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81. 发明申请

WO02002783A2 EXPRESSION VECTORS 审中-公开
标题翻译：表达向量
公开(公告)号：WO02002783A2
公开(公告)日：2002-01-10
申请号：PCT/US2001/020714
申请日：2001-06-29
IPC分类号： C12N15/09 , A61K48/00 , C07K16/00 , C07K16/12 , C07K16/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/867 , C12P21/02 , C12P21/08 , C12N15/63
CPC分类号： C12N15/86 , A61K48/00 , C07K16/1228 , C07K16/1282 , C07K16/3007 , C07K16/3061 , C12N2740/13043 , C12N2830/00 , C12N2830/15 , C12N2830/48 , C12N2830/85 , C12N2840/203
摘要： The present invention provides novel regulatory elements and vectors for the expression of one or more proteins in a host cell. The present invention also provides methods for espressing on or more proteins, such as antibodies, in a host cell. These methods utilize the novel regulatory elements and vectors of the present invention for the expression of proteins in a host cell. The host cells are used for producing various protein products, including but not limited to pharmaceutical proteins, antibodies, variants of proteins for use in screening assays, and for direct use in high throughput screening.
摘要翻译：本发明提供用于在宿主细胞中表达一种或多种蛋白质的新型调节元件和载体。本发明还提供了用于在宿主细胞中浓缩或多或多种蛋白质（例如抗体）的方法。这些方法利用本发明的新型调控元件和载体在宿主细胞中表达蛋白质。宿主细胞用于生产各种蛋白质产物，包括但不限于药物蛋白质，抗体，用于筛选测定的蛋白质的变体，以及直接用于高通量筛选。

82. 发明申请

WO00043020A1 EGG ANTI-INFLAMMATORY COMPOSITION AND METHOD OF TREATING AND PREVENTING INFLAMMATION 审中-公开
标题翻译： EGG抗炎组合物和治疗和预防炎症的方法
公开(公告)号：WO00043020A1
公开(公告)日：2000-07-27
申请号：PCT/US1999/030969
申请日：1999-12-28
IPC分类号： A61K39/00 , A61K35/54 , A61K35/57 , A61P1/16 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/06 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/00 , A61P37/02
CPC分类号： C07K16/02 , A61K35/57 , A61K2039/505 , A61K2039/507 , A61K2039/542 , C07K16/1018 , C07K16/1214 , C07K16/1228 , C07K16/1232 , C07K16/1235 , C07K16/1271 , C07K16/1275 , C07K16/1292 , C07K2317/11 , C07K2317/23
摘要： The invention is directed to a composition and method for the treatment and prevention of inflammation in general. The composition is an egg product obtained from an avian which has been hyperimmunized with no immunogenic mixture. The invention is further directed to an anti-inflammatory composition which has been partially purified from a hyperimmunized egg. The partially purified anti-inflammatory composition, when administered to a subject animal is effective in treating and preventing inflammation.
摘要翻译：本发明涉及一般用于治疗和预防炎症的组合物和方法。所述组合物是来自已经用免疫原性混合物超免疫的禽蛋的产品。本发明还涉及从免疫蛋中部分纯化的抗炎组合物。当部分纯化的抗炎组合物给予动物对象时，可有效治疗和预防炎症。

83. 发明申请

WO9941614A2 METHODS 审中-公开
标题翻译：方法
公开(公告)号：WO9941614A2
公开(公告)日：1999-08-19
申请号：PCT/GB9900467
申请日：1999-02-16
申请人： IMPERIAL COLLEGE , BATCHELOR MIRANDA , DOUGAN GORDON , FRANKEL GAD
发明人： BATCHELOR MIRANDA , DOUGAN GORDON , FRANKEL GAD
IPC分类号： A61K38/00 , A61K39/00 , C07K14/24 , C07K14/245 , C07K16/12 , C12Q1/04 , G01N33/569 , G01N33/68
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , C07K14/24 , C07K14/245 , C07K16/1228 , C12Q1/04 , G01N33/56916 , G01N2333/425
摘要： Methods of detecting and/or diagnosing intimin-expressing microorganisms such as enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli, C. rodentium and/or RDEC-1, as well as kits for use in such methods are provided. In particular, methods based antisera raised against conserved regions are described, as well as polypeptide regions useful in the production of antisera. Vaccines based on such peptides are also described herein. In addition, methods of typing/classification of such bacteria are also described herein. Finally, methods for the isolation of intimin-expressing microorganisms are also provided.
摘要翻译：提供了检测和/或诊断诸如致肠性致病性大肠杆菌（EPEC），肠出血性大肠杆菌，C.啮齿动物和/或RDEC-1的表达Intimin的微生物以及用于这些方法的试剂盒的方法。特别地，描述了针对保守区域产生的基于方法的抗血清，以及可用于生产抗血清的多肽区域。本文还描述了基于这些肽的疫苗。此外，本文还描述了这种细菌的分型/分类方法。最后，还提供了表达微生物的分泌表达微生物的方法。

84. 发明申请

WO1997040161A1 HISTIDINE-TAGGED INTIMIN AND METHODS OF USING INTIMIN TO STIMULATE AN IMMUNE RESPONSE AND AS AN ANTIGEN CARRIER WITH TARGETING CAPABILITY 审中-公开
标题翻译： HISTIDINE-TAGGED INTIMIN AND METHODS OF INTIMIN TO刺激免疫应答和作为具有目标能力的抗体携带者
公开(公告)号：WO1997040161A1
公开(公告)日：1997-10-30
申请号：PCT/US1997005832
申请日：1997-04-18
申请人： HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDECINE
发明人： HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDECINE , MCKEE, Marian, L. , O'BRIEN, Alison, D. , WACHTEL, Marian, R.
IPC分类号： C12N15/31
CPC分类号： C12N15/8258 , A61K38/00 , A61K39/025 , A61K39/0283 , A61K47/62 , A61K2039/6031 , C07K14/24 , C07K14/245 , C07K16/1228 , C07K16/1232 , C07K2319/00 , Y02A50/476 , Y02A50/484
摘要： The present invention describes the isolation and purification of histidine-tagged functional portions of intimin (his-tagged intimin or his-intimin), a protein associated with the ability of certain strains of pathogenic bacteria to adhere to epithelial cells. The invention further describes the use of intimin as an antigen to promote a protective immune response. In addition, the invention describes the combination of intimin with one or more other antigens and administration of the combination to promote a protective immune response against intimin and the one or more antigens. One aspect of the invention is the administration of intimin to target specific epithelial cells to promote a protective immune response to intimin proteins. Additional aspects of the invention include the use of intimin or intimin combined with one or more antigens and administration of the combination to target gastrointestinal mucosa and stimulate an immune response. Additionally, the invention describes administration of the combination of intimin combined with drugs, to provide a means for targeted delivery of drugs to specific epithelial cells. Other aspects of the invention include the production of antibodies directed against his-intimin and methods of using such antibodies to provide passive immune protection, and in an assay system.
摘要翻译：本发明描述了分泌和纯化组蛋白标记的功能性部分的intimin（his-tagged intimin或his-intimin），一种与某些病原菌菌株粘附于上皮细胞的能力相关的蛋白质。本发明进一步描述了作为抗原的肠溶蛋白作为促进保护性免疫应答的用途。此外，本发明描述了肠溶蛋白与一种或多种其它抗原的组合以及组合的施用，以促进针对胰岛素和一种或多种抗原的保护性免疫应答。本发明的一个方面是给予内膜以靶向特异性上皮细胞以促进对肠溶蛋白的保护性免疫应答。本发明的另外的方面包括使用与一种或多种抗原组合的肠溶蛋白或肠溶蛋白和给予组合以靶向胃肠粘膜并刺激免疫应答。另外，本发明描述了与药物组合的联合应用，以提供用于将药物靶向递送到特定上皮细胞的手段。本发明的其它方面包括产生针对他的肠溶蛋白的抗体以及使用这些抗体提供被动免疫保护的方法，以及在测定系统中。

85. 发明申请

WO9317115A3 DYSENTERY VACCINE STIMULATING AN IMMUNE RESPONSE AGAINST SHIGATOXIN, PLASMIDS AND HOST STRAINS FOR IT 审中-公开
标题翻译：激素疫苗刺激抗重组蛋白，血浆和宿主菌的免疫应答
公开(公告)号：WO9317115A3
公开(公告)日：1993-10-28
申请号：PCT/EP9300347
申请日：1993-02-12
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： SU GUO-FU , BRAHMBHATT HIMANSHU , WEHLAND JUERGEN , ROHDE MANFRED , TIMMIS KENNETH
IPC分类号： A61K39/00 , C07K14/25 , C07K16/12 , C12N15/62 , A61K39/112 , C12N15/31
CPC分类号： C07K14/25 , A61K39/00 , C07K16/1228 , C07K2319/02 , C07K2319/40 , C07K2319/55 , C07K2319/61
摘要： The invention concerns dysentery vaccines, methods, plasmids and gene products for their production.

86. 发明申请

WO1991006860A1 HYBRIDOMAS AND MONOCLONAL ANTIBODIES THEREFROM REACTIVE TOWARD ANTIGENS FROM EDWARDSIELLA ICTALURI 审中-公开
标题翻译：来自EDWARDSIELLA ICTALURI的抗体反应性抗体的混合抗体和单克隆抗体
公开(公告)号：WO1991006860A1
公开(公告)日：1991-05-16
申请号：PCT/US1990006232
申请日：1990-11-01
申请人： THE UNITED STATES OF AMERICA, represented by THE ...
发明人： THE UNITED STATES OF AMERICA, represented by THE ... , KLESIUS, Phillip, H.
IPC分类号： G01N33/53
CPC分类号： C07K16/1228
摘要： A hybridoma cell line produces a monoclonal antibody with reactivity directed specifically to immunodominant antigens from the catfish pathogen Edwardsiella ictaluri, the antigens having molecular weights of about 14,000, 39,000, 48,000, 60,000, 66,000, 83,000, and 93,000 daltons. This antibody is specific for proteins of E. ictaluri but not for other catfish pathogens. It is therefore useful for the positive identification of E. ictaluri from body fluids and tissue of catfish and for identification and purification of the reactive immunodominant antigens.

87. 发明申请

WO1991006320A1 COMPOSITIONS CONTAINING PLANT-PRODUCED GLYCOPOLYPEPTIDE MULTIMERS, MULTIMERIC PROTEINS, AND THEIR USE 审中-公开
标题翻译：含有植物生产的谷氨酰胺多聚体的组合物，多种蛋白质及其使用
公开(公告)号：WO1991006320A1
公开(公告)日：1991-05-16
申请号：PCT/US1990006179
申请日：1990-10-25
申请人： SCRIPPS CLINIC AND RESEARCH FOUNDATION
发明人： SCRIPPS CLINIC AND RESEARCH FOUNDATION , HAITT, Andrew, C. , HEIN, Mich. B.
IPC分类号： A61K39/395
CPC分类号： C12N15/8242 , A61K38/00 , C07K16/00 , C07K16/12 , C07K16/1228 , C07K16/44 , C07K2317/13 , C07K2319/00 , C07K2319/02 , C12N9/0002 , C12N9/18 , C12N15/8258 , Y10S424/804 , Y10S530/861
摘要： The present invention contemplates a transgenic plant having somatic and germ cells containing at least two mammalian genes coding for polypeptides capable of autogenously associating with each other to form a biologically active multimer. The present invention also contemplates glycopolypeptide multimers having a polypeptide that contains an immunoglobulin amino acid residue sequence and an oligosaccharide that comprises a core pentasaccharide and N-acetylglucosamine-containing outer branches, such that the multimer is free from sialic acid. The production of passive immunity against a preselected antigen by administering a sialic acid free glycopolypeptide multimer to an animal is also comtemplated.

88. 发明申请

WO1986000643A1 MONOCLONAL ANTIBODIES AND THEIR USE 审中-公开
标题翻译：单克隆抗体及其用途
公开(公告)号：WO1986000643A1
公开(公告)日：1986-01-30
申请号：PCT/GB1985000293
申请日：1985-07-02
申请人： TECHNOLOGY LICENCE COMPANY LIMITED , WRIGHT, Bruce, William , COX, Peter, John , NOYES, Alice, Margaret , WIDDOWS, Danny
发明人： TECHNOLOGY LICENCE COMPANY LIMITED
IPC分类号： C12P21/00
CPC分类号： C07K16/1228 , A61K38/00
摘要： Monoclonal antibodies to the genus Morganella, the labelled antibodies, compositions and kits containing them, and their use in diagnosis of antigen and treatment.
摘要翻译： Morganella单克隆抗体，标记抗体，含有它们的组合物和试剂盒，以及它们在诊断抗原和治疗中的用途。

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