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61. 发明申请

WO2011015359A1 BIOANALYTICAL DEVICE 审中-公开
标题翻译：生物装置
公开(公告)号：WO2011015359A1
公开(公告)日：2011-02-10
申请号：PCT/EP2010/004807
申请日：2010-08-05
申请人： ETH ZURICH , BALLY, Marta , VOEROES, Janos , TAKEUCHI, Shoji , BINKERT, Andreas , DELANGE Victoria
发明人： BALLY, Marta , VOEROES, Janos , TAKEUCHI, Shoji , BINKERT, Andreas , DELANGE Victoria
IPC分类号： B01L3/00 , C04B40/00 , C12Q1/00 , G01N33/543 , C40B50/00
CPC分类号： G01N33/5436 , B01L3/502707 , B01L2200/10 , B01L2200/12 , B01L2300/069 , B01L2300/0819
摘要： The present invention relates to a bioanalytical device comprising a sensor and a thin slice obtainable from a structured three-dimensional construct containing ligands embedded in a permeable matrix in a repetitive manner.
摘要翻译：本发明涉及一种生物分析装置，其包括传感器和可从重复方式含有嵌入可渗透基质中的配体的结构化三维构建体获得的薄切片。

62. 发明申请

WO2010105276A1 METHOD FOR CONSTRUCTING MUTAGENESIS LIBRARIES IN SITU 审中-公开
标题翻译：在实验室中构建突变体的方法
公开(公告)号：WO2010105276A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027364
申请日：2010-03-15
申请人： NANJING NORMAL UNIVERSITY , SHAO, Weilan , LE, Yilin , PEI, Jianjun
发明人： SHAO, Weilan , LE, Yilin , PEI, Jianjun
IPC分类号： C40B40/02 , C40B40/04 , C40B50/00
CPC分类号： C12N15/1093 , C12N15/10 , C12N15/102 , C12N15/64 , C40B40/08 , C40B50/06
摘要： Method and kit for constructing a random mutagenesis library. The method comprises providing a first expression vector comprising a target polynucleotide fragment, providing a pair of Vector-primers that are complementary to the vector portion of the first expression vector, wherein the Vector-primers comprise a second selection marker gene, and wherein the Vector-primers allow PCR amplification of the target polynucleotide; and performing a PCR reaction using the first expression vector as the template with the Vector-primers under error-prone PCR conditions in the presence of a thermostable DNA ligase, generating a second expression vector which comprises the second selection marker gene and a mutated target polynucleotide.
摘要翻译：构建随机诱变文库的方法和试剂盒。该方法包括提供包含靶多核苷酸片段的第一表达载体，提供与第一表达载体的载体部分互补的一对载体引物，其中载体引物包含第二选择标记基因，其中载体引物允许目标多聚核苷酸的PCR扩增; 并在易热PCR条件下，在热稳定DNA连接酶的存在下，使用载体引物，使用第一表达载体作为模板进行PCR反应，产生包含第二选择标记基因和突变的靶多核苷酸的第二表达载体。

63. 发明申请

WO2009152635A1 GRADIENT-BASED SCREENING TOOLS FOR POLYMORPH DETECTION AND IDENTIFICATION 审中-公开
标题翻译：基于梯度的筛选工具，用于多聚体检测和鉴定
公开(公告)号：WO2009152635A1
公开(公告)日：2009-12-23
申请号：PCT/CH2009/000210
申请日：2009-06-19
申请人： ETH ZÜRICH , SPENCER, Nicolas , BEURER, Eva , MORGENTHALER, Sara Maria , ZÜRCHER, Stefan
发明人： SPENCER, Nicolas , BEURER, Eva , MORGENTHALER, Sara Maria , ZÜRCHER, Stefan
IPC分类号： B01J19/00 , C30B35/00 , C40B50/00 , C40B30/10
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/0038 , B01J2219/00382 , B01J2219/00527 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00702 , B01J2219/00756 , B82Y30/00 , C30B7/06 , C30B23/00 , C30B29/58
摘要： Methods, kits and crystallization templates for inducing and determining polymorphs in a compound are described herein. In one embodiment, the crystallization templates contain one or more surface-chemical and/or surface morphology gradients. The crystallization template is typically exposed to a solution or vapor containing the composition to be tested. Then the compound of interest is allowed to crystallize on the surface. The nucleation effects can be either morphological or chemical in nature. A variety of surfaces, modified either chemically or morphologically in different ways, can be used to identify the presence and types of polymorphs in a compound or composition of interest. Analysis of the crystalline structure of the tested compound may be performed by any suitable detection and analysis technique. After identifying the different polymorphs one or more polymorphs may be selected for further testing, and/or production.
摘要翻译：本文描述了用于在化合物中诱导和测定多晶型物的方法，试剂盒和结晶模板。在一个实施方案中，结晶模板包含一种或多种表面化学和/或表面形态梯度。结晶模板通常暴露于含有待测试组合物的溶液或蒸气。然后使感兴趣的化合物在表面上结晶。成核效应可以是形态或化学性质。可以以不同的方式在化学或形态学上改变的多种表面，以鉴定目的化合物或组合物中多晶型物的存在和类型。测试化合物的结晶结构的分析可以通过任何合适的检测和分析技术进行。在鉴定不同的多晶型物之后，可以选择一种或多种多晶型物用于进一步测试和/或生产。

64. 发明申请

WO2009086624A1 MICROFLUIDIC MICROARRAY SYSTEM AND METHOD FOR THE MULTIPLEXED ANALYSIS OF BIOMOLECULES 审中-公开
标题翻译：微生物微生物微生物系统和生物分子多重分析方法
公开(公告)号：WO2009086624A1
公开(公告)日：2009-07-16
申请号：PCT/CA2009/000008
申请日：2009-01-05
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY , PLA, Mateu , JUNCKER, David
发明人： JUNCKER, David
IPC分类号： B81B7/04 , B81B1/00 , B81C1/00 , C40B30/00 , C40B30/04 , C40B60/12 , G01N35/10 , C40B50/00
CPC分类号： G01N35/1011 , B01J2219/00317 , B01J2219/00367 , B01J2219/00373 , B01J2219/00533 , B01J2219/00619 , B01J2219/00621 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00691 , B01J2219/00693 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2200/0642 , B01L2300/0819 , B01L2300/0887 , B01L2400/0688 , G01N2035/1037
摘要： A microfluidic system for fluid transfer to a microarray includes a liquid transfer needle having a fluid conduit therein within which is defined a withholding pressure P1, and a microcompartment defined within the microarray, the microcompartment being configured to generate a capillary pressure P2 therein. The capillary pressure P2 is less than the withholding pressure P1, such that a defined amount of liquid is transferred from the liquid transfer needle into the microcompartment when the liquid transfer needle and the microcompartment are disposed in fluid flow communication. A method of delivering multiple solutions to a plurality of microcompartments in an microarray while avoiding cross-contamination between the solutions is also provided.
摘要翻译：用于流体转移到微阵列的微流体系统包括其中具有流体导管的液体输送针，其中限定了保持压力P1，以及限定在微阵列内的微型隔室，微型隔室被配置为在其中产生毛细管压力P2。毛细管压力P2小于滞留压力P1，使得当液体输送针和微型隔室配置成流体连通时，限定量的液体从液体输送针转移到微型隔室中。还提供了一种将多种解决方案递送到微阵列中的多个微室，同时避免溶液之间的交叉污染的方法。

65. 发明申请

WO2009023018A1 METHODS FOR SYNTHESIZING A COLLECTION OF PARTIALLY INDENTICAL POLYNUCLEOTIDES 审中-公开
标题翻译：合成部分多重多核苷酸的方法
公开(公告)号：WO2009023018A1
公开(公告)日：2009-02-19
申请号：PCT/US2007/075664
申请日：2007-08-10
申请人： CENTOCOR, INC. , KOKA, Venkata, Chalapathi Rao
发明人： KOKA, Venkata, Chalapathi Rao
IPC分类号： C40B50/00 , C12Q1/68
CPC分类号： C12N15/1093 , C12N15/1089
摘要： Methods for synthesizing a collection of partially identical polynucleotides are disclosed.
摘要翻译：公开了用于合成部分相同多核苷酸的集合的方法。

66. 发明申请

WO2009015059A1 ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES 审中-公开
标题翻译：有机碳化物催化剂：化学图谱的一次生产
公开(公告)号：WO2009015059A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/070581
申请日：2008-07-21
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , MACMILLAN, David
发明人： MACMILLAN, David
IPC分类号： C40B50/00
CPC分类号： C07C45/61 , C40B40/04 , C40B50/08
摘要： A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y β-nucleophile substituted aldehydes and/or ketones, x⋅z α- electrophile substituted aldehydes and/or ketones or x⋅y⋅z β-nucleophile substituted, α- electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced.
摘要翻译：提供了一种用于生产化学文库的方法，其中所述方法包括：在单个容器中使a）多个x的醛和/或酮酮反应; 和b）（i）多个，y的亲核试剂，（ii）多个z，亲电子体，或（i）和（ii）两者; 在c）能够催化所述多个醛和/或酮和所述多个亲核试剂之间的反应的级联催化剂，所述多个亲电子体或两者; 以获得x-y-亲核试剂取代的醛和/或酮的混合物，x·z-亲电子取代的醛和/或酮或x·y·z-亲核试剂取代的亲电取代的醛和/或酮; 和如此生产的化学文库。

67. 发明申请

WO03106413A3 PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF 审中-公开
标题翻译：用于制备氧杂环丁酮的方法及其使用方法
公开(公告)号：WO03106413A3
公开(公告)日：2005-10-20
申请号：PCT/US0233181
申请日：2002-10-17
申请人： UNIV MICHIGAN STATE , SYNTHON CORP
发明人： HOLLINGSWORTH RAWLE I , WANG GUIJUN , PADMAKUMAR RAGHAVAKAIMAL , MAO JIANMIN , ZHANG HUIPING , DAI ZONGMIN , PUTHUPARAMPIL KANAKAMMA
IPC分类号： A61K31/421 , A61K31/4245 , A61K31/427 , A61K31/4375 , A61K31/496 , A61K31/5377 , A61K31/7056 , A61P31/04 , C07B53/00 , C07B61/00 , C07D263/20 , C07D263/24 , C07D263/26 , C07D413/12 , C07D417/12 , C07D471/04 , C07H15/26 , C07H17/00 , C12Q1/18 , C40B40/04 , C40B40/12 , C40B50/00 , C07D263/06 , G01N33/53 , G01N33/543
CPC分类号： C40B40/04 , C07D263/20 , C07D263/24 , C07D413/12 , C07D417/12 , C12Q1/18 , C40B30/04 , C40B50/08 , G01N2333/31
摘要： A process for preparing N-(substituted)-C- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl) oxazolidinones is described. The process can be used to produce combinatorial libraries of the above substituted oxazolidinones in a two or three step reaction comprising a plurality of reagents differing in numbers of carbons or particular substituted oxazolidinones. A number of substituted oxazolidinones produced using the above process have been discovered to have antimicrobial activity.
摘要翻译：从光学活性物质制备N-（取代的）-C-（取代的甲基）恶唑烷酮，C-（取代的甲基）恶唑烷酮和N-（取代的）-C-（取代的乙基）恶唑烷酮，优选手性的方法描述了C-（被保护的氧甲基）恶唑烷酮。该方法可用于在两步或三步反应中产生上述取代的恶唑烷酮的组合文库，其包含多个不同碳数或特定取代的恶唑烷酮的试剂。已经发现使用上述方法制备的许多取代的恶唑烷酮具有抗微生物活性。

68. 发明申请

WO2005022362A3 CHEMICAL ADDRESS TAGS 审中-公开
公开(公告)号：WO2005022362A3
公开(公告)日：2005-03-10
申请号：PCT/US2004/028558
申请日：2004-09-02
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ROSANIA, Gustavo, R. , SHEDDEN, Kerby, A.
发明人： ROSANIA, Gustavo, R. , SHEDDEN, Kerby, A.
IPC分类号： C40B30/02 , C40B30/06 , C40B30/10 , C40B40/00 , C40B40/04 , C40B50/00
摘要： The present invention provides methods and compositions related to the fields of chemoinformatics, chemogenomics, drug discovery and development, and drug targeting. In particular, the present invention provides subcellular localization signals ( e.g. , chemical address tags) that influence ( e.g. , direct) subcellular and organelle level localization of associated compounds ( e.g. , drugs and small molecule therapeutics, radioactive species, dyes and imagining agents, proapoptotic agents, antibiotics, etc ) in target cells and tissues. The compositions of the present invention modulate the pharmacological profiles of associated compounds by influencing the compound's accumulation, or exclusion, from subcellular loci such as mitochondria, endoplasmic reticulum, cytoplasm, vesicles, granules, nuclei and nucleoli and other subcellular organelles and compartments. The present invention also provides methods for identifying chemical address tags, predicting their targeting characteristics, and for rational designing chemical libraries comprising chemical address tags.

69. 发明申请

WO0138268A9 APPARATUS AND METHOD FOR SYNTHESIZING COMBINATORIAL LIBRARIES 审中-公开
标题翻译：用于合成组合图书馆的装置和方法
公开(公告)号：WO0138268A9
公开(公告)日：2002-05-23
申请号：PCT/US0032104
申请日：2000-11-22
申请人： SELECTIDE CORP
发明人： PATEK MARCEL , PAVEL SAFAR , SMRCINA MARTIN , WEGRZYNIAK ERIC , STROP PETER , FLYNN GARY A , BAUM STEPHEN A
IPC分类号： C07B61/00 , B01J19/00 , C40B40/06 , C40B40/10 , C40B50/00 , C40B50/14 , C40B60/00 , C40B60/14 , C40B70/00 , G01N33/543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00322 , B01J2219/00328 , B01J2219/00459 , B01J2219/00461 , B01J2219/00468 , B01J2219/00472 , B01J2219/00475 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00522 , B01J2219/00527 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00664 , B01J2219/00668 , B01J2219/00675 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0819 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/543 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-lanterns and gears.
摘要翻译：一种用于合成包含多种化学化合物的组合文库的装置和方法，使得易于追踪每种化合物的化学组成。文库化合物在固相载体上合成，根据预定的方案在合成过程中在空间上排列成帧，使得每个固相载体通过一系列独特的空间2D或3D地址，通过这些独特的空间2D或3D地址，化合物可以在合成过程中的任何时间点确定。固相支架包括中空管状灯笼和齿轮。

70. 发明申请

WO01036682A2 LONG OLIGONUCLEOTIDE ARRAYS 审中-公开
标题翻译：长时间排列阵列
公开(公告)号：WO01036682A2
公开(公告)日：2001-05-25
申请号：PCT/US2000/031562
申请日：2000-11-15
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B30/04 , C40B40/06 , C40B50/00 , G01N33/566 , G01N37/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , C12Q1/6837 , C40B40/06 , C40B50/00
摘要： Long oligonucleotide arrays, as well as methods for their preparation and use in hybridization assays, are provided. The subject arrays are characterized in that at least a portion of the probes of the array, and usually all of the probes of the array, are long oligonucleotides, e.g. oligonucleotides having a length of from about 50 to 120 nt. Each long oligonucleotide probe on the array is preferably chosen to exhibit substantially the same high target binding efficiency and substantially the same low non-specific binding under conditions in which the array is employed. The subject arrays find use in a number of different applications, e.g. differential gene expression analysis.
摘要翻译：提供长的寡核苷酸阵列，以及它们在杂交测定中的制备和使用的方法。主题阵列的特征在于阵列的探针和通常所有阵列的探针的至少一部分是长的寡核苷酸，例如，长度为约50至120nt的寡核苷酸。优选选择阵列上的每个长寡核苷酸探针，以在使用阵列的条件下表现出基本相同的高靶结合效率和基本上相同的低非特异性结合。主题阵列可用于许多不同的应用，例如，差异基因表达分析。

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