专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

WO1993020846A1 RECOMBINANT INFLUENZA VACCINES 审中-公开
标题翻译：重组流感疫苗
公开(公告)号：WO1993020846A1
公开(公告)日：1993-10-28
申请号：PCT/US1993003606
申请日：1993-04-19
申请人： ARNON, Yoram , YEDA RESEARCH AND DEVELOPMENT CO. LTD , ARNON, Ruth , LEVI, Raphael
发明人： ARNON, Yoram , YEDA RESEARCH AND DEVELOPMENT CO. LTD
IPC分类号： A61K39/295
CPC分类号： C07K14/005 , A61K39/00 , C07K14/255 , C12N2760/16122
摘要： Synthetic recombinant vaccines comprising one or more chimeric proteins comprising an amino acid sequence of flagellin and an amino acid sequence of an epitope of influenza virus hemagglutinin (HA) or nucleoprotein (NP), and aggregates thereof, are provided for immunization orally or intranasally against a plurality of different influenza virus strains. Preferred epitopes are HA 91-108, NP 55-69 and NP 147-158 or combination thereof. Such chimeric proteins can be administered individually or in combination. Further provided are vaccines comprising a genetically engineered non-virulent Salmonella strain expressing at least one of said epitopes in the flagella.
摘要翻译：包含一种或多种包含鞭毛蛋白氨基酸序列和流感病毒血凝素（HA）或核蛋白（NP）的表位的氨基酸序列及其聚集体）的嵌合蛋白的合成重组疫苗被提供用于口服或鼻内免疫多种不同的流感病毒株。优选的表位是HA 91-108，NP 55-69和NP 147-158或其组合。这样的嵌合蛋白可以单独或组合施用。还提供了疫苗，其包含表达鞭毛中至少一个所述表位的遗传工程化的非毒性沙门氏菌属菌株。

72. 发明申请

WO1992008486A1 AVIRULENT MICROBES AND USES THEREFOR: SALMONELLA TYPHI 审中-公开
标题翻译：微生物及其用途：SALMONELLA TYPHI
公开(公告)号：WO1992008486A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008376
申请日：1991-11-08
申请人： WASHINGTON UNIVERSITY
发明人： WASHINGTON UNIVERSITY , CURTISS, Roy, III , KELLY, Sandra, M.
IPC分类号： A61K39/112
CPC分类号： C12R1/42 , A61K39/00 , A61K39/0275 , A61K2039/522 , C07K14/255 , C12N15/01 , Y02A50/407 , Y02A50/482 , Y02A50/484
摘要： This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.
摘要翻译：本发明提供了用于免疫含脊椎动物或无脊椎动物的免疫原性组合物，其包含伤寒沙利氏菌的无毒性衍生物。具有cya和/或crp和/或cdt基因突变的衍生物。本发明还提供用于免疫脊椎动物和无脊椎动物的免疫原性组合物，其包含上述类型的无毒力衍生物，其能够表达源自所述脊椎动物或无脊椎动物个体的病原体的重组基因以产生能够诱导免疫应答的抗原针对所述病原体。本发明的其它实施方案包括从这些菌株制备免疫原性组合物的方法，以及可用于制备免疫原性组合物的菌株，以及通过施用免疫原性刺激免疫系统对伤寒沙门氏菌的免疫原性抗原作出反应的方法组成。

73. 发明申请

WO1989006971A1 CONSERVED ROTAVIRUS GENE SEGMENTS AND USE IN IMMUNIZATION AND NEUTRALIZATION 审中-公开
标题翻译：保护罗非鱼基因部分和免疫和中和使用
公开(公告)号：WO1989006971A1
公开(公告)日：1989-08-10
申请号：PCT/US1989000018
申请日：1989-01-03
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD ...
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD ... , GREENBERG, Harry, B. , MACKOW, Erich
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , C07K14/255 , C07K16/10 , C07K2319/00 , C07K2319/40 , C07K2319/735 , C12N2720/12322
摘要： A polypeptide immunogen is provided which polypeptide stimulates the production of neutralizing antibody to rotavirus strains. The polypeptide comprises an epitope of a conserved region of rhesus rotavirus (RRV) VP3 or VP7 protein. Usually the polypeptide comprises at least 10 amino acides having substantially the same amino acid sequence as consecutive amino acids within residues 75 to 200 or 370 to 490 of VP3 or residues 75 to 250 of VP7. DNA fragments and expression constructs encoding the polypeptides are also provided, together with vaccines and methods of protecting a susceptible host animal from rotavirus infection.
摘要翻译：提供了一种多肽免疫原，该多肽刺激了轮状病毒株中和抗体的产生。多肽包含恒河猴轮状病毒（RRV）VP3或VP7蛋白的保守区域的表位。通常，多肽包含至少10个氨基酸，其具有与VP3的残基75至200或370至490或VP7的残基75至250的残基中的连续氨基酸基本相同的氨基酸序列。还提供了编码多肽的DNA片段和表达构建体，以及疫苗和保护敏感宿主动物免受轮状病毒感染的方法。

74. 发明申请

WO1986003123A1 NOVEL NON-REVERTING SALMONELLA LIVE VACCINES 审中-公开
标题翻译：新型非反流型SALMONELLA LIVE VACCINES
公开(公告)号：WO1986003123A1
公开(公告)日：1986-06-05
申请号：PCT/US1985002260
申请日：1985-11-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ...
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ... , STOCKER, Bruce, A., D.
IPC分类号： A61K39/112
CPC分类号： C12N15/00 , A61K39/0275 , A61K2039/522 , C07K14/255 , C12R1/42 , Y02A50/482 , Y02A50/484 , Y10S435/879
摘要： Live vaccines and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification on a gene involved in at least one, normally at least two, biosynethetic pathways, involving the production of products which are unlikely to be found in the disease susceptible host. The modification results in a gene change which cannot be repaired by a single step e.g. polynucleotide deletions and inversions. Where the aro gene suffers such a change, the resultant auxotrophic mutants require aromatic amino acids, p-aminobenzoic acid and 2,3-dihydroxybenzoic acid or a highly concentrated source of absorbable iron. The auxotrophic mutations have substantially reduced or nonexistent virulence, while retaining the desired immunogenicity to initiate the immunogenic response. Various techniques can be employed for providing the desired change.
摘要翻译：活疫苗和制备用于保护宿主免受致病微生物的活疫苗的方法。通过在参与至少一个，通常至少两个生物合成途径的基因上引入至少一个修饰来制备疫苗，涉及产生在易感染的病毒宿主中不太可能发现的产物。该修饰导致不能通过单个步骤修复的基因变化，例如，多核苷酸缺失和反转。在aro基因遭受这种变化的地方，所得到的营养缺陷型突变体需要芳香族氨基酸，对氨基苯甲酸和2,3-二羟基苯甲酸或高浓度的可吸收铁源。营养缺陷型突变具有显着降低或不存在的毒力，同时保留所需的免疫原性以引发免疫原性应答。可以采用各种技术来提供所需的变化。

75. 发明申请

WO2018124407A1 약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물 审中-公开
公开(公告)号：WO2018124407A1
公开(公告)日：2018-07-05
申请号：PCT/KR2017/006150
申请日：2017-06-13
申请人： 주식회사 코미팜
发明人： 이존화 , 원가연 , 김제형 , 박수연 , 문성철 , 정호경
IPC分类号： C12N15/74 , C07K14/195 , C07K14/255 , A61K39/112 , A61K39/02 , A23K10/16 , A23K20/195 , C12R1/42
CPC分类号： A23K10/16 , A23K20/195 , A61K39/02 , C07K14/195 , C07K14/255 , C12N15/74 , C12R1/42 , Y02A50/482
摘要： 본 발명은 약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물에 관한 것이다. 본 발명은 로소니아 인트라셀룰라리스( Lawsonia intracellularis ) 유래 OptA, OptB, FliC 또는 Hly 항원의 분비를 증가시키도록 개발된 벡터로 약독화된 살모넬라균을 형질전환시키고 상기 형질전환된 약독화된 살모넬라 변이주 혼합물을 접종시킨 마우스에서 항원에 대한 체액성 및 세포 매개 면역 반응이 유도됨을 확인하였다. 따라서, 본 발명의 변이주는 안전하고 경제적이며 간편하게 접종할 수 있는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신으로 유용하게 사용될 것으로 기대된다.

76. 发明申请

WO2016054696A1 CHIMERIC PROTEINS 审中-公开
标题翻译： CHIMERIC蛋白质
公开(公告)号：WO2016054696A1
公开(公告)日：2016-04-14
申请号：PCT/AU2015/050614
申请日：2015-10-09
申请人： LIPOTEK PTY LTD , THE AUSTRALIAN NATIONAL UNIVERSITY
发明人： PRICE, Jason David , PARISH, Christopher , ATMOSUKARTO, Ines
IPC分类号： C07K19/00 , A61K39/02 , A61K39/21 , A61K9/14 , A61P37/02
CPC分类号： A61K39/0275 , A61K9/1271 , A61K39/00 , A61K39/12 , A61K39/295 , A61K2039/523 , A61K2039/55555 , A61K2039/572 , A61K2039/70 , C07K14/245 , C07K14/255 , C07K2319/00 , C07K2319/21 , C12N2740/16034 , Y02A50/476 , Y02A50/482
摘要： The present invention is directed generally to chimeric proteins that can facilitate targeting of nanoparticle carriers to antigen presenting cells, and to nanoparticulate carriers comprising these chimeric proteins. An embodiment of the chimeric protein comprises of a TLR5 agonist such as a flagellin, and a gpl20-derived peptide. The invention is also directed to methods of internalising an antigen in an antigen presenting cell, and methods of eliciting an immune response to an antigen in a subject, using the nanoparticulate carriers comprising the chimeric proteins.
摘要翻译：本发明一般涉及可以促进纳米颗粒载体靶向抗原呈递细胞的嵌合蛋白质，以及包含这些嵌合蛋白质的载体的纳米颗粒。嵌合蛋白的实施方案包括TLR5激动剂如鞭毛蛋白和来源于gp120的肽。本发明还涉及使用包含嵌合蛋白质的纳米颗粒载体，使抗原呈递细胞中的抗原内化的方法，以及引起受试者中的抗原的免疫应答的方法。

77. 发明申请

WO2015078840A1 FULL AND PARTIAL PROTEIN SECRETION AND CELL SURFACE DISPLAY USING TYPE III SECRETION SYSTEM 审中-公开
标题翻译：全部和部分蛋白质分泌和使用III型分泌系统的细胞表面显示
公开(公告)号：WO2015078840A1
公开(公告)日：2015-06-04
申请号：PCT/EP2014/075478
申请日：2014-11-25
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , IMBA - INSTITUTE OF MOLECULAR BIOTECHNOLOGY GMBH
发明人： MARLOVITS, Thomas , KOENIGSMAIER, Lisa , RADICS, Julia , STREBINGER, Daniel
IPC分类号： C07K14/435 , C12N15/70
CPC分类号： C12N15/1037 , C07K14/255 , C07K2319/035 , C07K2319/10 , C12P21/02
摘要： The present invention provides a cell which fully or partially secretes a protein of interest via a type III secretion system (T3SS). The cells comprising a type III secretion system and a protein of interest with having an N-terminal secretion tag. Partial secretion is achieved by using an anchoring sequence which plugs the entry point of the T3SS to prevent the complete secretion of the protein of interest.
摘要翻译：本发明提供了通过III型分泌系统（T3SS）完全或部分分泌感兴趣的蛋白质的细胞。包含III型分泌系统和目标蛋白质的细胞具有N-末端分泌标记。部分分泌是通过使用锚定序列来实现的，该锚定序列插入T3SS的入口点以防止感兴趣的蛋白质的完全分泌。

78. 发明申请

WO2013181404A3 COMPOSITIONS AND METHODS FOR PEPTIDE EXPRESSION AND PURIFICATION USING A TYPE lll SECRETION SYSTEM 审中-公开
标题翻译：使用类型III分泌系统进行肽表达和纯化的组合物和方法
公开(公告)号：WO2013181404A3
公开(公告)日：2015-06-04
申请号：PCT/US2013043384
申请日：2013-05-30
申请人： UNIV UTAH RES FOUND
发明人： HUGHES KELLY T , OLIVERA BALDOMERO M
IPC分类号： C12N15/04
CPC分类号： C07K14/245 , C07K14/255 , C07K14/34 , C07K14/43504 , C07K14/43518 , C07K14/43522 , C07K14/46 , C07K2319/036 , C07K2319/21 , C07K2319/50 , C12N15/62 , C12N15/70 , C12N15/74 , C12P21/02
摘要： Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FigM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FigM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FigM, a cleavage site and a peptide of interest are provided.
摘要翻译：公开了使用鞭毛III型分泌系统表达和纯化目标肽的组合物和方法。公开了含有FIGM核酸序列，切割位点和感兴趣的核酸序列的核酸序列。还公开了含有FIGM，切割位点和目的肽的多肽。提供了具有FIGM，切割位点和目标肽的多肽的制备方法。

79. 发明申请

WO2014093950A1 IMMUNE MODULATOR FOR IMMUNOTHERAPY AND VACCINE FORMULATION 审中-公开
标题翻译：免疫调节剂用于免疫和疫苗配方
公开(公告)号：WO2014093950A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/075210
申请日：2013-12-14
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , HEALTH RESEARCH, INC.
发明人： WANG, Xiang-Yang , YU, Xiaofei , SUBJECK, John, R.
IPC分类号： C12N15/00 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/63 , C12N15/861 , C12N5/10 , C07K19/00 , A61K39/02 , A61K48/00 , A61P35/00 , C12R1/42
CPC分类号： C07K14/47 , A61K35/17 , A61K35/761 , A61K39/0011 , A61K39/0275 , A61K2039/57 , A61K2039/572 , A61K2039/585 , A61K2039/6068 , A61K2039/70 , C07K14/255 , C07K2319/00 , C07K2319/40 , C12N5/0636 , C12N2710/10343 , C12Y306/03044 , Y02A50/466
摘要： A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170 protein comprises an NF- K B-activating domain of Flagellin and an ATP-binding domain truncated Grp170. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
摘要翻译：提供重组Flagrp170蛋白质和包含Flagrp170蛋白质和编码相关分子的相关分子的药物组合物，以及呈递这种蛋白质的细胞。 Flagrp170蛋白包含鞭毛蛋白的NF-κB活化结构域和ATP结合结构域截短的Grp170。本发明的药物组合物可用于治疗或预防癌症或感染性疾病。

80. 发明申请

WO2014043637A1 MULTIFUNCTIONAL ORAL VACCINE BASED ON CHROMOSOME RECOMBINEERING 审中-公开
标题翻译：基于色素重建的多功能口服疫苗
公开(公告)号：WO2014043637A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/059980
申请日：2013-09-16
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： DHARMASENA, Madushini Nirosha , KOPECKO, Dennis J.
IPC分类号： C12N1/21 , C12N15/31 , A61K35/74 , A61P31/04
CPC分类号： A61K39/0283 , A61K39/0275 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/70 , C07K14/25 , C07K14/255 , C07K2319/40 , C12N1/20 , Y02A50/476 , Y02A50/482 , Y02A50/484
摘要： A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome for the purpose of making multivalent vaccines to protect against one or more disease agents are described herein.
摘要翻译：本文描述了重组的伤寒沙门氏菌Ty21a，包含这种Ty21a的组合物和疫苗，以及用于重组的方法，包括将大的抗原区域插入到细菌染色体中，以制备多价疫苗以防止一种或多种疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式