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81. 发明申请

WO2004075918A1 LIQUID FORMULATIONS OF TUMOR NECROSIS FACTOR-BINDING PROTEINS 审中-公开
标题翻译：肿瘤坏死因子结合蛋白的液体制剂
公开(公告)号：WO2004075918A1
公开(公告)日：2004-09-10
申请号：PCT/EP2004/050118
申请日：2004-02-11
申请人： ARES TRADING S.A. , SAMARITANI, Fabrizio , DEL RIO, Alessandra , AGOSTINETTO, Rita
发明人： SAMARITANI, Fabrizio , DEL RIO, Alessandra , AGOSTINETTO, Rita
IPC分类号： A61K47/02
CPC分类号： A61K38/1793 , A61J1/14 , A61K9/08 , A61K47/02 , A61K47/12 , A61K47/26 , C07K16/241 , C07K2317/94
摘要： The invention relates to a stable, pharmaceutically acceptable, aqueous formulation of TNF-binding protein, comprising a TNF-binding protein, a buffer and an isotonicity agent.
摘要翻译：本发明涉及稳定的药学上可接受的TNF结合蛋白质的水性制剂，其包含TNF结合蛋白，缓冲液和等渗剂。

82. 发明申请

WO2004016654A1 IL-8 LIKE PROTEIN 审中-公开
标题翻译： IL-8样蛋白质
公开(公告)号：WO2004016654A1
公开(公告)日：2004-02-26
申请号：PCT/GB2003/003646
申请日：2003-08-19
申请人： ARES TRADING S.A. , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , DAVIES, Mark, Douglas , POWER, Christine
发明人： FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , DAVIES, Mark, Douglas , POWER, Christine
IPC分类号： C07K14/54
CPC分类号： C07K14/521
摘要： This invention relates to a novel protein, termed INSP085, herein identified as an IL-8 like protein and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及一种称为INSP085的新蛋白质，其在本文中被鉴定为IL-8样蛋白质，并且涉及该蛋白质和来自编码基因的核酸序列在诊断，预防和治疗中的用途的疾病。

83. 发明申请

WO2003100061A3 THREE FINGER TOXIN FOLD PROTEINS 审中-公开
公开(公告)号：WO2003100061A3
公开(公告)日：2003-12-04
申请号：PCT/GB2003/002214
申请日：2003-05-22
申请人： ARES TRADING S.A , DAVIES, Mark, Douglas , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , POWER, Christine
发明人： DAVIES, Mark, Douglas , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , POWER, Christine
IPC分类号： C12N15/12
摘要： This invention relates to novel proteins, termed INSPO62 and INSPO63, herein identified as members of the three finger toxin fold family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

84. 发明申请

WO2003066165A1 TUMOR NECROSIS FACTOR COMBINED WITH INTERFERON IN DEMYELINATING DISEASES 审中-公开
标题翻译：肿瘤坏死因子与干扰素相结合的肿瘤坏死因子
公开(公告)号：WO2003066165A1
公开(公告)日：2003-08-14
申请号：PCT/EP2003/050006
申请日：2003-01-29
申请人： ARES TRADING S.A. , De Luca, Giampiero
发明人： De Luca, Giampiero
IPC分类号： A61P25/00
CPC分类号： A61K38/191 , A61K31/573 , A61K38/02 , A61K38/1793 , A61K38/215 , A61K38/217 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of an agent having, stimulating or maintaining tumor necrosis factor (TNF) activity, together with an interferon (IFN) for treating and/or preventing demyelinating diseases, in particular multiple sclerosis (MS). The use of a combination of a TNF or a tumor necrosis factor binding protein in combination with an interferon for treating and/or preventing demyelinating diseases is preferred.
摘要翻译：本发明涉及具有刺激或维持肿瘤坏死因子TNF活性的药物与干扰素IFN一起用于治疗和/或预防脱髓鞘疾病，特别是多发性硬化症MS的用途。优选将TNF或肿瘤坏死因子结合蛋白与干扰素组合用于治疗和/或预防脱髓鞘疾病的用途。

85. 发明申请

WO2003055915A3 HUMAN NETRIN RECEPTOR AND USES THEREOF 审中-公开
公开(公告)号：WO2003055915A3
公开(公告)日：2003-07-10
申请号：PCT/GB2002/005856
申请日：2002-12-20
申请人： ARES TRADING S.A. , FITZGERALD, Stephen, Noel , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , POWER, Christine , YORKE, Melanie
发明人： FITZGERALD, Stephen, Noel , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , POWER, Christine , YORKE, Melanie
IPC分类号： C12N15/12
摘要： The invention is based on the discovery that the INSP017 protein functions as a trans-membrane protein molecule, preferably as a trans-membrane protein molecule of the netrin receptor family.

86. 发明申请

WO2003055912A3 SECRETED PROTEINS 审中-公开
公开(公告)号：WO2003055912A3
公开(公告)日：2003-07-10
申请号：PCT/GB2002/005890
申请日：2002-12-23
申请人： ARES TRADING S.A. , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , GUTTERIDGE, Alex , POWER, Christine
发明人： FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , GUTTERIDGE, Alex , POWER, Christine
IPC分类号： C07K14/53
摘要： This invention relates to novel proteins (INSP032, INSP033, INSP034, INSP036, INSP038), herein identified as members of the four helical bundle cytokine family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

87. 发明申请

WO2003034073A3 METHOD AND KIT FOR MONITORING RECRUITMENT OF PROTEINS TO THE INTRACELLULAR DOMAIN OF A RECEPTOR IN INTACT CELLS 审中-公开
公开(公告)号：WO2003034073A3
公开(公告)日：2003-04-24
申请号：PCT/IL2002/000828
申请日：2002-10-14
申请人： ARES TRADING S.A , EINAV, Henry , ENGELMANN, Hartmut
发明人： ENGELMANN, Hartmut
IPC分类号： G01N33/68
摘要： The present invention relates to an immunological method and kit for monitoring recruitment of a protein to the intracellular domain of a receptor in intact cells.

88. 发明申请

WO2002083240A1 AROMATASE INHIBITION TO ENHANCE ASSISTED REPRODUCTION 审中-公开
标题翻译：芳香化酶抑制以增强辅助生殖
公开(公告)号：WO2002083240A1
公开(公告)日：2002-10-24
申请号：PCT/CA2002/000522
申请日：2002-04-17
申请人： ARES TRADING S.A. , CASPER, Robert, F. , MITWALLY, Mohamed, F., M.
发明人： CASPER, Robert, F. , MITWALLY, Mohamed, F., M.
IPC分类号： A61P15/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/4196 , A61K31/56 , A61K31/5685 , A61K38/24 , A61K2300/00
摘要： The use of at least one aromatase inhibitor in the production of a medicament for improving the implantation and pregnancy rates for a female undergoing assisted reproduction treatment, which comprises one or more daily doses of an aromatase inhibitor (AI) for administration during assisted reproduction cycles or ovarian stimulation cycles, wherein the doses of AI are selected from amounts effective to reduce serum estradiol levels. Also disclosed are related pharmaceutical preparations and packages.
摘要翻译：至少一种芳香酶抑制剂在生产用于改善接受辅助繁殖治疗的女性的植入和妊娠率的药物中的用途，其包括一种或多种每日剂量的芳香酶抑制剂（AI）用于在辅助生殖周期期间施用;或卵巢刺激周期，其中AI的剂量选自有效降低血清雌二醇水平的量。还公开了相关的药物制剂和包装。

89. 发明申请

WO2002083146A1 MULTIPLE DOSE AROMATASE INHIBITOR FOR TREATING INFERTILITY 审中-公开
标题翻译：多剂量芳香酶抑制剂治疗感染
公开(公告)号：WO2002083146A1
公开(公告)日：2002-10-24
申请号：PCT/CA2001/000517
申请日：2001-04-17
申请人： ARES TRADING S.A. , CASPER, Robert, F. , MITWALLY, Mohamed, Farouk, Mohamed
发明人： CASPER, Robert, F. , MITWALLY, Mohamed, Farouk, Mohamed
IPC分类号： A61K31/56
CPC分类号： A61K31/5685 , A61K31/00 , A61K31/4196 , A61K38/24 , A61K2300/00
摘要： A method of inducing ovulation in a female suffering from anovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor. A method for augmenting ovulation in an ovulating female suffering from unexplained infertility or another type of ovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor early in one or more menstrual cycles. A method of substantially reducing dosage levels of follicle stimulating hormone (FSH) for administration to a female undergoing infertility treatment which comprises administering a combination of two or more daily doses of at least one aromatase inhibitor (AI) with a plurality of daily doses of follicle stimulating hormone (FSH). A method of increasing response to a follicle stimulating hormone from a female who is a poor responder to follicle stimulation, which comprises administering a combination of two or more daily doses or at least one aromatase inhibitor (AI) with a plurality of daily doses of follicle stimulating hormone (FSH). Also disclosed are related pharmaceutical preparations and uses.
摘要翻译：一种诱导患有排卵不孕症的女性排卵的方法，其包括向所述女性施用两次或更多次日剂量的至少一种芳香酶抑制剂。一种用于增加排卵女性排卵的方法，所述排卵女性患有不明原因的不育症或另一种类型的排卵不育症，其包括在一个或多个月经周期早期向所述雌性两剂或更多剂量的至少一种芳香酶抑制剂施用。一种用于施用于不孕不育治疗的女性的促卵泡激素（FSH）的剂量水平的方法，其包括将两种或更多日剂量的至少一种芳香酶抑制剂（AI）与多次日剂量的卵泡刺激激素（FSH）。增加对来自卵泡刺激的不良反应者的女性的促卵泡激素的反应的方法，其包括将两种或更多种每日剂量的组合或至少一种芳香酶抑制剂（AI）与多个每日剂量的卵泡刺激激素（FSH）。还公开了相关的药物制剂和用途。

90. 发明申请

WO2022090527A1 COMBINATION TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2022090527A1
公开(公告)日：2022-05-05
申请号：PCT/EP2021/080239
申请日：2021-11-01
申请人： ARES TRADING S.A. , GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 4) LTD.
发明人： SALA-HOJMAN, Ada , CZAUDERNA, Frank , LINDEMANN, Ralph , FERRETTI, Roberta , RAMASWAMY, Shivapriya
IPC分类号： A61K39/395 , A61P35/00 , C07K14/71 , C07K16/28 , C07D213/71
摘要： The present disclosure relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF-beta inhibitor, and a MCT4 inhibitor to treat cancer.

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