专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

WO2018197495A1 NOVEL ANTI-CRISPR GENES AND PROTEINS AND METHODS OF USE 审中-公开
公开(公告)号：WO2018197495A1
公开(公告)日：2018-11-01
申请号：PCT/EP2018/060481
申请日：2018-04-24
申请人： DUPONT NUTRITION BIOSCIENCES APS , UNIVERSITÉ LAVAL (CANADA)
发明人： FREMAUX, Christophe , HORVATH, Philippe , ROMERO, Dennis A. , HYNES, Alexander , MOINEAU, Sylvain , ROUSSEAU, Geneviève
IPC分类号： C12N7/01 , C12N1/36 , C07K14/005 , C07K14/315 , C12N15/33 , C12N15/31 , C12N15/63 , C12N1/21 , C12N15/74 , C12R1/46 , C12N1/20
摘要： The invention relates to anti-CRISPR genes and anti-CRISPR proteins, and their uses in various biotechnology applications.

62. 发明申请

WO2018149982A1 NOVEL VEGFR-2 TARGETING IMMUNOTHERAPY APPROACH 审中-公开
公开(公告)号：WO2018149982A1
公开(公告)日：2018-08-23
申请号：PCT/EP2018/053918
申请日：2018-02-16
申请人： VAXIMM AG
发明人： LUBENAU, Heinz
IPC分类号： C12N1/36 , A61K39/00
摘要： [0081] The present invention relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding a VEGF receptor protein for use in cancer immunotherapy, wherein the cancer is characterized by VEGF receptor protein expressing cancer cells. The present invention further relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding a VEGF receptor protein for use in cancer immunotherapy, wherein the cancer is characterized by VEGF receptor protein expressing cancer cells, and wherein the cancer is selected from the group consisting of glioblastoma, carcinoid cancer, kidney cancer, particularly renal cell carcinoma, thyroid cancer, lung cancer, particularly Non-Small Cell Lung Cancer (NSCLC), breast cancer, ovarian cancer, prostate cancer, gastrointestinal cancer, particularly colorectal cancer, more particularly colon cancer, and skin cancer, particularly melanoma. The present invention further relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding a VEGF receptor protein for use in cancer immunotherapy in a patient comprising at least one VEGF receptor protein expressing cancer cell.

63. 发明申请

WO2017150849A1 생산성 및 안전성이 향상된 약독화 녹농균 및 이를 포함하는 백신 조성물 审中-公开
标题翻译：具有改善的生产力和安全性的减毒铜绿假单胞菌和含有其的疫苗组合物
公开(公告)号：WO2017150849A1
公开(公告)日：2017-09-08
申请号：PCT/KR2017/002059
申请日：2017-02-24
申请人： 아이진 주식회사
发明人： 조양제 , 김광성 , 이나경 , 박신애
IPC分类号： C12N1/20 , C12N1/36 , A61K39/104 , C12R1/38
CPC分类号： A61K39/104 , C12N1/20 , C12N1/36 , C12R1/38
摘要： 본 발명은 생산성 및 안정성이 향상된 신규 약독화 녹농균 및 이를 포함하는 녹농균 감염증 예방 백신 조성물에 관한 것으로, 더욱 자세하게는 수탁번호 KCTC 12901BP, KCTC 12902BP, KCTC 12903BP 또는 KCTC 12904BP의 약독화 녹농균 및 이를 포함하는 녹농균 감염증 예방 백신 조성물에 관한 것이다.
摘要翻译：
本发明的生产率和稳定是减毒铜绿假单胞菌和铜绿假单胞菌感染预防包含相同，和疫苗组合物的改进的新颖更具体地，保藏号为KCTC 12901BP，KCTC 12902BP，KCTC 12903BP或KCTC 12904BP 涉及活含有它们的减毒铜绿假单胞菌和铜绿假单胞菌感染的疫苗组合物。

64. 发明申请

WO2017140683A3 STREPTOCOCCUS UBERIS EXTRACT AS AN IMMUNOGENIC AGENT 审中-公开
公开(公告)号：WO2017140683A3
公开(公告)日：2017-08-24
申请号：PCT/EP2017/053306
申请日：2017-02-14
申请人： HIPRA SCIENTIFIC, S.L.U.
发明人： COLLADO GIMBERT, Rosa Maria , PRENAFETA I AMARGÓS, Antoni
IPC分类号： C12N1/20 , C12N1/36 , A61K39/09 , A61K35/74
摘要： The present invention relates to an extract of Streptococcus uberis as an immunogenic agent. It also relates to a process for obtaining said agent which comprises incubating a biofilm-producing S. uberis strain to obtain a biofilm and thermally treating the biofilm obtained. It relates also to a pharmaceutical composition comprising teichoic acids, preferably lipoteichoic acids, for use in the prevention and/or treatment of mastitis and/or infections caused by Streptococcus sp . or by biofilm-producing bacteria. The present invention also relates to a vaccine which comprises said immunogenic agent and to said vaccine and immunogenic agent for use in the prevention and/or treatment of infections caused by Streptococcus sp ., especially in the prevention and/or treatment of mastitis caused by S. uberis . It also relates to a vaccination kit which comprises said agent or vaccine.

65. 发明申请

WO2017072296A1 METHOD FOR ADAPTATION 审中-公开
标题翻译：适应方法
公开(公告)号：WO2017072296A1
公开(公告)日：2017-05-04
申请号：PCT/EP2016/076064
申请日：2016-10-28
申请人： METABOGEN AB
发明人： KHAN, Muhammad-Tanweer , BÄCKHED, Fredrik
IPC分类号： C12N1/36 , C12N1/20
CPC分类号： C12N1/36 , C12R1/01
摘要： The present invention relates generally to growth of bacteria. More specifically the invention relates to a method for oxidative environment adaptation of anaerobic microorganisms and their use in developing new probiotics. In particular, the present invention provides a method for adaptation of anaerobic microorganisms and selection of more oxygen tolerant anaerobic microorganisms, said method comprising the steps of culturing said microorganisms with a stepwise dual induction of oxidative stress via applied voltage and oxygen diffusion, and a stepwise change of anti-oxidant/oxidized counterpart concentration ratio to adjust the redox state. New strains are also provided.
摘要翻译：本发明一般涉及细菌的生长。更具体地说，本发明涉及厌氧微生物的氧化环境适应方法及其在开发新益生菌中的应用。具体地说，本发明提供了一种用于适应厌氧微生物和选择更多耐氧厌氧微生物的方法，所述方法包括以下步骤：通过施加的电压和氧气扩散以逐步双重诱导氧化应激来培养所述微生物，并且逐步地改变抗氧化剂/氧化对应物的浓度比来调节氧化还原状态。新的菌株也提供。

66. 发明申请

WO2016174349A1 SOUCHE DE LEVURE PRESENTANT UNE CAPACITE AMELIOREE A FERMENTER LE XYLOSE EN PRESENCE D'ACIDE ACETIQUE 审中-公开
标题翻译：在乙酸存在下，具有改善甲基纤维素的能力的YEAST菌株
公开(公告)号：WO2016174349A1
公开(公告)日：2016-11-03
申请号：PCT/FR2016/050987
申请日：2016-04-27
申请人： LESAFFRE ET COMPAGNIE
发明人： BAVOUZET, Jean-Michel , DESFOUGERES, Thomas , PIGNEDE, Georges , TECHEL, Jennifer
IPC分类号： C12N1/18 , C12N1/19 , C12N1/36 , C12P7/10 , C12R1/865
CPC分类号： C12N1/18 , C12N1/16 , C12N1/36 , C12P7/06 , C12P7/10 , C12R1/865 , Y02E50/16 , Y02E50/17
摘要： Procédé de sélection d'une souche de levure présentant une capacité améliorée à fermenter un pentose, avantageusement le xylose, en présence d'acide organique, avantageusement d'acide acétique, sous forme non dissociée, dans lequel au moins une souche de levure présentant une capacité à fermenter ledit pentose est cultivée successivement dans les 2 milieux suivants: -un premier milieu de croissance comprenant comme seule source de carbone ledit pentose et ledit acide organique sous forme non dissociée; -un deuxième milieu de croissance comprenant comme seule source de carbone une autre source de carbone, avantageusement duglucose, et dépourvu dudit acide organique sous forme non dissociée, la culture successive dans au moins ces deux milieux de croissance étant répétée au moins deux fois, en présence de concentrations croissantes en acide organique sous forme non dissociée.
摘要翻译：本发明涉及一种用于选择酵母菌株的方法，所述酵母菌株在有机酸（有利地是乙酸）的存在下以非解离形式发酵戊糖（有利地是木糖）具有改进的能力，其中至少一种能够在以下两种培养基中连续培养所述戊糖的发酵：第一生长培养基，其包含所述戊糖作为唯一的碳源，所述有机酸为非解离形式; 第二生长培养基，其包含另一个碳源作为唯一的碳源，有利的是葡萄糖，其不含所述有机酸为非解离形式，至少在所述两种生长培养基中的连续培养物在升高的浓度存在下重复至少两次的非离解形式的有机酸。

67. 发明申请

WO2016012552A1 PHAGE RESISTANT LACTIC ACID BACTERIA 审中-公开
标题翻译：耐药性酸性细菌
公开(公告)号：WO2016012552A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066910
申请日：2015-07-23
申请人： DSM IP ASSETS B.V.
发明人： KOUWEN, Roelof Hendrik Matthijs , HANEMAAIJER, Laurens Leendert , VAN SINDEREN, Douwe , MCDONNELL, Brian , MAHONY, Jennifer
IPC分类号： C12N1/20 , C12N1/36 , A23C19/032 , A23C9/123
CPC分类号： A23C9/1238 , A23C19/0323 , A23Y2240/75 , C12N1/20 , C12N1/36 , C12N15/113 , C12N15/746 , C12N15/902 , C12N2310/11
摘要： The present invention provides a method for the construction of a bacteriophage- insensitive mutant of a Streptococcus thermophilus parent strain whereby the bacteriophage insensitivity is not based on the CRISPR resistance mechanism but based on another mechanism. The method provides a protocol by which this can be achieved by inactivating one or more of the CRISPR systems present in a given strain. The invention also provides the bacteriophage-insensitive mutants as well as their use in a process for making a dairy product.
摘要翻译：本发明提供了构建嗜热链球菌亲本菌株的噬菌体不敏感突变体的方法，其中噬菌体不敏感性不是基于CRISPR抗性机制而是基于另一种机制。该方法提供了通过使给定菌株中存在的一种或多种CRISPR系统失活来实现的方案。本发明还提供了噬菌体不敏感突变体以及它们在制备乳制品的方法中的用途。

68. 发明申请

WO2015028675A1 A MICROORGANISM FOR METHIONINE PRODUCTION WITH ENHANCED METHIONINE EFFLUX 审中-公开
标题翻译：一种具有增强甲硫氨酸的甲磺酸生产微生物
公开(公告)号：WO2015028675A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068540
申请日：2014-09-01
申请人： METABOLIC EXPLORER
发明人： FIGGE, Rainer , DUMON-SEIGNOVERT, Laurence
IPC分类号： C12N1/00 , C12N1/36
CPC分类号： C12P13/12 , C12N1/00 , C12N1/36 , C12N15/70
摘要： The present invention is related to arecombinant Escherichia coli(E. coli) strain optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant strain, the methionine import is attenuated and the methionine efflux is enhanced. It is also related to a method for optimising the fermentative production of methionine or its derivatives comprising the steps of: a. culturing a recombinant microorganism wherein in said microorganism, the methionine import is attenuated and the methionine efflux is enhanced,in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and b. recovering methionine and/or its derivatives from the culture medium.
摘要翻译：本发明涉及针对甲硫氨酸和/或其衍生物的发酵产生优化的重组大肠杆菌（E.coli）菌株，其中在所述重组菌株中，甲硫氨酸进入减毒，并且甲硫氨酸流出增强。它还涉及用于优化甲硫氨酸或其衍生物的发酵生产的方法，包括以下步骤：a。培养重组微生物，其中在包含可发酵碳源和硫源的适当培养基中，在所述微生物中，导入甲硫氨酸并且甲硫氨酸流出增强，b。从培养基中回收甲硫氨酸和/或其衍生物。

69. 发明申请

WO2014180820A3 GPD-YEAST STRAINS WITH IMPROVED OSMOTOLERANCE 审中-公开
标题翻译： GPD-YEAST菌株具有改善的易感性
公开(公告)号：WO2014180820A3
公开(公告)日：2015-01-08
申请号：PCT/EP2014059193
申请日：2014-05-06
申请人： DSM IP ASSETS BV
发明人： GUADALUPE MEDINA VICTOR GABRIEL , METZ BENJAMIN , OUD BART , GRAAF VAN DER CHARLOTTE M , MANS ROBERT , PRONK JACOBUS THOMAS , MARIS VAN ANTONIUS JEROEN ADRIAAN , KLAASSEN PAUL
IPC分类号： C12N1/36 , C12N9/02 , C12N9/04 , C12N9/16 , C12N15/01 , C12P7/06 , C12R1/865
CPC分类号： C12N9/0006 , C12N1/36 , C12N9/0008 , C12N9/16 , C12N15/01 , C12P7/06 , C12R1/865 , C12Y101/01008 , C12Y102/0101 , C12Y301/03021 , Y02E50/16 , Y02E50/17
摘要： Yeast cell that is genetically modified comprising: a) a deletion or disruption of one or more nucleotide sequence selected from the group of GPD1, GPD2, GPP1 and GPP2 and b) presence of one or more heterologous nucleotide sequence encoding a NAD+-dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10.), wherein the yeast cell has an osmotolerance of 0.5 OsM or more.
摘要翻译：经遗传修饰的酵母细胞包含：a）选自GPD1，GPD2，GPP1和GPP2的一个或多个核苷酸序列的缺失或破坏，以及b）存在一个或多个编码NAD +依赖性乙酰化乙醛的异源核苷酸序列脱氢酶（EC 1.2.1.10。），其中酵母细胞具有0.5 OsM以上的渗透性。

70. 发明申请

WO2014180820A2 GPD- YEAST STRAINS WITH IMPROVED OSMOTOLERANCE 审中-公开
标题翻译： GPD- YEAST菌株具有改善的耐受性
公开(公告)号：WO2014180820A2
公开(公告)日：2014-11-13
申请号：PCT/EP2014/059193
申请日：2014-05-06
申请人： DSM IP ASSETS B.V.
发明人： GUADALUPE MEDINA, Victor Gabriel , METZ, Benjamin , OUD, Bart , GRAAF, VAN DER, Charlotte M , MANS, Robert , PRONK, Jacobus Thomas , MARIS, VAN, Antonius Jeroen Adriaan , KLAASSEN, Paul
IPC分类号： C12N1/36
CPC分类号： C12N9/0006 , C12N1/36 , C12N9/0008 , C12N9/16 , C12N15/01 , C12P7/06 , C12R1/865 , C12Y101/01008 , C12Y102/0101 , C12Y301/03021 , Y02E50/16 , Y02E50/17
摘要： Yeast cell that is genetically modified comprising: a) a deletion or disruption of one or more nucleotide sequence selected from the group of GPD1, GPD2, GPP1and GPP2 and b) presence of one or more heterologous nucleotide sequence encoding a NAD+- dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10.), wherein the yeast cell has an osmotolerance of 0.5 OsM or more.
摘要翻译：经遗传修饰的酵母细胞包含：a）选自GPD1，GPD2，GPP1和GPP2组的一个或多个核苷酸序列的缺失或破坏; b）存在编码NAD +依赖性乙酰化乙醛脱氢酶的一个或多个异源核苷酸序列（EC 1.2.1.10。），其中酵母细胞的耐渗透性为0.5OmM以上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式