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    • 81. 发明申请
    • HAPTIC DEVICE
    • WO2012010911A3
    • 2012-01-26
    • PCT/GB2011/051416
    • 2011-07-25
    • NEW TRANSDUCERS LIMITEDHARRIS, Neil
    • HARRIS, Neil
    • G06F3/043G06F3/041G06F3/01
    • A method of generating a desired haptic sensation in a touch sensitive device comprising a touch-sensitive member and a plurality of transducers mounted to the member. The method comprises: determining an initial estimate of a filter to be applied to a respective signal input to each transducer whereby application of the filtered input signals the transducers generates vibration of the member which provides a haptic sensation; defining a model of the system whereby the vibration of the member can be calculated as a function of the input signal, the model having a plurality of parameters calculating the vibration of the member as an output of the mode of the system; calculating a reference error value for the output of the model by comparing the output of the model with a measured value of vibration of the member;determining changed parameter values of the parameters of the model;recalculating the error value for the output of the model by comparing the output of the model with the changed parameter values with the measured value of vibration of the member;comparing the recalculated error value with the reference error value;if the compared recalculated error value is less than the reference error value, setting the recalculated error value as the reference error value, setting the changed parameter values as the model parameters,and repeating the above steps, or,if the compared recalculated error value is greater than the reference error value, outputting the model parameters;generating a new filter using the output model parameters; and applying the new filters to respective input signals applied to each transducer to generate vibration within the member to provide the desired haptic sensation.
    • 82. 发明申请
    • TOUCH SENSITIVE DEVICE
    • 触感敏感设备
    • WO2011051722A2
    • 2011-05-05
    • PCT/GB2010051814
    • 2010-10-29
    • NEW TRANSDUCERS LTDHARRIS NEIL JOHNCOLLOMS MARTIN
    • HARRIS NEIL JOHNCOLLOMS MARTIN
    • G06F3/0433G06F3/016
    • A touch sensitive device comprising a touch sensitive display member capable of supporting bending wave vibration and having a user accessible display surface, an array of transducers coupled to the display member with the array of transducers comprising at least some transducers which are configured to both detect physical touching of the input surface by the user and to input impulses into the display member to produce a haptics sensation to the user in response to said detected touching of the display surface, and a signal processor to receive signals from at least some of transducers in the array of transducers and adapted to analyse the signals to determine the location of the physical touch on the display surface.
    • 一种触敏设备,包括能够支撑弯曲波振动并具有用户可访问的显示表面的触敏显示构件,耦合到所述显示构件的换能器阵列,所述换能器阵列包括至少一些换能器,所述换能器被配置为同时检测物理 触摸用户的输入表面并且将脉冲输入到显示构件中以响应于所述检测到的显示表面的触摸而产生对用户的触觉感觉;以及信号处理器,用于从至少一些传感器接收信号 传感器阵列,并适于分析信号以确定显示表面上物理触摸的位置。
    • 83. 发明申请
    • AQUEOUS POLYSILICATE COMPOSITION, ITS PREPARATION AND ITS USE IN PAPERMAKING
    • 水性聚硅酸酯组合物及其制备方法及其在造纸中的应用
    • WO2010060805A3
    • 2010-10-28
    • PCT/EP2009065069
    • 2009-11-12
    • BASF SESAASTAMOINEN SAKARIHARRIS NEIL SIDNEY
    • SAASTAMOINEN SAKARIHARRIS NEIL SIDNEY
    • C01B33/26D21H17/68
    • D21H17/68C01B33/143C01B33/20C01B33/26D21H21/10
    • The invention relates to an aqueous polysilicate composition comprising i) particles of polysilicate seeds, ii) polymerised silicate in intimate association with the polysilicate seeds, iii) cross linkages within the polymerised polysilicate formed from aluminium atoms, aluminium compounds or aluminium ions, iv) cross linkages within the polymerised polysilicate formed from atoms, compounds or ions of a multi-valent metal other than aluminium. Preferably the aqueous polysilicate composition further comprises component v) a water-soluble branched anionic polymer that has been formed from ethylenically unsaturated monomers. The invention also incorporates a method for preparing an aqueous polysilicate composition and also to the use of the aqueous polysilicate composition as a retention/drainage aid in a process of making paper or paperboard.
    • 本发明涉及一种含水聚硅酸盐组合物,其包含i)聚硅酸盐种子颗粒,ii)与聚硅酸盐种子密切结合的聚合硅酸盐,iii)由铝原子,铝化合物或铝离子形成的聚合聚硅酸盐内的交联键,iv) 由除铝之外的多价金属的原子,化合物或离子形成的聚合聚硅酸酯内的连接。 优选地,含水聚硅酸盐组合物还包含组分v)由烯键式不饱和单体形成的水溶性支化阴离子聚合物。 本发明还包括制备含水聚硅酸盐组合物的方法,并且还涉及含水聚硅酸盐组合物作为制备纸或纸板的过程中的助留/排出助剂的用途。
    • 87. 发明申请
    • THIAZOLYL-HYDROXAMIC ACIDS AND THIADIAZOLYL-HYDROXAMIC ACIDS, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY
    • 噻唑 - 羟肟酸和噻二唑 - 羟肟酸,以及其用于治疗与HISTONE脱乙酰酶活性相关的疾病的用途
    • WO2005075469A1
    • 2005-08-18
    • PCT/GB2005/000282
    • 2005-01-27
    • ARGENTA DISCOVERY LIMITEDBORDOGNA, WalterSUTTON, Jonathan, MarkHYND, GeorgeDYKE, Hazel, JoanPRICE, StephenHARRIS, Neil, VictorGILL, Mathew, Iain, Andrew
    • BORDOGNA, WalterSUTTON, Jonathan, MarkHYND, GeorgeDYKE, Hazel, JoanPRICE, StephenHARRIS, Neil, VictorGILL, Mathew, Iain, Andrew
    • C07D417/04
    • C07D417/04C07D417/14
    • A compound of formula: (I) in which A represents optionally substituted monocyclic heteroaryl or phenyl; B represents optionally substituted heteroaryl, aryl, aryl-fused-heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl, or B represents H when L represents a single bond; L represents a single bond, alkylene, (CH 2 ) n X(CH 2 ) m , (CH2) n X(CH 2 ) p Y(CH 2 ) m ; Q represents N or CR 2 ; T represents N or CR 2 , provided that Q and T do not both represent CR 2 simultaneously; X represents -O-, -NR 3 -, -CO-, -SO 2 -, -NR 3 C0-, -NR 3 SO 2 -, -CONR 3 -, -SO 2 NR 3 -, -NR 1 CONR 1 -; Y represents -NR 3 - or -O-; R l represents H or alkyl; R 2 represents hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, CN; R 3 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, or alkyl substituted by -OR 4 , -NR 5 R 6 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -CONR 5 R 6 or -SO 2 NR 5 R 6 ; R 4 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl; R 5 represents H or alkyl; R 6 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl or NR 5 R 6 represents a cyclic amine; R 7 represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; n represents 0-3; m represents 0-3; p represents 1-3; and corresponding N-oxides, pharmaceutically acceptable salts, solvates and prodrugs thereof; and use to treat a disease in which inhibition of histone deacetylase can prevent, inhibit or ameliorate the pathology and/or symptomatology of the disease.
    • 式(I)的化合物,其中A表示任选取代的单环杂芳基或苯基; B表示任选取代的杂芳基,芳基,芳基稠合 - 杂环烷基,杂芳基 - 稠合环烷基,杂芳基 - 稠合 - 杂环烷基或芳基 - 稠合环烷基,或当L表示单键时,B表示H; L表示单键,亚烷基,(CH 2)n X(CH 2)m,(CH 2)n X(CH 2)p Y(CH 2)m; Q表示N或CR 2; T表示N或CR 2,条件是Q和T不同时同时表示CR 2; X代表-O - , - NR 3 - , - CO - , - SO 2 - , - NR 3 C 0 - , - NR 3 SO 2 - , - CONR 3 - , - SO 2 NR 3 - ,-NR 1 CONR 1 - ; Y表示-NR 3 - 或-O-; R 1表示H或烷基; R 2表示氢,卤素,烷基,卤代烷基,烷氧基,卤代烷氧基,CN; R 3表示H,烷基,芳基烷基,杂芳基烷基,杂环烷基烷基,环烷基烷基或被-OR 4取代的烷基,-NR 5 R 6,-NR 6 COR 7, 6 SO 2 R 7,-CONR 5 R 6或-SO 2 NR 5 R 6; R 4表示H,烷基,芳基烷基,杂芳基烷基,杂环烷基烷基,环烷基烷基,芳基,杂芳基,杂环烷基或环烷基; R 5表示H或烷基; R 6代表H,烷基,芳基烷基,杂芳基烷基,杂环烷基烷基,环烷基烷基,芳基,杂芳基,杂环烷基或环烷基或NR 5 R 6表示环状胺; R 7表示烷基,芳基,杂芳基,环烷基,杂环烷基,芳烷基,杂芳基烷基,环烷基烷基或杂环烷基烷基; n表示0-3; m表示0-3; p表示1-3; 及其相应的N-氧化物,其药学上可接受的盐,溶剂合物和前药; 并且用于治疗组蛋白脱乙酰酶的抑制可以预防,抑制或改善疾病的病理学和/或症状学的疾病。
    • 88. 发明申请
    • SUBSTITUTED THIENYL-MERCAPTOKETONES, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY
    • 取代的三烯酰基甜菜碱及其用于治疗与组织脱乙酰酶酶活性相关的疾病
    • WO2005075466A1
    • 2005-08-18
    • PCT/GB2005/000283
    • 2005-01-27
    • ARGENTA DISCOVERY LIMITEDBORDOGNA, WalterBULL, RichardSUTTON, Jonathon, MarkSMITH, Helen, KatherineDYKE, Hazel, JoanPRICE, StephenHARRIS, Neil, Victor
    • BORDOGNA, WalterBULL, RichardSUTTON, Jonathon, MarkSMITH, Helen, KatherineDYKE, Hazel, JoanPRICE, StephenHARRIS, Neil, Victor
    • C07D409/04
    • C07D409/04
    • A compound of formula: (I): in which A represents optionally substituted monocyclic heteroaryl or phenyl; B represents optionally substituted heteroaryl, aryl, aryl-fused-heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl, or B represents H when L represents a single bond; L represents a single bond, alkylene, (CH 2 ) n X(CH 2 ) m , (CH 2 ) n X(CH 2 ) p Y(CH 2 ) m ; X represents -O-, -NR 3 -, -CO-, -SO 2 -, -NR 3 CO-, -NR 3 SO 2 -, -CONR 3 -, -SO 2 NR 3 -, -NR 5 CONR 5a -; Y represents NR 3 - or -O-; R 1 represents H, COR 8 ; R 2 represents halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, CN; R 3 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, or alkyl substituted by -OR 4 , -NR 5 R 6 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -CONR 5 R 6 or -SO 2 NR 5 R 6 ; R 4 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl; R 5 and R 5a represent H or alkyl; R 6 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl or NR 5 R 6 represents a cyclic amine; R 7 represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; R 8 represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; n represents 0-3; m represents 0-3; p represents 1-3; and corresponding disulphides, N -oxides, pharmaceutically acceptable salts, solvates and prodrugs thereof; and use to treat a disease in which inhibition of histone deacetylase can prevent, inhibit or ameliorate the pathology and/or symptomatology of the disease.
    • 式(I)的化合物:其中A表示任选取代的单环杂芳基或苯基; B表示任选取代的杂芳基,芳基,芳基稠合 - 杂环烷基,杂芳基 - 稠合环烷基,杂芳基 - 稠合 - 杂环烷基或芳基 - 稠合环烷基,或当L表示单键时,B表示H; L表示单键,亚烷基,(CH 2)n X(CH 2)m,(CH 2)n X(CH 2)p Y(CH 2)m; X表示-O - , - NR 3 - , - CO - , - SO 2 - , - NR 3 CO - , - NR 3 SO 2 - , - CONR 3 - , - SO 2 NR 3 - ,-NR 5 CONR 5a - ; Y表示NR 3 - 或-O-; R 1表示H,COR 8; R 2表示卤素,烷基,卤代烷基,烷氧基,卤代烷氧基,CN; R 3表示H,烷基,芳基烷基,杂芳基烷基,杂环烷基烷基,环烷基烷基或被-OR 4取代的烷基,-NR 5 R 6,-NR 6 COR 7, 6 SO 2 R 7,-CONR 5 R 6或-SO 2 NR 5 R 6; R 4表示H,烷基,芳基烷基,杂芳基烷基,杂环烷基烷基,环烷基烷基,芳基,杂芳基,杂环烷基或环烷基; R 5和R 5a代表H或烷基; R 6代表H,烷基,芳基烷基,杂芳基烷基,杂环烷基烷基,环烷基烷基,芳基,杂芳基,杂环烷基或环烷基或NR 5 R 6表示环状胺; R 7表示烷基,芳基,杂芳基,环烷基,杂环烷基,芳烷基,杂芳基烷基,环烷基烷基或杂环烷基烷基; R 8表示烷基,芳基,杂芳基,环烷基,杂环烷基,芳基烷基,杂芳基烷基,环烷基烷基或杂环烷基烷基; n表示0-3; m表示0-3; p表示1-3; 和相应的二硫化物,N-氧化物,其药学上可接受的盐,溶剂化物和前药; 并且用于治疗组蛋白脱乙酰酶的抑制可以预防,抑制或改善疾病的病理学和/或症状学的疾病。