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71. 发明申请

WO2018102469A1 PHARMACEUTICAL PREPARATIONS AND METHODS TO MANAGE WEIGHT AND TO MODULATE THE GUT MICROBIOTA 审中-公开
公开(公告)号：WO2018102469A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/063809
申请日：2017-11-29
申请人： XENO BIOSCIENCES INC.
发明人： CELIKER, Hasan
IPC分类号： A61K9/48 , A61K9/28 , A61K9/52 , A61K9/54 , A61K9/56 , A61K31/17 , A61K31/327 , A61K33/40
摘要： A pharmaceutical preparation, comprising: A) A plurality of particles, each particle comprising: 1) a core comprising at least one agent that increases oxygen tension and/or redox potential and/or pH in the colon of a subject following administration to the subject, and 2) an enteric coating encasing the core; and B) a capsule or sachet encasing the plurality of particles. Methods of weight management for a subject, comprising administering the pharmaceutical preparation to a subject in need thereof.

72. 发明申请

WO2017134524A3 SPHERICAL MICROCAPSULES WITH ENHANCED ORAL BIOAVAILABILITY 审中-公开
公开(公告)号：WO2017134524A3
公开(公告)日：2017-08-10
申请号：PCT/IB2017/000165
申请日：2017-02-01
申请人： I2O PHARMA LTD.
发明人： AFARGAN, Michel , GELVAN, Dan , NARAYKIN, Natalia
IPC分类号： A61K9/56
摘要： In one embodiment, the present invention provides a composition comprising a plurality of microcapsules, each comprising a shell and a core carrying an active agent selected from the group consisting of: (a) a non-hydrophilic active agent and (b) a hydrophilic active agent dissolved or suspended in an oil; wherein the shell comprises a polymeric coating, and wherein at least a portion of the microcapsules in a sample of the composition are spherical when the sample of the microcapsules is viewed in a scanning electron microscope with a magnification in the range of between X 2000 and X 50000.

73. 发明申请

WO2017074262A1 CORE-SHELL COMPOSITE MATERIAL 审中-公开
标题翻译：核壳复合材料
公开(公告)号：WO2017074262A1
公开(公告)日：2017-05-04
申请号：PCT/SG2016/050525
申请日：2016-10-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MASSEY UNIVERSITY , AGRESEARCH
发明人： SINGH, Harjinder , HAIGH, Brendan , ROY, Nicole , KIRYUKHIN, Maxim , ANTIPINA, Maria , NOVOSELOVA, Marina , SUKHORUKOV, Gleb
IPC分类号： A61K9/56 , A61K9/64 , A61K47/42
CPC分类号： A61K9/5073 , A61K9/19
摘要： Disclosed herein is a core-shell composite material comprising: a core optionally comprising an active ingredient compound; a shell structure comprising at least two alternating layers; the alternating layers being a protein layer and a polyphenol layer; and optionally a polyelectrolyte layer interfacing said core and said shell structure, said polyelectrolyte layer being disposed adjacent to said protein layer or said polyphenol layer, wherein said shell structure is selected to be resistant to degradation under gastric conditions but is degradable by one or more intestinal enzymes. In a preferred embodiment the protein is bovine serum albumin (BSA) or pepsin, the polyphenol layer is tannin or tannic acid, and the shell structure is degradable by pepsin.
摘要翻译：本文公开了一种核 - 壳复合材料，其包含：任选地包含活性成分化合物的核心; 包含至少两个交替层的壳结构; 交替层是蛋白质层和多酚层; 以及任选的与所述核心和所述壳结构相接的聚电解质层，所述聚电解质层与所述蛋白质层或所述多酚层相邻设置，其中选择所述壳结构以抵抗胃病条件下的降解，但可被一种或多种肠道降解酶。在一个优选的实施方案中，蛋白质是牛血清白蛋白（BSA）或胃蛋白酶，多酚层是单宁酸或鞣酸，并且壳结构可被胃蛋白酶降解。

74. 发明申请

WO2016128974A1 FORMULATIONS FOR ORAL ADMINISTRATION OF ACTIVE AGENTS 审中-公开
标题翻译：活性药剂口服药物制剂
公开(公告)号：WO2016128974A1
公开(公告)日：2016-08-18
申请号：PCT/IL2016/050155
申请日：2016-02-09
申请人： ENTERA BIO LTD.
发明人： BURSHTEIN, Gregory , ROTHNER, Ariel , SCHWARTZ, Phillip M. , GALITZER, Hillel
IPC分类号： A61K38/19 , A61K38/22 , A61K38/44 , A61K9/56 , A61K9/28 , A61K9/48
CPC分类号： A61K38/29 , A61K9/0053 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2086 , A61K9/28 , A61K9/2886 , A61K31/05 , A61K31/166 , A61K31/19 , A61K31/20 , A61K38/22 , A61K38/55 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition for oral administration is disclosed herein, comprising a therapeutically active agent, SNAC and at least one antacid compound. Further disclosed herein is a pharmaceutical composition unit dosage form for oral administration of a therapeutically active agent is provided herein, the unit dosage form comprising: a core comprising the therapeutically active agent and SNAC (sodium 8-N- (2-hydroxybenzoyl)aminocaprylate); and an external layer comprising at least one protective agent selected from the group consisting of an antacid compound and a protease inhibitor. Methods and uses utilizing the aforementioned pharmaceutical compositions, as well as methods and uses utilizing co-administration, by oral administration, of at least one antacid composition, and a composition comprising the therapeutically active agent and SNAC, are further disclosed herein, for use in treating a condition treatable by oral administration of the therapeutically active agent.
摘要翻译：本文公开了用于口服给药的药物组合物，其包含治疗活性剂SNAC和至少一种抗酸化合物。本文进一步公开的是用于口服施用治疗活性剂的药物组合物单位剂型，本文提供的单位剂型包含：包含治疗活性剂和SNAC（8-N-（2-羟基苯甲酰基）氨基辛酸钠） ; 以及包含至少一种选自抗酸化合物和蛋白酶抑制剂的保护剂的外层。利用上述药物组合物的方法和用途，以及利用口服给药至少一种抗酸组合物的方法和用途，以及包含治疗活性剂和SNAC的组合物在本文中进一步公开，用于治疗通过口服给予治疗活性剂可治疗的病症。

75. 发明申请

WO2015160706A1 SOLUTION BLOW SPUN POLYMER FIBERS, POLYMER BLENDS THEREFOR AND METHODS OF USE THEREOF 审中-公开
标题翻译：解决方案：泡沫SPUN聚合物纤维，聚合物共混物及其使用方法
公开(公告)号：WO2015160706A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/025576
申请日：2015-04-13
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK OFFICE OF TECHNOLOGY COMMERCIALIZATION , CHILDREN'S NATIONAL MEDICAL CENTER
发明人： BEHRENS, Adam , KOFINAS, Peter , SIKORSKI, Michael , SANDLER, Anthony , SRINIVASAN, Priya , LEE, Nora
IPC分类号： A61K9/00 , A61K9/56 , A61K9/70
CPC分类号： A61L24/043 , A61L24/0015 , A61L27/26 , A61L27/54 , C08L71/02 , C08L67/04
摘要： Compositions comprising biomedical polymers, and in particular unique blends of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are provided. Methods of forming polymer fibers using such compositions and solution blow spinning techniques are also provided, as well as methods of delivering the blow spun polymer fibers onto a surface (e.g., such as tissue for use as a surgical scaffold, sealant or tissue adhesive).
摘要翻译：提供包含生物医学聚合物的组合物，特别是聚（乳酸 - 共 - 乙醇酸）（PLGA）和聚（乙二醇）（PEG）的独特混合物。还提供了使用这种组合物形成聚合物纤维的方法和溶液吹塑技术，以及将吹塑聚合物纤维递送到表面（例如用作外科手术架，组织粘合剂的组织等）上的方法。

76. 发明申请

WO2012068270A3 ENTERIC-COATED SODIUM METABISULFITE LIVESTOCK FEED ADDITIVE FOR VOMITOXIN DETOXIFICATION 审中-公开
标题翻译：用于维生素脱氧酶的肠衣包被的盐代谢脂肪酸饲料添加剂
公开(公告)号：WO2012068270A3
公开(公告)日：2014-04-24
申请号：PCT/US2011061021
申请日：2011-11-16
申请人： PROVIMI NORTH AMERICA INC , COOK DOUGLAS R , ADAMS KEITH
发明人： COOK DOUGLAS R , ADAMS KEITH
IPC分类号： A61K9/60 , A61K9/56 , A61K33/04
CPC分类号： A61K9/145 , A23K20/158 , A23K20/22 , A23K40/30 , A23K40/35 , A23K50/10 , A23K50/30 , A61K9/5015 , A61K33/04
摘要： A livestock feed supplement in which a core particle containing sodium metabisulfite and at least one binder is enrobed with an enteric coating, wherein the thickness and composition of the coating protects the sodium metabisulfite from decomposition to sulfur dioxide in an aqueous acid stomach environment. Also disclosed are a method of delivering sodium metabisulfite to the lower gastrointestinal tract of an animal, and a method of delivering an antidote to relieve the toxic effect of vomitoxin in an animal, by administering to the animal the livestock feed supplement.
摘要翻译：一种家畜饲料添加剂，其中含有焦亚硫酸钠和至少一种粘合剂的核心颗粒与肠溶衣一起使用，其中该涂层的厚度和组成在酸性酸性胃环境中保护焦亚硫酸钠不分解成二氧化硫。还公开了将偏亚硫酸钠递送到动物的下胃肠道的方法，以及通过向动物施用家畜饲料补充剂来递送解毒剂以减轻呕吐毒素在动物中的毒性作用的方法。

77. 发明申请

WO2012010980A3 IMPROVED APPARATUS AND PROCESS FOR MAKING SOFT GEL CAPSULES 审中-公开
公开(公告)号：WO2012010980A3
公开(公告)日：2012-01-26
申请号：PCT/IB2011/002451
申请日：2011-07-18
申请人： PROCAPS SA , ALTAMAR, Carlos, Salazar , TORRES, Orlando , TERAN, Braulio , ANAYA, Gustavo , NAVARRO, Newman Aguas , HERRERA, Wilmer
发明人： ALTAMAR, Carlos, Salazar , TORRES, Orlando , TERAN, Braulio , ANAYA, Gustavo , NAVARRO, Newman Aguas , HERRERA, Wilmer
IPC分类号： A61K9/48 , A61K9/56 , A61J3/07
摘要： An apparatus for making softgel capsules comprising: two extrusion nozzles; two cooling and tension rollers; two rotary dies; a wedge; and a filling station. A method is also provided for for producing softgel capsules, comprising the steps of: (a) softening or melting a suitable film forming composition; (b) extruding said suitable film forming composition through two extrusion dies directly into two tension rollers; (c) passing the extruded films over rotating dies; (d) simultaneously forming, filling, heat-sealing and cutting capsules; and (e) washing and drying said capsules.

78. 发明申请

WO2008117814A1 大腸送達用経口製剤审中-公开
标题翻译：口腔特异性交付的口服药物制剂
公开(公告)号：WO2008117814A1
公开(公告)日：2008-10-02
申请号：PCT/JP2008/055652
申请日：2008-03-26
申请人：帝國製薬株式会社 , 久保浩之
发明人：久保浩之
IPC分类号： A61K9/16 , A61K9/56 , A61K47/02 , A61K47/32 , A61K47/36 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/00 , A61P5/44 , A61P7/12 , A61P15/04 , A61P19/10 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00
CPC分类号： A61K9/5078 , A61K31/00 , A61K31/58
摘要：　本発明は、優れた大腸への薬物送達能を有する経口製剤に関し、より詳しくは、本発明は、薬物を大腸に送達するための経口製剤であって、薬学的に許容可能な賦形剤から少なくともなる核と、該核を被覆する、薬物を含む内層と、該内層を被覆する、ｐＨ６．６以下で溶解または膨潤しうる陽イオン性ポリマーを含む中間層と、該中間層を被覆する、ｐＨ７．０以上で溶解しうる陰イオン性ポリマーを含む外層とを含んでなる、経口製剤に関する。
摘要翻译：一种口服药物制剂，其能够将药物递送至大肠，更具体地说，用于将药物递送至大肠的口服药物制剂，其包含含有药学上可接受的填充剂作为必需成分的核心，含药物覆盖芯的内层，覆盖内层并含有在6.6或更低的pH下可溶或可溶胀的阳离子聚合物的中间层和覆盖中间层并含有可溶于pH 7.0的阴离子聚合物的外层或以上。

79. 发明申请

WO2006044202A2 ENTERIC COATED COMPOSITIONS THAT RELEASE ACTIVE INGREDIENT(S) IN GASTRIC FLUID AND INTESTINAL FLUID 审中-公开
标题翻译：在液体流体和液体流体中释放活性成分的有效涂层组合物
公开(公告)号：WO2006044202A2
公开(公告)日：2006-04-27
申请号：PCT/US2005035787
申请日：2005-10-03
申请人： ARD OF HIGHER EDUCATION ON BEH , AYRES JAMES WALTER
发明人： AYRES JAMES W
IPC分类号： A61K9/56
CPC分类号： A61K9/5078
摘要： Embodiments of a pharmaceutical formulation comprising an enteric material are disclosed. The embodiments release at least a portion of an active ingredient upon contacting gastric fluid. The remaining portion of the formulation releases active ingredient upon contacting intestinal fluid. Certain embodiments of the pharmaceutical composition comprise at least one active ingredient in a core and a leaky enteric coating, such as an enteric coating comprising a gastric fluid channeling agent. Other embodiments of the pharmaceutical composition comprise at least one active ingredient substantially homogeneously admixed with at least one enteric material, such as an enteric material comprising a gastric fluid channeling agent. Disclosed embodiments of the pharmaceutical composition may comprise a single active ingredient, or may comprise plural active ingredients. Generally, but not necessarily, the active ingredient has a window of absorption. The present disclosure also describes a method for treating a subject having a condition treatable by an active ingredient. The method comprises providing one or more embodiments of the pharmaceutical composition disclosed herein comprising an active ingredient suitable for treating the condition. The pharmaceutical composition is administered to the subject. A method for making embodiments of the disclosed composition also is described. The method comprises providing a core comprising an active ingredient. An enteric material is applied to at least a portion of the core, and generally on or about a substantial portion of the core, to form a coat. The composition is then made leaky.
摘要翻译：公开了包含肠溶性物质的药物制剂的实施方案。实施例在接触胃液时释放活性成分的至少一部分。制剂的剩余部分在接触肠液时释放活性成分。药物组合物的某些实施方案包含核心中的至少一种活性成分和渗漏的肠溶衣，例如包含胃液引导剂的肠溶衣。药物组合物的其它实施方案包含至少一种与至少一种肠溶性物质（例如包含胃液引导剂的肠溶性物质）均匀混合的活性成分。药物组合物的公开实施方案可以包含单一活性成分，或可以包含多种活性成分。通常但不一定，活性成分具有吸收窗口。本公开还描述了用于治疗具有可由活性成分治疗的病症的受试者的方法。该方法包括提供本文公开的药物组合物的一种或多种实施方案，其包含适于治疗病症的活性成分。将药物组合物施用于受试者。还描述了制造所公开的组合物的实施方案的方法。该方法包括提供包含活性成分的核心。肠道材料被施加到芯的至少一部分，并且通常在芯的大部分上或周围，以形成外层。然后使组合物泄漏。

80. 发明申请

WO2005070401A1 ENCAPSULATION OF LIPID-BASED FORMULATIONS IN ENTERIC POLYMERS 审中-公开
标题翻译：肠内聚合物中基于脂质的制剂的包封
公开(公告)号：WO2005070401A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/001134
申请日：2005-01-13
申请人： GLAXO GROUP LIMITED , PILLAI, Raviraj, S.
发明人： PILLAI, Raviraj, S.
IPC分类号： A61K9/56
CPC分类号： A61K9/5042
摘要： A microcapsule comprising a lipid-based core that is encapsulated in an enteric polymer shell providing enhanced bioavailability of a sparingly water-soluble drug as well as modulated release of the drug, wherein the microcapsule is, in one embodiment, prepared by a centrifugal coextrusion process. The lipid-based core comprises lipids carriers, either liquid or solid (melting point
摘要翻译：一种微胶囊，其包含封装在肠溶性聚合物壳体中的脂质核，其提供了微量水溶性药物的增强的生物利用度以及药物的调节释放，其中在一个实施方案中，微胶囊通过离心共挤出方法。基于脂质的芯包括液体或固体（熔点<100℃）的脂质载体，其将提供足够的药物溶解并且与肠溶性物质相容。

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