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81. 发明申请

WO2004098033A1 SEQUENCING POWER SUPPLIES 审中-公开
标题翻译：顺序供电
公开(公告)号：WO2004098033A1
公开(公告)日：2004-11-11
申请号：PCT/CA2004/000642
申请日：2004-04-30
申请人： POTENTIA SEMICONDUCTOR, INC. , BROWN, David, Alan , GUHER, Muge
发明人： BROWN, David, Alan , GUHER, Muge
IPC分类号： H02M3/00
CPC分类号： G06F1/263 , H02M3/33507 , H02M2001/0012 , H02M2001/008
摘要： Power supplies are enabled and disabled in sequence in dependence upon monitored output voltages of, and an input voltage for, the power supplies. Bits stored in registers for each power supply represent the predetermined sequences in which the power supplies are enabled and disabled, and fault dependencies for the power supplies. The sequences can include independent, linear, divergent, and convergent paths. The registers are loaded from a non-volatile memory on power-up of a power supply controller also powered from the input voltage.
摘要翻译：依赖于电源的监控输出电压和输入电压，依次启用和禁用电源。存储在每个电源的寄存器中的位表示其中电源被启用和禁用的预定顺序以及电源的故障依赖性。序列可以包括独立的，线性的，发散的和收敛的路径。寄存器在从输入电压供电的电源控制器上电时也从非易失性存储器加载。

82. 发明申请

WO03073409A9 A SLIDE SHOW PRESENTATION AND METHOD FOR VIEWING SAME 审中-公开
标题翻译：幻灯片演示和查看方法
公开(公告)号：WO03073409A9
公开(公告)日：2004-06-10
申请号：PCT/US0305751
申请日：2003-02-26
申请人： BROWN DAVID K
发明人： BROWN DAVID K
IPC分类号： G06F3/14 , G09G5/00
CPC分类号： G06F3/1423
摘要： A method for interacting with a slide-show presentation, the slide-show including a plurality of slides (212). A slide is retrieved from among a plurality of slides from a memory storage device (106). The slide is displayed to a user on a display device (113) at a first resolution. The method provides the user with a capability for performing one or more operations corresponding the displayed slide. The operations include displaying a pop-up text window which provides details about the displayed slide. The operations further include a capability for displaying the slide in a zoom mode, whereby the slide is displayed at an enhanced resolution and a further capability for simultaneously displaying the plurality of slides in a thumbnail-sketch mode including descriptive text.
摘要翻译：一种用于与幻灯片放映呈现相互作用的方法，所述幻灯片显示包括多个幻灯片（212）。从存储器存储设备（106）中的多个幻灯片中检索幻灯片。幻灯片以第一分辨率显示给显示设备（113）上的用户。该方法向用户提供执行与所显示的幻灯片相对应的一个或多个操作的能力。这些操作包括显示弹出文本窗口，该窗口提供有关显示的幻灯片的详细信息。这些操作进一步包括以缩放模式显示幻灯片的能力，由此以增强的分辨率显示幻灯片，以及用于以包括描述性文本的缩略图模式同时显示多个幻灯片的进一步能力。

83. 发明申请

WO03037082A9 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIAL 审中-公开
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：WO03037082A9
公开(公告)日：2004-01-15
申请号：PCT/US0235135
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC , VOUTE NICOLAS , LOK MAXIME N , BROWN DAVID C , KENDALL JAMES W , GEISELHART EDWARD
发明人： VOUTE NICOLAS , LOK MAXIME N , BROWN DAVID C , KENDALL JAMES W , GEISELHART EDWARD
IPC分类号： A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/18 , F25D25/00 , F25D31/00 , A01N1/00 , B65D81/00
CPC分类号： F25D31/001 , A01N1/02 , A01N1/0257 , A01N1/0263 , A23L3/364 , A23L3/365 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25D25/00 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02
摘要： A system for controlled freezing, storing and thawing a biopharmaceutical material includes a flexible container and a supporting structure. The flexible container is adapted to receive the biopharmaceutical material therein for freezing, storing and thawing. The container further includes a flange and the supporting structure is engageable with the flange to receive the container. The supporting structure may position the container for freezing and may protect it during transport and storage.
摘要翻译：用于控制冷冻，储存和解冻生物药物材料的系统包括柔性容器和支撑结构。柔性容器适于容纳其中的生物药物用于冷冻，储存和解冻。容器还包括凸缘，并且支撑结构可与凸缘接合以容纳容器。支撑结构可以将容器定位成冷冻并且可以在运输和储存期间保护它。

84. 发明申请

WO2003091247A2 PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS 审中-公开
标题翻译：哌啶基和哌嗪基 - 磺基甲基羟基酸及其作为蛋白酶抑制剂的用途
公开(公告)号：WO2003091247A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/013123
申请日：2003-04-25
申请人： PHARMACIA CORPORATION , BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , BROWN, David, L. , CARROLL, Jeffery, N. , CHEN, Yiyuan , FOBIAN, Yvette , FRESKOS, John, N. , GASIECKI, Alan, F. , GRAPPERHAUS, Margaret , HEINTZ, Robert, M. , HOCKERMAN, Susan, L. , KASSAB, Darren, J. , KHANNA, Ish, Kumar , KOLODZIEJ, Stephen, A. , MASSA, Mark , MCDONALD, Joseph , MISCHKE, Brent, V. , MISCHKE, Deborah, A. , MULLINS, Patrick, B. , NAGY, Mark , NORTON, Monica, B. , RICO, Joseph, G. , SCHMIDT, Michelle, A. , STEHLE, Nathan, W. , TALLEY, John, J. , VERNIER, William, F. , VILLAMILL, Clara, I. , WANG, Lijuan, Jane , WYNN, Thomas, A.
发明人： BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , BROWN, David, L. , CARROLL, Jeffery, N. , CHEN, Yiyuan , FOBIAN, Yvette , FRESKOS, John, N. , GASIECKI, Alan, F. , GRAPPERHAUS, Margaret , HEINTZ, Robert, M. , HOCKERMAN, Susan, L. , KASSAB, Darren, J. , KHANNA, Ish, Kumar , KOLODZIEJ, Stephen, A. , MASSA, Mark , MCDONALD, Joseph , MISCHKE, Brent, V. , MISCHKE, Deborah, A. , MULLINS, Patrick, B. , NAGY, Mark , NORTON, Monica, B. , RICO, Joseph, G. , SCHMIDT, Michelle, A. , STEHLE, Nathan, W. , TALLEY, John, J. , VERNIER, William, F. , VILLAMILL, Clara, I. , WANG, Lijuan, Jane , WYNN, Thomas, A.
IPC分类号： C07D407/12
CPC分类号： C07D213/74 , C07D211/66 , C07D211/96 , C07D309/08 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： This invention is directed generally to proteinase (also known as "protease") inhibitors, and more particularly, to piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids that inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to formula (I), (Wherein A 1 , A 2 , Y, E 1 , E 2 , E 3 , and R x are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.
摘要翻译：本发明一般涉及蛋白酶（也称为“蛋白酶”）抑制剂，特别是涉及抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP”）的哌啶基和哌嗪基 - 磺酰基甲基异羟肟酸，活性和/或蛋白聚糖蛋白聚糖酶活性。这样的异羟肟酸通常在结构上对应于式（I），其中A 1，A 2，Y，E 1，E 2，E 3和R x如上定义在本说明书中），并且还包括这些化合物的盐。本发明还涉及这种异羟肟酸的组合物，用于合成这种异羟肟酸的中间体，制备这种异羟肟酸的方法，以及用于治疗与MMP活性和/或蛋白聚糖蛋白聚糖酶活性相关的病症（特别是病理状态）的方法。

85. 发明申请

WO02098055A3 LOAD BALANCING IN IP ADDRESS LOOKUP 审中-公开
标题翻译： IP地址查找中的负载平衡
公开(公告)号：WO02098055A3
公开(公告)日：2003-05-30
申请号：PCT/CA0200786
申请日：2002-05-28
申请人： MOSAID TECHNOLOGIES INC , AHMAD IMTIAZ , BROWN DAVID A
发明人： AHMAD IMTIAZ , BROWN DAVID A
IPC分类号： G06F7/00 , G06F17/00 , G06F17/30 , H04L12/00 , H04L12/56
CPC分类号： H04L45/745 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A load balancing mechanism maps a binary tree representation of a routing table into a set of fixed size memories. The mechanism efficiency utilizes the memory in the routing table without violating the tree precedence constraints and the memory access requirements of a pipelines system. The mechanism stores a subtree associated with a densely populated level of the binary tree in memory associated with lower levels.
摘要翻译：负载平衡机制将路由表的二叉树表示映射到一组固定大小的存储器中。机制效率利用路由表中的存储器，而不违反管道系统的树优先级约束和存储器访问要求。该机制将与二进制树的密集层次相关联的子树存储在与较低级别相关联的存储器中。

86. 发明申请

WO2003016938A2 DISTRIBUTED COMMUNICATIONS SYSTEM 审中-公开
标题翻译：分布式通信系统
公开(公告)号：WO2003016938A2
公开(公告)日：2003-02-27
申请号：PCT/GB2002/003794
申请日：2002-08-16
申请人： BROWN, David, James
发明人： BROWN, David, James
IPC分类号： G01S5/02
CPC分类号： H04W64/00 , G01S5/02 , G01S13/878 , G01S2205/002 , G01S2205/006 , G08B3/1083 , H04W84/22
摘要： A method for establishing the location of one or more individuals within a facility, the method comprising installing a plurality of radio-frequency transceiver devices (63, 64) at fixed positions throughout the facility and issuing the or each individual with a respective portable radio-frequency transceiver device (61). Each of the fixed-position transceiver devices (63, 64) is operated to communicate the identity of any of said one or more portable transceiver devices (61) located within communications range thereof to centralised electronic processing means (65).
摘要翻译：一种用于建立设施内的一个或多个个人的位置的方法，所述方法包括在整个设施的固定位置安装多个射频收发器设备（63,64），并且向相应或每个人发送相应的便携式无线电设备频率收发器装置（61）。每个固定位置收发器设备（63,64）被操作以将位于其通信范围内的所述一个或多个便携式收发器设备（61）中的任何一个的身份传送到集中式电子处理装置（65）。

87. 发明申请

WO2002098055A2 LOAD BALANCING IN IP ADDRESS LOOKUP 审中-公开
标题翻译： IP地址查找中的负载平衡
公开(公告)号：WO2002098055A2
公开(公告)日：2002-12-05
申请号：PCT/CA2002/000786
申请日：2002-05-28
申请人： MOSAID TECHNOLOGIES INCORPORATED , AHMAD, Imtiaz , BROWN, David, A.
发明人： AHMAD, Imtiaz , BROWN, David, A.
IPC分类号： H04L12/00
CPC分类号： H04L45/745 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A load balancing mechanism maps a binary tree representation of a routing table into a set of fixed size memories. The mechanism efficiency utilizes the memory in the routing table without violating the tree precedence constraints and the memory access requirements of a pipelines system. The mechanism stores a subtree associated with a densely populated level of the binary tree in memory associated with lower levels.
摘要翻译：负载平衡机制将路由表的二叉树表示映射到一组固定大小的存储器中。机制效率利用路由表中的存储器，而不违反管道系统的树优先级约束和存储器访问要求。该机制将与二进制树的密集层次相关联的子树存储在与较低级别相关联的存储器中。

88. 发明申请

WO0208152A3 PROCESS AND APPARATUS FOR IMPREGNATING PORUS PARTS 审中-公开
标题翻译：用于浸渍部件的方法和设备
公开(公告)号：WO0208152A3
公开(公告)日：2002-05-02
申请号：PCT/CA0101011
申请日：2001-07-11
申请人： BALLARD POWER SYSTEMS , GALLAGHER EMERSON , FONG PAUL HANG , CLEMENS OLIVER , THUMM HORST , BROWN DAVID
发明人： GALLAGHER EMERSON , FONG PAUL PO HANG , CLEMENS OLIVER , THUMM HORST , BROWN DAVID
IPC分类号： C04B41/48 , C04B41/83 , H01M8/02
CPC分类号： C04B41/009 , C04B41/483 , C04B41/83 , C04B2111/00853 , H01M8/0213 , H01M8/0221 , H01M8/0223 , C04B35/522 , C04B38/00
摘要： A process for impregnating at least one porous part with an impregnant comprises immersing the porous part(s) in impregnant, measuring at least one parameter indicative of the buoyancy of the porous part(s) as the impregnant impregnates same or of the effective volume of the impregnant, and interrupting impregnation when the measured parameter(s) indicates a predetermined level of impregnation is achieved. An apparatus for impregnating porous parts comprises a vessel for holding the porous part(s) and an impregnant, and a measuring device for measuring at least one parameter indicative of the buoyancy of the porous part(s) immersed in the impregnant within the vessel or of the effective volume of the impregnant.
摘要翻译：用浸渍剂浸渍至少一个多孔部件的方法包括将多孔部件浸渍在浸渍剂中，当浸渍剂浸渍相同或有效体积的时候，测量至少一个指示多孔部件浮力的参数当所测量的参数表明预定的浸渍水平时，实现浸渍剂和中断浸渍。用于浸渍多孔部件的设备包括用于容纳多孔部件和浸渍剂的容器以及用于测量至少一个参数的测量装置，所述参数指示浸没在容器内的浸渍剂中的多孔部件的浮力或者的浸渍剂的有效体积。

89. 发明申请

WO0124440A3 METHOD AND APPARATUS FOR A FOUR-WAY HASH TABLE 审中-公开
标题翻译：用于四路哈希表的方法和设备
公开(公告)号：WO0124440A3
公开(公告)日：2001-11-08
申请号：PCT/CA0001061
申请日：2000-09-18
申请人： MOSAID TECHNOLOGIES INC , BROWN DAVID A
发明人： BROWN DAVID A
IPC分类号： H04L12/56 , G06F12/08 , G06F12/10 , G06F17/30 , H04L29/06
CPC分类号： H04L45/00 , H04L45/745
摘要： A number of hash tables are accessed concurrently with a different computed index for each hash table. Each index identifies a location in one of the hash tables at which a forwarding entry may be stored. To search for a forwarding entry, the locations identified by the indices computed by performing a hash function on a search key are searched to a match for the search key. To insert a forwarding entry if single cycle inserting is not required and all the locations identified by the indices computed by performing a hash function on an insert key are used then the data base is reordered so that the forwarding entry can be inserted at one of the locations identified by one of the computed indices for the inset key. If single cycle insertion is required and all the locations identified by the computed indices are used, one of the locations identified by one of the computed indices for the insert key is randomly overwritten by the forwarding entry.
摘要翻译：对于每个哈希表，同时访问多个哈希表并使用不同的计算索引。每个索引标识可以存储转发条目的散列表之一中的位置。为了搜索转发条目，将通过对搜索关键字执行散列函数而计算出的指数所标识的位置被搜索到与搜索关键字匹配。为了插入转发条目，如果不需要单个循环插入，并且使用通过对插入关键字执行散列函数而计算出的所有索引所标识的位置，则数据库被重新排序，使得转发条目可以被插入到由插入关键字的计算索引之一标识的位置。如果需要进行单周期插入并且使用所计算的索引所标识的所有位置，则由插入密钥的所计算索引中的一个标识的位置之一被转发条目随机覆盖。

90. 发明申请

WO1998028406A1 METHOD AND DEVICE FOR MICROINJECTION OF MACROMOLECULES INTO NON-ADHERENT CELLS 审中-公开
标题翻译：用于将非离子细胞中的大分子微量化的方法和装置
公开(公告)号：WO1998028406A1
公开(公告)日：1998-07-02
申请号：PCT/US1997023781
申请日：1997-12-19
申请人： GENESYSTEMS, INC. , DAVIS, Brian , BROWN, David
发明人： GENESYSTEMS, INC.
IPC分类号： C12M03/00
CPC分类号： C12N15/89 , A61K48/00 , C12M35/00 , C12N2510/00
摘要： The present invention is directed to a method of incorporating foreign material into cells that exist in a non-adherent state. In some embodiments, the method employs a microinjection needle together with an adhesive molecule or apparatus capable of immobilizing cells that exist in a non-adherent state onto a substrate or other surface capable of supporting cell attachment to permit introduction of a desired material, such as nucleic acid, into the cell. The non-adherent cells can be genetically altered by the microinjection of nucleic acid sequences (DNA) of sufficient size to permit direct introduction of said nucleic acid into the chromosomal DNA of the cell, without the use of a retrovirus, adenovirus, or other carrier molecule. The invention also thus provides a method of gene therapy insofar as cells modified according to the defined method, particularly undifferentiated cells such as stem cells, may be created to include a gene or fragment thereof sufficient to replace a deficiency or correct an abnormality or deficiency in the cell, and used in a patient by injection of the cells. The corrected nucleic acid then gives rise to genetically corrected differentiated cell species, and hence an approach useful in treating a number of physiological disorders.
摘要翻译：本发明涉及将异物掺入以非粘附状态存在的细胞中的方法。在一些实施方案中，该方法使用显微注射针与能够将以非粘附状态存在的细胞固定在能够支持细胞附着的基底或其他表面上以允许引入所需材料的粘合剂分子或装置，例如核酸进入细胞。可以通过显微注射足够大小的核酸序列（DNA）来遗传地改变非贴壁细胞，以允许将所述核酸直接引入细胞的染色体DNA，而不使用逆转录病毒，腺病毒或其它载体分子。因此，本发明还提供了一种基因治疗方法，只要根据所定义的方法修饰的细胞，特别是未分化细胞例如干细胞，可以产生足够的基因或其片段来代替缺陷或纠正异常或缺陷细胞，并通过注射细胞在患者体内使用。校正的核酸然后产生遗传修正的分化细胞种类，因此可用于治疗许多生理障碍。

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