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    • 69. 发明申请
    • TOPICAL FILM DELIVERY SYSTEM
    • 主题电影传送系统
    • WO2017030555A1
    • 2017-02-23
    • PCT/US2015/045546
    • 2015-08-17
    • BHALANI, Vinayak, T.PAUL, Anjan, KumarSARKAR, Ashim, Kumar
    • BHALANI, Vinayak, T.PAUL, Anjan, KumarSARKAR, Ashim, Kumar
    • A61K9/70A61K47/30A61K31/165A61K31/496A61K31/465A61K31/202A61P17/00
    • A61K31/65A61K9/0014A61K9/06A61K9/7015A61K31/167A61K31/196A61K31/202A61K31/203A61K31/465A61K31/496A61K47/10A61K47/14A61K47/32A61K47/36
    • The described invention provides a topical bioadhesive film-forming pharmaceutical composition formulated for application directly to skin or to a substrate. The composition includes a therapeutic amount of an active agent; and one or more excipients selected from the group consisting of a non-cellulosic polymer or copolymer, a film forming agent, a plasticizer, a permeation enhancer, an antioxidant, a preservative, a solubilizer, a phase transfer catalyst, a viscosity modifier, a vitamin, a mineral nutrient, a solvent, a colorant and a fragrance. It further provides a delivery system comprising the composition and a means for administering the composition. It also describes uses of the delivery system in the manufacture of a medicament for treating a skin condition, disease or disorder, and a method for treating a skin condition, disease or disorder with the composition. The composition is characterized by: controlled release. The formed film is characterized by: locally sustained levels of a minimum effective concentration (MEC) of the active agent between applications; its adherence and conformance to a surface of the skin; its pliability, its resistance to breaking under tension (tensile strength); maintained potency of the active agent; and removability of the film from the skin without a residue.
    • 所述发明提供了一种配制用于直接施用于皮肤或底物的局部生物粘附膜形成药物组合物。 该组合物包含治疗量的活性剂; 和一种或多种选自非纤维素聚合物或共聚物,成膜剂,增塑剂,渗透促进剂,抗氧化剂,防腐剂,增溶剂,相转移催化剂,粘度调节剂, 维生素,矿物质营养物质,溶剂,着色剂和香料。 它进一步提供包含组合物的递送系统和用于施用组合物的装置。 它还描述了递送系统在制备用于治疗皮肤状况,疾病或病症的药物中的用途,以及用该组合物治疗皮肤病症,疾病或病症的方法。 组合物的特征在于:控释。 形成的膜的特征在于:应用之间活性剂的最小有效浓度(MEC)的局部持续水平; 其粘附和符合皮肤表面; 其柔韧性,抗张力(抗拉强度); 保持活性剂的效力; 以及皮肤上没有残留物的膜的可去除性。