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71. 发明申请

WO2016044300A2 LIGHT-EMITTING VERSIONS OF THE MONOCLONAL ANTIBODY TO C3D (MAB 3D29) FOR IMAGING 审中-公开
标题翻译：单克隆抗体对C3D（MAB 3D29）进行成像的发光版本
公开(公告)号：WO2016044300A2
公开(公告)日：2016-03-24
申请号：PCT/US2015/050232
申请日：2015-09-15
申请人： UNIVERSITY OF COLORADO DENVER , THE JOHNS HOPKINS UNIVERSITY
发明人： POMPER, Martin G. , FOSS, Catherine A. , THURMAN, Joshua M. , HOLERS, V. Michael
IPC分类号： G01N33/569 , G01N33/534 , A61K39/395 , A61K51/10 , A61P31/04
CPC分类号： A61K49/0058 , A61K49/0043 , A61K51/1009 , A61K51/1018 , C07K16/18 , C07K2317/92 , G01N33/534 , G01N33/5695 , G01N2469/10

72. 发明申请

WO2016024129A1 MYCOBACTERIUM TUBERCULOSIS PROTEINS 审中-公开
标题翻译： MYCOBACTERIUM TUBERCULOSIS蛋白
公开(公告)号：WO2016024129A1
公开(公告)日：2016-02-18
申请号：PCT/GB2015/052362
申请日：2015-08-14
申请人： OXFORD IMMUNOTEC LIMITED
发明人： AMICOSANTE, Massimo , DURRANT, Ian , TASKER, Scott
IPC分类号： C07K14/35 , A61K38/16 , G01N33/569 , G01N33/68
CPC分类号： G01N33/5695 , A61K38/164 , A61K39/04 , C07K14/35 , G01N33/5091 , G01N33/6866 , G01N2333/35 , G01N2333/57 , G01N2333/70514 , G01N2333/70517 , G01N2469/10
摘要： The present invention relates to Mycobacterium tuberculosis ( M tuberculosis ) proteins and immunologically active fragments (peptides or mimotope peptides) thereof. In particular, the invention relates to a group of M. tuberculosis proteins and peptides thereof that are both highly antigenic and characteristic of clinical strains of M. tuberculosis . Accordingly, the further relates to the use of these M. tuberculosis proteins or peptides in diagnosing, treating or preventing M. tuberculosis complex infection.
摘要翻译：本发明涉及结核分枝杆菌（M结核分枝杆菌）蛋白及其免疫活性片段（肽或模拟表位肽）。特别地，本发明涉及一种结核分枝杆菌蛋白及其肽，其具有高度抗原性和结核分枝杆菌临床菌株的特征。因此，进一步涉及这些结核分枝杆菌蛋白质或肽在诊断，治疗或预防结核分枝杆菌复合体感染中的用途。

73. 发明申请

WO2016024118A1 METHOD AND KIT FOR DETECTION OF MYCOBACTERIA 审中-公开
标题翻译：用于检测MYCOBACTERIA的方法和工具箱
公开(公告)号：WO2016024118A1
公开(公告)日：2016-02-18
申请号：PCT/GB2015/052340
申请日：2015-08-13
申请人： BANGOR UNIVERSITY
发明人： BAIRD, Mark Stephen , GWENIN, Christopher David , GWENIN, Vanessa Valerie , JONES, Alison
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/5695 , G01N33/543 , G01N33/54366 , G01N33/553 , G01N33/558 , G01N33/92 , G01N2333/35 , G01N2405/00 , G01N2800/50
摘要： A method of determining whether an individual is infected with mycobacteria. The method comprising the steps of (a) providing a system which comprises at least two different mycolic- acid derived antigens; (b) introducing a sample obtained from the individual into the system and into contact with each of the at least two different mycolic-acid derived antigens; and (c) detecting the presence or absence of the binding of a biomarker in the sample with each antigen in the system. The method may be particularly suitable for determining the presence or absence of a disease antibody indicative of infection with any disease caused by infection with mycobacteria, for example tuberculosis, leprosy, pulmonary disease, burili ulcer, Johne's disease and bovine tuberculosis. A kit and device are also described. The present invention may provide an over the counter device to allow individuals to check on a routine basis that they have normal immune responses.
摘要翻译：确定个体是否感染分枝杆菌的方法。该方法包括以下步骤：（a）提供包含至少两种不同的霉酚酸衍生的抗原的系统; （b）将从个体获得的样品引入系统并与至少两种不同的霉酚酸衍生的抗原接触; 和（c）检测样品中的生物标志物与系统中每种抗原的结合的存在或不存在。该方法可以特别适用于确定指示感染由分枝杆菌感染引起的任何疾病的疾病抗体的存在或不存在，例如结核病，麻风病，肺部疾病，布鲁利溃疡，约翰氏病和牛结核病。还描述了套件和装置。本发明可以提供一种超过对抗装置，以允许个体在常规的基础上检查它们具有正常的免疫应答。

74. 发明申请

WO2015153884A1 METHODS AND USES OF A BIOMARKER FOR THE PREVENTION AND TREATMENT OF MYOBACTERIUM TUBERCULOSIS INFECTIONS 审中-公开
标题翻译：生物标记物预防和治疗小肠结核感染的方法和用途
公开(公告)号：WO2015153884A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/024087
申请日：2015-04-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MODLIN, Robert, L. , MONTOYA, Dennis, Jay , BLOOM, Barry, R.
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/569 , G01N33/68 , C07K14/54
CPC分类号： C07K14/54 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2333/54
摘要： The invention described herein provides methods for determining a M. tuberculosis infection in a patient using an interleukin-32 (lL-32) biomarker. The invention further provides therapies for preventing, mitigating, treating, or ameliorating a M. tuberculosis infection in a patient with an agent that boosts the levels of lL-32 alone or in combination with an agent that boosts levels of 25 hydroxyvitamin D (25D). Provided herein are method for monitoring a latent or active state of M. tuberculosis infection in a patient to thereby determine the progression of the Mycobacterium tuberculosis infection.
摘要翻译：本文描述的本发明提供了使用白细胞介素-32（I-32）生物标志物测定患者结核分枝杆菌感染的方法。本发明进一步提供用于预防，减轻，治疗或改善患者结核分枝杆菌感染的疗法，所述药物可以单独增加lL-32的水平或与增加25羟基维生素D（25D）水平的药物联合使用，。本文提供了用于监测患者结核分枝杆菌感染潜伏或活跃状态从而确定结核分枝杆菌感染进展的方法。

75. 发明申请

WO2015077541A3 MYCOBACTERIUM BIOMARKERS AND METHODS 审中-公开
标题翻译：细菌生物标志物和方法
公开(公告)号：WO2015077541A3
公开(公告)日：2015-09-03
申请号：PCT/US2014066782
申请日：2014-11-21
申请人： UNIV MINNESOTA , SREEVATSAN SRINAND , LAMONT ELISE
发明人： SREEVATSAN SRINAND , LAMONT ELISE
IPC分类号： G01N33/569 , G01N33/92
CPC分类号： G01N33/5695 , G01N21/658 , G01N33/92 , G01N2333/35 , G01N2405/00 , G01N2800/50
摘要： This disclosure provides a method for detecting infection of an animal by Mycobacterium bovis. The method generally includes obtaining a biological sample from a host animal at risk of being infected by Mycobacterium bovis and analyzing the sample for the presence or absence of at least one M. bovis polypeptide. In some embodiments, the method can further include analyzing the sample for the presence or absence of at least one M. bovis lipid. In some embodiments, the method can further include detecting at least one host polypeptide whose expression is greater in a host infected with M. bovis compared to expression in a host known to be uninfected with M. bovis.
摘要翻译：本公开提供了检测牛分枝杆菌感染动物的方法。该方法通常包括从处于被牛分枝杆菌感染的风险的宿主动物获得生物样品，并分析样品中是否存在至少一种牛分枝杆菌多肽。在一些实施方案中，该方法可以进一步包括分析样品中是否存在至少一种牛分枝杆菌脂质。在一些实施方案中，所述方法可进一步包括检测至少一种宿主多肽，所述宿主多肽在感染牛分枝杆菌的宿主中表达较之已知未感染牛分枝杆菌的宿主中的表达更高。

76. 发明申请

WO2015127029A1 BIOMARKERS FOR TUBERCULOSIS INFECTION 审中-公开
标题翻译：生物标志物治疗结核菌感染
公开(公告)号：WO2015127029A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/016548
申请日：2015-02-19
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： SCHALLER, Matthew
IPC分类号： C12Q1/68 , G01N33/53 , A61K39/04
CPC分类号： G01N33/566 , C12Q1/6806 , C12Q1/6837 , C12Q1/6872 , C12Q1/6883 , C12Q2600/158 , G01N33/5695 , G01N2800/26
摘要： Provided herein are compositions, kits, devices, and methods for the detection and/or diagnosis of tuberculosis (TB) infection. In particular, detection and/or quantification of notch ligand delta-like 1 (dll1) expression, notch ligand delta-like 4 (dll4) expression, or a ration thereof in a subject is used as a biomarker for diagnosis of mycobacterial infection.
摘要翻译：本文提供了用于检测和/或诊断结核病（TB）感染的组合物，试剂盒，装置和方法。特别地，使用缺口配体δ样1（dll1）表达，缺口配体δ样4（dll4）表达或其受试者的比例的检测和/或定量作为诊断分枝杆菌感染的生物标志物。

77. 发明申请

WO2015042704A1 BIOMARKERS FOR MYCOBACTERIUM AVIUM PARATUBERCULOSIS (MAP) 审中-公开
标题翻译：生物标记物（MYCOBACTERIUM AVIUM PARATUBERCULOSIS）（MAP）
公开(公告)号：WO2015042704A1
公开(公告)日：2015-04-02
申请号：PCT/CA2014/050914
申请日：2014-09-24
申请人： UNIVERSITY OF GUELPH
发明人： MUTHARIA, Lucy M. , FACCIUOLO, Antonio
IPC分类号： C07K14/35 , A61K39/04 , A61P31/04 , A61P37/04 , C07K16/12 , C12P21/02 , G01N33/569
CPC分类号： C07K14/35 , A61K39/04 , C07K16/1289 , C07K2317/33 , G01N33/5695 , G01N2333/35 , G01N2469/20
摘要： Described are methods and products useful for identifying subjects with Mycobacterium avium subspecies paratuberculosis (MAP). A number of protein antigens secreted into culture filtrate by MAP are identified and binding proteins selective for these antigens are demonstrated to be useful for detecting subjects with MAP infections including subjects with Johne's disease.
摘要翻译：描述了用于鉴定具有分枝杆菌亚种副结核病（MAP）的受试者的方法和产品。鉴定了通过MAP分泌到培养物滤液中的许多蛋白质抗原，对这些抗原选择性的结合蛋白被证明可用于检测MAP感染的受试者，包括具有约翰氏病的受试者。

78. 发明申请

WO2015033237A1 NUCLEOTIDE SEQUENCES, NUCLEIC ACID SENSORS AND METHODS THEREOF 审中-公开
标题翻译：核苷酸序列，核酸传感器及其方法
公开(公告)号：WO2015033237A1
公开(公告)日：2015-03-12
申请号：PCT/IB2014/060734
申请日：2014-04-15
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES (NCBS-TIFR)
发明人： KRISHNAN, Yamuna , SHARMA, Suruchi
IPC分类号： C07H21/04 , C07H21/00
CPC分类号： G01N33/5308 , C07H21/00 , C07H21/04 , G01N33/5695
摘要： The present disclosure relates to particular nucleotide sequences comprising of at least one stem and/or loop structure and which optionally bind fluorescent labels, for example DFHBI and a process for obtaining said sequences. The present disclosure also provides nucleic acid sensor for cAMP comprising reporter domain, communication module and target recognition domain. Further, the present disclosure provides for ratiometric sensors 10 for quantifying cAMP using the nucleic sensors of the instant invention. The instant disclosure further provides method for obtaining the sensors, method for detecting and measuring small molecules, such as cAMP using the sensors of the instant disclosure and kits thereof.
摘要翻译：本公开涉及包含至少一个茎和/或环结构并且任选地结合荧光标记的特定核苷酸序列，例如DFHBI和获得所述序列的方法。本公开还提供了用于cAMP的核酸传感器，其包含报告域，通信模块和靶标识别结构域。此外，本公开提供了用于使用本发明的核酸传感器量化cAMP的比例传感器10。本公开还提供了用于获得传感器的方法，用于检测和测量小分子的方法，例如使用本发明的传感器及其试剂盒的cAMP。

79. 发明申请

WO2014145581A4 AUTOMATED IMMUNOANALYZER SYSTEM FOR PERFORMING DIAGNOSTIC ASSAYS FOR ALLERGIES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：自动免疫测定系统，用于进行过敏和自发性疾病的诊断测定
公开(公告)号：WO2014145581A4
公开(公告)日：2014-11-13
申请号：PCT/US2014030373
申请日：2014-03-17
申请人： HYCOR BIOMEDICAL INC
发明人： VAN CLEVE MARK DAVID , HUNG VICTORIA , LUO YI , RIEGER DENNIS EDWIN , TRONDLE LINDA MARIE , REID TAYLOR ADDISON , MCMENAMY EVAN PHILLIP , RAGHAVAN NANDITHA , RELIFORD MORKOAH BLAY , CANFIELD DOUGLAS JOHN , NIE YILING , SINSON EDSEL LAWRENCE NOCHE , VANDE WETERING SCOTT WILLIAM , TAYLOR TERI , KNOX TRAVIS , JACALNE FRAN ZYLO CUARESMA , WESTON JAMES , CHAN JENNIFER BAO-GUEY , TUVI VO STEPHANIE , SCHELL RACHEL SARAH , DIAMOND RONALD NORMAN , GANN STEVE MICHAEL , HALL ERIC DARNELL , HWANG TAE HO , MORTON JOHN LEWIS , MOSKALEV ANATOLY , STACK MARINELA GOMBOSEV , SARGEANT BRUCE ALAN
IPC分类号： G01N33/543 , G01N33/53 , G01N33/564 , G01N33/58 , G01N33/68 , G01N35/00
CPC分类号： G01N21/645 , G01N21/6428 , G01N21/76 , G01N33/5306 , G01N33/54326 , G01N33/5434 , G01N33/54393 , G01N33/564 , G01N33/569 , G01N33/5695 , G01N33/56983 , G01N33/582 , G01N33/6854 , G01N33/6893 , G01N35/0098 , G01N35/1011 , G01N2021/6484 , G01N2035/0453 , G01N2035/1062 , G01N2201/062 , G01N2201/08 , G01N2333/4703 , G01N2333/62 , G01N2333/78 , G01N2800/24 , Y10T436/119163
摘要： A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.
摘要翻译：一种用于进行自动诊断测定的定量方法，包括：将捕获试剂与链霉抗生物素蛋白包被的培养基孵育以形成固相络合物; 洗涤固相络合物以除去过量的捕获试剂; 将固相复合物与血清样品孵育以形成免疫复合物; 洗涤免疫复合物以去除任何未结合的样品; 将免疫复合物与缀合物孵育以产生免疫共轭复合物; 洗涤免疫共轭复合物以除去任何未结合的结合物; 引入能够产生可量化反应的基底; 并校准由引入衬底产生的响应。

80. 发明申请

WO2014164715A1 SAMPLE COLLECTION AND ANALYSIS 审中-公开
标题翻译：样本收集与分析
公开(公告)号：WO2014164715A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/023292
申请日：2014-03-11
申请人： IDEXX LABORATORIES, INC.
发明人： MYLES, Matthew, H.
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/10
CPC分类号： G01N33/56983 , G01N1/30 , G01N33/569 , G01N33/56911 , G01N33/5695 , G01N2469/10 , Y10S436/811
摘要： Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards. Members of the colony may be removed from the colony as a result of the analysis.
摘要翻译：使用多个采血卡对动物群落的健康状况进行管理，以及从已经收集在卡上的集落成员的干血分析。作为分析的结果，殖民地的成员可以从殖民地中移除。

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