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71. 发明申请

WO2013022727A1 STEERABLE CATHETERS 审中-公开
标题翻译：可变导管
公开(公告)号：WO2013022727A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049436
申请日：2012-08-03
申请人： COOK MEDICAL TECHNOLOGIES LLC , DILLON, Travis, E.
发明人： DILLON, Travis, E.
IPC分类号： A61M25/01
CPC分类号： A61M25/0136 , A61M25/0147 , A61M2025/015
摘要： A steerable catheter and a method of steering a catheter are provided. The steerable catheter includes a flexible elongate shaft having a proximal end portion, a distal end portion and a cable lumen extending from the proximal end portion to the distal end portion. The steerable catheter includes a control cable having a first portion and a second portion, the first portion of the control cable fixed in position relative to the shaft and the second portion movable relative to the shaft and at least a portion of the second portion is extendable through at least a portion of the cable lumen and extendable through the opening. The control cable has a first position where the at least the portion of the second portion is axially extendable away from a wall of the shaft and a second position for delivery of the catheter.
摘要翻译：提供了一种可导向的导管和一种导向导管的方法。可操纵导管包括柔性细长轴，其具有近端部分，远端部分和从近端部分延伸到远端部分的电缆内腔。可操纵导管包括具有第一部分和第二部分的控制电缆，控制电缆的第一部分相对于轴固定就位，第二部分可相对于轴移动，并且第二部分的至少一部分是可延伸的通过电缆内腔的至少一部分并且可以穿过开口延伸。控制电缆具有第一位置，其中第二部分的至少一部分可远离轴的壁轴向延伸，以及用于输送导管的第二位置。

72. 发明申请

WO2013003170A1 SPRING CONTROLLED STENT DELIVERY SYSTEM 审中-公开
标题翻译：弹簧控制的输送系统
公开(公告)号：WO2013003170A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/043435
申请日：2012-06-21
申请人： COOK MEDICAL TECHNOLOGIES LLC , COSTELLO, Kieran
发明人： COSTELLO, Kieran
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2002/9511 , A61F2002/9522 , A61F2002/9665
摘要： A stent delivery system (10) includes a stent (28) positioned at a stent receiving portion (29) of an elongate shaft (22), the stent having a constrained configuration (40) and an expanded configuration. A first biasing member (52) is operably connected to the shaft and the stent and a second biasing member (54) is operably connected to the shaft and the stent. The first and second biasing members have a first configuration cooperatively applying a longitudinal tensioning force to the stent and a second configuration cooperatively releasing the longitudinal tensioning force on the stent.
摘要翻译：支架输送系统（10）包括定位在细长轴（22）的支架接收部分（29）处的支架（28），所述支架具有约束构型（40）和扩张构型。第一偏置构件（52）可操作地连接到轴和支架，并且第二偏压构件（54）可操作地连接到轴和支架。第一和第二偏置构件具有协同地向支架施加纵向张紧力的第一构造和协同地释放支架上的纵向张紧力的第二构造。

73. 发明申请

WO2012177588A1 EXPANDABLE PROBE 审中-公开
标题翻译：可扩展的探测器
公开(公告)号：WO2012177588A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043061
申请日：2012-06-19
申请人： COOK MEDICAL TECHNOLOGIES LLC , MCLAWHORN, Tyler E. , SURTI, Vihar C.
发明人： MCLAWHORN, Tyler E. , SURTI, Vihar C.
IPC分类号： A61B18/14 , A61B18/18
CPC分类号： A61B18/1445 , A61B18/1815 , A61B18/20 , A61B2017/00867 , A61B2018/00488 , A61B2018/00577 , A61B2018/1467 , A61B2018/1472 , A61B2217/007
摘要： An expandable probe and a method of delivering energy to a tissue using the expandable probe are provided. The expandable probe includes an elongate shaft having a proximal portion, a distal portion, a lumen extending at least partially therethrough and a longitudinal axis. The expandable probe also includes an arm operably connected to the distal portion. The arm has a first surface including an electrode extending over at least a portion of the first surface and the electrode is operably connectable to an energy source. The arm has a closed configuration and an expanded configuration where the arm in the closed configuration extends substantially parallel to the longitudinal axis and in the expanded configuration the arm extends away from the longitudinal axis.
摘要翻译：提供了可扩展探针和使用可扩展探针将能量递送到组织的方法。可扩张探头包括细长轴，其具有近端部分，远侧部分，至少部分地穿过其延伸的内腔和纵向轴线。可扩张探头还包括可操作地连接到远端部分的臂。臂具有包括在第一表面的至少一部分上延伸的电极的第一表面，并且该电极可操作地连接到能量源。臂具有闭合构造和扩张构型，其中处于闭合构型的臂基本上平行于纵向轴线延伸，并且在扩展构造中臂延伸远离纵向轴线。

74. 发明申请

WO2011159751A1 BIFURCATED STENT INTRODUCER SYSTEM 审中-公开
标题翻译：双歧杆式引导系统
公开(公告)号：WO2011159751A1
公开(公告)日：2011-12-22
申请号：PCT/US2011/040431
申请日：2011-06-15
申请人： COOK MEDICAL TECHNOLOGIES LLC , MCHUGO, Vincent
发明人： MCHUGO, Vincent
IPC分类号： A61F2/84 , A61F2/06
CPC分类号： A61F2/954 , A61F2/966 , A61F2002/065 , A61F2002/9511 , A61F2002/9517 , A61F2002/9534 , A61F2002/9665
摘要： The stent delivery system includes first and second elongate shafts, each of said shafts including a proximal portion, a distal portion, and a lumen extending at least partially therethrough. The second elongate shaft is longitudinally movable relative to the first elongate shaft. The stent delivery system also includes a bifurcated stent having a first arm positioned on the first elongate shaft and a second arm positioned on the second elongate shaft and a main body position on the first and second elongate shafts. A proximal constraining member and first and second distal constraining member releasably connected to the stent and having a first position and a second position are also included. The said constraining members cooperatively apply longitudinal tensile force to at least a portion of the stent with the proximal and first and second distal constraining members each in the first position.
摘要翻译：支架输送系统包括第一和第二细长轴，每个所述轴包括近端部分，远端部分和至少部分地延伸穿过其中的内腔。第二细长轴相对于第一细长轴纵向移动。支架输送系统还包括分叉支架，其具有定位在第一细长轴上的第一臂和位于第二细长轴上的第二臂和在第一和第二细长轴上的主体位置。还包括近端约束构件和可释放地连接到支架并具有第一位置和第二位置的第一和第二远侧约束构件。所述约束构件协同地将纵向张力施加到支架的至少一部分，其中近侧和第一和第二远侧约束构件各自处于第一位置。

75. 发明申请

WO2011126929A1 HUB FOR LOOP TIP DEVICES 审中-公开
标题翻译：环路提示设备
公开(公告)号：WO2011126929A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/030864
申请日：2011-04-01
申请人： COOK MEDICAL TECHNOLOGIES LLC , ERICKSON, Leonard , HENNESSY, Eric, R.
发明人： ERICKSON, Leonard , HENNESSY, Eric, R.
IPC分类号： A61M25/00
CPC分类号： A61M25/0097 , A61M2025/09175
摘要： A hub device (10) is provided. The hub device includes a proximal portion having a substantially cylindrical opening defined in the proximal portion (22), a first connector (26) at a proximal end of the proximal portion for connecting to a medical device and a distal portion (24) connectable to an elongate shaft (20). The hub device further includes a lumen (36) extending from the cylindrical opening (38) in the proximal portion to a non- cylindrical cross - sectional lumen portion (46) in the distal portion of the hub device, the lumen including a distal tapered portion (44) tapering to the non - cylindrical cross sectional lumen portion. The distal tapered portion includes a first pair of longitudinal loop guides (54) positioned on opposite sides of the lumen and configured to receive and collapse a loop of an elongate device received and distally advanced through the lumen.
摘要翻译：提供了一种集线器设备（10）。所述轮毂装置包括近端部分，其具有限定在所述近端部分（22）中的基本上圆柱形的开口，在所述近端部分的近端处的第一连接器（26），用于连接到医疗装置和远端部分（24）细长轴（20）。所述轮毂装置还包括从所述近端部分中的圆柱形开口（38）延伸到所述轮毂装置的远端部分中的非圆柱形横截面内腔部分（46）的腔（36），所述内腔包括远端锥形部分（44）逐渐变细到非圆柱形横截面的内腔部分。远侧锥形部分包括位于内腔相对侧上的第一对纵向环导向件（54），并构造成容纳和折叠收容并向远端前进穿过内腔的细长装置的环。

76. 发明申请

WO2011112432A1 STENT GEOMETRY 审中-公开
标题翻译： STENT几何
公开(公告)号：WO2011112432A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027129
申请日：2011-03-04
申请人： COOK MEDICAL TECHNOLOGIES LLC , THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE , SHAH, Raj J. , DUCHARME, Richard W.
发明人： SHAH, Raj J. , DUCHARME, Richard W.
IPC分类号： A61M25/00
CPC分类号： A61M27/008 , A61F2002/041
摘要： A non-expandable stent and a method for implanting the stent are provided. The stent includes a generally tubular body having a lumen defined therethrough. The body includes a proximal portion having a curved portion configured for placement proximal to a sphincter. The body further includes a distal portion having retaining member extending outward from a proximal end of the distal portion. The retaining member is configured for placement distal to the sphincter and for engagement of the sphincter.
摘要翻译：提供了一种不扩张支架和用于植入支架的方法。支架包括具有通过其限定的内腔的大体管状体。主体包括近端部分，该近端部分具有被配置用于放置在括约肌附近的弯曲部分。所述主体还包括具有从所述远端部分的近端向外延伸的保持构件的远侧部分。保持构件构造成用于放置在括约肌的远端并且用于与括约肌的接合。

77. 发明申请

WO2010126824A1 ADAPTOR FOR AN ENDOSCOPE 审中-公开
标题翻译：适应症的内窥镜
公开(公告)号：WO2010126824A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/032398
申请日：2010-04-26
申请人： WILSON-COOK MEDICAL INC. , COOK IRELAND LIMITED , MCGRATH, Darach
发明人： MCGRATH, Darach
IPC分类号： A61B1/00 , A61B17/00 , A61B1/018
CPC分类号： A61B1/00105 , A61B1/00128 , A61B1/00133 , A61B1/00137 , A61B1/018 , A61B17/3439 , A61B2017/00296 , A61B2017/00477
摘要： An adaptor and a kit including an adaptor are provided. The adaptor is configured to connect an elongate medical device to an endoscope. The adaptor includes a first portion having a distal end sized and shaped to connect to an endoscope. The first portion includes a first opening defined therethrough. The adaptor further includes a second portion connectable to the first portion and including a second opening defined through the second portion and operably connectable to the first lumen. The second portion includes a connector at a proximal end portion sized and shaped to receive at least a portion of the elongate medical device so that a shaft of the elongate medical device is extendable distally through the first opening and the second opening and into the endoscope when the elongate medical device is connected to the adaptor.
摘要翻译：提供一个适配器和一个包含适配器的套件。适配器被配置成将细长的医疗装置连接到内窥镜。适配器包括具有尺寸和形状以连接到内窥镜的远端的第一部分。第一部分包括通过其限定的第一开口。适配器还包括可连接到第一部分的第二部分，并且包括限定穿过第二部分并且可操作地连接到第一管腔的第二开口。第二部分包括在近端部分处的连接器，其尺寸和形状设置成容纳细长医疗装置的至少一部分，使得细长医疗装置的轴可以通过第一开口和第二开口向远侧延伸并进入内窥镜，当细长的医疗设备连接到适配器。

78. 发明申请

WO2010078352A1 DELIVERY DEVICE 审中-公开
标题翻译：交货设备
公开(公告)号：WO2010078352A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069721
申请日：2009-12-29
申请人： WILSON-COOK MEDICAL INC. , COOK IRELAND LIMITED , RYAN, Michael , O'SULLIVAN, Donagh , KEADY, Fionan
发明人： RYAN, Michael , O'SULLIVAN, Donagh , KEADY, Fionan
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/9511 , A61F2002/9517 , A61F2002/9534
摘要： A delivery device (100) for deploying an expandable prosthesis and method of use thereof are described. The delivery device includes an outer sheath (1200) that is capable of retracting in a proximal direction and resheathing over the prosthesis in a distal direction. The device includes a drive pulley (901) that can engage gears (503,402) to retract or resheath the outer catheter in relation to the prosthesis. In some embodiments, the delivery device may include a reinforced outer sheath (3300) disposed over an inner elongate member, the reinforced outer sheath comprising a proximal section (3301) reinforced with a braid, a distal section (3302) reinforced with a coil and an overlapping (3303) section extending between the proximal section and the distal section. Additionally or alternatively, the delivery device may include a stabilizing element (290) for releasably holding the stent (301) to the inner catheter.
摘要翻译：描述了用于展开可扩张假体的输送装置（100）及其使用方法。输送装置包括外护套（1200），其能够在近端方向缩回并且在远端方向上再次穿过假体。该装置包括可啮合齿轮（503,402）的驱动滑轮（901），以相对于假体缩回或重新固定外导管。在一些实施例中，输送装置可以包括设置在内部细长构件上的增强外护套（3300），所述加强外护套包括用编织物增强的近端部分（3301），用线圈增强的远端部分（3302）在近端部分和远端部分之间延伸的重叠部分（3303）。附加地或替代地，递送装置可以包括用于将支架（301）可释放地保持到内导管的稳定元件（290）。

79. 发明申请

WO2022093767A1 ALPHA-2 ADRENERGIC RECEPTOR AGONISTS TO REDUCE MORTALITY AND IMPROVE OUTCOMES IN VIRAL RESPIRATORY SYNDROMES 审中-公开
公开(公告)号：WO2022093767A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056580
申请日：2021-10-26
申请人： RUSH UNIVERSITY MEDICAL CENTER
发明人： HAMILTON, John, L. , WIMMER, Markus, A.
IPC分类号： A61K31/135 , A61K31/4164 , A61K31/4168 , A61K31/4174
摘要： Methods for treating viral respiratory syndromes are disclosed. In some aspects, the methods include administering a non-sedative therapeutically effective amount of an α-2 adrenergic receptor (AR) agonist to the subject. In some aspects, the methods include administering a therapeutically effective amount of an α-2 adrenergic receptor (AR) agonist and a therapeutically effective amount of an α-1 adrenergic receptor (AR) antagonist to the subject.

80. 发明申请

WO2021231528A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
公开(公告)号：WO2021231528A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/031917
申请日：2021-05-12
申请人： RUSH UNIVERSITY MEDICAL CENTER
发明人： PAHAN, Kalipada
IPC分类号： A61K38/08 , A61P29/02 , A61P35/00 , A61P43/00 , C07K16/24
摘要： Methods of treating triple negative breast cancer (TNBC) using antibodies against p40 monomer are described herein. In some aspects, methods of treatment for TNBC include administration of antibodies against p40 monomer or administration of antibodies against p40 monomer in combination with a binding peptide such as TLR2-interacting domain of MyD88 (TIDM) peptide or NEMO- binding domain (NBD) peptide. Methods of treating other cancers using antibodies against p40 monomer in combination with a binding peptide such as TIDM peptide or NBD peptide are described herein.

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