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1. 发明申请

WO2012177656A2 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION 审中-公开
标题翻译：设备，解决方案和样品收集方法
公开(公告)号：WO2012177656A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043176
申请日：2012-06-19
申请人： ABOGEN, INC. , BIADILLAH, Youssef , ANDREWS, Stephen, Douglas
发明人： BIADILLAH, Youssef , ANDREWS, Stephen, Douglas
IPC分类号： C12M1/24 , G01N33/48 , G01N35/10 , G01N1/10
CPC分类号： G01N1/30 , A01N1/0273 , A61B10/0051 , A61B10/007 , A61B10/0096 , B01L3/502 , B01L3/5021 , B01L3/50825 , B01L2200/025 , B01L2200/0689 , B01L2200/085 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0832 , B01L2400/0683 , G01N1/10 , G01N2001/002 , G01N2001/305
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
摘要翻译：本公开涉及用于收集和处理含有细胞的体液样品（以及用于收集，加工和/或分析其它流体包括有毒和/或有害物质/流体的实施方案）的装置，解决方案和方法。此外，本公开一般涉及功能基因组研究以及从唾液和其他体液（例如尿液）分离和保存细胞用于细胞分析。关于用于收集体液的装置，一些实施例包括两个配合体，帽和管（例如），其中在一些实施例中，帽包括用于保持样品防腐剂溶液的封闭内部空间并与管构成（封闭）样品采集装置。在交配时，保存溶液流入封闭的内部空间以将细胞保存在体液中。管被配置为接收体液（例如，唾液，尿液）的供体样品，然后可以进行处理以提取多个细胞。可以进一步处理多个细胞以从其中分离出一种和/或另一种细胞类型。可以分析多个细胞以及分离的细胞类型用于功能基因组和表观遗传学研究以及生物标志物发现。

2. 发明申请

WO2016029020A1 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION RELATED APPLICATIONS 审中-公开
标题翻译：相关应用的设备，解决方案和方法
公开(公告)号：WO2016029020A1
公开(公告)日：2016-02-25
申请号：PCT/US2015/046119
申请日：2015-08-20
申请人： ABOGEN, INC.
发明人： BIADILLAH, Youssef , ANDREWS, Stephen
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1003
摘要： A bodily fluid sample collection device for the collection of naturally expressed bodily fluids (e.g. saliva), comprises a composition for extracting and preserving nucleic acids in the collected sample. In some embodiments, the composition is effective in extracting and preserving nucleic acids from a cell organelle. The organelle may be a mitochondrion. In some embodiments, the composition combines multiple lysing agents. In some embodiments, the composition comprises at least one ionic detergent, at least one non-ionic detergent, and a salt.
摘要翻译：用于收集天然表达的体液（例如唾液）的体液样品收集装置包括用于在收集的样品中提取和保存核酸的组合物。在一些实施方案中，组合物有效提取和保存来自细胞器的核酸。细胞器可能是线粒体。在一些实施方案中，组合物组合多种裂解剂。在一些实施方案中，组合物包含至少一种离子型洗涤剂，至少一种非离子洗涤剂和盐。

3. 发明申请

WO2015112496A3 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION 审中-公开
标题翻译：设备，解决方案和样品采集方法
公开(公告)号：WO2015112496A3
公开(公告)日：2015-07-30
申请号：PCT/US2015/012038
申请日：2015-01-20
申请人： ABOGEN, INC.
发明人： YOUSSEF, Biadillah , ANDREWS, Stephen , RUTTER, Bryce, G. , LEEDLE, Melvin, J. , SUNDY, Jonathan , PRIESS, Benjamin, Cooper , BRIDEN, Chris
IPC分类号： A61M5/00 , B65D81/00
摘要： Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.
摘要翻译：一些实施例涉及用于收集天然表达的体液的体液样本收集装置，并且包括可与管接合以封闭管口的盖。该帽包括用于容纳试剂的腔室。该管至少部分地限定用于接收天然表达的体液的样品收集空间。帽包括相对于彼此可相对移动的第一和第二帽部分。第一和第二盖帽部分构造成使得响应盖帽在管上的接合，引起盖帽部分中的一个相对于另一盖帽部分整体移动以打开腔室并且允许腔室和腔室之间的流体连通样本收集空间。由此允许腔室中的试剂与样本收集空间中的体液混合。还介绍了一种组织和处理样本的方法。

4. 发明申请

WO2015112496A2 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION 审中-公开
公开(公告)号：WO2015112496A2
公开(公告)日：2015-07-30
申请号：PCT/US2015/012038
申请日：2015-01-20
申请人： ABOGEN, INC.
发明人： YOUSSEF, Biadillah , ANDREWS, Stephen , RUTTER, Bryce, G. , LEEDLE, Melvin, J. , SUNDY, Jonathan , PRIESS, Benjamin, Cooper , BRIDEN, Chris
IPC分类号： A61M5/31
CPC分类号： B01L3/502 , A61B10/0051 , A61B10/007 , A61B10/0096 , B01L2300/042 , B01L2300/047 , B01L2300/0672 , B01L2400/043 , B01L2400/0683 , B65D25/56 , B65D41/04 , B65D51/2835 , B65D51/2871 , B65D51/2878 , B65D51/2892 , B65D55/02
摘要： Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.

5. 发明申请

WO2012177656A3 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION 审中-公开
标题翻译：设备，解决方案和样品收集方法
公开(公告)号：WO2012177656A3
公开(公告)日：2013-04-25
申请号：PCT/US2012043176
申请日：2012-06-19
申请人： ABOGEN INC , BIADILLAH YOUSSEF , ANDREWS STEPHEN DOUGLAS
发明人： BIADILLAH YOUSSEF , ANDREWS STEPHEN DOUGLAS
IPC分类号： C12M1/24 , G01N1/10 , G01N33/48 , G01N35/10
CPC分类号： G01N1/30 , A01N1/0273 , A61B10/0051 , A61B10/007 , A61B10/0096 , B01L3/502 , B01L3/5021 , B01L3/50825 , B01L2200/025 , B01L2200/0689 , B01L2200/085 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0832 , B01L2400/0683 , G01N1/10 , G01N2001/002 , G01N2001/305
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
摘要翻译：本公开涉及用于收集和处理含有细胞的体液样品（以及用于收集，加工和/或分析其它流体包括有毒和/或有害物质/流体的实施方案）的装置，解决方案和方法。此外，本公开一般涉及功能基因组研究以及从唾液和其他体液（例如尿液）分离和保存细胞用于细胞分析。关于用于收集体液的装置，一些实施例包括两个配合体，帽和管（例如），其中在一些实施例中，帽包括用于保持样品防腐剂溶液的封闭内部空间并与管构成（封闭）样品采集装置。在交配时，保存溶液流入封闭的内部空间以将细胞保存在体液中。管被配置为接收体液（例如，唾液，尿液）的供体样品，然后可以进行处理以提取多个细胞。可以进一步处理多个细胞以从其中分离出一种和/或另一种细胞类型。可以分析多个细胞以及分离的细胞类型用于功能基因组和表观遗传学研究以及生物标志物发现。

6. 发明申请

WO2016130543A1 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION RELATED APPLICATIONS, ANALYSIS AND DIAGNOSIS 审中-公开
标题翻译：相关应用，分析和诊断的设备，解决方案和方法
公开(公告)号：WO2016130543A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017147
申请日：2016-02-09
申请人： ABOGEN, INC.
发明人： ANDREWS, Stephen , BIADILLAH, Youssef , JAIN, Manasi , FRANK, David S. , ZEMAN, John R. , TACKNEY, Charles, T.
IPC分类号： G01N31/00
CPC分类号： G01N33/5091 , G01N33/5005 , G01N33/54393 , G01N2333/16 , G01N2333/70514 , G01N2333/70517
摘要： A solution is described for preserving cells and/or extra-cellular components in naturally expressed bodily fluids (e.g. saliva, sputum, urine) for further downstream analysis and/or for diagnosis of a medical condition. The solution may be hypertonic with respect to blood. Techniques are described for enriching cells from a sample of a naturally expressed bodily fluid, and/or for analysis, e.g. to diagnose medical conditions such as cancer, obesity, infections, autism, Alzheimer disease, hetotological disorders, cardiovascular disease or disorders, diabetes, vulnerable plack, LTBI, HIV infection, COPD, ACQS.
摘要翻译：描述了用于保存天然表达的体液（例如唾液，痰液，尿液）中的细胞和/或细胞外组分用于进一步下游分析和/或诊断医学病症的溶液。该溶液对于血液可能是高渗的。描述了用于从天然表达的体液样品中富集细胞的技术，和/或用于分析，例如，诊断疾病如癌症，肥胖症，感染，自闭症，阿尔茨海默病，组织学障碍，心血管疾病或病症，糖尿病，易受攻击的病毒，LTBI，HIV感染，COPD，ACQS。

7. 发明申请

WO2015112496A9 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION 审中-公开
公开(公告)号：WO2015112496A9
公开(公告)日：2015-07-30
申请号：PCT/US2015/012038
申请日：2015-01-20
申请人： ABOGEN, INC.
发明人： YOUSSEF, Biadillah , ANDREWS, Stephen , RUTTER, Bryce, G. , LEEDLE, Melvin, J. , SUNDY, Jonathan , PRIESS, Benjamin, Cooper , BRIDEN, Chris
IPC分类号： A61M5/00 , B65D81/00
摘要： Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.

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