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    • 72. 发明申请
    • ASEPTIC CHEMICAL TRANSFER SYSTEM
    • 自由化学传递系统
    • WO1996006780A1
    • 1996-03-07
    • PCT/US1995010425
    • 1995-08-23
    • THE UPJOHN COMPANYSMEKENS, Daniel, P.
    • THE UPJOHN COMPANY
    • B65B55/02
    • B65B55/02
    • A method and an apparatus for aseptically producing, harvesting and packaging a pharmaceutical product. A section of the apparatus includes an aseptic reactor (16) and structure for introducing a reactant thereinto so that a reaction can be conducted for the purpose of producing a pharmaceutical product. The pharmaceutical product is subsequently introduced into a filter/dryer (18) for the purpose of recovering the pharmaceutical product. Thereafter, the filtered/dried pharmaceutical product is delivered to a hammer mill (26) for delumping or micronizing mill for calibration and sizing the recovered product to produce a final powdered product. Thereafter, the final powdered product is introduced into a dosing device (31) and aseptically introduced into a transportable bin (34). The small bins are encased inside of a sterile bag for transport and further aseptic handling.
    • 用于无菌生产,收获和包装药品的方法和装置。 该装置的一部分包括无菌反应器(16)和用于将反应物引入其中的结构,从而可以进行用于制备药物产品的反应。 随后将药物产品引入过滤器/干燥器(18)中以恢复药物产品。 此后,过滤/干燥的药物产品被输送到锤磨机(26),用于使磨浆粉碎或微粉化,以校准和调整回收产物的尺寸以产生最终的粉末状产品。 此后,将最后的粉末状产品引入计量装置(31)中,并将其无菌地导入运送箱(34)中。 小箱被封装在无菌袋内,用于运输和进一步的无菌处理。
    • 73. 发明申请
    • DEVICE FOR USE IN AN ASEPTIC METHOD OF FILLING CONTAINERS AND PROCESSING EQUIPMENT THEREFOR
    • 用于填充集装箱的无方式方法和其加工设备的装置
    • WO1996006010A1
    • 1996-02-29
    • PCT/FR1994001024
    • 1994-08-25
    • GUILLOUX, Dominique
    • B65B55/02
    • B65B55/02
    • Device for use in an aseptic method of filling containers (2) comprising the steps of sterilizing, filling and closing the containers and optionally cooling them. The device of the invention enables containers containing solid products, which are processed before the container is sterilized, to be sterilized. In at least one processing method of the invention, the processing equipment (B) comprises cells (1) with a single open side, in which the containers are placed; preferably, the cylinder includes at least one fixed cover (8) that forms with one or more cells at least one closed area, in which at least one of the processing methods of the invention can be carried out including vegetable preprocessing, sterilization and an optional cooling operation. The cover forms at least one opening for insertion and removal of the containers in the cells. The cylinder can also be housed in a fixed enclosure containing a processing atmosphere.
    • 用于填充容器(2)的无菌方法的装置,包括消毒,填充和关闭容器以及任选地冷却容器的步骤。 本发明的装置使得在容器被灭菌之前加工的固体产品的容器能被灭菌。 在本发明的至少一种处理方法中,处理设备(B)包括其中放置容器的单个开口侧的单元(1) 优选地,圆筒包括至少一个固定盖(8),其与一个或多个单元形成至少一个封闭区域,其中可以执行本发明的至少一个处理方法,包括植物预处理,灭菌和可选择的 冷却运行。 所述盖形成用于插入和移除所述电池中的容器的至少一个开口。 圆筒也可以容纳在包含处理气氛的固定外壳中。
    • 76. 发明申请
    • FILLING PACKAGING CONTAINERS
    • 填充包装容器
    • WO8802722A3
    • 1988-05-19
    • PCT/GB8700711
    • 1987-10-08
    • METAL BOX PLCMILLER JOHN DEREKHARDY PETER DEREK
    • MILLER JOHN DEREKHARDY PETER DEREK
    • B65B20060101B65B3/32B65B55/00B65B55/02B65B59/00B67C3/00B67C3/20B67D1/08
    • B65B55/02B65B3/326B67C3/001B67C3/206
    • A machine for filling packaging containers (14) with a flowable product (18, 20), the machine comprising a control valve in the form of a plug valve (30) having a body (28) defining a bore (29) forming a frusto-conical valve seat, a plug (32) having a complementary frusto-conical surface and a valve chamber (31) for pressurised fluid formed at the wider end of the plug. The chamber communicates with the bore. The plug is axially displaceable between a first position, in which its frusto-conical surface seals against the valve seat and in which it is rotatable to control flow through the valve, and a second position, in which it is withdrawn into the chamber to provide clearance between the mating surfaces of the plug and the seat but retaining clearance between its wider end and the opposite surface of the chamber so that all the surfaces of the plug are exposed for cleaning and sterilisation.
    • 一种用于用可流动产品(18,20)填充包装容器(14)的机器,所述机器包括呈旋塞阀(30)形式的控制阀,所述旋塞阀具有限定孔(29)的主体(28) - 圆锥形阀座,具有互补的截头圆锥形表面的塞子(32)和用于在塞子的较宽端处形成的加压流体的阀室(31)。 腔室与孔连通。 塞子可在第一位置和第二位置之间轴向移动,在第一位置中,其截头圆锥形表面密封抵靠阀座并且其中第二位置可旋转以控制通过阀的流动,在第二位置中,塞子被抽回到腔室中以提供 插头和座的配合表面之间的间隙,但保持其较宽端和腔室的相对表面之间的间隙,使得插头的所有表面暴露以进行清洁和消毒。