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71. 发明申请

WO2011110570A1 TREATMENT OF STREPTOCOCCAL INFECTIONS 审中-公开
标题翻译：治疗结核感染
公开(公告)号：WO2011110570A1
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053485
申请日：2011-03-08
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , DENOEL, Philippe , HERMAND, Philippe Vincent , LABBE, Steve , POOLMAN, Jan , RIOUX, Stephane
发明人： DENOEL, Philippe , HERMAND, Philippe Vincent , LABBE, Steve , POOLMAN, Jan , RIOUX, Stephane
IPC分类号： A61K39/09 , A61P31/04
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572
摘要： The present invention discloses a method of treating or preventing a Streptococcus pneumoniae infection wherein the Streptococcus pneumoniae infection occurs in an environment where the free concentration of Zn 2+ and/or Mn 2+ is sufficiently low to upregulate the expression of at least one PhtX protein (for example PhtD) in the Streptococcus pneumoniae ; comprising the step of administering a pharmaceutically effective amount of the PhtX protein to a human patient.
摘要翻译：本发明公开了一种治疗或预防肺炎链球菌感染的方法，其中肺炎链球菌感染发生在Zn2 +和/或Mn2 +的游离浓度足够低以至上调至少一种PhtX蛋白（例如PhtD ）在肺炎链球菌中; 包括向人类患者施用药学有效量的PhtX蛋白的步骤。

72. 发明申请

WO2011051445A1 PROCESS FOR PREPARING AN INFLUENZA SEED VIRUS FOR VACCINE MANUFACTURE 审中-公开
标题翻译：制备流感病毒疫苗用于疫苗制造的方法
公开(公告)号：WO2011051445A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/066466
申请日：2010-10-29
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , FABRY, Luc Gilbert , KNOTT, Isabelle , VASSILEV, Ventzislav Bojidarov
发明人： FABRY, Luc Gilbert , KNOTT, Isabelle , VASSILEV, Ventzislav Bojidarov
IPC分类号： A61K39/145
CPC分类号： A61K39/12 , A61K2039/525 , A61K2039/55566 , A61K2039/58 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234
摘要： The present invention relates to the use of avian cell lines for the preparation of seed influenza vaccines, and to vaccines made therefrom.
摘要翻译：本发明涉及禽流式细胞系用于制备种子流感疫苗以及由其制备的疫苗。

73. 发明申请

WO2011047900A2 NOVEL PROCESS 审中-公开
标题翻译：新进程
公开(公告)号：WO2011047900A2
公开(公告)日：2011-04-28
申请号：PCT/EP2010/062103
申请日：2010-08-19
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , GERARD, Jacques, Dominique, Marie , KNOTT, Isabelle, Solange, Lucie
发明人： GERARD, Jacques, Dominique, Marie , KNOTT, Isabelle, Solange, Lucie
CPC分类号： C12M47/02 , C12M25/16
摘要： The present invention relates to a process for detaching cells of an adherent cell type from particles of carrier which comprises the steps of: (a) providing in a vessel said cells adhered to particles of carrier in the presence of a growth medium, said vessel being characterised in that it comprises two internal zones, A and B, separated by a sieve, the sieve having an aperture size such that it is pervious to the cells if detached from the particles of carrier but substantially impervious to the particles of carrier, whereby the particles of carrier having cells adhered thereto are located within zone A but not zone B and zone B contains a drain opening under control of a valve adapted to permit vacation of liquid from zone A under an influence comprising gravity and/or pressure; (b) optionally washing the particles of carrier having cells adhered thereto by vacating liquid from the vessel via the drain opening in zone B under an influence comprising gravity and/or pressure and replenishing the vessel with another wash liquid and optionally repeating this step one or more times; (c) replacing the liquid in the vessel with a detachment buffer by vacating liquid from the vessel via the drain opening in zone B under an influence comprising gravity and/or pressure and replenishing the vessel with the detachment buffer; (c) detaching the cells from the particles of carrier by a process comprising an enzymatic detachment step performed in a detachment buffer.
摘要翻译：本发明涉及从载体颗粒中分离粘附细胞类型的细胞的方法，其包括以下步骤：（a）在生长培养基存在下，在容器中提供附着于载体颗粒的细胞，所述容器为其特征在于它包括由筛子分隔的两个内部区域A和B，所述筛子具有孔径尺寸，使得如果从载体颗粒分离而基本上不透过载体颗粒，其可以透过细胞，由此具有附着细胞的细胞的颗粒位于区域A内，而不是区域B，而区域B在适于在包含重力和/或压力的影响下允许从区域A中排出液体的阀控制下包含排水口; （b）任选地在包含重力和/或压力的影响下通过区域B中的排水开口从容器中排出液体来洗涤附着细胞的载体颗粒，并用另一种洗涤液补充该容器，并任选重复该步骤一或更多次（c）通过在包含重力和/或压力的影响下通过区域B中的排水开口从容器中排出液体，用分离缓冲液代替容器中的液体，并用分离缓冲液补充容器; （c）通过包括在脱离缓冲液中进行的酶解脱离步骤的方法从载体颗粒中分离细胞。

74. 发明申请

WO2011042516A2 EXPRESSION SYSTEM 审中-公开
标题翻译：表达系统
公开(公告)号：WO2011042516A2
公开(公告)日：2011-04-14
申请号：PCT/EP2010/065047
申请日：2010-10-07
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BLAIS, Normand , DEHOTTAY, Philippe Marc Helene , DEWERCHIN, Marianne , GOFFIN, Philippe , MARTIN, Denis
发明人： BLAIS, Normand , DEHOTTAY, Philippe Marc Helene , DEWERCHIN, Marianne , GOFFIN, Philippe , MARTIN, Denis
IPC分类号： C07K14/34
CPC分类号： C07K14/34 , C07K1/00 , C07K2319/034 , C12N9/1077 , C12Y204/02036
摘要： Compositions and methods related to periplasmic expression of a toxin including diphtheria toxin or CRM197 are provided herein.
摘要翻译：本文提供了与毒素（包括白喉毒素或CRM197）的周质表达有关的组合物和方法。

75. 发明申请

WO2011036220A1 IMMUNODIFFUSION ASSAY FOR INFLUENZA VIRUS 审中-公开
标题翻译：流感病毒免疫测定
公开(公告)号：WO2011036220A1
公开(公告)日：2011-03-31
申请号：PCT/EP2010/064075
申请日：2010-09-23
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BARAS, Benoit, Guy, Jules , JACOB, Valerie, Audry, Micheline
发明人： BARAS, Benoit, Guy, Jules , JACOB, Valerie, Audry, Micheline
IPC分类号： G01N33/559
CPC分类号： G01N33/559 , C07K16/1018 , G01N33/56983 , G01N2333/11
摘要： The present invention relates to a method for performing an immunodiffusion assay comprising at least the following steps of (a) preparing one or more test samples comprising an influenza virus antigen, (b) treating the test samples with at least 5% (w/v) of detergent, (c) applying the treated test samples to a gel comprising an antibody specific to the influenza virus antigen, and (d) allowing the samples to diffuse into the gel.
摘要翻译：本发明涉及一种进行免疫扩散测定的方法，其包括至少以下步骤：（a）制备一种或多种包含流感病毒抗原的测试样品，（b）用至少5％（w / v）），（c）将经处理的测试样品施用于包含对流感病毒抗原特异性的抗体的凝胶，和（d）允许样品扩散到凝胶中。

76. 发明申请

WO2010063685A1 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2010063685A1
公开(公告)日：2010-06-10
申请号：PCT/EP2009/066089
申请日：2009-12-01
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , INSTITUT PASTEUR , BARAS, Benoit , CALLENDRET, Benoit , ESCRIOU, Nicolas , LORIN, Valerie , MARIANNEAU, Philippe , VAN DER WERF, Sylvie , WETTENDORFF, Martine, Anne, Cecile
发明人： BARAS, Benoit , CALLENDRET, Benoit , ESCRIOU, Nicolas , LORIN, Valerie , MARIANNEAU, Philippe , VAN DER WERF, Sylvie , WETTENDORFF, Martine, Anne, Cecile
IPC分类号： A61K39/39
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , A61K39/39 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , C07K16/10 , C07K2317/76 , C12N2770/20022 , C12N2770/20034
摘要： The present invention provides an immunogenic composition comprising: an immunogenic SARS coronavirus S (spike) polypeptide, or a fragment or variant thereof; and an adjuvant comprising an oil-in-water emulsion.
摘要翻译：本发明提供免疫原性组合物，其包含：免疫原性SARS冠状病毒S（穗状）多肽或其片段或变体; 和包含水包油乳剂的佐剂。

77. 发明申请

WO2010052214A2 NOVEL METHOD 审中-公开
标题翻译：新方法
公开(公告)号：WO2010052214A2
公开(公告)日：2010-05-14
申请号：PCT/EP2009/064537
申请日：2009-11-03
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , ANDRE, Bruno Rene , CHAMPLUVIER, Benoit Paul Suzanne , VAN DER HEYDEN, Benedicte
发明人： ANDRE, Bruno Rene , CHAMPLUVIER, Benoit Paul Suzanne , VAN DER HEYDEN, Benedicte
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , C12N2760/16134 , C12N2760/16151 , C12N2760/16251
摘要： The present invention relates to a method for degrading host cell nucleic acids associated with a virus or a viral antigen thereof produced by cell culture, the method comprising at least two steps of nucleic acids degradation with a compound selected from i) an endonuclease and ii) a DNA alkylating agent.
摘要翻译：本发明涉及用于降解通过细胞培养产生的与病毒或其病毒抗原相关的宿主细胞核酸的方法，所述方法包括至少两个核酸降解步骤以及选择的化合物从i）内切核酸酶和ii）DNA烷化剂。

78. 发明申请

WO2010025964A1 VACCINE COMPRISING PROTEIN NMBO964 FROM MEISSERIA MENINGITIDIS 审中-公开
标题翻译：包含蛋白质NMBO964的疫苗来自MEISSERIA MENINGITIDIS
公开(公告)号：WO2010025964A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/052689
申请日：2009-03-06
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , UTRECHT UNIVERSITY , BOS, Martine Petronella , POOLMAN, Jan , STORK, Michiel , TOMMASSEN, Johannes Petrus Maria , WEYNANTS, Vincent
发明人： BOS, Martine Petronella , POOLMAN, Jan , STORK, Michiel , TOMMASSEN, Johannes Petrus Maria , WEYNANTS, Vincent
IPC分类号： A61K39/095 , C07K14/22
CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/575 , C07K14/22 , C12P21/00
摘要： The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and therefore methods are provided to upregulated expression through removal of the zinc repression mechanism of the cell or promoter, or through removal of zinc from the culture medium.
摘要翻译：本发明涉及免疫原性组合物，其包含具有上调NMB0964抗原水平的奈瑟氏球菌，使得针对所述抗原产生杀菌抗体。首次发现该抗原的表达是锌调节的，因此通过除去细胞或启动子的锌抑制机制或通过从培养基中除去锌来提供方法来上调表达。

79. 发明申请

WO2010023260A1 VACCINE COMPOSITIONS 审中-公开
标题翻译：疫苗组合物
公开(公告)号：WO2010023260A1
公开(公告)日：2010-03-04
申请号：PCT/EP2009/061105
申请日：2009-08-28
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , INSTITUT PASTEUR , FEVRIER, Michele , LORIN, Clarisse Marie-Madeleine , TANGY, Frederic , VOSS, Gerald Hermann
发明人： FEVRIER, Michele , LORIN, Clarisse Marie-Madeleine , TANGY, Frederic , VOSS, Gerald Hermann
IPC分类号： C07K14/16 , C07K14/445 , C12N15/861 , A61K39/00
CPC分类号： A61K39/015 , A01K2207/15 , A01K2217/15 , A01K2267/0337 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2740/16034 , C12N2760/18443 , Y02A50/412
摘要： The present invention relates, inter alia, to a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more viral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said pathogen; and (iii) an adjuvant; wherein the one or more first immunogenic polypeptides, the one or more viral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, viral vectors and adjuvants.
摘要翻译：本发明尤其涉及提高针对病原体的免疫应答的方法，该方法包括施用（i）一种或多种源自所述病原体的第一免疫原性多肽; （ii）一种或多种病毒载体，其包含一种或多种编码一种或多种源自所述病原体的第二免疫原性多肽的异源多核苷酸; 和（iii）佐剂; 其中一个或多个第一免疫原性多肽，一种或多种病毒载体和佐剂同时施用。本发明还涉及使用所述多肽，病毒载体和佐剂的疫苗，药物组合物，试剂盒和用途。

80. 发明申请

WO2010010179A1 THE TUBERCULOSIS RV2386C PROTEIN, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： TUBERCULOSIS RV2386C蛋白，组合物及其用途
公开(公告)号：WO2010010179A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059585
申请日：2009-07-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , GLAXO GROUP LIMITED , BROWN, James , METTENS, Pascal , MURPHY, Dennis
发明人： BROWN, James , METTENS, Pascal , MURPHY, Dennis
IPC分类号： C12N15/60 , C12N15/61 , C12N9/88 , C12N9/90 , C07K14/35 , A61K38/51 , A61K38/52 , A61K39/04
CPC分类号： A61K39/04 , A61K38/00 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , C07K14/35 , C12N9/88 , C12N9/90
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; or (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
摘要翻译：本发明涉及一种多肽，其包含：（i）Rv2386c蛋白质序列; （ii）Rv2386c蛋白序列的变体; 或（iii）Rv2386c蛋白序列的免疫原性片段。在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。

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