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1. 发明申请

WO2014113704A3 ENHANCED DIFFERENTIATION OF MESENCHYMAL STEM CELLS 审中-公开
标题翻译：增强细胞干细胞的分化
公开(公告)号：WO2014113704A3
公开(公告)日：2015-11-26
申请号：PCT/US2014012097
申请日：2014-01-17
申请人： ESCAPE THERAPEUTICS INC
发明人： HANTASH BASIL M
CPC分类号： C12N5/0662 , A61K35/28 , C12N5/0667
摘要： Isolated populations of mesenchymal stem cells (MSCs) are provided, including mammalian mesenchymal stem cells (MSCs) characterized by the lack of CD54 (CD54 ) or low cell-surface CD54 (CD54low). Methods of in vitro cell differentiation and methods of treatment using said isolated populations are also provided.
摘要翻译：提供了分离的间充质干细胞群体，包括以缺乏CD54（CD54）或低细胞表面CD54（CD54low）为特征的哺乳动物间充质干细胞（MSC）。还提供了体外细胞分化方法和使用所述分离群体的治疗方法。

2. 发明申请

WO2015081306A3 PEPTIDE TYROSINASE ACTIVATORS 审中-公开
标题翻译：肽类酪氨酸酶激活剂
公开(公告)号：WO2015081306A3
公开(公告)日：2015-11-19
申请号：PCT/US2014067783
申请日：2014-11-26
申请人： ESCAPE THERAPEUTICS INC
发明人： HANTASH BASIL M , UBEID ANAN ABU
IPC分类号： A61K38/08 , A61K38/00
CPC分类号： C07K7/06 , A61K8/64 , A61K2800/78 , A61Q19/04
摘要： Peptides that increase melanin synthesis are provided. These peptides include pentapeptides YSSWY, YRSRK, and their variants. The peptides may activate the enzymatic activity of tyrosinase to increase melanin synthesis. The pharmaceutical, cosmetic, and other compositions including the peptides are also provided. The methods of increasing melanin production in epidermis of a subject are provided where the methods include administering compositions comprising an amount of one or more peptides effective to increase the melanin production. The methods also include treating vitiligo or other hypopigmentation disorders with compositions including one or more peptides.
摘要翻译：提供增加黑色素合成的肽。这些肽包括五肽YSSWY，YRSRK及其变体。肽可激活酪氨酸酶的酶活性以增加黑色素合成。还提供了药物，化妆品和其他包含肽的组合物。提供了增加受试者表皮中黑色素产生的方法，其中所述方法包括施用包含一定量的一种或多种有效增加黑色素产生的肽的组合物。该方法还包括用包含一种或多种肽的组合物治疗白癜风或其他色素沉着不足病症。

3. 发明申请

WO2009155334A1 DIFFERENTIATION OF MESENCHYMAL STEM CELLS INTO FIBROBLASTS, COMPOSITIONS COMPRISING MESENCHYMAL STEM CELL-DERIVED FIBROBLASTS, AND METHODS OF USING THE SAME 审中-公开
标题翻译：骨髓间充质干细胞分化成纤维蛋白，包含间质干细胞衍生的纤维蛋白的组合物及其使用方法
公开(公告)号：WO2009155334A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047647
申请日：2009-06-17
申请人： ESCAPE THERAPEUTICS, INC. , HANTASH, Basil, M.
发明人： HANTASH, Basil, M.
IPC分类号： C12N5/02 , A61P17/02 , C12N5/06
CPC分类号： C12N5/0656 , A61L27/60 , C12N2501/11 , C12N2501/115 , C12N2501/15
摘要： Methods and compositions are provided for the differentiation and characterization of mammalian fibroblast from mesenchymal stem cells. The methods of the invention provide a means to obtain mesenchymal stem cell-derived fibroblast populations, e.g., seeded on a scaffold, which may be used in wound healing.
摘要翻译：提供了用于从间充质干细胞分化和表征哺乳动物成纤维细胞的方法和组合物。本发明的方法提供了获得间充质干细胞来源的成纤维细胞群体的手段，例如接种在支架上，其可用于伤口愈合。

4. 发明申请

WO2022087026A1 ENHANCED SKIN PERMEATION OF A NOVEL PEPTIDE VIA STRUCTURAL MODIFICATION, CHEMICAL ENHANCEMENT, AND MICRONEEDLES 审中-公开
公开(公告)号：WO2022087026A1
公开(公告)日：2022-04-28
申请号：PCT/US2021/055692
申请日：2021-10-19
申请人： ESCAPE THERAPEUTICS, INC.
发明人： HANTASH, Basil M.
IPC分类号： C07K7/06 , A61K38/08 , A61P17/00 , A61Q19/02 , A61Q19/08
摘要： Hyperpigmentation is a common skin condition with serious psychosocial consequences. Decapeptide-12, a newly synthesized peptide, has been found to be safer than hydroquinone in reducing content of melanin, with efficacy up to more than 50 percent upon 16 weeks of twice daily treatment. However, the peptide suffers from limited transcutaneous penetration due to its hydrophilicity and large molecular weight. Therefore, decapeptide-12 was modified by adding a palmitate chain in an attempt to overcome this limitation. We also tested the effects of chemical penetration enhancers and microneedles to deliver two peptides through skin. Enhanced human skin permeation was found using an in vitro skin permeation model. Moreover, we examined peptide retention of different formulations. Our data showed that palm-peptides in microneedle patch was the most effective.

5. 发明申请

WO2020150718A1 TYROSINE INHIBITORS WITH IMMUNOSUPPRESSIVE ACTIVITY IN HUMAN NEONATAL KERATINOCYTE PROGENITORS 审中-公开
公开(公告)号：WO2020150718A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/014298
申请日：2020-01-20
申请人： ESCAPE THERAPEUTICS, INC.
发明人： HANTASH, Basil M.
IPC分类号： A61K38/08 , A61P29/00
摘要： Embodiments relate to tyrosine inhibitors that exhibit immunosuppressive activity in human neonatal keratinocyte progenitors. Particular embodiments feature the immunosuppressive effects of a decapeptide and/or oxyresveratrol, as measured by two different methods: blockade of stimulated cell growth, and inhibition of cytotoxic killing.

6. 发明申请

WO2011116072A1 HYBRID HYDROGEL SCAFFOLD COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： HYBRID HYDROGEL SCAFFOL组合物和使用方法
公开(公告)号：WO2011116072A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028638
申请日：2011-03-16
申请人： ESCAPE THERAPEUTICS, INC. , HANTASH, Basil, M. , WANG, Ying
发明人： HANTASH, Basil, M. , WANG, Ying
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： C12N5/0068 , A61K38/08 , A61K47/34 , A61K47/42 , C12N2533/30 , C12N2533/50 , C12N2533/78
摘要： The present invention includes new hybrid hydrogel scaffolds comprised of a polyoxyethylene-polyoxypropylene (block) copolymer (a "poloxamer") and a self- assembling peptide, which maintain the mechanical and bioactive properties of its individual constituents (as compared to when the individual constituents are scaffolds or hydrogels by themselves). For example, a hybrid hydrogel can be designed to maintain the mechanical strength from the poloxamer component and favorable cellular functionality (viability, proliferation, migration, and differentiation) from its self-assembling peptide component. In addition to hybrid hydrogels, the invention also includes hydrogels that do not include a self- assembling peptide and are made from one or more poloxamers and one or more elements that contribute in some form to the structure and/or function of the hydrogel. The hydrogels of the invention can include a combination of materials from different origins or with different properties that provides a hybrid material that meets the multiple needs of a scaffold for tissue engineering.
摘要翻译：本发明包括由聚氧乙烯 - 聚氧丙烯（嵌段）共聚物（“泊洛沙姆”）和自组装肽组成的新的混合水凝胶支架，其保持其各个组分的机械和生物活性性质（与单独成分是支架或水凝胶）。例如，可以设计混合水凝胶以保持来自泊洛沙姆组分的机械强度和有益的细胞功能（活力，增殖，迁移和分化）与其自组装肽组分。除了混合水凝胶外，本发明还包括水凝胶，其不包括自组装肽，并且由一种或多种泊洛沙姆和一种或多种对水凝胶的结构和/或功能有贡献的元素制成。本发明的水凝胶可以包括来自不同来源的材料或不同性质的组合，其提供满足用于组织工程的支架的多种需要的混合材料。

7. 发明申请

WO2015081306A2 PEPTIDE TYROSINASE ACTIVATORS 审中-公开
标题翻译：肽类酪氨酸激活剂
公开(公告)号：WO2015081306A2
公开(公告)日：2015-06-04
申请号：PCT/US2014/067783
申请日：2014-11-26
申请人： ESCAPE THERAPEUTICS, INC.
发明人： HANTASH, Basil M. , UBEID, Anan Abu
IPC分类号： C07K7/06 , A61K8/64 , A61Q19/04
CPC分类号： C07K7/06 , A61K8/64 , A61K2800/78 , A61Q19/04
摘要： Peptides that increase melanin synthesis are provided. These peptides include pentapeptides YSSWY, YRSRK, and their variants. The peptides may activate the enzymatic activity of tyrosinase to increase melanin synthesis. The pharmaceutical, cosmetic, and other compositions including the peptides are also provided. The methods of increasing melanin production in epidermis of a subject are provided where the methods include administering compositions comprising an amount of one or more peptides effective to increase the melanin production. The methods also include treating vitiligo or other hypopigmentation disorders with compositions including one or more peptides.
摘要翻译：提供增加黑色素合成的肽。这些肽包括五肽YSSWY，YRSRK及其变体。肽可以激活酪氨酸酶的酶活性以增加黑色素合成。还提供了包括肽的药物，化妆品和其它组合物。提供了增加受试者表皮中黑色素产生的方法，其中所述方法包括施用组合物，其包含一定量的一种或多种有效增加黑色素产生的肽。所述方法还包括用包含一种或多种肽的组合物治疗白癜风或其它色素沉着失调。

8. 发明申请

WO2008121894A3 ENDOGENOUS EXPRESSION OF HLA-G AND/OR HLA-E BY MESENCHYMAL CELLS 审中-公开
标题翻译： HLA-G和/或HLA-E的内源性表达由细胞外基质表达
公开(公告)号：WO2008121894A3
公开(公告)日：2009-04-23
申请号：PCT/US2008058779
申请日：2008-03-28
申请人： ESCAPE THERAPEUTICS INC , HANTASH BASIL
发明人： HANTASH BASIL
IPC分类号： C12N5/0775 , G01N33/569
CPC分类号： C12N5/0667 , A61K35/28 , A61K45/06 , C12N5/0663 , C12N15/85 , G01N33/56977
摘要： Methods and compositions are provided for the identification and isolation of mammalian HLA-G+ MSC, HLA-E+ MSC, or HLA-G4VHLA-E+ MSC. The methods of the invention provide a means to obtain enriched HLA-G+ MSC, HLA-E+ MSC, or HLA-G+/HLA-E+ MSC populations.
摘要翻译：提供了用于鉴定和分离哺乳动物HLA-G + MSC，HLA-E + MSC或HLA-G4VHLA-E + MSC的方法和组合物。本发明的方法提供了获得富集的HLA-G + MSC，HLA-E + MSC或HLA-G + / HLA-E + MSC群体的方法。

9. 发明申请

WO2021163701A1 MELANOMA THERAPEUTICS 审中-公开
公开(公告)号：WO2021163701A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/018247
申请日：2021-02-16
申请人： ESCAPE THERAPEUTICS, INC.
发明人： HANTASH, Basil M.
IPC分类号： C07K5/097 , C07K7/06 , A61K38/06 , A61K38/08 , A61P35/00
摘要： Two therapeutics, oligopeptides P5 and P14, which have proven to be selectively cytotoxic towards multiple melanoma cell lines in vitro. These oligopeptides offer an efficacious treatment for all types of pathogenic melanocytes and stages of melanoma, and a cost effective prophylactic to all individuals who are at high risk of developing skin cancer. In addition, these oligopeptides can be formulated into a sunscreen to serve as a prophylactic against any precancerous lesion or dysplastic nevi that might develop in high risk groups.

10. 发明申请

WO2018183882A1 DECAPEPTIDE-12 MODULATION OF SIRTUIN GENE EXPRESSION IN EPIDERMAL KERATINOCYTE PROGENITORS 审中-公开
公开(公告)号：WO2018183882A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025450
申请日：2018-03-30
申请人： ESCAPE THERAPEUTICS, INC.
发明人： HANTASH, Basil, M. , UBEID, Anan, Abu
IPC分类号： C07K7/06 , A61K38/08
摘要： Recent reports detail the pleiotropic roles sirtuins play in repressing premature aging, delaying cellular senescence, enhancing longevity, and ameliorating a wide range of aging disorders. Herein, we report our findings on the potent sirtuin activator, decapeptide-12, and compare its performance to the well documented oxyresveratrol. Treatment of human epidermal keratinocyte progenitors with 100µM decapeptide-12 increased transcription of SIRT1 by 141 ±11 percent relative to control cells, whereas levels of SIRT3, SIRT6, and SIRT7 were increased by 121± 13 percent, 147± 8 percent and 95.4 ±14 percent, respectively. Decapeptide-12 upregulated sirtuin transcription to similar levels as oxyresveratrol but with reduced cytotoxicity.

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