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1. 发明申请

WO2019123453A1 COMPOSITIONS COMPRISING DEXAMETHASONE 审中-公开
公开(公告)号：WO2019123453A1
公开(公告)日：2019-06-27
申请号：PCT/IL2018/051361
申请日：2018-12-17
申请人： DEXCEL PHARMA TECHNOLOGIES LTD.
发明人： KREYENBORG, Caterina , MEIMBERG, Elisabeth , TISSEN, Corinna , BANNEFELD, Karl-Heinz , GOLD, Tomer
IPC分类号： A61K31/573 , A61K9/20 , A61K47/22 , A61K47/36 , A61P35/00 , A61K31/454
摘要： A pharmaceutical composition useful for the treatment of multiple myeloma in combination with an anti-cancer drug is provided. The pharmaceutical composition includes high-dose dexamethasone or a pharmaceutically acceptable salt or solvate thereof.

2. 发明申请

WO2018047163A1 OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：眼科组合物
公开(公告)号：WO2018047163A1
公开(公告)日：2018-03-15
申请号：PCT/IL2017/050980
申请日：2017-09-03
申请人： DEXCEL PHARMA TECHNOLOGIES LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
发明人： BENITA, Simon , NASSAR, Taher
IPC分类号： A61K47/36 , A61K47/38 , A61K9/00 , A61K9/06 , A61K31/56 , A61P31/04 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/06 , A61K31/575 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/186 , A61K47/26 , A61K47/36 , A61K47/38 , A61P27/02 , A61P31/04
摘要： An ophthalmic composition useful for the treatment of bacterial eye infections is provided. The ophthalmic composition includes the suspension of particles of active anti-bacterial agent in a gelled matrix.
摘要翻译：提供了用于治疗细菌性眼感染的眼科用组合物。眼用组合物包括凝胶基质中的活性抗菌剂颗粒的悬浮液。

3. 发明申请

WO2011001425A1 LOCAL THERAPEUTIC RELEASE DEVICE 审中-公开
标题翻译：局部治疗装置
公开(公告)号：WO2011001425A1
公开(公告)日：2011-01-06
申请号：PCT/IL2010/000509
申请日：2010-06-24
申请人： DEXCEL PHARMA TECHNOLOGIES LTD. , PENHASI, Adel , REUVENI, Albert , SHOSHANI, Eyal
发明人： PENHASI, Adel , REUVENI, Albert , SHOSHANI, Eyal
IPC分类号： A61K9/00 , A61K9/16 , A61K9/70 , A61K31/192
CPC分类号： A61K9/0063 , A61K9/1635 , A61K9/1652 , A61K9/1658 , A61K9/7007 , A61K31/192
摘要： An oral delivery device for the treatment of periodontal disease, the device being in a solid unit dosage form configured for insertion into a periodontal pocket of a patient. The device consists of: (a) a biodegradable pharmaceutically acceptable water-insoluble polymer in the form of a matrix; (b) a therapeutically effective amount of at least one anti-inflammatory agent dispersed within the matrix; (c) optionally a plasticizing agent; (d) optionally at least one of a wetting agent, a suspending agent and a dispersing agent; and (e) optionally an enzymatically biodegradable pharmaceutically acceptable water soluble polymer dispersed within the matrix. The biodegradable water-insoluble polymer is degradable by enzymatic degradation, physical disintegration or a combination thereof. Also disclosed is a periodontal implant comprising the device and a method for the treatment of periodontal disease comprising administering to a periodontal pocket of a patient in need of such treatment the delivery device.
摘要翻译：一种用于治疗牙周病的口服递送装置，该装置是被配置成插入到患者的牙周袋中的固体单位剂型。该装置包括：（a）基质形式的可生物降解的可药用的不溶于水的聚合物; （b）分散在基质内的治疗有效量的至少一种抗炎剂; （c）任选的增塑剂; （d）任选的润湿剂，悬浮剂和分散剂中的至少一种; 和（e）任选地分散在基质内的可酶促生物降解的药学上可接受的水溶性聚合物。可生物降解的水不溶性聚合物可通过酶降解，物理崩解或其组合降解。还公开了一种牙周植入物，其包含该装置和用于治疗牙周疾病的方法，包括向需要这种治疗的患者的牙周袋施用递送装置。

4. 发明申请

WO2006103657A2 A SOLID COMPOSITION FOR INTRA-ORAL DELIVERY OF INSULIN 审中-公开
标题翻译：一种用于胰岛素内皮递送的固体组合物
公开(公告)号：WO2006103657A2
公开(公告)日：2006-10-05
申请号：PCT/IL2006/000381
申请日：2006-03-27
申请人： DEXCEL PHARMA TECHNOLOGIES LTD. , PINHASI, Adel , GOMBERG, Mila
发明人： PINHASI, Adel , GOMBERG, Mila
CPC分类号： A61K9/006 , A61K9/127 , A61K9/7007
摘要： The invention provides a solid composition for intra-oral delivery of insulin, comprising; insulin; a hydrophilic polymer matrix; and a phospholipid, providing insulin bioavailability of at least 5%.
摘要翻译：本发明提供了用于口服胰岛素递送的固体组合物，其包含：胰岛素; 亲水性聚合物基体; 和磷脂，提供至少5％的胰岛素生物利用度。

5. 发明申请

WO2006054307A3 CONTROLLED ABSORPTION OF STATINS IN THE INTESTINE 审中-公开
公开(公告)号：WO2006054307A3
公开(公告)日：2006-05-26
申请号：PCT/IL2005/001234
申请日：2005-11-22
申请人： DEXCEL PHARMA TECHNOLOGIES LTD. , PENHASI, Adel
发明人： PENHASI, Adel
IPC分类号： A61K9/24
摘要： The present invention provides a controlled absorption formulation in which modified release of the active ingredient preferentially occurs in the lower gastrointestinal tract, including the colon. The formulation supports a significantly higher bioavailability of the active ingredient in the body of the subject than that can be achieved from the currently used conventional formulation, such that therapeutically significant plasma levels of statin are maintained for an extended period after administration. The formulation preferably features a core, over which an outer coating is layered. The core is optionally and preferably in the form of a tablet.

6. 发明申请

WO2018178963A1 COMPOSITIONS COMPRISING BIODEGRADABLE COPOLYMERS 审中-公开
公开(公告)号：WO2018178963A1
公开(公告)日：2018-10-04
申请号：PCT/IL2017/050389
申请日：2017-03-29
申请人： DEXCEL PHARMA TECHNOLOGIES LTD.
发明人： DOMB, Abraham, J. , GRISHKO, Michael , HANUKA, Ezra , SCHLINGER, Ron , HAGIGIT, Tal
IPC分类号： A61K47/34 , A61K9/00 , A61K47/30 , C08G63/06
摘要： A depot system containing at least one antibiotic and a biodegradable poly(ester-anhydride) is provided. The system provides prolonged local release of the antibiotic at the site of injection while maintaining the systemic antibiotic levels at sub-therapeutic concentrations.

7. 发明申请

WO2006103657A3 A SOLID COMPOSITION FOR INTRA-ORAL DELIVERY OF INSULIN 审中-公开
标题翻译：一种用于胰岛素内皮递送的固体组合物
公开(公告)号：WO2006103657A3
公开(公告)日：2007-05-31
申请号：PCT/IL2006000381
申请日：2006-03-27
申请人： DEXCEL PHARMA TECHNOLOGIES LTD , PINHASI ADEL , GOMBERG MILA
发明人： PINHASI ADEL , GOMBERG MILA
IPC分类号： A61K9/127
CPC分类号： A61K9/006 , A61K9/127 , A61K9/7007
摘要： The invention provides a solid composition for intra-oral delivery of insulin, comprising; insulin; a hydrophilic polymer matrix; and a phospholipid, providing insulin bioavailability of at least 5%.
摘要翻译：本发明提供了用于口服胰岛素递送的固体组合物，其包含：胰岛素; 亲水性聚合物基体; 和磷脂，提供至少5％的胰岛素生物利用度。

8. 发明申请

WO2006054308A3 STABLE ATORVASTATIN FORMULATIONS 审中-公开
标题翻译：稳定的阿托伐他汀制剂
公开(公告)号：WO2006054308A3
公开(公告)日：2006-12-07
申请号：PCT/IL2005001235
申请日：2005-11-22
申请人： DEXCEL PHARMA TECHNOLOGIES LTD , PENHASI ADEL , ATTALI YAAKOV STEPHANE
发明人： PENHASI ADEL , ATTALI YAAKOV STEPHANE
IPC分类号： A61K31/40
CPC分类号： A61K31/401 , A61K9/2018 , A61K9/2059
摘要： A simple yet efficient formulation for providing excellent bioefficacy, wherein the formulation comprises atorvastatin or a salt thereof, optionally in a crystalline or amorphous form, wherein at least one pharmaceutical excipient is selected according to a form of atorvastatin, for example for greater stability. Preferably the formulation lacks a stabilizer.
摘要翻译：用于提供优异生物功效的简单而有效的制剂，其中所述制剂包含阿托伐他汀或其盐，任选呈结晶或无定形形式，其中根据阿托伐他汀的形式选择至少一种药物赋形剂，例如用于更高的稳定性。优选该制剂不含稳定剂。

9. 发明申请

WO2006103661A2 CONTROLLED ABSORPTION OF STATINS IN THE INTESTINE 审中-公开
标题翻译：控制在INTESTINE中吸收统计数据
公开(公告)号：WO2006103661A2
公开(公告)日：2006-10-05
申请号：PCT/IL2006/000387
申请日：2006-03-27
申请人： DEXCEL PHARMA TECHNOLOGIES LTD. , PENHASI, Adel , RUDERMAN, Marina , GOMBERG, Maxim
发明人： PENHASI, Adel , RUDERMAN, Marina , GOMBERG, Maxim
IPC分类号： A61K9/56
CPC分类号： A61K31/00 , A61K9/2846 , A61K9/2866
摘要： A delayed onset controlled release formulation is provided in which controlled release of the active ingredient occurs preferentially in the lower gastrointestinal tract including the colon. The formulation supports a significantly higher bioavailability of the active ingredient in the body of the subject than can be achieved from the currently used conventional formulation, such that therapeutically significant plasma levels of statin are maintained for an extended period after administration. The formulation preferably features a core, over which an outer coating is layered. The core is optionally and preferably in the form of a tablet.
摘要翻译：提供延迟发作控制释放制剂，其中活性成分的控制释放优先在包括结肠的下胃肠道中。该制剂支持比目前使用的常规制剂可以实现的受试者体内活性成分显着更高的生物利用度，使得他汀在给药后长时间内维持治疗上显着的血浆水平。制剂优选具有芯，其上层叠有外涂层。芯可选地优选为片剂的形式。

10. 发明申请

WO2006054308A2 STABLE ATORVASTATIN FORMULATIONS 审中-公开
标题翻译：稳定的ATORVASTATIN制剂
公开(公告)号：WO2006054308A2
公开(公告)日：2006-05-26
申请号：PCT/IL2005/001235
申请日：2005-11-22
申请人： DEXCEL PHARMA TECHNOLOGIES LTD. , PENHASI, Adel , ATTALI, Yaakov Stephane
发明人： PENHASI, Adel , ATTALI, Yaakov Stephane
IPC分类号： A61K31/401 , A61K9/14
CPC分类号： A61K31/401 , A61K9/2018 , A61K9/2059
摘要： A simple yet efficient formulation for providing excellent bioefficacy, wherein the formulation comprises atorvastatin or a salt thereof, optionally in a crystalline or amorphous form, wherein at least one pharmaceutical excipient is selected according to a form of atorvastatin, for example for greater stability. Preferably the formulation lacks a stabilizer.
摘要翻译：一种用于提供优异生物功效的简单而有效的制剂，其中所述制剂包含阿托伐他汀或其盐，任选呈结晶或无定形形式，其中根据阿托伐他汀的形式选择至少一种药物赋形剂，例如用于更大的稳定性。优选地，制剂缺乏稳定剂。

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