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    • 8. 发明申请
    • PERSONALIZED DELIVERY VECTOR-BASED IMMUNOTHERAPY AND USES THEREOF
    • 个性化递送基于传播的免疫疗法及其应用
    • WO2017132547A1
    • 2017-08-03
    • PCT/US2017/015403
    • 2017-01-27
    • ADVAXIS, INC.
    • PETIT, RobertPERRY, KylePRINCIOTTA, Michael F.
    • C12N15/74C12N15/66C07K5/10C07K14/705A61K35/74A61K39/00A61K48/00
    • A61K35/74A01K2267/0331A61K38/1709A61K39/0011A61K47/64A61K47/646A61K2039/522A61K2039/523A61K2039/6068C07K5/10C07K14/47C07K14/705C07K19/00
    • Disclosed herein is a personalized immunotherapy composition for a subject having a disease or condition, including therapeutic vaccine delivery vectors and methods of making the same comprising gene expression constructs expressing frameshift-mutation-derived peptides associated with one or more neo-epitopes encoded by nucleic acid sequences comprising at least one frameshift mutation, wherein the frameshift mutation is specific to a subject's cancer or unhealthy tissue. A delivery vector of this disclosure includes bacterial vectors; or viral vectors, or peptide vaccine vectors; or DNA vaccine vectors including Listeria bacterial vectors comprising one or more fusion proteins comprising one or more frameshift-mutation-derived peptides comprising one or more neo-epitopes present in disease-bearing biological samples obtained from the subject. Disclosed are also methods of using these compositions for inducing an immune response against a disease or condition, including a tumor or cancer, or an infection in the subject.
    • 本文公开了用于患有疾病或病症的受试者的个体化免疫治疗组合物,包括治疗性疫苗递送载体及其制备方法,所述方法包括表达移码突变衍生肽与基因表达构建体相关的基因表达构建体, 由包含至少一个移码突变的核酸序列编码的更多新表位,其中移码突变对个体的癌症或不健康组织特异。 本公开的递送载体包括细菌载体; 或病毒载体或肽疫苗载体; 或DNA疫苗载体,包括含有一种或多种融合蛋白的李斯特菌细菌载体,所述融合蛋白包含一种或多种移码突变衍生的肽,所述肽包含存在于患有受试者的疾病的生物样品中存在的一种或多种新表位。 还公开了使用这些组合物诱导抗疾病或病症(包括肿瘤或癌症)或受试者感染的免疫应答的方法。