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81. 发明申请

WO2009158625A2 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GASTROINTESTINAL DISORDERS AND GERD-RELATED RESPIRATORY DISORDERS 审中-公开
标题翻译：用于治疗或预防胃肠疾病和胃肠相关呼吸道疾病的组合物和方法
公开(公告)号：WO2009158625A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/048870
申请日：2009-06-26
申请人： IRONWOOD PHARMACEUTICALS, INC. , CURRIE, Mark, G.
发明人： CURRIE, Mark, G.
IPC分类号： A61K31/785 , A61K31/56 , A61K33/10 , A61P1/04 , A61P11/00
CPC分类号： A61K31/785 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are novel compositions and methods for treating or preventing GI tract disorders and/or GERD-related respiratory disorders as well as protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H 2 -receptor antagonists, Υ-aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.
摘要翻译：本文公开了用于治疗或预防胃肠道疾病和/或GERD相关呼吸障碍以及保护分层鳞状上皮免受有害物质损伤的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的包含至少一种胆汁酸多价螯合剂的药物组合物，其单独或与至少一种质子泵抑制剂组合，以及任选的一种或多种选自抗酸剂，组胺 H2-受体拮抗剂，γ-氨基丁酸-B（GABA-B）激动剂，GABA-B激动剂的前药和蛋白酶抑制剂。

82. 发明申请

WO2009065154A3 METHOD OF AND APPARATUS FOR PROTECTING PRIVATE DATA ENTRY WITHIN SECURE WEB SESSIONS 审中-公开
标题翻译：在安全网络会议中保护私有数据输入的方法和装置
公开(公告)号：WO2009065154A3
公开(公告)日：2009-07-09
申请号：PCT/ZA2008000104
申请日：2008-11-11
申请人： CURRIE MARK
发明人： CURRIE MARK
IPC分类号： H04L29/06
CPC分类号： H04L63/1466 , H04L63/0853 , H04L63/1483 , H04L63/166
摘要： A method of providing secure communication over a communication network from a client computer to at least one server computer using a cryptographic security protocol which includes the steps of connecting a secure hardware device to the client computer, and using the device to prevent disclosure on the client computer of login and private information of a user of the client computer.
摘要翻译：一种通过通信网络从客户端计算机向使用密码安全协议的至少一个服务器计算机提供安全通信的方法，该方法包括以下步骤：将安全硬件设备连接到客户端计算机，以及使用该设备来防止在客户端上公开计算机的客户端计算机的用户的登录和私人信息。

83. 发明申请

WO2009065154A2 METHOD OF AND APPARATUS FOR PROTECTING PRIVATE DATA ENTRY WITHIN SECURE WEB SESSIONS 审中-公开
标题翻译：用于在安全的Web会话中保护私人数据输入的方法和设备
公开(公告)号：WO2009065154A2
公开(公告)日：2009-05-22
申请号：PCT/ZA2008/000104
申请日：2008-11-11
申请人： CURRIE, Mark
发明人： CURRIE, Mark
IPC分类号： H04L29/06
CPC分类号： H04L63/1466 , H04L63/0853 , H04L63/1483 , H04L63/166
摘要： A method of providing secure communication over a communication network from a client computer to at least one server computer using a cryptographic security protocol which includes the steps of connecting a secure hardware device to the client computer, and using the device to prevent disclosure on the client computer of login and private information of a user of the client computer.
摘要翻译：一种使用密码安全协议通过通信网络从客户端计算机向至少一个服务器计算机提供安全通信的方法，该方法包括以下步骤：将安全硬件设备连接到客户端计算机;以及使用该设备防止在客户计算机上泄露客户计算机的用户的登录和隐私信息。

84. 发明申请

WO2008157537A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS 审中-公开
标题翻译：用于治疗或预防脂肪相关疾病的组合物和方法
公开(公告)号：WO2008157537A2
公开(公告)日：2008-12-24
申请号：PCT/US2008/067204
申请日：2008-06-17
申请人： IRONWOOD PHARMACEUTICALS, INC , CURRIE, Mark , TALLEY, John , CALI, Brian
发明人： CURRIE, Mark , TALLEY, John , CALI, Brian
IPC分类号： C07D207/22 , C07D207/34 , C07D209/24 , C07D239/42 , C07D257/06 , C07D263/28 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , A61K31/33 , C07C59/70 , C07C69/017 , C07C69/612 , C07C203/00
CPC分类号： C07D257/06 , C07C69/712 , C07C69/732 , C07C203/04 , C07C235/30 , C07C259/06 , C07C279/12 , C07C279/14 , C07C279/22 , C07C281/16 , C07C291/02 , C07C2602/10 , C07C2602/28 , C07D207/22 , C07D207/34 , C07D209/24 , C07D239/42 , C07D263/28 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12
摘要： Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more fibric acid or statin derivative compositions alone or in combination with one or more lipid altering agents and/or PDE inhibitors.
摘要翻译：本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含单独一种或多种纤维酸或他汀类衍生物组合物或与一种或多种脂质改变剂和/或PDE抑制剂组合。

85. 发明申请

WO2008137318A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS ASSOCIATED WITH SALT OR FLUID RETENTION 审中-公开
标题翻译：用于治疗与盐或液体保留有关的疾病的组合物和方法
公开(公告)号：WO2008137318A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/061205
申请日：2008-04-23
申请人： IRONWOOD PHARMACEUTICALS, INC. , CURRIE, Mark G. , ZIMMER, Daniel P.
发明人： CURRIE, Mark G. , ZIMMER, Daniel P.
IPC分类号： A61K31/4706 , A61K31/675
CPC分类号： A61K31/675 , A61K31/4706 , A61K38/04 , A61K38/10 , A61K38/16 , A61K45/06 , Y02A50/414 , A61K2300/00
摘要： Methods for reducing the risk of or treating a disorder associated with fluid and/or salt retention in a patient are described. The methods include administering to the patient an agent selected from: a) an agent that reduces sodium absorption in the intestine; b) an agent that increases anion secretion in the intestine; or c) an agent that both reduces sodium absorption in the intestine and increases anion secretion in the intestine.
摘要翻译：描述了减少与患者中的流体和/或盐保留相关的病症的风险或治疗疾病的方法。所述方法包括向患者施用选自以下的试剂：a）降低肠中钠吸收的试剂; b）增加肠中阴离子分泌的药剂; 或c）既减少肠中钠吸收并增加肠内阴离子分泌的试剂。

86. 发明申请

WO2008106429A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEART FAILURE AND OTHER DISORDERS 审中-公开
标题翻译：治疗心力衰竭和其他疾病的方法和组合
公开(公告)号：WO2008106429A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/054972
申请日：2008-02-26
申请人： MICROBIA, INC. , MILNE, G. Todd , ZIMMER, Daniel P. , CURRIE, Mark G. , FRETZEN, Angelika
发明人： ZIMMER, Daniel P. , CURRIE, Mark G. , FRETZEN, Angelika
IPC分类号： C07K14/00
CPC分类号： C07K7/08 , A61K38/00
摘要： Peptides that act as GC-C receptor agonists and contain at least one D-cys and are useful for the treatment of diuresis and heart disease as well as other disorders are described.
摘要翻译：描述了充当GC-C受体激动剂并且含有至少一种D-cys并且可用于治疗利尿和心脏病以及其它病症的肽。

87. 发明申请

WO2008080092A2 METHODS AND COMPOSITIONS FOR TREATING ESOPHAGEAL DISORDERS 审中-公开
标题翻译：治疗食管障碍的方法和组合
公开(公告)号：WO2008080092A2
公开(公告)日：2008-07-03
申请号：PCT/US2007088624
申请日：2007-12-21
申请人： IRONWOOD PHARMACEUTICALS INC , CURRIE MARK G
发明人： CURRIE MARK G
IPC分类号： A61K9/00 , A61K31/195 , A61K31/27 , A61K31/341 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/444 , A61K31/575 , A61K31/785 , A61K33/08 , A61K33/10 , A61K45/06 , A61P1/04
CPC分类号： A61K9/0065 , A61K31/195 , A61K31/27 , A61K31/341 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/444 , A61K31/575 , A61K31/785 , A61K33/08 , A61K33/10 , A61K45/06 , C08F226/02 , A61K2300/00
摘要： Disclosed herein are novel compositions and methods for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, -aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.
摘要翻译：本文公开了用于治疗或预防上胃肠道疾病并保护分层鳞状上皮免受有害物质损伤的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的包含至少一种胆汁酸多价螯合剂的药物组合物，其单独或与至少一种质子泵抑制剂组合，以及任选的一种或多种选自抗酸剂，组胺 H 2受体拮抗剂，氨基丁酸-b（GABA-B）激动剂，GABA-B激动剂的前药和蛋白酶抑制剂。

88. 发明申请

WO2007101161A8 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：治疗胃肠疾病的方法和组合
公开(公告)号：WO2007101161A8
公开(公告)日：2007-12-27
申请号：PCT/US2007062820
申请日：2007-02-26
申请人： MICROBIA INC , CURRIE MARK G
发明人： CURRIE MARK G
IPC分类号： A61K38/17
CPC分类号： A61K31/56 , A61K38/10 , C07K7/08 , A61K2300/00

89. 发明申请

WO2007101158A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：治疗胃肠疾病的方法和组合
公开(公告)号：WO2007101158A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062815
申请日：2007-02-26
申请人： MICROBIA, INC. , CURRIE, Mark G.
发明人： CURRIE, Mark G.
CPC分类号： A61K38/10 , A61K38/164 , C07K14/4705
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor and predicted metabolites of such peptides.
摘要翻译：用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘描述了其他病症和病症，组合物特征在于激活鸟苷酸环化酶C（GC-C）受体和预测的这些肽的代谢物的肽。

90. 发明申请

WO2007022501A3 USEFUL INDOLE COMPOUNDS 审中-公开
公开(公告)号：WO2007022501A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/032573
申请日：2006-08-18
申请人： MICROBIA, INC. , BARTOLINI, Wilmin , CALI, Brian M. , CHEN, Barbara , CHIEN, Yueh-Tyng , CURRIE, Mark G. , MILNE, G. Todd , PEARSON, James Philip , TALLEY, John Jeffrey , YANG, Jing Jing , ZIMMERMAN, Craig , MONREAL, Alex W.
发明人： BARTOLINI, Wilmin , CALI, Brian M. , CHEN, Barbara , CHIEN, Yueh-Tyng , CURRIE, Mark G. , MILNE, G. Todd , PEARSON, James Philip , TALLEY, John Jeffrey , YANG, Jing Jing , ZIMMERMAN, Craig , MONREAL, Alex W.
IPC分类号： C07D209/12 , C07D417/06 , A61K31/404 , A61K31/426 , C07D401/06 , C07D403/06 , A61K31/4439 , A61K31/454
摘要： Indoles having various activities, including indoles that are CRTH2 are described. The compounds are useful for treating asthma, neuropathic pain, allegic rhinitis and other disorders.

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