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81. 发明申请

WO2009017464A1 RELATION EXTRACTION SYSTEM 审中-公开
标题翻译：关系抽取系统
公开(公告)号：WO2009017464A1
公开(公告)日：2009-02-05
申请号：PCT/SG2008000281
申请日：2008-07-31
申请人： AGENCY SCIENCE TECH & RES , YONG STANELY WAI KEONG , SU JIAN , YANG XIAO FENG
发明人： YONG STANELY WAI KEONG , SU JIAN , YANG XIAO FENG
IPC分类号： G06F17/21 , G01L15/00 , G10L13/08
CPC分类号： G06F17/2715
摘要： A classification system comprising a first supervised classifier module configured to access an annotated corpus during a training mode, a second semi-supervised module configured to access a raw text and index at least one pseudo document extracted from the raw text according to the location of a skip bigram within the at least one pseudo document during the training mode, a third classifier module configured to receive the output of the first supervised classifier module and a plurality of skip bigram similarity features derived from the skip bigram from the second semi-supervised module during a validation mode, and to receive a raw text document for relation extraction during a normal operation mode. Also a method.
摘要翻译：一种分类系统，包括：第一监督分类器模块，被配置为在训练模式期间访问被注释的语料库;第二半监督模块，被配置为访问原始文本并且索引从原始文本提取的至少一个伪文档，在训练模式期间跳过所述至少一个伪文档内的二元组;第三分类器模块，被配置为接收所述第一监督分类器模块的输出以及从所述第二半监督模块期间从所述第二半监督模块导出的多个跳过二元组相似性特征验证模式，并且在正常操作模式期间接收用于关系提取的原始文本文档。也是一种方法。

82. 发明申请

WO2008070669A9 METHOD AND APPARATUS FOR MEMS OSCILLATOR 审中-公开
标题翻译： MEMS振荡器的方法和装置
公开(公告)号：WO2008070669A9
公开(公告)日：2008-09-25
申请号：PCT/US2007086389
申请日：2007-12-04
申请人： MIRADIA INC , YANG XIAO , CHEN DONGMIN , WANG YE , PAYNE JUSTIN , WANG YUXIANG , JI WOOK
发明人： YANG XIAO , CHEN DONGMIN , WANG YE , PAYNE JUSTIN , WANG YUXIANG , JI WOOK
IPC分类号： H03H9/24
CPC分类号： H03H3/0072 , H03H3/0073 , H03H9/02244 , H03H9/2463 , H03H2009/02511 , H03H2009/02519
摘要： A resonator includes a CMOS substrate having a first electrode and a second electrode. The CMOS substrate is configured to provide one or more control signals to the first electrode. The resonator also includes a resonator structure including a silicon material layer. The resonator structure is coupled to the CMOS substrate and configured to resonate in response to the one or more control signals.
摘要翻译：谐振器包括具有第一电极和第二电极的CMOS衬底。 CMOS衬底被配置为向第一电极提供一个或多个控制信号。谐振器还包括包括硅材料层的谐振器结构。谐振器结构耦合到CMOS衬底并且被配置为响应于一个或多个控制信号而谐振。

83. 发明申请

WO2008077113A1 OPTIMIZED DIRECTIONAL MIMO ANTENNA SYSTEM 审中-公开
标题翻译：优化的方向MIMO天线系统
公开(公告)号：WO2008077113A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/088183
申请日：2007-12-19
申请人： AIRGAIN, INC. , ABRAMOV, Oleg Y. , VISURI, Pertti , SALO, Randy , YANG, Xiao Ping
发明人： ABRAMOV, Oleg Y. , VISURI, Pertti , SALO, Randy , YANG, Xiao Ping
IPC分类号： H04B7/10
CPC分类号： H04B7/0689 , H04B7/0452 , H04B7/0617 , H04B7/0697 , H04B7/0814 , H04B7/0842 , H04B7/0871
摘要： A wireless communication device with a plurality of radios and a plurality of configurable antenna systems. Determining a plurality of transmit and receive signal quality metrics for connections between the wireless communication device and a plurality of stations for a plurality of radios and configurable antenna systems in a plurality of configurations. Determining a connection matrix that includes the transmit and receive signal quality. Selecting antenna configurations for the configurable antennas using the connection matrix.
摘要翻译：一种具有多个无线电设备和多个可配置天线系统的无线通信设备。确定用于多个配置中的多个无线电和可配置天线系统的无线通信设备与多个站之间的连接的多个发送和接收信号质量度量。确定包含发送和接收信号质量的连接矩阵。使用连接矩阵选择可配置天线的天线配置。

84. 发明申请

WO2008070669A2 METHOD AND APPARATUS FOR MEMS OSCILLATOR 审中-公开
公开(公告)号：WO2008070669A2
公开(公告)日：2008-06-12
申请号：PCT/US2007086389
申请日：2007-12-04
申请人： MIRADIA INC , YANG XIAO , CHEN DONGMIN , WANG YE , PAYNE JUSTIN , WANG YUXIANG , JI WOOK
发明人： YANG XIAO , CHEN DONGMIN , WANG YE , PAYNE JUSTIN , WANG YUXIANG , JI WOOK
IPC分类号： H01L41/22 , H01L41/09 , H03B5/36
CPC分类号： H03H3/0072 , H03H3/0073 , H03H9/02244 , H03H9/2463 , H03H2009/02511 , H03H2009/02519
摘要： A resonator includes a CMOS substrate having a first electrode and a second electrode. The CMOS substrate is configured to provide one or more control signals to the first electrode. The resonator also includes a resonator structure including a silicon material layer. The resonator structure is coupled to the CMOS substrate and configured to resonate in response to the one or more control signals.

85. 发明申请

WO2008027800A3 METHOD FOR ENHANCING THE EFFICACY OF ANTIGEN SPECIFIC TUMOR IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2008027800A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/076717
申请日：2007-08-24
申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , YANG, Xiao-feng
发明人： YANG, Xiao-feng
IPC分类号： G01N33/53 , C12P21/00 , C07K1/00 , C07K5/00
摘要： The invention provides a method for the improved processing efficiency of T cell tumor antigen epitopes using bioinformatic means. The proteolytic sites in the generation of 47 experimentally identified HLA-A2.1-restricted immunodominant tumor antigen epitopes was compared to those of 52 documented HLA-A2.1-restricted immunodominant viral antigen epitopes. The amino acid frequencies in the C-terminal cleavage sites of the tumor antigen epitopes, as well as several positions within the 10 amino acid (aa) flanking regions, were significantly different from those of the viral antigen epitopes. These two groups of epitopes may be cleaved by distinct sets of proteasomes and peptidases or similar enzymes with lower efficiencies for tumor epitopes, targeted activation of the immunoproteasomes and peptidases can be achieved that mediate the cleavage of viral epitopes in order to more effectively generate tumor antigen epitopes thus enhancing antigen-specific tumor immunotherapy.

86. 发明申请

WO2008027800A2 METHOD FOR ENHANCING THE EFFICACY OF ANTIGEN SPECIFIC TUMOR IMMUNOTHERAPY 审中-公开
标题翻译：提高抗原特异性肿瘤免疫功能的方法
公开(公告)号：WO2008027800A2
公开(公告)日：2008-03-06
申请号：PCT/US2007076717
申请日：2007-08-24
申请人： UNIV TEMPLE , YANG XIAO-FENG
发明人： YANG XIAO-FENG
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/29 , A61K39/292 , C12N2730/10134 , C12N2740/16034 , C12N2760/16134 , C12N2770/24234
摘要： The invention provides a method for the improved processing efficiency of T cell tumor antigen epitopes using bioinformatic means. The proteolytic sites in the generation of 47 experimentally identified HLA-A2.1-restricted immunodominant tumor antigen epitopes was compared to those of 52 documented HLA-A2.1-restricted immunodominant viral antigen epitopes. The amino acid frequencies in the C-terminal cleavage sites of the tumor antigen epitopes, as well as several positions within the 10 amino acid (aa) flanking regions, were significantly different from those of the viral antigen epitopes. These two groups of epitopes may be cleaved by distinct sets of proteasomes and peptidases or similar enzymes with lower efficiencies for tumor epitopes, targeted activation of the immunoproteasomes and peptidases can be achieved that mediate the cleavage of viral epitopes in order to more effectively generate tumor antigen epitopes thus enhancing antigen-specific tumor immunotherapy.
摘要翻译：本发明提供使用生物信息学手段提高T细胞肿瘤抗原表位的加工效率的方法。将47个实验鉴定的HLA-A2.1限制免疫显性肿瘤抗原表位的蛋白水解位点与52个记录的HLA-A2.1限制性免疫显性病毒抗原表位的蛋白水解位点进行比较。肿瘤抗原表位的C末端切割位点的氨基酸频率以及10个氨基酸（aa）侧翼区域内的几个位置与病毒抗原表位的氨基酸频率显着不同。这两组表位可以被不同组的蛋白酶体和肽酶或相似的酶切割，对肿瘤表位具有较低的效率，可以实现介导病毒表位的切割以更有效地产生肿瘤抗原的免疫蛋白酶体和肽酶的靶向激活表位因此增强抗原特异性肿瘤免疫治疗。

87. 发明申请

WO2008022253A2 AN UNCONVENTIONAL ANTIGEN TRANSLATED BY A NOVEL INTERNAL RIBOSOME ENTRY SITE ELICITS ANTITUMOR HUMORAL IMMUNE REACTIONS 审中-公开
标题翻译：一个新的内部入侵者网站转载的非传统抗原抗体抗体免疫反应
公开(公告)号：WO2008022253A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/076088
申请日：2007-08-16
申请人： TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , YANG, Xiao-Feng
发明人： YANG, Xiao-Feng
IPC分类号： A61K48/00
CPC分类号： C07K14/4702 , A61K39/00 , A61K39/0011 , A61K2039/53 , C07K14/4748 , C12N2840/002 , C12N2840/105 , C12N2840/203 , C12N2840/85
摘要： The invention provides a novel antigen, MPD6, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3'untranslated region (3'UTR) of myotrophin mRNA. MPD6 elicits IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD6 was mediated by a novel internal ribosome entry site (IRES) upstream of the MPD6 reading frame. Furthermore, the MPD6-IRES mediated translation, but not myotrophin-MPD6 transcription, was significantly upregulated in response to IFN-α stimulation. These findings demonstrate that a novel IRES-mediated mechanism is responsible for the translation of unconventional self-antigen MPD6 in responsive to IFN-α stimulation. The eliciting anti-tumor immune response against unconventional antigen MPD6 in patients with myeloproliferative diseases indicates MPD6 as a target of novel immunotherapy.
摘要翻译：本发明提供了一种新型抗原，MPD6属于无常规基因组结构的隐性抗原组，由位于肌营养蛋白mRNA的3'非翻译区（3'UTR）的隐性开放阅读框编码。 MPD6在PV患者的一个亚组以及慢性骨髓性白血病和前列腺癌患者中引起IgG抗体应答。 MPD6翻译由MPD6阅读框上游的新型内部核糖体进入位点（IRES）介导。此外，MPD6-IRES介导的翻译，但不是myotrophin-MPD6转录，在对IFN-α刺激的响应中显着上调。这些研究结果表明，一种新的IRES介导的机制负责非传染性自身抗原MPD6对IFN-α刺激的反应。在骨髓增生性疾病患者中引发针对非常规抗原MPD6的抗肿瘤免疫应答表明MPD6是新型免疫治疗的靶标。

88. 发明申请

WO2006105100A3 SUPPRESSION OF EMI RADIATION IN EAS SYSTEM 审中-公开
标题翻译：抑制EAS系统中的EMI辐射
公开(公告)号：WO2006105100A3
公开(公告)日：2007-10-25
申请号：PCT/US2006011302
申请日：2006-03-28
申请人： WG SECURITY PRODUCTS INC , YANG XIAO HUI
发明人： YANG XIAO HUI
IPC分类号： G08B13/14
CPC分类号： G08B13/2408 , G08B13/2488
摘要： An electronic article surveillance system (EAS) comprises a transmitter and a receiver. An amplifier is associated with the transmitter whereby non-linear signals are generated. A filter is provided for filtering the transmitted signal to reduce the strength of the harmonic content of the transmitted signal. A switch bypasses the filtering and turns off the transmitter to shorten ringing transient duration of the transmitted signal and thereby reduce interference at the receiver.
摘要翻译：电子物品监视系统（EAS）包括发射机和接收机。放大器与发射器相关联，由此产生非线性信号。提供了一个滤波器，用于对传输的信号进行滤波，以降低传输信号的谐波含量的强度。开关旁路滤波并关闭发射机，以缩短发射信号的振铃瞬态持续时间，从而减少接收机的干扰。

89. 发明申请

WO2006068953A3 ANTIBODIES DIRECTED TO ANGIOPOIETIN-2 AND USES THEREOF 审中-公开
标题翻译：抗体依赖于ANGIOPOIETIN-2的抗体及其用途
公开(公告)号：WO2006068953A3
公开(公告)日：2007-08-02
申请号：PCT/US2005045657
申请日：2005-12-19
申请人： ASTRAZENECA AB , GREEN LARRY L , ZHOU QING , KEYT BRUCE A , YANG XIAO-DONG , EMERY STEPHEN CHARLES , BLAKEY DAVID C
发明人： GREEN LARRY L , ZHOU QING , KEYT BRUCE A , YANG XIAO-DONG , EMERY STEPHEN CHARLES , BLAKEY DAVID C
IPC分类号： C07K16/22 , C07K16/28 , C12N15/13 , C12N15/85
CPC分类号： C07K16/22 , A61K39/39558 , A61K2039/505 , C07K14/515 , C07K2317/21 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementary determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobin molecules and monoclonal antibodies.
摘要翻译：描述针对抗原Ang-2的抗体和这种抗体的用途。特别是针对抗原Ang-2的完全人单克隆抗体。编码重组和轻链免疫球蛋白分子的核苷酸序列和氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。杂交瘤或表达这种免疫球蛋白分子的其它细胞系和单克隆抗体。

90. 发明申请

WO2006105100A2 SUPPRESSION OF EMI RADIATION IN EAS SYSTEM 审中-公开
标题翻译：抑制EAS系统中的EMI辐射
公开(公告)号：WO2006105100A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011302
申请日：2006-03-28
申请人： WG SECURITY PRODUCTS, INC. , YANG, Xiao Hui
发明人： YANG, Xiao Hui
IPC分类号： G01S13/08
CPC分类号： G08B13/2408 , G08B13/2488
摘要： An electronic article surveillance system (EAS) comprises a transmitter and a receiver. An amplifier is associated with the transmitter whereby non-linear signals are generated. A filter is provided for filtering the transmitted signal to reduce the strength of the harmonic content of the transmitted signal. A switch bypasses the filtering and turns off the transmitter to shorten ringing transient duration of the transmitted signal and thereby reduce interference at the receiver.
摘要翻译：电子物品监视系统（EAS）包括发射机和接收机。放大器与发射器相关联，由此产生非线性信号。提供了一个滤波器，用于对传输的信号进行滤波，以降低传输信号的谐波含量的强度。 A开关旁路滤波并关闭发射机以缩短发射信号的振铃瞬态持续时间，从而减少接收机的干扰。

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