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1. 发明申请

WO1997024446A2 GENE DELIVERY VEHICLE-TARGETING LIGANDS 审中-公开
标题翻译：基因交付车辆目标配对
公开(公告)号：WO1997024446A2
公开(公告)日：1997-07-10
申请号：PCT/US1996020295
申请日：1996-12-20
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , CHADA, Sunil , BANKS, Theresa , MOORE, Margaret, D. , CHANG, Stephen, M., W.
IPC分类号： C12N15/62
CPC分类号： C07K16/2881 , A61K38/00 , A61K48/00 , C07K14/005 , C07K14/505 , C07K14/70539 , C07K2319/00 , C12N2710/16222 , C12N2740/13043
摘要： Fusion proteins composed of an MHC Class I molecule, MHC Class II molecule, or beta 2 microglobulin, and a targeting ligand are disclosed. Also disclosed are nucleic acid molecules which encode such fusion proteins as well as suitable expression cassettes and host cells. Also provided are methods for targeting a gene delivery vehicle to a selected cell type utilizing gene delivery vehicles which contain on their surfaces one of the above-mentioned fusion proteins.
摘要翻译：公开了由MHC I类分子，MHC II类分子或β2微球蛋白组成的融合蛋白和靶向配体。还公开了编码这种融合蛋白以及合适的表达盒和宿主细胞的核酸分子。还提供了使用基因递送载体将基因递送载体靶向所选细胞类型的方法，所述基因递送载体在其表面上含有上述融合蛋白之一。

2. 发明申请

WO1996017072A2 RECOMBINANT ALPHAVIRUS VECTORS 审中-公开
标题翻译：重组ALPHAVIRUS矢量
公开(公告)号：WO1996017072A2
公开(公告)日：1996-06-06
申请号：PCT/US1995015490
申请日：1995-11-30
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , DUBENSKY, Thomas, W., Jr. , POLO, John, M. , IBANEZ, Carlos, E. , CHANG, Stephen, M., W. , JOLLY, Douglas, J. , DRIVER, David, A. , BELLI, Barbara, A.
IPC分类号： C12N15/86
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/705 , C07K14/755 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2830/002 , C12N2840/203 , C12N2840/206
摘要： The present invention provides composition and methods for utilizing recombinant alphavirus vectors.
摘要翻译：本发明提供了利用重组甲病毒载体的组合物和方法。

3. 发明申请

WO1997024452A2 TOXIC-PROTEIN EXPRESSING VIRUSES AND PRODUCER CELL LINES 审中-公开
标题翻译：毒素蛋白表达病毒和生产细胞系
公开(公告)号：WO1997024452A2
公开(公告)日：1997-07-10
申请号：PCT/US1996020587
申请日：1996-12-20
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , CHADA, Sunil , DePOLO, Nicholas, J. , SAUTER, Sybille , ROBBINS, Joan , JOLLY, Douglas, J. , MANNING, William, C. , MURPHY, John, E. , RALSTON, Robert, O., II
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , C12N2740/13043 , C12N2760/20222 , C12N2830/00 , C12N2830/003 , C12N2840/105
摘要： Expression vectors are provided which have a tightly controllable promoter which directs the expression of a fusogenic protein. Also provided are nucleic acid molecules which encode toxic of fusogenic proteins, wherein one or more cysteine residues in the nucleic acid molecule has been altered to an opal termination codon.
摘要翻译：提供了表达载体，其具有指导融合蛋白的表达的可控启动子。还提供了编码融合蛋白毒性的核酸分子，其中核酸分子中的一个或多个半胱氨酸残基已被改变为蛋白石终止密码子。

4. 发明申请

WO1996021035A3 RETROVIRAL DELIVERY OF FULL LENGTH FACTOR VIII 审中-公开
公开(公告)号：WO1996021035A3
公开(公告)日：1996-07-11
申请号：PCT/US1995016582
申请日：1995-12-18
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , BODNER, Mordechai , DE POLO, Nicholas, J. , CHANG, Stephen , CHI-TANG HSU, David
IPC分类号： C12N15/86

5. 发明申请

WO1996020731A1 DIRECT ADMINISTRATION OF GENE DELIVERY VEHICLES AT MULTIPLE SITES 审中-公开
标题翻译：基因交付机构在多个站点的直接管理
公开(公告)号：WO1996020731A1
公开(公告)日：1996-07-11
申请号：PCT/US1995016471
申请日：1995-12-15
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , IRWIN, Michael, J. , WARNER, John, F.
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/51 , A61K2039/545 , C07K14/005 , C12N2740/13043 , C12N2740/16134 , C12N2740/16222
摘要： Methods of stimulating an immune response, either humoral or cell-mediated, in a warm-blooded animal through the administration at multiple sites of one or more gene delivery vehicles is provided. Each of the gene delivery vehicles directs the expression of at least one substance in host cells modified with the vehicle, such that an immune response is generated. Within preferred embodiments, the expressed substance elicits a cell-mediated immune response, preferably an HLA Class I-restricted immune response.
摘要翻译：提供了通过在一种或多种基因递送载体的多个位点施用来刺激温血动物体液或细胞介导的免疫应答的方法。基因递送载体中的每一种引导至少一种物质在用载体修饰的宿主细胞中的表达，使得产生免疫应答。在优选实施方案中，所表达的物质引发细胞介导的免疫应答，优选HLA I类限制性免疫应答。

6. 发明申请

WO1997024447A1 IMMUNOSTIMULATION MEDIATED BY GENE-MODIFIED DENDRITIC CELLS 审中-公开
标题翻译：由基因修饰的细胞介导的免疫调节
公开(公告)号：WO1997024447A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020105
申请日：1996-12-20
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , SONG, Elizabeth, S. , CHADA, Sunil , LEE, Virginia , JOLLY, Douglas, J.
IPC分类号： C12N15/63
CPC分类号： A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156 , Y02A50/412
摘要： Compositions and methods useful for stimulating an immune response against one or more disease associated antigens by genetically modifying dentritic cells in vivo or ex vivo are provided. These compositions and methods allow for administration of lower dosages of gene delivery vehicles in order to achieve levels of immune stimulation comparable to those obtainable by conventional methods. Alternatively, administration of conventional dosages of gene delivery vehicles will enhance the resultant immune response.
摘要翻译：提供了可用于通过在体内或体外遗传修饰树突状细胞来刺激针对一种或多种疾病相关抗原的免疫应答的组合物和方法。这些组合物和方法允许施用较低剂量的基因递送载体以实现与通过常规方法可获得的免疫刺激相当的免疫刺激水平。或者，施用常规剂量的基因递送载体将增强所得的免疫应答。

7. 发明申请

WO1997023608A1 COMPOSITIONS AND METHODS FOR TARGETING GENE DELIVERY VEHICLES USING COVALENTLY BOUND TARGETING ELEMENTS 审中-公开
标题翻译：使用共有的边界指标要素来指定基因交付车辆的组合物和方法
公开(公告)号：WO1997023608A1
公开(公告)日：1997-07-03
申请号：PCT/US1996020543
申请日：1996-12-18
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , MOORE, Margaret, D. , RESPESS, James, G.
IPC分类号： C12N15/00
CPC分类号： C12N15/87 , A61K47/65
摘要： The invention described herein relates to compositions and methods for targeting gene delivery vehicles. Specifically, the invention relates to utilizing multifunctional linking agents, e.g., homobifunctional, heterobifunctional, and trifunctional linking agents, to covalently bind targeting elements to the exterior of gene delivery vehicles. Following administration of such targeted gene delivery vehicles to an animal, the targeted elements interact with a specific molecule on the surface of the target cells, after which the desired nucleic acid molecule is introduced into the target cell and expressed. The described targeting mechanism allows gene delivery vehicles to be delivered to specific target cell or tissue types with greater specificity than occurs when the gene delivery vehicle administered lacks such a covalently bound targeting element.
摘要翻译：本文描述的本发明涉及靶向基因递送载体的组合物和方法。具体地，本发明涉及利用多功能交联剂，例如同双功能的，异双功能的和三官能的连接剂，以将靶向元件共价结合到基因递送载体的外部。在向动物施用这样的靶向基因递送载体之后，目标元件与靶细胞表面上的特定分子相互作用，之后将所需的核酸分子引入靶细胞并表达。所描述的靶向机制允许将基因递送载体递送到特异性比特异性更高的特异性靶向细胞或组织类型，这比所施用的基因递送载体缺乏这种共价结合的靶向元件时发生的。

8. 发明申请

WO1996037626A1 POSITION-SPECIFIC INTEGRATION OF VECTOR CONSTRUCTS INTO EUKARYOTIC GENOMES MEDIATED BY A CHIMERIC INTEGRASE PROTEIN 审中-公开
标题翻译：矢量结构位置特异性整合到由重组蛋白质介导的原核生物基因组
公开(公告)号：WO1996037626A1
公开(公告)日：1996-11-28
申请号：PCT/US1996006727
申请日：1996-05-10
申请人： CHIRON VIAGENE, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CHIRON VIAGENE, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , RESPESS, James, G. , SANDMEYER, Suzanne, B. , JOLLY, Douglas, J. , BILANCHONE, Virginia, W. , DILDINE, Sandra, L.
IPC分类号： C12N15/90
CPC分类号： C12N15/86 , A61K48/00 , C07K2319/00 , C12N9/22 , C12N15/90 , C12N2740/13043 , C12N2830/00 , C12N2830/60 , C12N2840/44
摘要： Compositions and methods are provided for directing the position-specific integration of a vector construct encoding one or more desired genes into a specific region of a target eukaryotic genome. Such compositions and methods are useful for performing somatic and germ cell gene therapy. Among the benefits provided by position-specific integration are more uniform levels of expression of a desired gene(s) and substantial elimination of the potential for insertional mutagenesis.
摘要翻译：提供组合物和方法用于将编码一种或多种所需基因的载体构建体的位置特异性整合导入靶真核基因组的特定区域。这样的组合物和方法可用于进行体细胞和生殖细胞基因治疗。通过位置特异性整合提供的益处是期望基因的更均匀的表达水平，并且显着消除插入诱变的潜力。

9. 发明申请

WO1996021007A3 BACTERIOPHAGE-MEDIATED GENE TRANSFER SYSTEMS CAPABLE OF TRANSFECTING EUKARYOTIC CELLS 审中-公开
公开(公告)号：WO1996021007A3
公开(公告)日：1996-07-11
申请号：PCT/US1995016966
申请日：1995-12-20
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , CHAFA, Sunil , DUBENSKY, Thomas, W., Jr.
IPC分类号： C12N15/34

10. 发明申请

WO1996020732A2 NON-TRAUMATIC ADMINISTRATION OF GENE DELIVERY VEHICLES 审中-公开
标题翻译：基因交付车辆的非交叉管理
公开(公告)号：WO1996020732A2
公开(公告)日：1996-07-11
申请号：PCT/US1995016967
申请日：1995-12-20
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , SONG, Elizabeth, S. , KOWAL, Kieron, J. , JOLLY, Douglas, J. , MONTISANO, Dominic
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K38/162 , A61K38/37 , A61K38/45 , A61K48/00 , C07K14/005 , C07K14/755 , C12N2710/10322 , C12N2710/10343 , C12N2740/13043 , C12N2840/44
摘要： The non-traumatic administration of one or more gene delivery vehicles ("GDVs") to an animal. Such non-traumatic administration provides significant advantages over prior methods of administration because it does not require any injection or other invasion of the recipient, and therefore is much less injurious to the recipient. Further, because there is no injection or invasion, there is typically less need for highly skilled personnel to administer the GDVs, there is less need for sterile conditions, and there is less risk of infection, injury and other side effects.
摘要翻译：一种或多种基因递送载体（“GDV”）对动物的非创伤性给药。这种非创伤性给药提供了优于现有施用方法的显着优点，因为它不需要接受者的任何注射或其他侵入，因此对接受者的伤害更小。此外，由于没有注射或入侵，通常较少需要高技能人员来管理GDV，因此对无菌条件的需求较少，并且感染，损伤和其它副作用的风险较小。

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