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81. 发明申请

WO2010080831A1 METHOD OF TREATING NEUROPATHIC PAIN 审中-公开
标题翻译：治疗神经痛疼痛的方法
公开(公告)号：WO2010080831A1
公开(公告)日：2010-07-15
申请号：PCT/US2010/020255
申请日：2010-01-06
申请人： ZHANG, Jie
发明人： ZHANG, Jie
IPC分类号： A01N37/12 , A01N37/44 , A61K31/24
CPC分类号： A61K31/24 , A61K9/7015 , A61K31/167 , A61K47/32 , A61K2300/00
摘要： A method for treating subjects experiencing neuropathic pain is provided. The method involves the application of a solid-forming local anesthetic formulation to a skin surface of the subject experiencing the neuropathic pain and then maintaining the formulation on the skin surface for a period of time sufficient to allow itself to transdermally deliver the local anesthetic to the subject thereby providing relief from the neuropathic pain within about 45 minutes.
摘要翻译：提供了治疗经历神经性疼痛的受试者的方法。该方法涉及将固体形成局部麻醉剂制剂施用于经历神经性疼痛的受试者的皮肤表面，然后将制剂保持在皮肤表面上足以允许其自身将局部麻醉剂递送至从而在约45分钟内提供神经性疼痛的缓解。

82. 发明申请

WO2009048527A1 SUBSTITUTED BIPHENYL GPR40 MODULATORS 审中-公开
标题翻译：取代的BIPHENYL GPR40调节器
公开(公告)号：WO2009048527A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011422
申请日：2008-10-03
申请人： AMGEN INC. , KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
发明人： KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
IPC分类号： C07C59/68 , C07C217/54 , C07C323/19 , C07D213/64 , A61K31/192 , A61K31/4415 , A61P3/10
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

83. 发明申请

WO2007050579A2 SEMICONDUCTOR DEVICE AND METHOD FOR PROVIDING A REDUCED SURFACE AREA ELECTRODE 审中-公开
标题翻译：用于提供减少表面区域电极的半导体器件和方法
公开(公告)号：WO2007050579A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041429
申请日：2006-10-24
申请人： MOTOROLA INC. , BRAZIS, Paul W. , GAMOTA, Daniel R. , KALYANASUNDARAM, Krishna , ZHANG, Jie
发明人： BRAZIS, Paul W. , GAMOTA, Daniel R. , KALYANASUNDARAM, Krishna , ZHANG, Jie
IPC分类号： G06F17/50
CPC分类号： H01L29/41733 , H01L27/1292 , H01L51/0022 , H01L51/055 , H01L51/102 , H01L2924/19043 , H01L2924/30105
摘要： An apparatus (200) such as a semiconductor device comprises a gate electrode (201) and at least a first electrode (202). The first electrode preferably has an established perimeter that at least partially overlaps with respect to the gate electrode to thereby form a corresponding transistor channel. In a preferred approach the first electrode has a surface area that is reduced notwithstanding the aforementioned established perimeter. This, in turn, aids in reducing any corresponding parasitic capacitance. This reduction in surface area may be accomplished, for example, by providing openings (203) through certain portions of the first electrode.
摘要翻译：诸如半导体器件的装置（200）包括栅电极（201）和至少第一电极（202）。第一电极优选地具有与栅电极至少部分重叠的确定的周边，从而形成对应的晶体管沟道。在优选的方法中，尽管具有上述建立的周长，第一电极具有减小的表面积。这又有助于减少任何相应的寄生电容。表面积的这种减小可以例如通过提供通过第一电极的某些部分的开口（203）来实现。

84. 发明申请

WO2007050427A2 PATH DETERMINATION FACILITATION METHOD 审中-公开
标题翻译：路线确定方法
公开(公告)号：WO2007050427A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/040893
申请日：2006-10-19
申请人： MOTOROLA INC. , GYORFI, Julius, S , GAMOTA, Daniel, R. , MOK, Swee, M. , SZCZECH, John, B. , TOLOO, Mansour , ZHANG, Jie
发明人： GYORFI, Julius, S , GAMOTA, Daniel, R. , MOK, Swee, M. , SZCZECH, John, B. , TOLOO, Mansour , ZHANG, Jie
IPC分类号： G06N3/12
CPC分类号： G06N3/126
摘要： One facilitates determination of a path that comprises a plurality of locations (201). In an optional embodiment these specific locations comprise locations where a given functional ink will preferably be printed using a continuous printing spray. Also in an optional embodiment this path will also avoid at least one predetermined area (701) where such a functional ink should not be printed. In a preferred approach this process (100) generally provides for identifying (101) these specific locations and further identifying (102), when applicable, the one or more predetermined areas to be avoided. This process uses a processor to effect at least one of using (103) a genetic algorithm to identify a preferred path that includes the plurality of specific locations and using (104) an A* algorithm to process a candidate path to provide a selected path that includes the plurality of specific locations while avoiding the at least one predetermined area.
摘要翻译：有利于确定包括多个位置（201）的路径。在可选实施例中，这些具体位置包括优选使用连续印刷喷涂印刷给定功能油墨的位置。此外，在可选实施例中，该路径还将避免至少一个预定区域（701），其中不应打印这种功能性油墨。在优选方法中，该过程（100）通常提供识别（101）这些特定位置，并且在适用时进一步识别（102）要避免的一个或多个预定区域。该过程使用处理器来实现使用（103）遗传算法来识别包括多个特定位置的优选路径中的至少一个，并且使用（104）A *算法来处理候选路径以提供选择的路径，包括多个特定位置，同时避免至少一个预定区域。

85. 发明申请

WO2007050403A3 AN INVERTER CIRCUIT HAVING A FEEDBACK SWITCH AND METHODS CORRESPONDING THERETO 审中-公开
公开(公告)号：WO2007050403A3
公开(公告)日：2007-05-03
申请号：PCT/US2006/040791
申请日：2006-10-20
申请人： MOTOROLA INC. , BRAZIS, Paul W. , GAMOTA, Daniel R. , TSUI, Kin P. , SZCZECH, John B. , ZHANG, Jie
发明人： BRAZIS, Paul W. , GAMOTA, Daniel R. , TSUI, Kin P. , SZCZECH, John B. , ZHANG, Jie
IPC分类号： H03K19/094 , H03K19/20 , H03K19/003 , H03K17/16 , H03K17/00
摘要： An inverter circuit (500) having a drive transistor (102) that operably couples to a voltage bias input (101) (and where that drive transistor controls the inverter circuit output by opening and closing a connection between the output (105) and ground (104)) is further operably coupled to a feedback switch (401). In a preferred approach the feedback switch is itself also operably coupled to the voltage bias input and the output and preferably serves, when the drive transistor is switched “off”, to responsively couple the voltage bias input to the drive transistor in such a way as to cause a gate terminal of the drive transistor to have its polarity relative to a source terminal of the drive transistor reversed and hence permit the inverter circuit to operate across a substantially full potential operating range of the drive transistor.

86. 发明申请

WO2007050337A1 MULTIPLE GATE PRINTED TRANSISTOR METHOD AND APPARATUS 审中-公开
标题翻译：多门打印晶体管方法和装置
公开(公告)号：WO2007050337A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/040319
申请日：2006-10-16
申请人： MOTOROLA, INC. , ZHANG, Jie , ADEWOLE, Hakeem, B. , BRAZIS, Paul, W. , COLLINS, Timothy, J. , GAMOTA, Daniel, R. , SZCZECH, John, B. , WIELGUS, Jerzy
发明人： ZHANG, Jie , ADEWOLE, Hakeem, B. , BRAZIS, Paul, W. , COLLINS, Timothy, J. , GAMOTA, Daniel, R. , SZCZECH, John, B. , WIELGUS, Jerzy
IPC分类号： H01L35/24 , H01L51/00 , H01L49/02 , H01L21/336
CPC分类号： H01L51/0554 , H01L27/1292 , H01L29/78681 , H01L29/7869 , H01L51/0004 , H01L51/0022
摘要： A printed transistor has a first gate (202) printed and disposed on a first side of a printed deposit of semiconductor material (201) and a second printed gate (301) disposed on an opposite side of the printed deposit of semiconductor material. By one approach these elements are provided using a serial printing process. By another approach these elements are provided through use of a lamination process.
摘要翻译：印刷晶体管具有印刷并设置在半导体材料（201）的印刷沉积物的第一侧上的第一栅极（202）和设置在半导体材料的印刷沉积物的相对侧上的第二印刷栅极（301）。通过一种方法，使用串行打印处理提供这些元件。通过另一种方法，通过使用层压方法提供这些元件。

87. 发明申请

WO2006078711A2 DIAZABENZO[DE]ANTHRACEN-3-ONE COMPOUNDS AND METHODS FOR INHIBITING PARP 审中-公开
标题翻译： DIAZABENZO [DE] ANTHRACEN-3-ONE化合物和抑制PARP的方法
公开(公告)号：WO2006078711A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001729
申请日：2006-01-19
申请人： MGI GP, INC. , XU, Weizheng , DELAHANTY, Greg , ZHANG, Jie
发明人： XU, Weizheng , DELAHANTY, Greg , ZHANG, Jie
IPC分类号： A61K31/502
CPC分类号： C07D491/06 , A61K31/495 , A61K31/5025
摘要： The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase ("PARP"), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（“PARP”）的二氮杂苯并[de]蒽-3-酮化合物，含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述条件的效果。

88. 发明申请

WO2006017483A2 CONTENT PERFORMANCE ASSESSMENT OPTIMIZATION FOR SEARCH LISTINGS IN WIDE AREA NETWORK SEARCHES 审中-公开
标题翻译：内容网络搜索中搜索列表的性能评估优化
公开(公告)号：WO2006017483A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027383
申请日：2005-08-02
申请人： OVERTURE SERVICES, INC. , MORTENSEN, Kurt , CHEUNG, Dominic Dough-Ming , LANG, Alan, E. , SNELL, Scott, Williams , ZHANG, Jie , WANG, Pierre, W.
发明人： MORTENSEN, Kurt , CHEUNG, Dominic Dough-Ming , LANG, Alan, E. , SNELL, Scott, Williams , ZHANG, Jie , WANG, Pierre, W.
IPC分类号： G06F7/00
CPC分类号： G06F17/30864 , G06F17/30699 , G06F17/30867
摘要： A system and method for improving the relevance of search results given by, and favorable user experience with, a search engine by automatically detecting and removing search listings which are unusually infrequently selected by users from among other search listings. Data representing presentation of individual search listings as part of search results and data representing selection of such search listing by a user are accumulated and analyzed to evaluate performance of the search listing. Rates of selection of search listings are compared to rates of selections of search listings in similar and different positions within search results sets. Search listings with unusually low selection rates are marked from removal from the search database and/or are demoted from generalizing matching mechanisms to more specific matching mechanisms. Parameters of the accumulation and performance evaluation are adjusted according to the search volume of the search listing.
摘要翻译：一种用于通过自动检测和去除由其他搜索列表中的用户异常选择的搜索列表来提高由搜索引擎给出的搜索结果的相关性和有利的用户体验的系统和方法。表示作为搜索结果的一部分的单独搜索列表的表示的数据和表示用户对这种搜索列表的选择的数据被累积和分析以评估搜索列表的表现。将搜索列表的选择速率与搜索结果集中相似和不同位置的搜索列表的选择速率进行比较。具有异常低选择率的搜索列表标记为从搜索数据库中删除和/或从广义匹配机制降级到更具体的匹配机制。根据搜索列表的搜索量调整累积和绩效评估的参数。

89. 发明申请

WO2005115354A2 COMPOSITIONS AND METHODS FOR BONE FORMATION AND REMODELING 审中-公开
标题翻译：用于骨形成和重建的组合物和方法
公开(公告)号：WO2005115354A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/017199
申请日：2005-05-18
申请人： ENZO THERAPEUTICS, INC. , ZHANG, Yazhou , LIU, Peng , LI, Xiaofeng , ZHANG, Jie , SHAN, Jufang , ENGELHARDT, Dean , WU, Dianqing
发明人： ZHANG, Yazhou , LIU, Peng , LI, Xiaofeng , ZHANG, Jie , SHAN, Jufang , ENGELHARDT, Dean , WU, Dianqing
IPC分类号： A61K9/68
CPC分类号： G01N33/6893 , A61K38/00 , G01N33/6887 , G01N2500/00 , G01N2800/10 , G01N2800/108
摘要： The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. Together with the observation that osteoblast cells produce autocrine canonical Wnt, Wnt7b, and that osteocytes produce paracrine Dkk1, we believe that the G171V mutation may cause an increase in Wnt activity in osteoblastls by reducing the numnber of targets for paracrine Dkk1 to antagonize without affecting the activity of autocrine Wnt.
摘要翻译：研究了Wnt共同受体LRP5的高骨量（HBM）突变（G171V）调节规范Wnt信号传导的机制。以前显示突变可以降低Dkk蛋白-1介导的拮抗作用，这表明G171位于第一个YWTD重复结构域可能是Dkk蛋白介导的拮抗作用的原因。然而，我们发现第三个YWTD重复，但不是第一个重复结构域，是DKK1介导的拮抗作用所必需的。相反，我们发现G171V突变破坏了LRP5与Mesd的相互作用，Mesd是细胞表面上LRP5 / 6分子的伴侣蛋白。尽管细胞表面LRP5分子水平的降低导致旁分泌范例中Wnt信号传导的降低，但突变似乎不影响共表达Wnt在自分泌范式中的活性。连同观察到，成骨细胞产生自分泌标准Wnt，Wnt7b，并且该骨细胞产生旁分泌Dkk1，我们认为G171V突变可能通过减少旁分泌Dkk1的靶标的数目来拮抗而引起成骨细胞中Wnt活性的增加而不影响成骨细胞自分泌Wnt的活性。

90. 发明申请

WO2005093944A1 ORGANIC SEMICONDUCTOR INVERTING CIRCUIT 审中-公开
标题翻译：有机半导体逆变电路
公开(公告)号：WO2005093944A1
公开(公告)日：2005-10-06
申请号：PCT/US2005/002885
申请日：2005-02-01
申请人： MOTOROLA, INC. , BRAZIS, Paul, W. , ADEWOLE, Hakeem, B. , GAMOTA, Daniel, R. , ZHANG, Jie
发明人： BRAZIS, Paul, W. , ADEWOLE, Hakeem, B. , GAMOTA, Daniel, R. , ZHANG, Jie
IPC分类号： H03B1/00
CPC分类号： H03K19/08
摘要： An organic semiconductor inverting circuit includes at least three organic transistors, an output terminal (110, 210, 310, 410), a reference supply voltage input (115, 215, 315, 415), a first positive supply voltage input (120, 220, 320, 420), and a negative supply voltage input (125, 225, 325, 425). One of the three organic transistors is an input transistor having a gate to which is coupled an input terminal (105, 205, 305, 405). The output terminal (110, 210, 310, 410) is coupled to a first electrode of at least one of the at least three organic transistors.
摘要翻译：有机半导体反相电路包括至少三个有机晶体管，输出端（110,210,310,410），参考电源电压输入（115,215,315,415），第一正电源电压输入端（120,220），320,420）和负电源电压输入（125,225,325,425）。三个有机晶体管中的一个是具有与输入端（105,205,305,405）耦合的栅极的输入晶体管。输出端子（110,210,310,410）耦合到至少三个有机晶体管中的至少一个的第一电极。

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