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71. 发明申请

WO2010091150A1 NOVEL BENZODIAZEPINE DERIVATIVES 审中-公开
标题翻译：新的苯二甲酸衍生物
公开(公告)号：WO2010091150A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023150
申请日：2010-02-04
申请人： IMMUNOGEN, INC. , LI, Wei , FISHKIN, Nathan, Elliott , ZHAO, Robert, Yongxin , MILLER, Michael, Louis , CHARI, Ravi, V., J.
发明人： LI, Wei , FISHKIN, Nathan, Elliott , ZHAO, Robert, Yongxin , MILLER, Michael, Louis , CHARI, Ravi, V., J.
IPC分类号： A01N43/62 , A61K31/55
CPC分类号： C07K16/2896 , A61K31/5517 , A61K38/07 , A61K45/06 , A61K47/60 , A61K47/6835 , A61K47/6849 , A61K47/6863 , A61P35/00 , C07D487/04 , C07D498/04 , C07D519/00 , C07K5/0202 , C07K5/1008 , C07K16/2803 , C07K16/46 , C07K19/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗增殖活性的新型苯并二氮杂衍生物，更具体地涉及式（I）和（II）的新型苯并二氮杂，其中二氮杂环（B）与杂环（CD）稠合，其中杂环是双环的或其中二氮杂环（B）与杂环（C）稠合的式（III）化合物，其中杂环是单环的。本发明提供这些化合物的细胞毒二聚体。本发明还提供了单体和二聚体的共轭物。本发明还提供了使用本发明的化合物或缀合物来抑制哺乳动物异常细胞生长或治疗增殖性病症的组合物和方法。本发明还涉及将化合物或缀合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

72. 发明申请

WO2010062437A1 METHODS, MEDIA, AND SYSTEMS FOR DETECTING ATTACK ON A DIGITAL PROCESSING DEVICE 审中-公开
标题翻译：用于检测数字处理设备上的攻击的方法，媒体和系统
公开(公告)号：WO2010062437A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/056623
申请日：2009-09-11
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , STOLFO, Salvatore, J. , LI, Wei-Jen
发明人： STOLFO, Salvatore, J. , LI, Wei-Jen
IPC分类号： G06F11/00
CPC分类号： G06F21/50 , G06F21/56 , G06F21/562 , G06F21/566
摘要： Methods, media, and systems for detecting attack are provided. In some embodiments, the methods include: selecting a data segment in at least one portion of an electronic document; determining whether the arbitrarily selected data segment can be altered without causing the electronic document to result in an error when processed by a corresponding program; in response to determining that the arbitrarily selected data segment can be altered, arbitrarily altering the data segment in the at least one portion of the electronic document to produce an altered electronic document; and determining whether the corresponding program produces an error state when the altered electronic document is processed by the corresponding program.
摘要翻译：提供了检测攻击的方法，媒体和系统。在一些实施例中，所述方法包括：在电子文档的至少一部分中选择数据段; 确定是否可以改变任意选择的数据段，而不会导致电子文档在由相应的程序处理时导致错误; 响应于确定可以改变任意选择的数据段，任意地更改电子文档的至少一部分中的数据段以产生改变的电子文档; 以及当所述改变的电子文档被相应的程序处理时，确定相应的程序是否产生错误状态。

73. 发明申请

WO2008137816A8 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的三聚体化合物
公开(公告)号：WO2008137816A8
公开(公告)日：2010-01-28
申请号：PCT/US2008062593
申请日：2008-05-05
申请人： WYETH CORP , LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
发明人： LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
IPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , A61P19/00 , A61P35/00 , C07D333/76 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D307/91 , C07D333/76 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，R 4，X和Y如本文所定义。本教导还提供制备式I化合物的方法和抑制基质金属蛋白酶特别是MMP-12的方法，所述方法可能涉及哺乳动物（包括人）中发现的病理学障碍。

74. 发明申请

WO2009137382A1 THERMOFORMED ARTICLE MADE FROM BIO-BASED BIODEGRADABLE POLYMER COMPOSITION 审中-公开
标题翻译：基于生物可降解聚合物组合物的热变形物
公开(公告)号：WO2009137382A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/042662
申请日：2009-05-04
申请人： INTERNATIONAL PAPER COMPANY , LI, Wei , TAN, Zheng , CHRISTIE, Thomas, Robert , THOMAN, Bruce, J. , TEDFORD, Richard, A. , FAGAN, Mark
发明人： LI, Wei , TAN, Zheng , CHRISTIE, Thomas, Robert , THOMAN, Bruce, J. , TEDFORD, Richard, A. , FAGAN, Mark
IPC分类号： B32B9/02 , B32B27/08 , B32B27/36 , B65D1/28 , C08J5/04 , C08L101/16
CPC分类号： B32B9/02 , B32B1/02 , B32B5/022 , B32B7/02 , B32B7/12 , B32B9/045 , B32B23/08 , B32B23/16 , B32B23/18 , B32B23/20 , B32B27/08 , B32B27/18 , B32B27/20 , B32B27/22 , B32B27/281 , B32B27/302 , B32B27/32 , B32B27/34 , B32B27/36 , B32B27/40 , B32B2262/062 , B32B2262/065 , B32B2262/067 , B32B2270/00 , B32B2307/30 , B32B2307/306 , B32B2307/7163 , B32B2435/02 , B32B2439/06 , B32B2439/46 , B32B2439/60 , B32B2439/70 , B65D1/28 , B65D43/02 , B65D2543/00314 , C08J5/045 , C08J2300/16 , Y02W90/13 , Y10T428/3179
摘要： The present invention provides a biodegradable polymer composition useful for manufacturing biodegradable in which, the process comprising: (1) providing a renewable polymer and/or natural fiber having: (a) a T s value of up to about 90°C; and (b) a heat distortion index of up to about 90°C; (2) providing a heat-resistant polymer having: (a) a T s of greater than about 60°C; and (b) a heat distortion index greater than about 50°C, wherein the T s value and heat distortion index of the heat-resistant polymer is greater than that of the renewable polymer and/or natural fiber; and (3) coextruding the heat-resistant polymer and the renewable polymer to provide a theπnoformable composite comprising a core comprising the renewable polymer and/or natural fiber, wherein the renewable polymer and/or natural fiber comprises at least about 50% by weight of the composite and a heat-resistant outer layer comprising the heat-resistant polymer which substantially surrounds the core.
摘要翻译：本发明提供了可生物降解的聚合物组合物，其可用于制造可生物降解的方法，其中该方法包括：（1）提供可再生的聚合物和/或天然纤维，其具有：（a）高达约90℃的Ts值; 和（b）高达约90℃的热变形指数; （2）提供耐热聚合物，其具有：（a）大于约60℃的Ts; 和（b）大于约50℃的热变形指数，其中耐热聚合物的Ts值和热变形指数大于可再生聚合物和/或天然纤维的TS值和热变形指数; 和（3）共挤出耐热聚合物和可再生聚合物以提供包含可再生聚合物和/或天然纤维的芯的不可形成复合材料，其中可再生聚合物和/或天然纤维包含至少约50重量％所述复合材料和包含基本上围绕所述芯的所述耐热聚合物的耐热外层。

75. 发明申请

WO2009129361A2 MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：大环化合物及其制备和使用方法
公开(公告)号：WO2009129361A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040747
申请日：2009-04-16
申请人： UNIV UTAH RES FOUND , KECK GARY E , KRAFT MATTHEW B , TRUONG ANH P , SANCHEZ CARINA C , LI WEI , COVEL JONATHAN A , WELCH DENNIE , POUDEL YAM
发明人： KECK GARY E , KRAFT MATTHEW B , TRUONG ANH P , SANCHEZ CARINA C , LI WEI , COVEL JONATHAN A , WELCH DENNIE , POUDEL YAM
IPC分类号： C07D493/22 , A61K31/365 , A61P25/28 , A61P35/00 , C07F7/08
CPC分类号： C07D259/00 , A61K31/351 , A61K31/695 , C07D309/22 , C07D323/00 , C07D471/04 , C07D493/18 , C07D493/22 , C07F7/08 , C07F7/1876 , C07F7/1892
摘要： Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
摘要翻译：本文描述的是三环大环内酯。该大环内酯对PKC具有高的结合亲和力。本文所述的化合物可用于许多治疗应用，包括癌症和阿尔茨海默病的预防和治疗。本文所述的化合物还可以治疗记忆丧失。本文还描述了生产羟基己内酯的方法。该方法允许以较少的步骤和更高的取代度和特异性高产率地合成大分子内酯。

76. 发明申请

WO2009072095A3 PAGE INDEXER 审中-公开
公开(公告)号：WO2009072095A3
公开(公告)日：2009-10-15
申请号：PCT/IB2008055666
申请日：2008-12-03
申请人： FRANCE TELECOM , BAJAJ RASHMI , LI WEI
发明人： BAJAJ RASHMI , LI WEI
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30867
摘要： The invention relates to a method to enhance the relevance of search results provided by a search engine server accessible through an operator network, said method comp rising the acts of: - collecting data related to a subscriber to said operator network, - aggregating said data to built a network profile for said subscriber, - receiving a search query from said subscriber addressed to the search engine server, - transmitting the search query to said search engine server through the network, said query being associated to at least part of the subscriber network profile, - receiving search results from the search engine server, said search results being ranked according to said at least part of the subscriber network profile.
摘要翻译：本发明涉及一种增强搜索引擎服务器提供的搜索结果的相关性的方法，所述搜索引擎服务器通过运营商网络可访问，所述方法提升以下行为： - 将与用户有关的数据收集到所述运营商网络; - 将所述数据聚合到为所述订户建立网络简档， - 从所述订户接收到寻址到搜索引擎服务器的搜索查询， - 通过网络将搜索查询发送到所述搜索引擎服务器，所述查询与至少部分订户网络简档 - 从搜索引擎服务器接收搜索结果，所述搜索结果根据所述至少部分订户网络简档进行排序。

77. 发明申请

WO2009105423A1 COATING METHODS AND APPARATUS FOR MAKING A CIGS SOLAR CELL 审中-公开
标题翻译：用于制造CIGS太阳能电池的涂覆方法和装置
公开(公告)号：WO2009105423A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/034280
申请日：2009-02-17
申请人： FILM SOLAR TECH INC. , LI, Wei-zhong
发明人： LI, Wei-zhong
IPC分类号： C25D5/00 , B01J19/00 , H01L21/02
CPC分类号： H01L21/67207 , C23C14/14 , C23C14/568 , C23C14/5866 , H01L21/02568 , H01L21/02614 , H01L21/67011 , H01L31/0322 , Y02E10/541 , Y02P70/521
摘要： A method for manufacturing a thin film solar cell involves applying an inductively-coupled-plasma during the deposition of selenium. A precursor thin film is formed. The precursor thin film can include copper, indium, and gallium. The inductively-coupled-plasma is applied to the selenium as the selenium is deposited into the precursor thin film to produce the thin film. The selenium is deposited into precursor thin film by evaporation, sputtering, or using a reactive gas. An inert gas is used as a carry and discharge gas. The precursor thin film and the selenium are deposited using a deposition system. The deposition system includes an inductively-coupled-plasma device. The inductively-coupled-plasma device includes a quartz plate, a plasma discharge coil, and an inlet system. The deposition can be an in-line system, a roll-to-roll system, or a hybrid system.
摘要翻译：制造薄膜太阳能电池的方法包括在硒的沉积期间施加电感耦合等离子体。形成前体薄膜。前体薄膜可以包括铜，铟和镓。当硒沉积到前体薄膜中以产生薄膜时，电感耦合等离子体被施加到硒。硒通过蒸发，溅射或使用反应性气体沉积到前体薄膜中。使用惰性气体作为携带和排出气体。使用沉积系统沉积前体薄膜和硒。沉积系统包括电感耦合等离子体装置。电感耦合等离子体装置包括石英板，等离子体放电线圈和入口系统。沉积可以是在线系统，卷对卷系统或混合系统。

78. 发明申请

WO2009004600A3 BPSK PPM CDMA SYSTEM 审中-公开
标题翻译： BPSK PPM CDMA系统
公开(公告)号：WO2009004600A3
公开(公告)日：2009-03-19
申请号：PCT/IB2008053509
申请日：2008-06-26
申请人： FRANCE TELECOM , LI WEI , BENKO JOHN
发明人： LI WEI , BENKO JOHN
IPC分类号： H04L25/49 , H04B1/707
CPC分类号： H04L25/4902 , H04B1/707 , H04B14/026
摘要： A method and system for modulating a signal includes providing a carrier including periodic waves, peaks of the periodic waves defining a carrier shape of the carrier; changing a plurality of the periodic waves so that peaks of the changed waves form a shaped signal having a signal shape which is different from the carrier shape; and detecting the shaped signal. The system is identical to a BPSK PPM CDMA system.
摘要翻译：用于调制信号的方法和系统包括提供包括周期波的载波，定义载波的载波形状的周期波的峰值; 改变多个周期波，使得改变的波的峰值形成具有不同于载体形状的信号形状的成形信号; 并检测成形信号。该系统与BPSK PPM CDMA系统相同。

79. 发明申请

WO2008141479A1 METHODS AND APPARATUSES FOR PROVIDING HIERARCHICAL CALL HISTORY INFORMATION IN HANDHELD COMMUNICATIONS DEVICES 审中-公开
标题翻译：在手持通信设备中提供分层呼叫历史信息的方法和装置
公开(公告)号：WO2008141479A1
公开(公告)日：2008-11-27
申请号：PCT/CN2007/001668
申请日：2007-05-22
申请人： MOTOROLA, INC. , LI, Wei-Qiu , CHEN, Yin-Hu
发明人： LI, Wei-Qiu , CHEN, Yin-Hu
IPC分类号： H04M1/57
CPC分类号： H04M1/575 , H04M1/72519 , H04M2250/60
摘要： Methods and apparatuses provide a handheld device with functionality for implementing a hierarchical recent call history log that is displayed on the handheld device to provide the user with varying levels of information about recent calls. The level of information provided for a given call listed in the log depends on one or more characteristics associated with the call, including but are not limited to, the number of calls from the same caller that have been detected by the handheld device.
摘要翻译：方法和装置为手持设备提供了用于实现在手持设备上显示的分级最近的呼叫历史日志的功能，以向用户提供关于最近呼叫的不同级别的信息。为日志中列出的给定呼叫提供的信息的级别取决于与呼叫相关联的一个或多个特征，包括但不限于手持设备检测到的来自同一呼叫者的呼叫数量。

80. 发明申请

WO2008076244A1 PREPREG LAMINATES 审中-公开
标题翻译： PREPREG层压板
公开(公告)号：WO2008076244A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/025227
申请日：2007-12-10
申请人： HENKEL CORPORATION , LEHMANN, Stanley, L., , LI, Wei, Helen , WONG, Raymond, S.,
发明人： LEHMANN, Stanley, L., , LI, Wei, Helen , WONG, Raymond, S.,
IPC分类号： B32B27/28
CPC分类号： B32B27/12 , B29C70/086 , B29K2995/0089 , B32B27/04 , B32B27/18 , C08J5/24 , C08K5/357 , Y10T428/249924 , Y10T428/249939
摘要： The present invention relates to a prepreg laminate, constructed from a first prepreg; a second prepreg; and a thermoplastic layer therebetween. In the inventive laminate, at least one of the first prepreg or the second prepreg is made from a matrix resin comprising a benzoxazine-containing composition.
摘要翻译：本发明涉及由第一预浸料坯构成的预浸料层压板; 第二预浸料; 和它们之间的热塑性层。在本发明的层压材料中，第一预浸料坯或第二预浸料坯中的至少一个由包含含苯并恶嗪的组合物的基质树脂制成。

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