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1. 发明申请

WO1995027205A1 SALIVA ASSAY METHOD AND DEVICE 审中-公开
标题翻译： SALIVA测定方法和装置
公开(公告)号：WO1995027205A1
公开(公告)日：1995-10-12
申请号：PCT/US1995003809
申请日：1995-03-29
申请人： EPITOPE, INC. , THIEME, Thomas, R. , CIMLER, B., Melina , KLIMKOW, Nanette, M.
发明人： EPITOPE, INC.
IPC分类号： G01N33/52
CPC分类号： G01N33/521 , A61B10/0051 , G01N33/5302 , G01N33/558 , Y10S435/805 , Y10S435/81
摘要： An improved method for determining the presence of an analyte in an oral fluid sample. In the method, a reaction mixture is produced containing at least a portion of the collected sample and a chromogenic substrate effective to produce a colored product upon reaction with amylase present in the sample. After a selected reaction time, the reaction medium is inspected to determine the level of colored product produced in the medium within the selected reaction time. Production of colored product above a preselected threshold level within the selected reaction time indicates that an effective volume of undiluted saliva sample has been collected sufficient to allow detection of the analyte. The invention also includes a device for use in the method.
摘要翻译：用于确定口腔液样品中分析物的存在的改进方法。在该方法中，制备含有至少一部分收集的样品和显色底物的反应混合物，其有效地在与样品中存在的淀粉酶反应时产生着色产物。在选择的反应时间后，检查反应介质以确定在所选反应时间内在培养基中产生的着色产物的水平。在所选择的反应时间内生产高于预选阈值水平的有色产品表明已经收集足够量的未稀释唾液样品以有效检测分析物。本发明还包括用于该方法的装置。

2. 发明申请

WO1994022298A1 FLORAL PRESERVATIVE METHOD AND COMPOSITION 审中-公开
标题翻译：花卉保鲜方法和组合物
公开(公告)号：WO1994022298A1
公开(公告)日：1994-10-13
申请号：PCT/US1994003287
申请日：1994-03-25
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , BESTWICK, Richard, K. , MOKKAPATI, Vijaya, K.
IPC分类号： A01N03/02
CPC分类号： A01N3/02
摘要： Method for extending bloom life of a cut flower by bathing the flower in a solution which contains isoniazid. Also disclosed are compositions for use in the method.
摘要翻译：通过将花洗在含有异烟肼的溶液中来延长切花的花期寿命的方法。还公开了用于该方法的组合物。

3. 发明申请

WO1991013355A1 ORAL COLLECTION FOR IMMUNOASSAY 审中-公开
标题翻译：口服收集免疫试剂
公开(公告)号：WO1991013355A1
公开(公告)日：1991-09-05
申请号：PCT/US1991001121
申请日：1991-02-27
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , GOLDSTEIN, Andrew, S. , GAVOJDEA, Stefan , ZOGG, David, F.
IPC分类号： G01N33/53

4. 发明申请

WO1995035387A1 REGULATED EXPRESSION OF HETEROLOGOUS GENES IN PLANTS AND TRANSGENIC FRUIT WITH A MODIFIED RIPENING PHENOTYPE 审中-公开
标题翻译：在植物和转基因水稻中改造的RIPENING PHENOTYPE的异位基因的调控表达
公开(公告)号：WO1995035387A1
公开(公告)日：1995-12-28
申请号：PCT/US1994012364
申请日：1994-10-27
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , BESTWICK, Richard, Keith , FERRO, Adolph, J.
IPC分类号： C12N15/82
CPC分类号： C07K14/415 , C12N9/14 , C12N15/8235 , C12N15/8249
摘要： The present invention relates to chimeric genes having (i) a DNA sequence encoding a product that is effective to reduce ethylene biosynthesis in fruit from the plant, and (ii) a promoter whose expression is induced during fruit ripening or by ethylene synthesis by the fruit, where the DNA sequence is heterologous to the promoter and the DNA sequence is operably linked to the promoter to enable expression of the product. The invention describes vectors and transgenic plants, vegetables, flowers and fruits carrying the chimeric gene, as well as methods related thereto.
摘要翻译：本发明涉及嵌合基因，其具有（i）编码有效减少来自植物的果实中的乙烯生物合成的产物的DNA序列，和（ii）在果实成熟期间诱导其表达或通过水果乙烯合成的启动子，其中DNA序列与启动子是异源的，并且DNA序列可操作地连接到启动子以使得能够表达产物。本发明描述了携带嵌合基因的载体和转基因植物，蔬菜，花和果实以及与之相关的方法。

5. 发明申请

WO1994004078A1 ORAL COLLECTION DEVICE AND KIT 审中-公开
标题翻译：口腔采集装置和套件
公开(公告)号：WO1994004078A1
公开(公告)日：1994-03-03
申请号：PCT/US1993007597
申请日：1993-08-13
申请人： EPITOPE, INC. , THIEME, Thomas, R. , GOLDSTEIN, Andrew, S. , PIACENTINI, Stephen, C. , KLIMKOW, Nanette, M.
发明人： EPITOPE, INC.
IPC分类号： A61B10/00
CPC分类号： G01N33/5302 , A61B10/0051 , A61B2010/0003 , A61B2010/0009 , B01L3/502 , G01N33/54366 , G01N33/569 , G01N33/56988 , G01N33/68 , G01N33/6854 , G01N2001/149
摘要： A device (8) for obtaining oral fluid containing substances for testing. In one embodiment, the device includes a syringe (12) having a plunger (11) at the end of which an absorbent pad (10) is attached. A test assembly containing the device (8) is also disclosed.
摘要翻译：一种用于获得含有测试物质的口腔液的装置（8）。在一个实施例中，该装置包括具有柱塞（11）的注射器（12），其端部附接有吸收垫（10）。还公开了一种包含装置（8）的测试组件。

6. 发明申请

WO1992011028A1 HIV REVERSE TRANSCRIPTASE VACCINE 审中-公开
标题翻译： HIV逆转录病毒疫苗
公开(公告)号：WO1992011028A1
公开(公告)日：1992-07-09
申请号：PCT/US1991009603
申请日：1991-12-18
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , FERRO, Adolph, J. , BESTWICK, Richard, K.
IPC分类号： A61K39/12
CPC分类号： A61K39/275 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/545 , A61K2039/55566 , C07K14/005 , C12N15/86 , C12N2710/10043 , C12N2710/24143 , C12N2740/16034 , C12N2740/16122 , A61K2300/00
摘要： A synthetic vaccine comprises a recombinant vaccine vector that incorporates a nucleotide sequence capable of being expressed as all or part of an HIV reverse transcriptase. The vector is combined with all or part of a purified HIV reverse transcriptase in an adjuvant. The vaccine vectors include poxvirus, herpes virus, and adenovirus. The synthetic vaccine applies particularly to the augmentation of immune responses in HIV-infected asymptomatic, immunosuppressed, or immunodeficient animals or humans.
摘要翻译：合成疫苗包含重组疫苗载体，其包含能够表达为全部或部分HIV逆转录酶的核苷酸序列。载体与佐剂中纯化的HIV逆转录酶的全部或部分组合。疫苗载体包括痘病毒，疱疹病毒和腺病毒。合成疫苗特别适用于HIV感染的无症状，免疫抑制或免疫缺陷的动物或人类中免疫应答的增加。

7. 发明申请

WO1990009013A1 GERMICIDAL BARRIERS 审中-公开
标题翻译：杀菌剂
公开(公告)号：WO1990009013A1
公开(公告)日：1990-08-09
申请号：PCT/US1990000377
申请日：1990-01-25
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , FELLMAN, Jack, H.
IPC分类号： G08F226/00

8. 发明申请

WO1996041165A1 SYNTHETIC ORAL FLUID STANDARD 审中-公开
标题翻译：合成口腔液标准
公开(公告)号：WO1996041165A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009649
申请日：1996-06-06
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , GOLDSTEIN, Andrew, S.
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , Y02A50/54
摘要： A substitute oral fluid standard for testing, calibration, and standardization of devices and methods for collection, storage, and analysis of oral fluids. The oral fluid standard comprises a mucin and protease inhibitor.
摘要翻译：用于口腔液收集，储存和分析的装置和方法的测试，校准和标准化的替代口服液标准。口服液标准品包括粘蛋白和蛋白酶抑制剂。

9. 发明申请

WO1995035388A1 PLANT GENETIC TRANSFORMATION METHODS AND TRANSGENIC PLANTS 审中-公开
标题翻译：植物遗传转化方法和转基因植物
公开(公告)号：WO1995035388A1
公开(公告)日：1995-12-28
申请号：PCT/US1995007753
申请日：1995-06-16
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , MATHEWS, Helena, V. , BESTWICK, Richard, Keith , FERRO, Adolph, J.
IPC分类号： C12N15/82
CPC分类号： C12N9/0071 , A01H4/001 , A01H4/008 , C12N9/14 , C12N15/8205 , C12N15/8209 , C12N15/8249 , C12Y114/17004
摘要： An efficient transformation system for plants has been developed that yields high transformation efficiencies and pure transgenic plants and products thereof. Genomic integration of transgenes was confirmed by genomic DNA hybridization analysis. Pure transgenic plants have been successfully established in soil. Pure transgenic products of these plants have been produced.
摘要翻译：已经开发了一种有效的植物转化系统，其产生高转化效率和纯转基因植物及其产物。通过基因组DNA杂交分析证实转基因的基因组整合。在土壤中成功建立了纯转基因植物。已经生产了这些植物的纯转基因产品。

10. 发明申请

WO1990008957A1 AVIDIN-BIOTIN ASSISTED IMMUNOASSAY 审中-公开
标题翻译： AVIDIN-BIOTIN辅助免疫
公开(公告)号：WO1990008957A1
公开(公告)日：1990-08-09
申请号：PCT/US1990000378
申请日：1990-01-25
申请人： EPITOPE, INC.
发明人： EPITOPE, INC. , THIEME, Thomas , FERRO, Adolph , FELLMAN, Jack, H. , GAVOJDEA, Stefan
IPC分类号： G01N33/543
CPC分类号： B82Y5/00 , A61K47/6898 , G01N33/548 , G01N33/566 , G01N33/581
摘要： A method for detection for screening and diagnostic purposes of antibodies in a body fluid by means of an antibody-binding protein covalently bound to a porous matrix trapped within a transparent column. A test fluid containing antibody is contacted with the protein-bound matrix whereby the protein reacts with to immobilize any antibody present in the test fluid. A biotinylated antigen of interest is contacted with the immobilized antibody whereby the biotinylated antigen binds to the immobilized antibody. Avidin covalently linked to an enzyme is contacted with the immobilized biotinylated antigen-immobilized antibody-protein bound matrix complex whereby the enzyme-labelled avidin binds to the immobilized complex. This immobilized complex is contacted with a substrate solution wherein the enzyme linked to avidin catalyzes a reaction of the substrate and produces a detectable reaction product which correlates to the presence of the antibody to be detected.
摘要翻译：用于通过与截留在透明柱中的多孔基质共价结合的抗体结合蛋白在体液中筛选和诊断目的的方法。含有抗体的测试液体与蛋白质结合的基质接触，由此蛋白质与固定测试流体中存在的任何抗体反应。感兴趣的生物素化抗原与固定的抗体接触，由此生物素化的抗原与固定的抗体结合。与酶共价连接的亲和素与固定化的生物素化抗原 - 固定的抗体 - 蛋白质结合的基质复合物接触，由此酶标记的抗生物素蛋白与固定的复合物结合。将该固定化的复合物与底物溶液接触，其中与抗生物素蛋白连接的酶催化底物的反应并产生可检测的反应产物，其与待检测的抗体的存在相关。

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