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61. 发明申请

WO2013184527A1 OPTIMIZED METHODS FOR GENERATION OF CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY 审中-公开
标题翻译： CARDIAC组织中心脏干细胞生成的优化方法及其在心脏病治疗中的应用
公开(公告)号：WO2013184527A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/043772
申请日：2013-05-31
申请人： CAPRICOR, INC.
发明人： KREKE, Michelle , SMITH, Rachel
IPC分类号： A61K35/34 , A61K35/12 , A61K45/00 , A61P9/00 , C12N5/02
CPC分类号： A61K35/34 , A61K35/00 , C12N5/0657 , C12N2500/32 , C12N2501/91 , C12N2509/00 , C12N2523/00
摘要： The present disclosure relates generally to methods for the increased processing of tissue for the generation of cardiac stem cells, wherein the stem cells are suitable for use in cardiac stem cell therapy. In particular, several embodiments relate to the processing of allogeneic donor cardiac tissue for the generation of multiple patient doses of cardiac stem cells.
摘要翻译：本公开一般涉及增加用于产生心脏干细胞的组织处理的方法，其中所述干细胞适合用于心脏干细胞治疗。特别地，几个实施方案涉及用于产生多个患者剂量的心脏干细胞的同种异体供体心脏组织的处理。

62. 发明申请

WO2013119118A1 EX VIVO NK CELL DIFFERENTIATION FROM CD34+ HEMATOPOIETIC CELLS 审中-公开
标题翻译：从CD34 + HEMATOPOIETIC细胞的EX VIVO NK细胞分化
公开(公告)号：WO2013119118A1
公开(公告)日：2013-08-15
申请号：PCT/NL2013/050073
申请日：2013-02-07
申请人： IPD-THERAPEUTICS B.V.
发明人： SPANHOLTZ, Jan
IPC分类号： A61K35/14 , C12N5/0783
CPC分类号： C12N5/0646 , A61K35/17 , A61K39/39558 , C12N2501/125 , C12N2501/145 , C12N2501/21 , C12N2501/22 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2501/26 , C12N2501/91
摘要： The present invention relates to the ex vivo differentiation of NK cells from CD34 + hematopoietic stem cells. Such NK cells and their progenitor cells can be used in therapies of a broad range of malignancies. In the present invention it is shown that IL-12 modulates ex vivo NK cell differentiation. Specific, we achieved significantly higher expression of KIR, CD16 and CD62L in the presence of IL-12 in the cell culture system. The induction of receptor expression by IL-12 occurred predominantly on an augmented population of CD33+NKG2A+ NK cells early during NK cell differentiation. These cells further show enhanced cytolytic activity against MHC class I positive AML targets. In line with the enhanced CD16 expression, IL-12 modulated ex vivo generated NK cells exhibit an improved antibody-dependent-cytotoxicity, using anti CD20 antibody on various B cell targets. Additional to the enhanced expression of CD62L, we show that this cell population consists of a specific chemokine receptor profile. By showing an increased capacity for adhesion to lymphendothelial cells and a specific chemokine receptor profile, we show that IL-12 provided the ex vivo generated NK cells with specific tissue-homing abilities.
摘要翻译：本发明涉及NK细胞从CD34 +造血干细胞的离体分化。这种NK细胞及其祖细胞可用于广泛恶性肿瘤的治疗。在本发明中，显示IL-12调节离体NK细胞分化。具体来说，我们在细胞培养系统中，在IL-12存在下，实现了KIR，CD16和CD62L的显着更高的表达。 IL-12受体表达的诱导主要发生在NK细胞分化早期CD33 + NKG2A + NK细胞增殖群体上。这些细胞进一步显示对MHC I类阳性AML靶标的细胞溶解活性增强。根据增强的CD16表达，IL-12调节的离体产生的NK细胞在各种B细胞靶上使用抗CD20抗体表现出改善的抗体依赖性细胞毒性。除了增强CD62L的表达外，我们还显示这种细胞群由特异性趋化因子受体谱组成。通过显示增加粘附于淋巴细胞上皮细胞和特定趋化因子受体分布的能力，我们显示IL-12提供具有特定组织定位能力的离体产生的NK细胞。

63. 发明申请

WO2013090919A1 FGF-2 HAVING ENHANCED STABILITY 审中-公开
标题翻译： FGF-2具有增强的稳定性
公开(公告)号：WO2013090919A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/070166
申请日：2012-12-17
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , CHEN, Guokai , THOMSON, James, A. , HOU, Zhonggang
发明人： CHEN, Guokai , THOMSON, James, A. , HOU, Zhonggang
IPC分类号： C07K14/50 , C12N5/0735 , C12N5/071
CPC分类号： C12N5/0606 , C07K14/503 , C12N5/0607 , C12N5/0696 , C12N2501/115 , C12N2501/91
摘要： Thermostable FGF-2 proteins having enhanced ability to support human pluripotent stem cell cultures are provided. Also provided are methods and compositions utilizing thermostable FGF-2 proteins.
摘要翻译：提供了具有增强的支持人多能干细胞培养能力的热稳定性FGF-2蛋白质。还提供了使用热稳定性FGF-2蛋白质的方法和组合物。

64. 发明申请

WO2012020101A1 METHOD FOR PRODUCING CELLS HAVING CHARACTERISTICS OF HEPATOCYTES 审中-公开
标题翻译：用于生产具有肝细胞特征的细胞的方法
公开(公告)号：WO2012020101A1
公开(公告)日：2012-02-16
申请号：PCT/EP2011/063871
申请日：2011-08-11
申请人： GERBES, Alexander , BENESIC, Andreas
发明人： GERBES, Alexander , BENESIC, Andreas
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , C12N2500/40 , C12N2501/11 , C12N2501/119 , C12N2501/22 , C12N2501/2303 , C12N2501/33 , C12N2501/335 , C12N2501/91 , C12N2506/115
摘要： The present invention relates to a method of producing cells having at least one characteristic of human hepatocytes as well as to cells produced by said method and uses of these cells.
摘要翻译：本发明涉及生产具有人肝细胞的至少一种特征的细胞的方法以及通过所述方法产生的细胞和这些细胞的用途。

65. 发明申请

WO2011108766A1 METHOD FOR DIAGNOSING A PROTEIN MISFOLDING DISEASE USING NERVE CELLS DERIVED FROM iPS CELLS 审中-公开
标题翻译：使用从iPS细胞衍生的神经细胞诊断蛋白质失调疾病的方法
公开(公告)号：WO2011108766A1
公开(公告)日：2011-09-09
申请号：PCT/JP2011/055570
申请日：2011-03-03
申请人： KYOTO UNIVERSITY , RIKEN , INOUE, Haruhisa , KITAOKA, Shiho , YAHATA, Naoki , IWATA, Nobuhisa , SAIDO, Takaomi
发明人： INOUE, Haruhisa , KITAOKA, Shiho , YAHATA, Naoki , IWATA, Nobuhisa , SAIDO, Takaomi
IPC分类号： C12N15/09 , C12Q1/02 , G01N33/48 , G01N33/50
CPC分类号： G01N33/6896 , C12N5/0619 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/155 , C12N2501/385 , C12N2501/41 , C12N2501/91 , C12N2503/02 , C12N2506/00 , C12N2506/45 , C12N2533/32 , G01N2333/4709 , G01N2333/96486 , G01N2800/2821
摘要： The present invention provides a method for detecting onset of, or the risk of development of, a protein misfolding disease, and a method for predicting the age of onset of a protein misfolding disease using nerve cells derived from iPS cells. The present invention also provides a kit to be used in these methods.
摘要翻译：本发明提供了一种用于检测蛋白质错折叠疾病的发病或发展的风险的方法，以及使用源自iPS细胞的神经细胞来预测蛋白质错折叠疾病发病年龄的方法。本发明还提供了用于这些方法的试剂盒。

66. 发明申请

WO2011045765A1 TEMPORALLY PATTERNED OVEREXPRESSION OF Foxg1 AND Emx2 TRANSCRIPTION FACTOR GENES IN NEURAL PRECURSORS FOR BRAIN TISSUE REPAIR 审中-公开
标题翻译： Foxg1和Emx2转录因子在脑组织修复的神经前体中的过度表达
公开(公告)号：WO2011045765A1
公开(公告)日：2011-04-21
申请号：PCT/IB2010/054657
申请日：2010-10-14
申请人： SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI , BRANCACCIO, Marco , MALLAMACI, Antonio
发明人： BRANCACCIO, Marco , MALLAMACI, Antonio
IPC分类号： A61K48/00 , C12N15/867 , C12N5/0797
CPC分类号： C12N5/0623 , A61K48/00 , C12N15/86 , C12N2500/34 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/60 , C12N2501/91 , C12N2510/00 , C12N2740/16043 , C12N2830/003 , C12N2830/008
摘要： The present invention relates to a recombinant expression vector suitable for gene therapy and able to effectively express in a differentially state specific manner Emx2 and/or Foxg polypeptides or functional fragments thereof in neural stem cells (NSCs) and/or in neuron- restricted progenitors (NPs)as well as a neural stem cell (NSCs), or a neuron-restricted progenitor (NPs) cell or a mixed cell population thereof transformed with such10 recombinant expression vector.
摘要翻译：本发明涉及适用于基因治疗并能够以差异状态特异性方式有效表达神经干细胞（NSCs）和/或神经元限制性祖细胞中的Emx2和/或Foxg多肽或其功能片段的重组表达载体 NPs）以及用这种10个重组表达载体转化的神经干细胞（NSCs）或神经元限制性祖细胞（NPs）细胞或其混合细胞群体。

67. 发明申请

WO2010011185A1 STEM CELLS OBTAINED THROUGH IN VITRO CULTURE WITH HEPARAN SULFATE 审中-公开
标题翻译：通过与HEPARAN硫酸盐在体外培养物获得的STEM细胞
公开(公告)号：WO2010011185A1
公开(公告)日：2010-01-28
申请号：PCT/SG2009/000255
申请日：2009-07-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , COOL, Simon McKenzie , NURCOMBE, Victor
发明人： COOL, Simon McKenzie , NURCOMBE, Victor
IPC分类号： C12N5/06 , A61K35/12
CPC分类号： C12N5/0647 , C12N5/0663 , C12N2501/91
摘要： The present invention relates to cell cultures, methods and pharmaceutical compositions comprising stem cells, in particular mesenchymal stem cells (hMSC), obtained though in vitro culture with heparan sulphate, preferably HS-2. The invention further relates to the provision of therapeutic numbers of multipotent stem cells.
摘要翻译：本发明涉及细胞培养物，方法和药物组合物，其包括干细胞，特别是间充质干细胞（hMSC），通过体外培养硫酸乙酰肝素，优选HS-2获得。本发明还涉及提供治疗数量的多能干细胞。

68. 发明申请

WO2009057313A1 内皮前駆細胞（ＥＰＣ）の増殖・分化誘導方法审中-公开
标题翻译：诱导内皮祖细胞增殖/分化的方法
公开(公告)号：WO2009057313A1
公开(公告)日：2009-05-07
申请号：PCT/JP2008/003125
申请日：2008-10-30
申请人：国立大学法人旭川医科大学 , 川辺淳一 , 牛首文隆
发明人：川辺淳一 , 牛首文隆
IPC分类号： C12N5/06 , A61K35/12 , A61P9/10 , C12N15/09
CPC分类号： C12N5/0692 , A61K35/12 , C12N2501/02 , C12N2501/91
摘要：内皮前駆細胞（ＥＰＣ）の増殖効率や内皮細胞への分化効率がより高く、より安全でより低コストな、ＥＰＣの増殖・分化方法を提供するものである。プロスタサイクリン又はプロスタサイクリンアナログ、及び、ヘパリン存在下で、内皮前駆細胞（ＥＰＣ）をインビトロ培養することにより、ＥＰＣの増殖効率を向上させると共に、内皮細胞への分化効率を向上させることが可能となった。この知見を利用することにより、上記課題を解決することができる。
摘要翻译：公开了一种内皮祖细胞（EPC）增殖/分化方法，其具有较高的EPC增殖效率和更高分化效率的EPC进入内皮细胞，其更安全，并且可以以较低的成本进行。通过在前列环素或前列环素类似物和肝素存在下体外培养EPCin可以改善内皮祖细胞（EPC）的增殖效率和EPC对内皮细胞的分化效率。

69. 发明申请

WO2008153813A3 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 审中-公开
标题翻译：使用肌肉衍生的孕激素组合物的骨质康复及其治疗
公开(公告)号：WO2008153813A3
公开(公告)日：2009-02-12
申请号：PCT/US2008006781
申请日：2008-05-29
申请人： UNIV PITTSBURGH , PAYNE THOMAS , PRUCHNIC RYAN , JANKOWSKI RONALD
发明人： PAYNE THOMAS , PRUCHNIC RYAN , JANKOWSKI RONALD
IPC分类号： A61K35/34 , A61K35/12 , A61P43/00 , C12N5/077
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0654 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2506/13 , C12N2510/00
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加非软组织进入非软组织部位（例如，骨）。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供了使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类骨组织，以治疗各种功能状况，包括骨质疏松症，佩吉特氏病，成骨不全，骨折，骨软化，减少在骨小梁强度，骨皮质强度下降和老年骨密度降低。

70. 发明申请

WO2008153813A2 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 审中-公开
标题翻译：使用肌肉衍生的孕激素组合物的骨质康复及其治疗
公开(公告)号：WO2008153813A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/006781
申请日：2008-05-29
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , PAYNE, Thomas , PRUCHNIC, Ryan , JANKOWSKI, Ronald
发明人： PAYNE, Thomas , PRUCHNIC, Ryan , JANKOWSKI, Ronald
IPC分类号： A61K35/34 , A61K35/12 , C12N5/08 , A61P43/00
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0654 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2506/13 , C12N2510/00
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加非软组织进入非软组织部位（例如，骨）。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供了使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类骨组织，以治疗各种功能状况，包括骨质疏松症，佩吉特氏病，成骨不全，骨折，骨软化，减少在骨小梁强度，骨皮质强度下降和老年骨密度降低。

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