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71. 发明申请

WO2007106802A2 METHOD FOR LINEAR AMPLIFICATION OF BISULFITE CONVERTED DNA 审中-公开
标题翻译：双链转化DNA的线性扩增方法
公开(公告)号：WO2007106802A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/063860
申请日：2007-03-13
申请人： SIEMENS MEDICAL SOLUTIONS DIAGNOSTICS , LI, Zheng
发明人： LI, Zheng
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q1/6858 , C12Q2523/125 , C12Q2525/143 , C12Q2521/131 , C12Q2525/173
摘要： Provided is a method of detecting DNA methylation at CpG sites and at SNP sites in a sample through the linear amplification of bisulfite converted DNA (referred to as the "L-ABCD" method). Unlike prior art DNA methylation assays, the L-ABCD method of the present invention may be applied on single-stranded DNA and from samples that have degraded DNA. The amplification products of the L-ABCD method may be assayed by using methods known in the art such as methylation specific primer extension ("MSPE"), DNA microarrays, microbead assays, and planar waveguid ("PWG") chips.
摘要翻译：提供了通过亚硫酸氢盐转化的DNA的线性扩增（称为“L-ABCD”）法检测样品中CpG位点和SNP位点的DNA甲基化的方法。与现有技术的DNA甲基化测定不同，本发明的L-ABCD方法可以应用于单链DNA和已经降解DNA的样品。 L-ABCD方法的扩增产物可以通过使用本领域已知的方法如甲基化特异性引物延伸（“MSPE”），DNA微阵列，微珠测定和平面波导（“PWG”）芯片进行测定。

72. 发明申请

WO2007097567A1 DECODER AND DECODING METHOD SUPPORTING OFDM/OFDMA 审中-公开
标题翻译：支持OFDM / OFDMA的解码和解码方法
公开(公告)号：WO2007097567A1
公开(公告)日：2007-08-30
申请号：PCT/KR2007/000897
申请日：2007-02-21
申请人： POSDATA CO., LTD. , LI, Zheng Zi , HWANG, Yong Suk , KIM, Jae Hyeong
发明人： LI, Zheng Zi , HWANG, Yong Suk , KIM, Jae Hyeong
IPC分类号： H04L27/26
CPC分类号： H04B7/0857 , H04L27/2647
摘要： Provided are an apparatus and method for efficiently decoding signals input through a plurality of antennas in a system supporting an Orthogonal Frequency Division Multiplexing (OFDM)/Orthogonal Frequency Division Multiple Access (OFDMA) scheme. A method for decoding signals received via at least two paths through a plurality of antennas in a system supporting an 0FDM/0FDMA scheme, the method comprising the steps of: measuring power of a signal received via each path; generating correlation metrics by calculating inner products of basis vector sets or multiplying the basis vector sets in units of tiles or bins of the signal; generating decoding metrics based on the measured power of each path and the correlation metrics; and determining a payload on the basis of the decoding metrics. An apparatus for decoding signals received via at least two paths through a plurality of antennas in a system supporting an 0FDM/0FDMA scheme, the apparatus comprising: a signal power measuring means for measuring power of a signal received via each path; a demodulation/decoding means for generating correlation metrics corresponding to likelihood of potential payload values of a signal received via each path; and a maximum ratio combining (MRC)/determination means for determining a payload based on the measured power of each path and the correlation metrics.
摘要翻译：提供了一种用于在支持正交频分复用（OFDM）/正交频分多址（OFDMA）方案的系统中有效地解码通过多个天线输入的信号的装置和方法。一种用于对支持0FDM / 0FDMA方案的系统中的多个天线经由至少两条路径进行解码的方法，所述方法包括以下步骤：测量经由每个路径接收的信号的功率; 通过计算基矢量集的内积或乘以信号的瓦或块的单位的基矢量集来产生相关度量; 基于每个路径的测量功率和相关度量来生成解码度量; 以及基于所述解码度量来确定有效载荷。一种用于对支持0FDM / 0FDMA方案的系统中的多个天线经由至少两条路径进行解码的装置，所述装置包括：信号功率测量装置，用于测量经由每个路径接收的信号的功率; 解调/解码装置，用于产生对应于经由每个路径接收的信号的潜在有效载荷值的似然度的相关度量; 以及用于基于每个路径的测量功率和相关度量来确定有效载荷的最大比组合（MRC）/确定装置。

73. 发明申请

WO2007002895A1 INTEGRATIVE FRAMEWORK FOR THREE-STAGE INTEGRATIVE PATHWAY SEARCH 审中-公开
标题翻译：三阶段综合路径搜索的一体化框架
公开(公告)号：WO2007002895A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/025556
申请日：2006-06-29
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY , CHAN, Christina , LI, Zheng
发明人： CHAN, Christina , LI, Zheng
IPC分类号： G06F19/00
CPC分类号： G06F19/12 , G06F19/20
摘要： Processes for constructing improved networks, such as Bayesian networks, of putative biomolecular pathways, that can e used to identify candidate biomolecular targets for validation as drug development targets, and the like; networks prepared thereby, use of the networks to predict the effect of biomolecule perturbations on cell phenotypes, and microprocessors and data processing systems programmed to automate the processes and software having instructions for performing the processes.
摘要翻译：用于构建改进的网络的过程，例如贝叶斯网络，推定的生物分子途径，可用于鉴定作为药物开发目标的验证的候选生物分子靶标等; 由此制备的网络，使用网络来预测生物分子扰动对细胞表型的影响，以及被编程为使具有执行过程的指令自动化的过程和软件的微处理器和数据处理系统。

74. 发明申请

WO2006003513A1 METHOD FOR PREPARING 5-`4-(2-HYDROXY-ETHYL)-3,5-DIOXO-4,5-DIHYDRO-3H-`1,2,4!-TRIAZIN-2-YL!BENZAMIDE DERIVATIVES WITH P2X7 INHIBITING ACTIVITY BY REACTION OF THE DERIVATIVE UNSUBSTITUTED IN 4-POSITION OF THE TRIAZINE WITH AN OXIRAN IN THE PRESENCE OF A LEWIS ACID 审中-公开
标题翻译：用于制备具有P2X7抑制活性的5-“4-（2-羟基 - 乙基）-3,5-二氧代-4,5-二氢-3H-1,2,4' - 噻嗪-2-基]苯甲酰胺衍生物的方法通过在一个LEWIS酸的存在下，在含有氧化铁的四苯并噻唑中不引起衍生物的反应
公开(公告)号：WO2006003513A1
公开(公告)日：2006-01-12
申请号：PCT/IB2005/002102
申请日：2005-06-17
申请人： PFIZER PRODUCTS INC. , LEONARD, Jason, Albert , LI, Zheng, Jane , LI, Zhengong, Bryan , URBAN, Frank, John
发明人： LEONARD, Jason, Albert , LI, Zheng, Jane , LI, Zhengong, Bryan , URBAN, Frank, John
IPC分类号： C07D253/06
CPC分类号： C07D253/075 , C07D253/07
摘要： The present invention relates to methods of preparing compounds of formula (I), R 7 is -CH 2 -C(R 10 R 11 )-OH, wherein R 10 and R 11 are independently selected from the group consisting of: hydrogen, phenyl, and (C 1 -C 6 )alkyl optionally substituted with one to three halos, hydroxy, -CN, (C 1 -C 6 )alkoxy-,((C 1 -C 6 )alkyl) n -N-,(C 1 -C 6 )alkyl-(C=O)-,(C 3 -C 8 )cycloalkyl-(C=O)-, 5 or 6-membered heterocycloalkyl-(C=O)-,phenyl-(C=O)-,naphthyl-(C=O)-,5- or 6-membered heteroaryl-(C=O)-,(C 1 -C 6 )alkyl-(C=O)O-,(C 1 -C 6 )alkyl-O(C=O)-,(C 3 -C 8 )cycloalkyl, phenyl, naphthyl, 5 or 6-membered heterocycloalkyl, and 5- or 6-membered heteroaryl; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and R 4 have any of the values as defined in the specification. Wherein said method comprises reacting a compound of formula (II) with a compound of formula (VIII) in the presence of at least one Lewis acid. The compounds are useful as agents in the treatment of diseases, including inflammatory diseases such as rheumatoid arthritis. Also provided are compositions of crystalline 2-Chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[4-(2R-hydroxy-3-methoxy-propyl)-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl]-benzamide comprising less than 2.5% residual organic solvent, and methods for preparing said compositions. Further provided are methods for crystallizing 2-Chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[4-(2R-hydroxy-3-methoxy-propyl)-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl]-benzamide.
摘要翻译：本发明涉及制备式（I）化合物的方法，R 7为-CH 2 R 2（R 10） > 11）-OH，其中R 10和R 11独立地选自：氢，苯基和（C 1 H 4）任选被一至三个卤素，羟基，-CN，（C 1 -C 6）烷基取代的C 1 -C 6烷基-C（= C 1 -C 6）烷氧基 - ，（（C _{1 -C _{6 ）烷基）_{名词 -N - ，（C _{1 - C 1 -C 6烷基 - （C = O） - ，（C 3 -C 8）环烷基 - （C = O） - ，5 （C = O） - ，（C = O） - ，（C = O） - ，5-或6-元杂芳基 - （C = O） - ，（C < > 1 -C _{6 ）烷基 - （C = O）O - ， - （C _{1 -C _{6 ）烷基 O（C = O） - ，（C 3 -C 8 -C 8）环烷基，苯基，萘基，5或6元杂环烷基和5-或6-元杂芳基 ; 或其药学上可接受的盐，其中R 1，R 2和R 4具有说明书中定义的任何值。其中所述方法包括在至少一种路易斯酸存在下使式（II）化合物与式（Ⅷ）化合物反应。这些化合物可用作治疗疾病的药剂，包括炎性疾病如类风湿性关节炎。还提供了结晶的2-氯-N-（1-羟基 - 环庚基甲基）-5- [4-（2R-羟基-3-甲氧基 - 丙基）-3,5-二氧代-4,5-二氢-3H- - [1,2,4]三嗪-2-基] - 苯甲酰胺，以及制备所述组合物的方法。还提供了将2-氯-N-（1-羟基 - 环庚基甲基）-5- [4-（2R-羟基-3-甲氧基 - 丙基）-3,5-二氧代-4,5-二氢-3H - [1,2,4]三嗪-2-基] - 苯甲酰胺。}}}}}}}

75. 发明申请

WO2005059160A2 IDENTIFICATION AND VERIFICATION OF METHYLATION MARKER SEQUENCES 审中-公开
标题翻译：甲基标记序列的鉴定和验证
公开(公告)号：WO2005059160A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/042189
申请日：2004-12-15
申请人： BAYER HEALTHCARE LLC , BEARD, Chris , BURGESS, Chris , GANNON, Allison , HARVEY, Jeanne , LECHNER, John, F. , LI, Zheng
发明人： BEARD, Chris , BURGESS, Chris , GANNON, Allison , HARVEY, Jeanne , LECHNER, John, F. , LI, Zheng
IPC分类号： C12Q
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6827 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125 , C12Q2565/501
摘要： The present invention relates to methods for identifying among the genes that are downregulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also provides methods of using the selected CpG sites for purposes of diagnosis, prognosis, staging, assessing or monitoring the therapy of or recovery from a disease such as cancer.
摘要翻译：本发明涉及用于鉴定在具有疾病的细胞或组织中下调的基因的方法，所述基因在所述基因的CpG岛内的CpG位点，其中所鉴定的CpG位点具有很大的诊断效用潜力。另一方面，本发明还提供了使用所选择的CpG位点用于诊断，预后，分期，评估或监测疾病如癌症的治疗或恢复的方法。

76. 发明申请

WO2005017681A2 CLOSED LOOP INTEGRATION OF DIGITAL MODELS OF IN SILICO SYSTEMS AND EXPERIMENTAL PROCEDURES 审中-公开
标题翻译：硅胶系统和实验程序中数字模型的闭环整合
公开(公告)号：WO2005017681A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/025171
申请日：2004-08-03
申请人： TERANODE CORPORATION , ARNSTEIN, Lawrence, F. , FANGER, Neil, A. , KELLEN, Michael, R. , LI, Zheng
发明人： ARNSTEIN, Lawrence, F. , FANGER, Neil, A. , KELLEN, Michael, R. , LI, Zheng
IPC分类号： G06F
CPC分类号： G06F17/5009 , G06F2217/04
摘要： A method for integrating models of biological systems (i.e., molecules, cells, organs, organisms) that can be simulated with models of laboratory procedures that can be executed, to support close-loop iteration between in silico and physical modeling and experimentation in support of scientific research, discovery, and product development.
摘要翻译：用于整合可以用可执行的实验室程序模型模拟的生物系统（即分子，细胞，器官，生物体）的模型的方法，以支持计算机和物理建模与实验之间的闭环迭代，以支持科学研究，发现和产品开发。

77. 发明申请

WO2004086174A2 BATCH-BASED METHOD AND TOOL FOR GRAPHICAL MANIPULATION OF WORKFLOWS 审中-公开
标题翻译：基于批处理的方法和工具的图形处理工具
公开(公告)号：WO2004086174A2
公开(公告)日：2004-10-07
申请号：PCT/US2004007748
申请日：2004-03-11
申请人： TERANODE CORP , ARNSTEIN LAWRENCE F , LI ZHENG , HILL JOHN M , KELLEN MICHAEL R , POULAIN CHRISTOPHE , FANGER NEIL A , CHEN KUANG
发明人： ARNSTEIN LAWRENCE F , LI ZHENG , HILL JOHN M , KELLEN MICHAEL R , POULAIN CHRISTOPHE , FANGER NEIL A , CHEN KUANG
IPC分类号： G06F20060101 , G06F3/00 , G06F7/00 , G06F9/00 , G06F17/00 , G06Q10/00 , G06F
CPC分类号： G06Q10/06
摘要： An autofill algorithm provides tools for defining and automatically executing batch based procedures in an adaptive hierarchical workflow environment, and may be suitable for a large variety of applications including laboratory procedure planning, execution, documentation, as wells ad driving robotic apparatus.
摘要翻译：自动填充算法提供用于在自适应分级工作流环境中定义和自动执行基于批处理的过程的工具，并且可适用于各种各样的应用，包括实验室程序规划，执行，文档以及广告驱动机器人装置。

78. 发明申请

WO2004079347A1 METHOD OF ANALYSIS OF NIR DATA 审中-公开
标题翻译：近红外数据分析方法
公开(公告)号：WO2004079347A1
公开(公告)日：2004-09-16
申请号：PCT/IB2004/000566
申请日：2004-02-23
申请人： PFIZER PRODUCTS INC. , LI, Zheng, Jane
发明人： LI, Zheng, Jane
IPC分类号： G01N21/35
CPC分类号： G01N21/359 , G01N21/3563
摘要： A method for providing qualitative analysis of solid forms of a chemical compound/or drug candidate including polymorphous, hydrates, solvates and amorphous solids that does not require an a priori knowledge of either the solid form or the total number of groups of solid forms. The invention includes application of cluster analysis of NIR spectra using principal component anlysis (PCA) techniques for segregating the samples into groups. A Malalanobis distance algorithm is then utilised to calculate the Mahalanobis distance between the clustered data and established discrete groups of the samples having the same solid form. Accordingly, utilisation of the method of the invention quickly provides a determination of the number of groups of solid forms thereby increasing the efficiency by eliminating redundant screening of the same solid forms.
摘要翻译：提供定性分析化合物/ /药物候选物的固体形式的方法，包括多形态，水合物，溶剂化物和无定形固体，其不需要固体形式或固体形式的基团数量的先验知识。本发明包括使用主成分分解（PCA）技术将样品分离成组的NIR光谱的聚类分析的应用。然后使用马拉诺比斯距离算法来计算聚类数据与具有相同固体形式的样本的已建立的离散组之间的马氏距离。因此，利用本发明的方法可快速确定固体形式的组数，从而通过消除相同固体形式的冗余筛选来提高效率。

79. 发明申请

WO2004012458A2 EFFICIENT VIDEO TRANSMISSION 审中-公开
标题翻译：有效的视频传输
公开(公告)号：WO2004012458A2
公开(公告)日：2004-02-05
申请号：PCT/SG2002/000168
申请日：2002-07-26
申请人： NANYANG TECHNOLOGICAL UNIVERSITY , YANG, Xiao, Kang , YU, Rong, Shan , ZHU, Ce , LIM, Keng, Pang , LI, Zheng, Guo , PAN, Feng , FENG, Ge, Nan , WU, Da, Jun , WU, Si
发明人： YANG, Xiao, Kang , YU, Rong, Shan , ZHU, Ce , LIM, Keng, Pang , LI, Zheng, Guo , PAN, Feng , FENG, Ge, Nan , WU, Da, Jun , WU, Si
IPC分类号： H04N7/26
CPC分类号： H04N19/51 , H04N19/557
摘要： A method and system for reducing the complexity of block motion estimation is described. According to the invention, the block distortion measure is determined by calculating a partial error result using a proportion of pixels in the block, comparing the partial error result with a threshold value and rejecting blocks where the partial error result is greater than the threshold value, and calculating a full error result for non-rejected blocks only. The threshold value is a function of the current minimum partial error result, and is preferably the current minimum partial error result multiplied by a threshold constant λ. Another aspect of the invention provides a video transport scheme which exploits the different importance of both GOP and re-synchronisation levels. According to this aspect, an unequal loss protection (ULP) philosophy is utilized. That is, the bit stream data is partitioned into several parts according to different importance, and the parts are unequally protected against packet loss using forward error correction codes.
摘要翻译：描述了一种降低块运动估计复杂度的方法和系统。根据本发明，通过使用块中的像素的比例来计算部分误差结果来确定块失真度量，将部分错误结果与阈值进行比较，并且拒绝部分错误结果大于阈值的块，并仅计算未拒绝块的完整错误结果。阈值是当前最小部分误差结果的函数，并且优选地是当前最小部分误差结果乘以阈值常数λ1。本发明的另一方面提供一种视频传输方案，其利用GOP和重新同步级别的不同重要性。根据这一方面，利用了不平等的损失保护（ULP）理念。也就是说，根据不同的重要性将比特流数据划分成若干部分，并且使用前向纠错码对这些部分进行不均匀的保护以防止丢包。

80. 发明申请

WO2002076286A2 PROGNOSTIC METHODS FOR BREAST CANCER 审中-公开
标题翻译：乳腺癌预防方法
公开(公告)号：WO2002076286A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/009068
申请日：2002-03-20
申请人： CALIFORNIA PACIFIC MEDICAL CENTER , DAIRKEE, Shanaz, H. , LI, Zheng
发明人： DAIRKEE, Shanaz, H. , LI, Zheng
IPC分类号： A61B
CPC分类号： G01N33/57415 , A61B10/0041 , C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , G01N2333/723 , G01N2500/10
摘要： Methods of determining the likelihood of the re-occurrence of tumors and of determining the aggressiveness of post-surgical treatment are provided which rely on analysis of a loss of heterogeneity at the particular chromosomal locus 3p24.3. Loss of expression or hypermethylation of the thyroid hormone receptor β1 gene is also predictive of an increased re-occurrence of tumors.
摘要翻译：提供了确定肿瘤再发生的可能性和确定手术后治疗的侵略性的方法，其依赖于在特定染色体位点3p24.3处的异质性丧失的分析。甲状腺激素受体β1基因的表达丧失或高甲基化也预示着肿瘤的再次出现。

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