专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2019105870A1 MEASUREMENT SYSTEM AND METHOD THEREFORE 审中-公开
公开(公告)号：WO2019105870A1
公开(公告)日：2019-06-06
申请号：PCT/EP2018/082478
申请日：2018-11-26
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： BURCHESKY, Robert, Douglas , MOLLOY, James
IPC分类号： G01M3/00 , C12M1/00 , G01M3/32 , G01G17/04
摘要： The present invention relates to a method (300) for a measurement system (100) configured to test a flexible bio-process bag (120), the method comprising providing (310) at least one flexible bio- process bag (120) having a volume, wherein the at least one flexible bio-process bag (120) is initially filled with a gas and inflated to a reference pressure (Pu), obtaining (320) a leak model, obtaining (330) baseline information, wherein the baseline information comprises at least a weighed first mass value (m b ase l ine) and a first time value (ti), obtaining (340) evaluation information, wherein the evaluation information comprises at least a weighed second mass value (meva l uation) and a second time value (t 2 ), testing (350) the flexible bio-process bag based on the leak model, the baseline information and the evaluation information.

2. 发明申请

WO2019001766A1 BIOREACTORS WITH FILTERS 审中-公开
公开(公告)号：WO2019001766A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/000318
申请日：2018-06-26
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE LIMITED
发明人： ALI, Yasser S.
IPC分类号： C12M1/00 , C12M3/00 , C12M3/06 , C12M1/09
摘要： The invention discloses a bioreactor 10 for cell culture and expansion, comprising a bioreactor chamber 17, a filter 13 disposed within the chamber 17 and at least one tether 14 loosely tethering the filter to the bioreactor chamber. In an embodiment, the tether(s) allow the filter 13 to move from side to side and/or up and down within the chamber 17, preferably without touching an inner surface of the bioreactor chamber 17. Alternatives show, two, three or four tethers, but one or more tethers can be used.

3. 发明申请

WO2018195313A1 SITE-SPECIFIC DNA MODIFICATION USING A DONOR DNA REPAIR TEMPLATE HAVING TANDEM REPEAT SEQUENCES 审中-公开
公开(公告)号：WO2018195313A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028366
申请日：2018-04-19
申请人： GE HEALTHCARE BIO-SCIENCES CORP
发明人： NELSON, John Richard , DUTHIE, Robert Scott , SPOONER, Patrick McCoy , SCHIEL, John Anthony , LOWERY, Lisa Anne , SMITH, Anja Josifa
IPC分类号： C12N15/10
摘要： /A method of site-specific modification of an endogenous target DNA of a eukaryotic cell is provided. The method includes contacting the endogenous target DNA having an intended modification site with (i) a gene editing system configured to introduce a double strand break in the endogenous target DNA at or near the intended modification site, and (ii) a donor DNA repair template comprising a plurality of tandem repeat sequences. In the method, each of the plurality of tandem repeat sequences comprises an exogenous donor DNA sequence flanked by a donor 5' flanking sequence and a donor 3' flanking sequence. The donor 5' flanking sequence and the donor 5' flanking sequence are homologous to a continuous DNA sequence on either side of the intended modification site in the endogenous target DNA.

4. 发明申请

WO2017109083A1 IMPROVEMENTS IN AND RELATING TO INSTRUMENTS FOR PROCESSING CELLS 审中-公开
标题翻译：仪器在加工细胞方面的改进和相关
公开(公告)号：WO2017109083A1
公开(公告)日：2017-06-29
申请号：PCT/EP2016/082401
申请日：2016-12-22
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE UK LIMITED
发明人： GRIFFIN, Weston, Blaine , TIMMINS, Mark, Robert , HARRIS, Dan , LOVETTE, Spenser , DOWLING, Jim , O'SULLIVAN, Dan
IPC分类号： C12M1/00 , B01L3/00 , C12M1/34 , C12M1/36 , A61M1/02
CPC分类号： C12M23/28 , C12M23/00 , C12M23/40 , C12M29/00 , C12M41/00 , C12M41/44 , C12M41/48 , C12M47/02
摘要： Disclosed herein is an instrument suitable for processing cells for example culturing, concentrating or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump; and a disposable processing kit complementary to the mechanical elements within the housing and comprising a fluid circuit including a fluid reservoir and plural fluid paths capable of carrying fluid flow caused by said pump(s), the instrument further including a mechanism for determining the quantity, or change in quantity of the fluid in the reservoir resulting from said fluid flow, the instrument yet further comprising a controller operable to control at least the pump and operable to perform a fault determination process, which includes the steps of determining the expected flow rate of said pump(s) calculated from the speed of the pump(s) and comparing that expected flow with the change in quantity of the fluid in the reservoir as determined by said mechanism.
摘要翻译：这里公开了一种适用于处理细胞的仪器，例如培养，浓缩或洗涤所述细胞，所述仪器包括：用于容纳包括至少一个流体泵的机械元件的壳体; 以及与所述壳体内的所述机械元件互补的一次性处理套件，所述处理套件包括流体回路，所述流体回路包括流体储存器和能够承载由所述泵引起的流体流动的多条流体路径，所述器械还包括用于确定所述数量的机构，或由于所述流体流动导致的储存器中流体的量的变化，所述仪器还包括控制器，所述控制器可操作以控制至少所述泵并且可操作以执行故障确定过程，所述故障确定过程包括以下步骤：所述泵根据泵的速度计算并将该预期流量与由所述机构确定的储存器中流体量的变化进行比较。

5. 发明申请

WO2017029259A1 PASSIVE AUTOMATIC ANTIFOAM DELIVERY SYSTEM FOR USE WITH SINGLE-USE BIOREACTORS 审中-公开
标题翻译：被动式自动抗菌输送系统，用于单用途生物反应器
公开(公告)号：WO2017029259A1
公开(公告)日：2017-02-23
申请号：PCT/EP2016/069334
申请日：2016-08-15
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： DAMREN, Richard, Lee
IPC分类号： C12M1/00 , C12M1/21
CPC分类号： C12M41/02 , C12M23/14 , C12M23/28
摘要： The aspects of the disclosed embodiments generally relate to an apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments also generally relate toa method of using such apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments generally relate to antifoam systems, methods and apparatus, and more particularly, to an antifoam device operably connected to a single use biobag.
摘要翻译：所公开的实施方案的方面通常涉及允许以可靠的方式将消泡剂控制加入到一次性一次性生物反应器的顶部空间中的泡沫的装置。所公开的实施方案的方面还通常涉及使用这种装置的方法，其允许以可靠的方式将消泡剂控制在存在于一次性一次性生物反应器的顶部空间中的泡沫中。所公开的实施方案的方面通常涉及消泡剂系统，方法和装置，更具体地，涉及可操作地连接到单次使用的生物袋的消泡装置。

6. 发明申请

WO2016166046A1 BIOPROCESS MIXER 审中-公开
标题翻译：生物混合器
公开(公告)号：WO2016166046A1
公开(公告)日：2016-10-20
申请号：PCT/EP2016/057884
申请日：2016-04-11
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： AKERSTROM, Patrik, Berndt , DAMREN, Richard, Lee , TUOHEY, Colin, R. , ERDENBERGER, Thomas , KENNEY, Jonathan , BRAZELL, David, Lawrence , JIN, Wei , CABRAL, Roberto, Miguel , TELIKHERLA KANDALA, Sampath
IPC分类号： B01F13/08 , B01F15/00
CPC分类号： B01F13/0827 , B01F15/0085 , B01F15/00863 , B01F2215/0073 , C12M27/02
摘要： A bioprocess mixer (1), which comprises: - a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and - a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.
摘要翻译：一种生物过程混合器（1），其包括：具有至少一个侧壁（3,4,5,6）和底壁（7）的支撑容器（2），其中所述壁限定支撑容器内部容积 8）和至少第一（9）和第二（10）磁叶轮驱动单元; 以及 - 柔性袋（11,111），其适于装配在所述支撑容器内部容积内，其中所述袋具有至少一个袋侧壁（12,112,13,133,14,15），袋底壁（16），116）和限定袋内容积（18）的袋顶壁（17,117）以及可旋转地附接到袋内容积中的袋壁的至少第一（19）和第二（20）磁叶轮。

7. 发明申请

WO2016105934A2 SELECTIVE PLANE ILLUMINATION MICROSCOPY INSTRUMENTS 审中-公开
标题翻译：选择性平面照明显微镜仪器
公开(公告)号：WO2016105934A2
公开(公告)日：2016-06-30
申请号：PCT/US2015/064512
申请日：2015-12-08
申请人： GE HEALTHCARE BIO-SCIENCES CORP.
发明人： COOPER, Jeremy, R.
IPC分类号： H04N1/56 , G02B21/02
CPC分类号： G02B21/086 , G02B21/0088 , G02B21/02 , G02B21/16 , G02B21/18 , G02B21/367
摘要： Disclosed is an optical arrangement providing selective plane illumination, including an inverted illumination objective mounted below a sample support in use providing a line or plane of light at the sample support, and at least one image collection objective mounted above the support, said inverted illumination objective having an illumination objective optic axis, and said image collection objective having an image collection objective optical axis, wherein illumination light is arranged to propagate toward the illumination objective lateral offset to the illumination objective optical axis such that the illumination light leaving the illumination objective propagates toward the sample support at an oblique angle relative to the illumination objective optical axis, and wherein the image objective optical axis has an angle α which is obtuse to the illumination objective optical axis and generally perpendicular to light propagating at the sample support.
摘要翻译：公开了一种提供选择性平面照明的光学装置，包括安装在使用中的样品支架下方的倒置照明物体，在样品支撑件处提供光线或平面，以及安装在支撑体上方的至少一个图像采集目标，所述反相照明物镜具有照明物镜光轴，并且所述图像采集目标具有图像采集物镜光轴，其中照明光被布置成朝向照明物镜光轴的照明物镜横向偏移传播，使得离开照明物体的照明光向着样品以相对于照明物镜光轴倾斜的角度支撑，并且其中图像物镜光轴具有与照明物镜光轴无关的角度α，并且通常垂直于在样品支撑体处传播的光。

8. 发明申请

WO2016091744A1 SYSTEMS AND METHODS FOR ASEPTIC SAMPLING 审中-公开
标题翻译：用于自由采样的系统和方法
公开(公告)号：WO2016091744A1
公开(公告)日：2016-06-16
申请号：PCT/EP2015/078643
申请日：2015-12-04
申请人： GE HEALTHCARE BIO-SCIENCES CORP , GE HEALTHCARE UK LIMITED
发明人： YASSER, Ali
IPC分类号： C12M1/26 , C12M1/32 , B01L3/00 , C12M1/00 , C12M1/12
CPC分类号： C12M23/40 , B01L3/563 , C12M33/06 , C12M37/00 , C12M41/00
摘要： A product and method for sampling cells from a bioreactor, for the purposes of determine the cell count or to remove a sample and retain sterility of the sample for quality control (OC) assessment. More specifically, a product and a method for sampling of cells during a cell expansion in a bioreactor using vacuum tubes.
摘要翻译：用于从生物反应器取样细胞的产物和方法，用于确定细胞计数或除去样品并保留样品的无菌性以进行质量控制（OC）评估。更具体地，涉及使用真空管在生物反应器中细胞扩增期间细胞取样的产物和方法。

9. 发明申请

WO2015102528A1 APPARATUS FOR CELL CULTIVATION 审中-公开
标题翻译：细胞培养装置
公开(公告)号：WO2015102528A1
公开(公告)日：2015-07-09
申请号：PCT/SE2014/051575
申请日：2014-12-29
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： PIZZI, Vincent, Fracis
IPC分类号： B01D15/02 , B01D15/08 , B01J19/10 , C07K1/22 , C12M1/12
CPC分类号： C12M35/04 , B01D15/02 , B01D15/125 , B01D15/1807 , B01D15/1821 , B01D21/01 , B01D61/145 , B01D61/147 , B01D63/02 , C07K1/22 , C07K1/34 , C12M23/14 , C12M23/26 , C12M33/14 , C12M47/02 , C12M47/10
摘要： The invention discloses an apparatus (1;11;31) for cell cultivation, comprising a bioreactor (2;12;32), an acoustic standing wave cell separator (5;15;35) and a filter (7;17;37), wherein an outlet (3;13;33) of the bioreactor is fluidically connected to an inlet (4;14;34) of the acoustic standing wave cell separator and a media outlet (6;16;36) of the acoustic standing wave cell separator is fluidically connected to the filter (7;17;37).
摘要翻译：本发明公开了一种用于细胞培养的装置（1; 11; 31），包括生物反应器（2; 12; 32），声驻波隔离器（5; 15; 35）和过滤器（7; 17; 37），其中所述生物反应器的出口（3; 13; 33）流体连接到所述声驻波分离器的入口（4; 14; 34）和所述声驻波的介质出口（6; 16; 36）电池隔板流体连接到过滤器（7; 17; 37）。

10. 发明申请

WO2015063155A1 OBJECTIVE LENS CHANGER 审中-公开
标题翻译：目标镜头更换
公开(公告)号：WO2015063155A1
公开(公告)日：2015-05-07
申请号：PCT/EP2014/073228
申请日：2014-10-29
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： STEWART, David, Andrew
IPC分类号： G02B21/24
CPC分类号： G02B21/248 , G02B7/004 , G02B7/005 , G02B7/14 , G02B21/06 , G02B21/16 , G02B21/36
摘要： Objective lens changer (104) comprising: a changer frame (130) arranged to be positioned with respect to the optical path of an optical apparatus, an objective lens carrier (135) moveably attached to the frame by a mechanical link arrangement (140), the objective lens carrier comprising at least two objective lens positions (145) that can be selectively positioned in the optical path by the mechanical link arrangement, wherein the mechanical link arrangement comprises a first link section (150) to provide translation of the objective lens carrier between the objective lens positions and a second link section (155) spaced apart from the first link section in the direction of the optical axis, and arranged to control the alignment of the objective lens position positioned in the optical path with respect to the optical axis, and wherein the mechanical link arrangement is arranged to move the objective lens carrier in one plane and so that the translation between the objective lens positions involves both an angular movement and a linear movement of the objective lens carrier with respect to the optical axis.
摘要翻译：物镜转换器（104）包括：相对于光学设备的光路定位的变换器框架（130），通过机械连杆装置（140）可移动地附接到框架的物镜支架（135）所述物镜载体包括至少两个可通过所述机械连杆装置选择性地定位在所述光路中的物镜位置（145），其中所述机械连杆装置包括第一连杆部分（150），以提供所述物镜载体在所述物镜位置与在所述光轴方向上与所述第一连接部分间隔开的第二连杆部分（155）之间，并且被配置为控制位于所述光路中的所述物镜相对于所述光轴的对准并且其中所述机械连杆装置被布置成在一个平面中移动所述物镜载体，并且使得所述物镜之间的平移位置 ons涉及物镜相对于光轴的角运动和线性运动。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式