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71. 发明申请

WO0238177A3 ADJUVANT COMBINATION FORMULATIONS 审中-公开
标题翻译： ADJUVANT组合制剂
公开(公告)号：WO0238177A3
公开(公告)日：2003-01-16
申请号：PCT/US0146943
申请日：2001-11-08
申请人： AMERICAN CYANAMID CO , HAGEN MICHAEL
发明人： HAGEN MICHAEL
IPC分类号： A61K39/00 , A61K39/21 , A61K39/35 , A61K39/39 , A61P25/18 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/00 , C07K14/155 , C07K14/47 , C07K14/535 , C07K14/54 , C07K16/00
CPC分类号： A61K39/39 , A61K39/0007 , A61K39/12 , A61K39/21 , A61K2039/55511 , A61K2039/55522 , A61K2039/55538 , A61K2039/55566 , C12N2740/16134
摘要： The use of an aminoalkyl glucosamine phosphate compound, or a derivative or analog thereof, in combination with a cytokine or lymphokine such as granulocyte macrophage colony stimulating factor or interleukin-12, is useful as an adjuvant combination in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen.
摘要翻译：使用氨基烷基葡糖胺磷酸酯化合物或其衍生物或类似物与细胞因子或淋巴因子如粒细胞巨噬细胞集落刺激因子或白介素-12组合可用作抗原组合物中的佐剂组合以增强免疫应答在脊椎动物宿主中选择抗原。

72. 发明申请

WO02074922A2 COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE 审中-公开
标题翻译：用于调节免疫应答的组合物和方法
公开(公告)号：WO02074922A2
公开(公告)日：2002-09-26
申请号：PCT/US0208207
申请日：2002-03-15
申请人： UNIV CALIFORNIA , BROIDE DAVID H , RAZ EYAL
发明人： BROIDE DAVID H , RAZ EYAL
IPC分类号： A61K31/7088 , A61K39/145 , A61K39/35 , C12N
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/145 , A61K39/35 , A61K39/39 , A61K2039/53 , A61K2039/54 , A61K2039/55561 , A61K2039/57 , C12N2760/16134
摘要： The present invention provides methods of maintaining suppression of a Th2 immune response, and methods of maintaining an increase in a Th1 immune response in an individual. The methods generally involve administering to an individual an effective amount of a first dose of a composition comprising an immunomodulatory nucleic acid, and, after a suitable time, administering at least a second dose of a composition comprising an immunomodulatory nucleic acid.
摘要翻译：本发明提供了保持Th2免疫应答抑制的方法，以及保持个体中Th1免疫应答增加的方法。所述方法通常涉及向个体施用有效量的第一剂量的包含免疫调节核酸的组合物，并且在合适的时间后，施用至少第二剂量的包含免疫调节核酸的组合物。

73. 发明申请

WO2002070005A1 COMPOSITIONS OF MULTIMERIC PROFILIN FOR DIAGNOSIS AND TREATMENT OF ALLERGIES 审中-公开
标题翻译：用于诊断和治疗过敏症的多形态化合物的组合物
公开(公告)号：WO2002070005A1
公开(公告)日：2002-09-12
申请号：PCT/US2002/005911
申请日：2002-02-27
申请人： IMMVARX, INCORPORATED , BABICH, Michael
发明人： BABICH, Michael
IPC分类号： A61K39/35
CPC分类号： A61K39/36 , A61K39/35 , C07K14/415 , C07K16/16
摘要： Multimers of plant profilin or functionally equivalent peptides are a preferred form for diagnosis and treatment of allergies. Natural and synthetic whole molecules or fragments that represent the multimeters are used 1) as hyposensitizing agents for treatment of allergies and 2) for screening patients to determine profilin allergenicity.
摘要翻译：植物profilin或功能等同肽的多聚体是用于诊断和治疗过敏的优选形式。使用代表万用表的天然和合成全分子或片段1）作为用于治疗过敏症的低敏感剂，以及2）筛选患者以确定profilin变应原性。

74. 发明申请

WO02056905A2 MOLECULAR ANTIGEN ARRAY 审中-公开
标题翻译：分子抗体阵列
公开(公告)号：WO02056905A2
公开(公告)日：2002-07-25
申请号：PCT/IB2002/000166
申请日：2002-01-21
IPC分类号： A61K39/00 , A61K35/76 , A61K38/00 , A61K38/11 , A61K39/02 , A61K39/12 , A61K39/29 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/48 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/00 , C07K14/005 , C07K14/02 , C07K14/08 , C07K14/245 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/08 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/42 , C12N15/40
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序的和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病的疫苗，用于预防或治愈癌症以及有效地诱导自身特异性免疫应答（特别是抗体应答）的过敏症药物和药物。

75. 发明申请

WO02040517A2 BIOLOGICAL MATERIALS AND ANTI-CANCER USES THEREOF 审中-公开
标题翻译：生物材料及其抗癌用途
公开(公告)号：WO02040517A2
公开(公告)日：2002-05-23
申请号：PCT/GB2001/005066
申请日：2001-11-16
IPC分类号： A61K48/00 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/04 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/10 , A61K39/102 , A61K39/106 , A61K39/112 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/165 , A61K39/20 , A61K39/205 , A61K39/25 , A61K39/285 , A61K39/29 , A61K39/35 , A61K39/39 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/04 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P27/14 , A61P29/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/35 , C12N15/09 , G01N33/68 , C07K14/195
CPC分类号： A61K39/39 , A61K39/35 , A61K2039/55516 , A61K2039/57
摘要： The invention relates to the use in the manufacture of a medicament for use in the treatment and/or prevention of a cancerous condition of an approx 60 kDa polypeptide (or its encoding nucleic acid molecules) or functionally equivalent molecules or fragments thereof from Mycobacterium tuberculosis or related prokaryotes.
摘要翻译：本发明涉及用于制备用于治疗和/或预防来自患者的约60kDa多肽（或其编码核酸分子）或功能等同的分子或其片段的癌性病症的药物的用途，结核分枝杆菌或相关的原核生物。

76. 发明申请

WO0140266A3 INSECT POISON ALLERGENS WITH REDUCED IGE REACTIVITY AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：杀虫剂过敏原具有减少的IgE反应及其制造方法
公开(公告)号：WO0140266A3
公开(公告)日：2002-02-28
申请号：PCT/EP0011776
申请日：2000-11-27
申请人： MERCK PATENT GMBH , SUCK ROLAND , CROMWELL OLIVER , FIEBIG HELMUT
发明人： SUCK ROLAND , CROMWELL OLIVER , FIEBIG HELMUT
IPC分类号： G01N33/53 , A61K39/00 , A61K39/35 , A61P37/08 , C07K14/00 , C07K14/435 , C12N15/09 , C12P21/00 , C12P21/02 , A61K38/17 , G01N33/68
CPC分类号： C07K14/43568 , A61K39/00 , C07K14/43563
摘要： The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds (conformations) that are identical or different to those that occur naturally. The proteins with folds that do not occur naturally have a reduced IgE reactivity or allergenity and can therefore be used as therapeutic agents in the immunotherapy of allergies.
摘要翻译：本发明涉及一种重组昆虫毒液变应原，而对于目标生产的方法，其中所述变应原可以是，根据由天然等同或非天然折叠（构象）是不同的执行情况的制造过程的。蛋白质显示出与天然外国折叠减小的IgE反应性和过敏，并因此如在过敏的免疫治疗的治疗剂使用。

77. 发明申请

WO0143695A3 PEPTIDE CONSTRUCTS FOR TREATING AUTOIMMUNE AND RELATED DISEASES 审中-公开
标题翻译：用于治疗自身免疫性疾病和相关疾病的肽结构
公开(公告)号：WO0143695A3
公开(公告)日：2002-02-21
申请号：PCT/US0041647
申请日：2000-10-27
申请人： CEL SCI CORP , TALOR EYAL I
发明人： TALOR EYAL I
IPC分类号： A61K38/00 , A61P37/06 , A61P37/08 , C07K14/74 , C07K19/00 , C07K14/00 , A61K38/10 , A61K38/16 , A61K38/17 , A61K39/35 , A61K39/385 , C07K17/00
CPC分类号： C07K19/00 , A61K38/00 , C07K14/70539
摘要： Conjugated peptides include a first peptide component which is an antigen associated with autoimmune disease, allergy, asthma or transplantation rejection and binds to an antigen-specific receptor on a T cell, and a second peptide component which corresponds to an "antigen presenting molecule", namely, a peptide binding to a T cell surface receptor, which would normally promote T cell activation when the first peptide is bound to its antigen-specific T cell receptor. However, in this invention, the second peptide component has an amino acid sequence which is a modification of an antigen presenting T cell binding peptide, such modification blocking or inhibiting the engagement of receptor sites on the T cell surface (other than the antigen-specific T cell receptor). As a result, T cell activation is prevented, and is directed through antigen-specific T cell receptor occupation, without T cell activation, leading to antigen-specific T cell anergy and cell death. Administration of the conjugated peptide to an animal will provide protection against disease associated with the first peptide component, resulting from the elimination of the T cells bearing the antigen-specific receptors for that antigenic peptide. The conjugated peptides of this invention provide antigen-specific protection without impairing the immune response to other antigens.
摘要翻译：共轭肽包括与自身免疫疾病，变态反应，哮喘或移植排斥相关的抗原的第一肽组分和与T细胞上的抗原特异性受体结合的第一肽组分和对应于“抗原呈递分子”的第二肽组分，即结合T细胞表面受体的肽，当第一个肽与其抗原特异性T细胞受体结合时，其通常促进T细胞活化。然而，在本发明中，第二肽成分具有作为抗原呈递T细胞结合肽的修饰的氨基酸序列，这种修饰阻断或抑制T细胞表面上的受体位点（除抗原特异性 T细胞受体）。结果，T细胞激活被阻止，并且通过抗原特异性T细胞受体占据被引导，没有T细胞活化，导致抗原特异性T细胞无反应性和细胞死亡。将缀合肽施用于动物将提供针对与第一种肽组分相关的疾病的保护，这是由于消除具有该抗原肽的抗原特异性受体的T细胞而产生的。本发明的缀合肽提供抗原特异性保护，而不损害对其他抗原的免疫应答。

78. 发明申请

WO0156611B1 ORAL DELIVERY OF ALLERGENS IN MILK 审中-公开
标题翻译：过敏原的口服输送
公开(公告)号：WO0156611B1
公开(公告)日：2002-01-10
申请号：PCT/EP0101029
申请日：2001-01-31
申请人： NOVARTIS NUTRITION AG , SCHNEIDER HEINZ
发明人： SCHNEIDER HEINZ
IPC分类号： A61K47/46 , A61K9/00 , A61K39/35 , A61K39/36 , A61P37/06 , A61P37/08
CPC分类号： A61K39/35 , A61K39/36 , A61K47/46 , A61K2039/542 , A61K2300/00
摘要： The present invention relates to the use of milk and milk-related products as a carrier or delivery vehicle for allergens in the process of oral tolerance induction. In one preferred embodiment, infants are subjected to primary oral tolerance through provision of a cocktail of allergens in infant milk formula. In another preferred embodiment, secondary oral tolerances is induced through administration of one or more allergens mixed with milk to a mammal of any age. The benefits of using milk as a carrier are evident from experiments which show that ovalbumin tolerance can effectively be induced in an allergic dog model at low dosages. A possible explanation for this is that milk stabilizes the allergen and presents it to the immune system in such a way that it is very potent in effecting a tolerance response.
摘要翻译：本发明涉及在口服耐受诱导过程中使用乳和乳相关产品作为过敏原的载体或递送载体。在一个优选的实施方案中，通过在婴儿奶粉配方中提供过敏原的混合物，对婴儿进行初步口服耐受。在另一个优选的实施方案中，通过向任何年龄的哺乳动物施用与乳混合的一种或多种过敏原诱导次要口服耐受性。使用牛奶作为载体的好处从实验中可以看出，这表明卵白蛋白耐受能够以低剂量在过敏性狗模型中有效诱导。这样做的一个可能的解释是，牛奶可以稳定变应原，并将其呈递给免疫系统，使其在实现耐受反应方面非常有效。

79. 发明申请

WO01035991A3 IMMUNOMODULATORY COMPOSITIONS CONTAINING AN IMMUNOSTIMULATORY SEQUENCE LINKED TO ANTIGEN AND METHODS OF USE THEREOF 审中-公开
标题翻译：含有与抗原连接的免疫调节序列的免疫组化合成物及其使用方法
公开(公告)号：WO01035991A3
公开(公告)日：2001-11-22
申请号：PCT/US2000/031385
申请日：2000-11-15
IPC分类号： C12N15/09 , A61K39/00 , A61K39/04 , A61K39/10 , A61K39/112 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/29 , A61K39/36 , A61K39/385 , A61K48/00 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/20 , A61P35/00 , A61P37/04 , C07K14/415 , A61K39/39 , A61K39/35 , A61P37/00
CPC分类号： A61K39/385 , A61K39/36 , A61K2039/57 , A61K2039/6025
摘要： The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to antigen. The extent of conjugation affects immunomodulatory properties, such as extent of antigen-specific antibody formation, including Th1-associated antibody formation, and thus these various conjugate classes are useful for modulating the type and extent of immune response. The invention also includes methods of modulating an immune response using these compositions.
摘要翻译：本发明提供免疫调节组合物的种类，其包含平均含有与抗原缀合或连接的含有多核苷酸的多核苷酸的免疫刺激序列（ISS）。缀合的程度影响免疫调节特性，例如抗原特异性抗体形成的程度，包括Th1相关抗体形成，因此这些各种缀合物类别可用于调节免疫应答的类型和程度。本发明还包括使用这些组合物调节免疫应答的方法。

80. 发明申请

WO01079281A1 SHEEP LICE, BOVICOLA OVIS, ALLERGEN TREATMENT 审中-公开
标题翻译：保守的LICE，BOVICOLA OVIS，过敏治疗
公开(公告)号：WO01079281A1
公开(公告)日：2001-10-25
申请号：PCT/NZ2001/000065
申请日：2001-04-19
IPC分类号： G01N33/53 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61K48/00 , A61P33/14 , A61P37/08 , C07K14/435 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/564 , A61K39/35 , C07H21/04 , G01N33/535
CPC分类号： C07K14/43563 , A61K39/00
摘要： The present invention concerns novel nucleotide sequences encoding a louse allergen, particularly although by no means exclusively from the chewing louse Bovicola ovis , and the use of said nucleotide sequences and protein allergen in the diagnosis, treatment and prevention of lice infestation and associated allergic disease.
摘要翻译：本发明涉及编码虱变应原的新型核苷酸序列，特别是尽管绝不仅仅来自咀嚼痘病毒（Bovicola ovis），并且所述核苷酸序列和蛋白质过敏原在诊断，治疗和预防中的用途虱感染及相关过敏性疾病。

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