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    • 80. 发明申请
    • USE OF CANNABINOID COMPOUNDS FOR STIMULATING MELANOGENESIS
    • 使用CANNABINOID化合物刺激造血细胞
    • WO2013021128A3
    • 2013-08-08
    • PCT/FR2012051846
    • 2012-08-03
    • OREALZUCCOLO MICHELAJOURDAIN ROLANDBRETON LIONELMACCARRONE MAURO
    • ZUCCOLO MICHELAJOURDAIN ROLANDBRETON LIONELMACCARRONE MAURO
    • A61K8/42A61K31/164A61P17/00A61Q5/10A61Q19/04
    • A61K8/42A61K31/16A61K31/164A61Q5/00A61Q5/10A61Q19/00A61Q19/04
    • The invention relates to the non-therapeutic, cosmetic use, as an agent for coloring keratin materials, of at least one cannabinoid compound selected from among the compounds of general formula (I), as well as the geometric and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof, i.e. the compounds of formula (I) where: R1 is a hydrogen atom or a C1-C30 alkyl group, said alkyl group being optionally substituted with a hydroxyl group (OH); R2 is a halogen atom, or a group selected from among hydroxyl, thiol (SH), and amino, optionally substituted with one or more C1-C6 alkyl groups; R3 and R4 form an oxo group together with the carbon atom having same, or R3 and R4 are a hydrogen atom; R5 is a hydrogen atom or a C1-C6 alkyl group; X is a heteroatom selected from among the oxygen and sulphur atoms and the divalent group -N(R6)-, where R6 is a hydrogen atom or a C1-C6 alkyl group; - - - - is a single or double bond; n is 1, 2 or 3, preferably 1 or 2, it being understood that when R3 and R4 form an oxo group together with the carbon atom having same, and X is an oxygen atom, then R1 cannot be a hydroxymethyl group. The invention also relates to one of said specific cannabinoid compounds, to be used in the treatment of vitiligo or pityriasis versicolor, to non-therapeutic, cosmetic methods for coloring the skin or for treating the whitening of the hair, which includes topically applying, to the skin and/or to the hair, or orally delivering a composition including, in a physiologically acceptable medium, one of said cannabinoid compounds, and to a method for selecting an active agent that promotes the pigmentation of the keratin materials.
    • 本发明涉及至少一种选自通式(I)的化合物中的大麻素化合物以及其几何和光学异构体,化妆品的角蛋白材料着色剂的非治疗性美容用途, 可接受的酸或碱盐及其水合物,即式(I)化合物,其中:R1是氢原子或C1-C30烷基,所述烷基任选被羟基(OH)取代; R2是卤素原子,或选自羟基,硫醇(SH)和氨基的基团,任选被一个或多个C 1 -C 6烷基取代; R3和R4与具有相同碳原子一起形成氧基,或R3和R4是氢原子; R5是氢原子或C1-C6烷基; X是选自氧和硫原子的杂原子和二价基团-N(R 6) - ,其中R 6是氢原子或C 1 -C 6烷基; - - - - 是单键或双键; n为1,2或3,优选为1或2,应理解当R3和R4与具有相同碳原子一起形成氧代基时,X为氧原子,则R1不能为羟甲基。 本发明还涉及用于治疗白癜风或疣状斑疹的所述特定大麻素化合物之一,用于非治疗性皮肤着色或化妆方法,其包括局部施用于 皮肤和/或头发,或口服递送包含在生理学上可接受的介质中的一种所述大麻素化合物的组合物,以及用于选择促进角蛋白材料着色的活性剂的方法。