专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

WO1994029262A1 LIPOXIN COMPOUNDS 审中-公开
标题翻译： LIPOXIN化合物
公开(公告)号：WO1994029262A1
公开(公告)日：1994-12-22
申请号：PCT/US1994006822
申请日：1994-06-15
申请人： BRIGHAM & WOMEN'S HOSPITAL
发明人： BRIGHAM & WOMEN'S HOSPITAL , SERHAN, Charles, N.
IPC分类号： C07C69/732
CPC分类号： C07C59/58 , C07C59/42 , C07C59/46 , C07C59/52 , C07C69/732 , C07C69/734 , C07C69/736 , C07C2601/14
摘要： Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. These small molecules are useful for treating vasoconstrictive, inflammatory, myeloid suppressive, cardiovascular, and gastrointestinal diseases.
摘要翻译：公开了具有天然脂氧素活性位点但具有较长组织半衰期的化合物。这些小分子可用于治疗血管收缩，炎症，骨髓抑制，心血管和胃肠道疾病。

62. 发明申请

WO1990003962A1 PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-HEPT-6-ENOIC AND -HEPTANOIC ACIDS AND DERIVATIVES AND INTERMEDIATES THEREOF 审中-公开
标题翻译：制备7-取代的六羟基-6-羟基和己二酸及其衍生物的方法及其中间体
公开(公告)号：WO1990003962A1
公开(公告)日：1990-04-19
申请号：PCT/EP1989001201
申请日：1989-10-11
申请人： SANDOZ AG
发明人： SANDOZ AG , CHEN, Kau-Ming , KAPA, Prasad, Koteswara , LEE, George, T. , REPIC, Oljan , HESS, Petr , CREVOISIER, Michel
IPC分类号： C07C69/732
CPC分类号： C07D233/64 , C07C51/367 , C07C59/48 , C07C223/02 , C07D209/12 , C07D209/24 , C07C59/46 , C07C59/11 , C07C59/115 , C07C59/56
摘要： A novel process for the preparation of compounds of formula (I), wherein X is -CH2CH2- or -CH=CH-; R1 is an ester group inert to the reaction conditions; and R is an organic radical having groups which are inert under reducing conditions, by stereoselective reduction of a corresponding compound of formula (II), wherein R, R1 and X are as defined above and one of Z1 and Z2 is oxygen and the other is hydroxy and hydrogen, is disclosed. The process may also be applied to the preparation of compounds of formula (Iu), wherein u is triphenylmethyl (trityl) and Ru is allyl or a radical forming an ester inert under the reaction conditions, which are intermediates in the preparation of some of the compounds of formula (I). A specific embodiment of the above inventive concept is illustrated with the preparation of the compound of formula (Ia) in racemic or optically pure form; in free acid, salt, ester or δ-lactone, i.e. internal ester, form. The compounds of formula (I) are pharmaceuticals, especially antiatherosclerotic, antihyperlipidemic and antihypercholesterolemic agents.

63. 发明申请

WO1989009202A1 METHOD OF CRYSTALLIZATION AND PURIFICATION FOR OBTAINING STABE 'beta' CRYSTAL OF TETRAKIS[3-(3,5-DI-TERTIARY-BUTYL-4-HYDROXYPHENYL)PROPIONYLOXYMETHYL]METHANE ON AN INDUSTRIAL SCALE 审中-公开
标题翻译：用于获得TETRAKIS的稳定化和纯化方法[3-（3,5-二叔丁基-4-羟基苯基）丙炔基]甲基]工业规模甲烷
公开(公告)号：WO1989009202A1
公开(公告)日：1989-10-05
申请号：PCT/JP1989000333
申请日：1989-03-29
申请人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. , NARITA, Tadatsugu , MARUNO, Makoto
发明人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
IPC分类号： C07C69/732
CPC分类号： C07C67/48 , C07C69/732
摘要： An industrial method for crystallizing and purifying tetrakis[3-(3,5-di-tertiary-butyl-4-hydroxyphenyl)propionyloxymethyl]methane which comprises stabilizing the beta crystal structure produced by dissolving in a water-soluble solvent under reflux a reaction mixture containing tetrakis [3-(3,5-di-tertiary-butyl-4-hydroxyphenyl)propionyloxymethyl]methane obtained by transesterification between pentaerythritol and a lower alkyl ester of 3-(3,5-di-tertiary-butyl-4-hydroxyphenyl)propionic acid crystallizing the obtained solution by pouring it into a cooled solvent composed of a water-soluble solvent in an amount 0.2 - 1.5 times by weight of the reaction mixture and water in an amount 0.06 - 0.09 time by weight of the water-soluble solvent. This method will not cause operational inconveniences such as scaling and incapability of agitation resulting from particle size reduction. It is also possible to manufacture, with stability and ease, the aforementioned compounds in the form of beta crystal which is white in color, excellent in hue and practically satisfactory in purity, on an industrial scale.
摘要翻译：一种用于结晶和纯化四[3-（3,5-二叔丁基-4-羟基苯基）丙酰氧基甲基]甲烷的工业方法，其包括将通过在回流下溶解在水溶性溶剂中而产生的β晶体结构稳定反应混合物通过季戊四醇与3-（3,5-二叔丁基-4-羟基苯基）的低级烷基酯的酯交换得到的含有四[3-（3,5-二叔丁基-4-羟基苯基）丙酰氧基甲基]甲烷的四[ ）丙酸将所得溶液倒入由反应混合物重量的0.2〜1.5倍的水溶性溶剂组成的冷却溶剂中，水的重量计为0.06〜0.09倍溶剂。该方法不会引起诸如由于粒径减小引起的搅动和搅拌不能引起的操作上的不便。也可以以稳定和容易的方式制造上述化合物，其为白色，白色，色纯度优异，纯度实际满意的β晶型。

64. 发明申请

WO1989005789A1 METHOD OF EXTRACTING PENTAERYTHRYL-TETRAKIS-[3-(3,5-DITERT. BUTYL-4-OXYPHENYL)PROPIONATE] FROM THE REACTION MASS OBTAINED DURING SYNTHESIS OF SAID PRODUCT 审中-公开
标题翻译：从合成产品中获得的反应物质中提取戊二酸四丁酯（3-（3,5-二叔丁基-4-氧代苯基）丙酸酯）的方法
公开(公告)号：WO1989005789A1
公开(公告)日：1989-06-29
申请号：PCT/SU1987000144
申请日：1987-12-14
申请人： NAUCHNO-ISSLEDOVATELSKY INSTITUT KHIMIKATOV DLYA ...
发明人： NAUCHNO-ISSLEDOVATELSKY INSTITUT KHIMIKATOV DLYA ... , GLUSHKOVA, Ljudmila Vasilievna , BELOVA, Svetlana Jurievna , PARAMONOV, Vladimir Ivanovich , GORBUNOV, Boris Nikolaevich , EGIDIS, Felix Mikhailovich
IPC分类号： C07C69/732
CPC分类号： C07C67/52 , C07C69/732
摘要： A method of extracting pentaerythryl-tetrakis-[3-(3,5-ditert.-butyl-4-oxyphenyl)propionate] from the reaction mass obtained during the synthesis of said product by means of reetherification of methyl ether 3-(3,5-ditert. butyl-4-oxyphenyl) propionic acid by pentaerythrite in the presence of an alkaline catalyst, and consisting of the desired product, initial non-reacted reagents, secondary reaction products, resinous oxidation products and residues of the alkaline catalyst, provides for treating the reaction mass with cyclohexane (the volume ratio between the reaction mass and the cyclohexane being 1:1.2-2) at a reaction mass temperature of 100-120°C, separating by filtration the initial non-reacted pentaerythrite and the residues of the alkaline catalyst at a temperature of 60-75°C, thus obtaining the cyclohexane solution of this desired product, the initial non-reacted methyl ether, secondary reaction products and the resinous oxidation products. The cyclohexane solution is cooled to a temperature of 15-20°C, so as to obtain a crystalline sediment of a combination of the desired product occlusions with the cyclohexane. The sediment is separated by filtration and dissolved in normally structured hydrocarbons at a temperature of 45-75°C and at a weight ratio between the sediment and the hydrocarbons equal to 1:1-2, respectively, the combination with occlusions being decomposed and the desired product being thus obtained. The desired product is extracted by crystallization from said hydrocarbons at 15-20°C. The desired product is a highly effective non-toxic antioxidant for polymer materials.

65. 发明申请

WO2022233919A2 SPIN ON METAL-ORGANIC FORMULATIONS 审中-公开
公开(公告)号：WO2022233919A2
公开(公告)日：2022-11-10
申请号：PCT/EP2022/061946
申请日：2022-05-04
申请人： MERCK PATENT GMBH
发明人： POLISHCHUK, Orest , KUDO, Takanori
IPC分类号： C01G25/02 , C23C18/12 , C07C39/15 , C07C39/17 , C07C69/732 , C07D311/92 , C07F7/00 , C07C69/73 , C07F7/003 , C23C18/1216 , C23C18/1295
摘要： The disclosed and claimed subject matter relates to spin-on metal-organic formulations that include zirconium.

66. 发明申请

WO2022213904A1 分子内复合型受阻酚化合物、其制备方法及应用审中-公开
公开(公告)号：WO2022213904A1
公开(公告)日：2022-10-13
申请号：PCT/CN2022/084886
申请日：2022-04-01
申请人：天津利安隆新材料股份有限公司
发明人：孙春光 , 林旭锋 , 范小鹏 , 李海平
IPC分类号： C07C69/732 , C07C67/03 , C09K15/00
摘要：本发明提供了一种分子内复合型受阻酚化合物、其制备方法及应用。该分子内复合型受阻酚化合物，其具有式I所示结构，其中，m为1～3，n为1～3，且m+n为4。本发明提供的分子内复合型受阻酚化合物具有良好的自身耐黄变性特性，且兼具了抗氧化效率高、与基体相容性好、熔点低、应用范围广等优势，尤其是用于塑料加工领域显示了耐NOx的着色性，具有良好的应用性能。

67. 发明申请

WO2021179094A1 COMPOSITION AND USE OF A CAFFEIC ACID PHENETHYL ESTER (CAPE) COMPOUND TO TREAT CANCER 审中-公开
公开(公告)号：WO2021179094A1
公开(公告)日：2021-09-16
申请号：PCT/CA2021/050339
申请日：2021-03-15
申请人： UNIVERSITY OF NEW BRUNSWICK
发明人： MURUGESAN, Alli , REIMAN, Anthony
IPC分类号： A61K31/216 , A61P35/00 , C07C69/732
摘要： Methods, compositions and uses of combination treatments for cancers are disclosed including administering to the patient a therapeutically effective amount of CAPE or CAPE analog(s), and CAPE or CAPE analog(s) in combination with a histone deacetylase inhibitor or an Immunomodulatory class of compounds or Sp1 or a MYC regulating agent, wherein administration of such combinations reduces the number or growth of cancer cells or the tumor burden or tumour growth in the patient, thereby treating the patient.

68. 发明申请

WO2021169241A1 一种可实现低聚蓖麻油酸酯制备和原位分离的方法审中-公开
公开(公告)号：WO2021169241A1
公开(公告)日：2021-09-02
申请号：PCT/CN2020/114192
申请日：2020-09-09
申请人：南开大学 , 天津南开大学蓖麻工程科技有限公司
发明人：叶锋 , 何良年 , 李红茹 , 李刚 , 游飞 , 王庆瑞 , 高嵩 , 何兴 , 崔晓莹
IPC分类号： C07C67/08 , C07C67/58 , C07C69/732 , C10M145/22 , C10N30/06 , C10N30/08 , C10N40/22
摘要：一种可实现低聚蓖麻油酸酯制备和原位分离的方法，以蓖麻油酸为原料，以质子酸型离子液体为催化剂，使蓖麻油酸分子之间发生脱水酯化反应，在减压条件下将生成的水不断蒸出，可获得聚合度在2～10之间的低聚蓖麻油酸酯。反应结束后，根据催化剂特性，选择水洗或静置分层的方法回收催化剂。该方法使用可再生原料，工艺清洁无污染，操作简单，产品在金属切削和食品、医药工业具有广泛的应用。

69. 发明申请

WO2021167074A1 光反応性基を含む化合物、重合体、位相差膜审中-公开
公开(公告)号：WO2021167074A1
公开(公告)日：2021-08-26
申请号：PCT/JP2021/006403
申请日：2021-02-19
申请人：東ソー株式会社
发明人：坂下　竜一 , 村上　範武 , 一條　洋樹 , 七田　優輝
IPC分类号： G02B5/30 , C08G63/193 , C07C69/732 , C07C69/734
摘要：配向膜を必要とせず、偏光紫外線照射または斜め入射紫外線照射、および加熱処理により、優れた液晶配向性を示す光学薄膜、およびそれからなる位相差膜を得ることを目的とする。　目的は、以下の式（１）で表される化合物、によって達成された。式中、Ｘ１～Ｘ３は所定の芳香環等、Ｙ１およびＹ２はヒドロキシ基等、Ａｒ１およびＡｒ２は所定の芳香環、Ｒ１～Ｒ４は水素原子等、Ｌ１およびＬ４は単結合等、Ｌ２およびＬ３は単結合等、Ｒ７およびＲ８は水素原子等、ａおよびｂは０または１を表す。

70. 发明申请

WO2021123904A1 POLYMERIC FATTY ACID COMPOUNDS FOR THE TREATMENT OF FIBROUS AMINO ACID-BASED SUBSTRATES, ESPECIALLY HAIR 审中-公开
公开(公告)号：WO2021123904A1
公开(公告)日：2021-06-24
申请号：PCT/IB2020/001036
申请日：2020-12-15
申请人： MOMENTIVE PERFORMANCE MATERIALS GMBH
发明人： WAGNER, Roland , STREICHER, Katharina , ROHMANN, Laura , WENSKE, Christian , HAVELI, Shrutisagar, Dattatraya
IPC分类号： C07C69/732 , C07C211/63 , A61Q5/00 , A61K8/375 , A61K8/41 , A61K8/416 , A61K8/922 , A61Q5/02 , A61Q5/12 , C07C219/06 , C07C219/08 , C07C229/12 , C07C229/16
摘要： The present invention is directed at mono-, di- or polyquaternary ammonium compounds of the formula (I) wherein x is 1 to 50, and F can be the same or different and is represented by the general formula (II) wherein at least one of the optionally substituted and optionally functional-group-containing hydrocarbon radicals R1, R2, R3, R4 or R5 contains at least one estolide moiety comprising two or more ester or amide moieties. The invention also relates to a process for the synthesis of such compounds, the use of the compounds in cosmetic formulations for skin and hair care, cosmetic compositions for the treatment of fibers, and compositions containing one or more of the compounds for the treatment of hair.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式