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71. 发明申请

WO2012018397A2 MOLECULAR SUBTYPING OF ORAL SQUAMOUS CELL CARCINOMA TO DISTINGUISH A SUBTYPE THAT IS UNLIKELY TO METASTASIZE 审中-公开
标题翻译：口腔鳞状细胞癌的分子分型鉴定为不能进行METASTASIZE的亚型
公开(公告)号：WO2012018397A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/001377
申请日：2011-08-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ALBERTSON, Donna G. , SCHMIDT, Brian L. , BHATTACHARYA, Aditi , OLSHEN, Adam B.
发明人： ALBERTSON, Donna G. , SCHMIDT, Brian L. , BHATTACHARYA, Aditi , OLSHEN, Adam B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16
摘要： The present invention provides methods of analyzing a sample from a subject having oral epithelial dysplasia or oral SCC or suspected of having oral epithelial dysplasia or oral SCC.
摘要翻译：本发明提供了分析来自具有口腔上皮发育异常或口服SCC或怀疑具有口腔上皮发育不良或口服SCC的受试者的样品的方法。

72. 发明申请

WO2011103306A1 ENERGY STORAGE SYSTEM 审中-公开
标题翻译：能源储存系统
公开(公告)号：WO2011103306A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025267
申请日：2011-02-17
申请人： DYNASEP LLC , WAIBEL, Brian J.
发明人： WAIBEL, Brian J.
IPC分类号： F25D17/02
CPC分类号： F01K3/12 , F01K9/003 , F01K25/10 , F25B6/04 , F25B25/005 , F25B27/00 , F25B2339/047 , F25B2400/24
摘要： The present invention provides an energy storage device that utilizes a cold sink that undergoes cycles of freezing and thawing. The device converts electrical energy to stored thermal energy, and then re-converts the stored thermal energy to electrical energy, as needed or desired. The device can store energy on a large scale (e.g., on the order of megawatts or greater) and for an extended period of time (e.g., for at least 12 hours, or longer, as needed).
摘要翻译：本发明提供了一种利用经历冷冻和解冻循环的冷却槽的储能装置。该装置将电能转换为储存的热能，然后根据需要或期望将储存的热能重新转换成电能。该设备可以大规模地存储能量（例如，兆瓦或更大量级），并且可以延长时间段（例如，根据需要至少12小时或更长时间）存储能量。

73. 发明申请

WO2011038142A3 BLADDER CANCER SPECIFIC LIGAND PEPTIDES 审中-公开
标题翻译：膀胱癌特异性配体肽
公开(公告)号：WO2011038142A3
公开(公告)日：2011-03-31
申请号：PCT/US2010/050037
申请日：2010-09-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PAN, Chong-xian , ZHANG, Hongyong , LAM, Kit S. , AINA, Olulanu H.
发明人： PAN, Chong-xian , ZHANG, Hongyong , LAM, Kit S. , AINA, Olulanu H.
IPC分类号： C07K7/06 , G01N33/68 , G01N33/574 , G01N33/58 , A61K38/08 , A61P35/00
摘要： The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X 1 DGRX 5 GF (SEQ ID NO:1), and methods of their use, e.g ., for imaging detection for diagnosis of bladder, tumor localization to guide transurethral resection of bladder cancer, imaging detection of bladder cancer for follow-up after the initial treatment that can replace or complement costly cystoscopy, imaging detection of metastatic bladder cancer, and targeted therapy for superficial and metastatic bladder cancer.
摘要翻译：本发明涉及膀胱癌特异性配体肽，其包含氨基酸序列X 1 DGRX_5 GF（SEQ ID NO：1））及其使用方法，例如用于膀胱诊断的成像检测，指导膀胱癌的经尿道切除的肿瘤定位，膀胱癌的成像检测以在初始治疗后进行随访可以替代或补充昂贵的膀胱镜，转移性膀胱癌的影像学检测，以及浅表性和转移性膀胱癌的靶向治疗。

74. 发明申请

WO2010101579A1 NYLON EXTRACTION FROM COMMINGLED MATERIALS 审中-公开
标题翻译：尼龙从商品材料中提取
公开(公告)号：WO2010101579A1
公开(公告)日：2010-09-10
申请号：PCT/US2009/040776
申请日：2009-04-16
申请人： DYNASEP LLC , WAIBEL, Brian, J. , SCHONEMANN, Hans , KRUKONIS, Val , LAWRENCE, David, J. , CAULFIELD, Joseph, N.
发明人： WAIBEL, Brian, J. , SCHONEMANN, Hans , KRUKONIS, Val , LAWRENCE, David, J. , CAULFIELD, Joseph, N.
IPC分类号： C08J11/08
CPC分类号： C08J11/08 , C08J2377/04 , Y02W30/701
摘要： The present invention provides energetically and economically efficient methods for separating polyamide polymer(s) from commingled materials. The methods generally involve precipitating a polyamide polymer dissolved in a solvent (e.g., formic acid) using dimethyl ether (DME) as an antisolvent. The methods comprise dissolving the polyamide polymer in a solvent that (i) selectively dissolves the polyamide polymer relative to the other materials and (ii) has a higher solubility for DME relative to the polyamide polymer; and then contacting the mixture of the solvent with the dissolved polyamide polymer with DME, thereby precipitating the polyamide polymer.
摘要翻译：本发明提供了用于将聚酰胺聚合物与混合材料分离的能量和经济有效的方法。所述方法通常涉及使用二甲醚（DME）作为反溶剂使溶解在溶剂（例如甲酸）中的聚酰胺聚合物沉淀。所述方法包括将聚酰胺聚合物溶解在溶剂中，（i）相对于其它材料选择性地溶解聚酰胺聚合物，和（ii）相对于聚酰胺聚合物具有较高的DME溶解度; 然后将溶剂与溶解的聚酰胺聚合物的混合物与DME接触，从而沉淀聚酰胺聚合物。

75. 发明申请

WO2009140206A1 IMPROVED EXPRESSION OF IL-12 FAMILY HETERODIMERS 审中-公开
标题翻译：改善IL-12家族成纤维细胞的表达
公开(公告)号：WO2009140206A1
公开(公告)日：2009-11-19
申请号：PCT/US2009/043481
申请日：2009-05-11
申请人： THE GOV. OF THE U. S. A., AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES , FELBER, Barbara, K. , PAVLAKIS, George, N.
发明人： FELBER, Barbara, K. , PAVLAKIS, George, N.
IPC分类号： C12N15/67 , C07K14/54
CPC分类号： C07K14/5434 , C07K14/54
摘要： The present invention provides methods of improving the levels and stability of expression of interleukin-12 family cytokine polypeptides by expressing the alpha and beta subunits of the polypeptides at their determined relative molar ratios that increase the levels and stability of expression of the heterodimer, e.g ., in comparison to heterodimer expressed at an equimolar ratio.
摘要翻译：本发明提供了通过以确定的相对摩尔比表达多肽的α和β亚基来提高白细胞介素-12家族细胞因子多肽的表达水平和稳定性的方法，其增加了异二聚体的表达水平和稳定性，与以等摩尔比表示的异源二聚体相比。

76. 发明申请

WO2009009439A3 SNPS ASSOCIATED WITH FATTY ACID COMPOSITION OF BOVINE MEAT AND MILK 审中-公开
公开(公告)号：WO2009009439A3
公开(公告)日：2009-01-15
申请号：PCT/US2008/069235
申请日：2008-07-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MEDRANO, Juan F. , RINCON, Gonzalo
发明人： MEDRANO, Juan F. , RINCON, Gonzalo
IPC分类号： C12Q1/68 , G06F19/00
摘要： The present invention provides compositions and methods for genotyping bovines including dairy cows and beef cattle More particularly, the invention is directed to single nucleotide polymorphisms in Stearoyl-CoA-Desaturase 5 (SCD5) Sterol regulatory element-binding protein-1 (SREBP1). SREBP cleavage-activating protein (SCAP), Insulin induced protein 1 (INSlG1). Insulin induced protein 2 (INS1G2) and Signal recognition particle receptor (SRPR) associated with fatty acid composition of bovine meat and milk.

77. 发明申请

WO2008154085A1 SIGNAL AMPLIFICATION USING CIRCULAR HAIRPIN PROBES 审中-公开
标题翻译：使用圆形毛刺探测器的信号放大
公开(公告)号：WO2008154085A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/062197
申请日：2008-05-01
申请人： BIO-RAD LABORATORIES, INC. , TAN, Woei , MOERSCHELL, Rick
发明人： TAN, Woei , MOERSCHELL, Rick
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , G01N2458/10 , C12Q2563/131 , C12Q2531/125 , C12Q2525/301
摘要： The present invention provides methods for detecting a target nucleic acid using a circular dual-hairpin probe that is formed upon the presence of the target nucleic acid. The detection methods find use in detecting the presence of antibody-antigen complexes and for detecting the binding of a ligand to its binding partner. Kits and reaction mixtures for performing the present methods are also provided.
摘要翻译：本发明提供使用在靶核酸存在下形成的环状双发夹探针来检测靶核酸的方法。检测方法用于检测抗体 - 抗原复合物的存在并检测配体与其结合配偶体的结合。还提供了用于实施本方法的试剂盒和反应混合物。

78. 发明申请

WO2008127842A1 DENSE GAS MEANS FOR EXTRACTION OF SOLUTE FROM SOLIDS 审中-公开
标题翻译：从固体中提取溶剂的气味
公开(公告)号：WO2008127842A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/057741
申请日：2008-03-20
申请人： ACCUDYNE SYSTEMS, INC. , WAIBEL, Brian J. , MORTON, Wayne C. , COPE, Sandra M.
发明人： WAIBEL, Brian J. , MORTON, Wayne C. , COPE, Sandra M.
IPC分类号： B08B7/00 , C23G1/00
CPC分类号： B01D11/0203 , B01D11/0226 , B01D11/028
摘要： The present invention provides methods and systems for the extraction of solutes from solid matter using dense gases in a mechanical auger separation system, the method comprising: a) passing the insoluble composition comprising solute into a pressurized inclined housing containing an auger; b) combining the insoluble composition with a solvent gas in either the supercritical or liquid phase to dissolve the solute c) maintaining pressure in the housing sufficient to create a biphasic dense gas comprising a vapor phase and a liquid phase; and d) rotating the auger to promote the separation of the insoluble composition from the solute; whereby the solute and the liquid phase o the dense gas flow to the bottom of the auger for removal and the insoluble composition and vapor phase of the dense gas move to th top of the auger for removal, thereby separating the solute from the Insoluble composition.
摘要翻译：本发明提供了用于在机械螺旋分选系统中使用致密气体从固体物质中提取溶质的方法和系统，所述方法包括：a）使包含溶质的不溶性组合物进入含有螺旋钻的加压倾斜壳体; b）将不溶性组合物与超临界或液相中的溶剂气体混合以溶解溶质c）保持壳体中的压力足以产生包含气相和液相的双相致密气体; 和d）旋转螺旋钻以促进不溶性组分与溶质的分离; 由此致密气体中的溶质和液相流到螺旋钻的底部以除去，并且致密气体的不溶性组成和气相移动到螺旋钻的顶部以除去，从而将溶质与不溶物组合物分离。

79. 发明申请

WO2008118644A1 TREATMENT OF FEMALE SEXUAL DYSFUNCTION BY COMPOUNDS THAT POSITIVELY MODULATE AMPA-TYPE GLUTAMATE RECEPTORS 审中-公开
标题翻译：通过化学稳定的AMPA型谷氨酸受体的化合物治疗女性性功能障碍
公开(公告)号：WO2008118644A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/056793
申请日：2008-03-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SIMMONS, Danielle , LYNCH, Gary
发明人： SIMMONS, Danielle , LYNCH, Gary
IPC分类号： A61K31/54
CPC分类号： A61K31/54
摘要： The present invention provides methods of increasing sexual arousal and performance behaviors in female mammals by administration of a therapeutically acceptable amount of a positive modulator of an AMPA-type glutamate receptor.
摘要翻译：本发明提供通过施用AMPA型谷氨酸受体的治疗上可接受量的正调节剂来增加女性哺乳动物的性唤起和性能行为的方法。

80. 发明申请

WO2008115759A3 COMPOSITIONS AND METHODS FOR REDUCING H2S LEVELS IN FERMENTED BEVERAGES 审中-公开
公开(公告)号：WO2008115759A3
公开(公告)日：2008-09-25
申请号：PCT/US2008/056847
申请日：2008-03-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BISSON, Linda F. , LINDERHOLM, Angela , DIETZEL, Kevin L.
发明人： BISSON, Linda F. , LINDERHOLM, Angela , DIETZEL, Kevin L.
IPC分类号： C12N15/63 , C12N1/00 , C12N1/15 , C07K14/00
摘要： The present invention provides compositions and methods for reducing H 2 S levels in fermented beverages.

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