENTS 审中-公开
公开(公告)号：WO2020142347A3
公开(公告)日：2020-07-09
申请号：PCT/US2019/068570
申请日：2019-12-26
申请人： GEN-PROBE INCORPORATED
发明人： BASHAR, Reza , KINDRED, Andrew
IPC分类号： B01L3/00
摘要： A tray for transferring a plurality of solid reagents to a multi-well cartridge, the tray including a top surface having a plurality of depressions formed therein, each depression being configured to receive and hold a single one of the solid reagents, and a barrier wall projecting above and substantially surrounding the top surface, where the barrier wall is discontinuous at a first end of the tray.

4. 发明申请

WO2020132408A3 COMPOSITIONS AND METHODS FOR DETECTING PLASMODIUM SPECIES NUCLEIC ACID 审中-公开
公开(公告)号：WO2020132408A3
公开(公告)日：2020-06-25
申请号：PCT/US2019/067777
申请日：2019-12-20
申请人： GEN-PROBE INCORPORATED , GRIFOLS DIAGNOSTIC SOLUTIONS INC.
发明人： SELF, Deanna , LINNEN, Jeffrey M. , BRES, Vanessa
IPC分类号： C12Q1/6893
摘要： Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and capture probes, for detection of Plasmodium species nucleic acid in a sample. Also disclosed are methods of specific nucleic acid amplification and detection, including amplification and detection of target nucleic acid in real time, using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

5. 发明申请

WO2020069085A3 COMPOSITIONS AND METHODS FOR DETECTING BORDETELLA PERTUSSIS AND BORDETELLA PARAPERTUSSIS NUCLEIC ACID 审中-公开
公开(公告)号：WO2020069085A3
公开(公告)日：2020-04-02
申请号：PCT/US2019/053099
申请日：2019-09-26
申请人： GEN-PROBE INCORPORATED
发明人： EATON, Barbara L. , GROBARCZYK, Benjamin , BARHDADI, Samira
IPC分类号： C12Q1/689
摘要： Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Bordetella pertussis and Bordetella parapertussis nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

6. 发明申请

WO2020033557A1 COMPOSITIONS, METHODS AND KITS FOR DETECTING MYCOPLASMA GENITALIUM 审中-公开
公开(公告)号：WO2020033557A1
公开(公告)日：2020-02-13
申请号：PCT/US2019/045520
申请日：2019-08-07
申请人： GEN-PROBE INCORPORATED
发明人： KIRKCONNELL, Brett W. , WEINBAUM, Barbara S. , GETMAN, Damon K. , JIANG, Alice
IPC分类号： C12Q1/689 , C12Q1/686
摘要： The present disclosure relates to oligonucleotides useful for determining the presence of Mycoplasma genitalium in a test sample. The oligonucleotides of the present disclosure may be incorporated into hybridization assay probes, capture probes and amplification primers, and used in various combinations thereof.

7. 发明申请

WO2019118550A1 METHODS FOR BIOLOGICAL SAMPLE PROCESSING 审中-公开
公开(公告)号：WO2019118550A1
公开(公告)日：2019-06-20
申请号：PCT/US2018/065105
申请日：2018-12-12
申请人： GEN-PROBE INCORPORATED
发明人： PETERSON, Patrick Lynn
IPC分类号： G01N1/00
CPC分类号： G01N1/4055
摘要： Methods, apparatuses, and systems are provided for processing a biological sample. Exemplary methods comprise transferring a swab associated with an aliquot of the biological sample into a wash liquid, wherein a first portion of the aliquot is released into the wash liquid; and transferring the swab into a carrier liquid, wherein a second portion of the aliquot is released into the carrier liquid. The methods can provide efficient transfer of analyte such as cells or nucleic acid into the carrier liquid while releasing particulate matter, viscous polymers, or other undesired material into the wash liquid. Alternatively or in addition, the methods can also release desired material into the wash liquid, e.g., cells, which can be used in applications such as culturing.

8. 发明申请

WO2019032809A1 COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS 审中-公开
公开(公告)号：WO2019032809A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045975
申请日：2018-08-09
申请人： GEN-PROBE INCORPORATED
发明人： PETERSON, Patrick , DARBY, Paul , JOST, Matthias , MIICK, Siobhan , BRENTNALL, Matthew , JACKSON, JoAnn
IPC分类号： C12Q1/689
摘要： Provided herein are compositions, kits, and methods for detecting methicillin-resistant Staphylococcus aureus (MRSA) nucleic acids. In some embodiments, the compositions, kits, and methods can be used to detect one or more of type i, ii, iii, iv, v, vi, vii, viii, ix, xii, xiii, xiv, xv, or xxi SCC mec right extremity junction (MREJ) MRSA nucleic acids and one or more of mecA, mecC , and/or an additional S. aureus- specific gene.

9. 发明申请

WO2017143037A3 LABORATORY AUTOMATED INSTRUMENTS, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：WO2017143037A3
公开(公告)日：2017-08-24
申请号：PCT/US2017/018133
申请日：2017-02-16
申请人： GEN-PROBE INCORPORATED
发明人： WALKER, George T. , MERTEN, Matthias , LAIR, Gary D.
IPC分类号： G01N35/04
摘要： A laboratory automated system can include a host conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto between at least a sample processing instrument and at least one assay instrument. The system includes an intermediate conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto from within sample processing instrument to the host conveyor assembly. The system also includes an intermediate conveyor assembly for each assay instrument configured to transport a plurality of carriers from host conveyor assembly to a respective processing position within the assay instrument. The intermediate conveyor assembly coupled to the assay instrument can include a buffer conveyor subassembly configured to receive carriers from the host conveyor assembly, and a spur conveyor assembly configured to transport a carrier to the processing position of the assay instrument.

10. 发明申请

WO2017070663A1 SYSTEMS AND METHODS FOR READING MACHINE-READABLE MARKS ON RACKS AND RECEPTACLES 审中-公开
标题翻译：用于在机架和接收器上读取机器可读标记的系统和方法
公开(公告)号：WO2017070663A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058452
申请日：2016-10-24
申请人： GEN-PROBE INCORPORATED
发明人： OPALSKY, David
IPC分类号： G01N35/00 , B01L3/00 , G06K7/10
CPC分类号： G06K7/10811 , B01L3/545 , B01L3/5453 , B01L9/06 , B01L2300/021 , G01N35/00732 , G01N2035/00752 , G01N2035/00801 , G01N2035/00831 , G06K7/10732 , G06K7/10861 , G06K7/10881 , G06K7/1447 , G06K19/06028
摘要： A sample processing or assay instrument (100) includes a moveable support (112). The moveable support (112) defines a first pocket (140A) configured to receive a first object (136) having a first machine-readable mark (147). The moveable support (112) defines a second pocket (140B) configured to receive a second object (136) having a second machine-readable mark (147). The moveable support (112) also includes a first fiducial machine-readable mark (150A) and a second fiducial machine-readable mark (150B). The instrument also includes an image capture device (128) that captures a first image including the first fiducial machine-readable mark (150A) and the first machine-readable mark (147) of the first object (136). The image capture device (128) captures a second image that includes the second fiducial machine-readable mark (150B) and the second machine-readable mark (147) of the second object (136). The instrument (100) also includes a processor configured to associate information decoded from the first and second machine-readable marks (150A, 150B) with first and second locations on the moveable support (112).
摘要翻译：样品处理或测定仪器（100）包括可移动支撑件（112）。可移动支撑件（112）限定了构造成接收具有第一机器可读标记（147）的第一对象（136）的第一凹座（140A）。可移动支撑件（112）限定第二凹座（140B），第二凹座构造成接收具有第二机器可读标记（147）的第二对象（136）。可移动支撑件（112）还包括第一基准机器可读标记（150A）和第二基准机器可读标记（150B）。该仪器还包括捕获包括第一对象（136）的第一基准机器可读标记（150A）和第一机器可读标记（147）的第一图像的图像捕获设备（128）。图像捕捉设备（128）捕捉包括第二对象（136）的第二基准机器可读标记（150B）和第二机器可读标记（147）的第二图像。该仪器（100）还包括处理器，该处理器被配置为将从第一机器可读标记和第二机器可读标记（150A，150B）解码的信息与可移动支撑（112）上的第一位置和第二位置相关联。

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