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61. 发明申请

WO1985001224A1 SOLID PHASE PEPTIDE SYNTHESIZER 审中-公开
标题翻译：固相肽合成仪
公开(公告)号：WO1985001224A1
公开(公告)日：1985-03-28
申请号：PCT/US1984001486
申请日：1984-09-20
申请人： SANEII, Hossain, H.
IPC分类号： B01J14/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00389 , B01J2219/00418 , B01J2219/00488 , B01J2219/005 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： A method and apparatus for peptide synthesis in which a plurality of supply valves (5, 11, 21, 26, 48) are arranged in series to define a line (6, 45) for supplying successive reagents to a reaction vessel (35) in which a peptide is to be synthesized. A plurality of containers (S1, S2, Sn, C1, Cn) contain respective reagents and each, by actuation of its corresponding valve, is connectable through downstream ones of the series of valves (5, 11, 21, 26... 48) to supply its respective reagent to the reaction vessel (35). For cleaning or reacting with peptide starting material therein valving (12, 13, 14, 15) permits draining of the reaction vessel (35) to waste (w) and cleaning of the line of valves by flushing with a cleaning reagent sent from the upstream end of the series of valves (5, 11, 21, 26, 48) through the line (6, 54) to waste.
摘要翻译：一种用于肽合成的方法和装置，其中多个供给阀（5,11,21,26,48）串联布置以限定用于向反应容器（35）供应连续试剂的管线（6,45）哪一种肽被合成。多个容器（S1，S2，Sn，C1，Cn）包含各自的试剂，并且通过其相应的阀的致动，可以通过下列的一系列阀（5,11,21,26 ... 48 ）以将其各自的试剂供应到反应容器（35）。为了清洗或与其中的肽起始材料反应，阀（12,13,14,15）允许通过用上游发送的清洁剂冲洗将反应容器（35）排出到废物（w）并清洗阀的管线通过管线（6,54）的一系列阀门（5,11,21,26,48）的端部浪费。

62. 发明申请

WO2017013103A1 AUTOMATED SAMPLE TO NGS LIBRARY PREPARATION 审中-公开
标题翻译：自动化图书馆对NGS图书馆的准备
公开(公告)号：WO2017013103A1
公开(公告)日：2017-01-26
申请号：PCT/EP2016/067149
申请日：2016-07-19
申请人： BIOCARTIS NV
发明人： VERGAUWE, Nicolas , MEERSSEMAN, Geert
IPC分类号： B01L3/00
CPC分类号： B01L7/52 , B01J2219/00418 , B01J2219/00495 , B01J2219/00547 , B01J2219/00722 , B01L3/5027 , B01L2200/10 , C12Q1/6806 , C12Q1/6869 , C12Q2531/113 , C12Q2535/122 , C12Q2537/143 , C12Q2561/113
摘要： The present invention generally-relates to cartridges for automated systems and automated methods for fully automated processing of biological samples to next-generation sequencing-ready nucleic acid libraries. In particular, the present invention concerns a fluidic cartridge comprising a compartment for receiving a biological sample, means for liberating and/or purifying nucleic acids from the received sample and for transporting said nucleic acids to a compartment wherein NGS library can be prepared from said nucleic acids using provided therein reagents. In a particular aspect, the present invention also concerns cartridges for automated systems and automated methods for preparing an NGS nucleic acid library from a biological sample simultaneously or sequentially with a qPCR assay performed on the same biological sample.
摘要翻译：本发明一般涉及用于自动化系统的盒和用于将生物样品全面自动化处理到下一代测序准备好的核酸文库的自动化方法。特别地，本发明涉及一种流体盒，其包括用于接收生物样品的隔室，用于从所接收的样品中释放和/或纯化核酸的装置，以及用于将所述核酸转运到其中可以从所述核酸制备NGS文库的隔室使用其中提供的试剂。在一个特定方面，本发明还涉及用于自动化系统的盒和用于通过在相同生物样品上进行的qPCR测定同时或顺序地从生物样品制备NGS核酸文库的自动化方法。

63. 发明申请

WO2016125072A1 A CATALYTIC REACTION ANALYSIS DUAL REACTOR SYSTEM AND A CALIBRATION METHOD FOR CORRECTING NON-CATALYTIC EFFECTS USING THE DUAL REACTOR SYSTEM 审中-公开
标题翻译：一种催化反应分析双反应器系统和一种校正方法，用于使用双反应器系统校正非催化作用
公开(公告)号：WO2016125072A1
公开(公告)日：2016-08-11
申请号：PCT/IB2016/050503
申请日：2016-02-01
申请人： SABIC GLOBAL TECHNOLOGIES B.V.
发明人： CHOI, YongMan , BUNAMA, Ramsey , EL-YAHYAOUI, Khalid M.
IPC分类号： B01J8/02 , G01N31/10
CPC分类号： B01J8/001 , B01J8/025 , B01J8/0278 , B01J8/0285 , B01J8/067 , B01J19/0013 , B01J19/0046 , B01J19/2445 , B01J2208/00061 , B01J2208/0007 , B01J2208/00407 , B01J2208/00504 , B01J2208/00628 , B01J2208/021 , B01J2219/00157 , B01J2219/00286 , B01J2219/00306 , B01J2219/00391 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00707 , B01J2219/00747 , C10G11/10 , C10G29/00 , G01N31/10
摘要： A catalytic reaction analysis dual reactor system and a method for measuring the catalytic activity of a catalyst by correcting for non-catalytic effects with the catalytic reaction analysis dual reactor system. The dual reactor system contains a first reactor comprising a first catalyst on a first catalyst support, and a second reactor comprising a second catalyst support, wherein the particle size and amount of the first catalyst and the second catalyst support are substantially the same, and the effect of the catalyst is isolated by correcting the result obtained from the first reactor containing the catalyst with the result obtained from the second reactor containing the catalyst support.
摘要翻译：催化反应分析双反应器系统和通过用催化反应分析双反应器系统校正非催化作用的催化剂的催化活性的方法。双反应器系统包含第一反应器，其包括第一催化剂载体上的第一催化剂和包含第二催化剂载体的第二反应器，其中第一催化剂和第二催化剂载体的粒度和量基本上相同，通过校正从含有催化剂的第一反应器获得的结果，从含有催化剂载体的第二反应器得到的结果来分离催化剂的作用。

64. 发明申请

WO2015116627A1 MICROREACTOR ARRAY PLATFORM 审中-公开
标题翻译： MICROREACTOR ARRAY平台
公开(公告)号：WO2015116627A1
公开(公告)日：2015-08-06
申请号：PCT/US2015/013198
申请日：2015-01-28
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： WIKTOR, Peter
IPC分类号： G01N33/543
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00396 , B01J2219/00414 , B01J2219/00416 , B01J2219/00418 , B01L3/0282 , B01L3/0293 , B01L3/50851 , B01L2200/025 , B01L2200/0642 , B01L2200/0684 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2200/16 , B01L2300/044 , B01L2300/046 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0864 , B01L2300/161 , B01L2300/165 , B01L2400/0409 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0666 , B01L2400/0683 , B01L2400/0688
摘要： A microreactor array platform and method for sealing a reagent in microreactors of an array of microreactors are provided. The microreactor array platform includes an array of microreactors, and a sealing film having a first surface and an opposite second surface, the sealing film configured to movably seal the array of microreactors. The microreactor array platform also includes an injector for delivering a reagent into the array of microreactors via a fluid path between the array and the second surface of the sealing film, and an applicator for directing a sealing liquid against the first surface of the sealing film. The microreactor array platform further includes a system for creating a pressure differential between the reagent in the injector and a space between the array of microreactors and the second surface of the sealing film.
摘要翻译：提供了一种用于密封微反应器阵列的微反应器中的试剂的微反应器阵列平台和方法。微反应器阵列平台包括微反应器阵列和具有第一表面和相对的第二表面的密封膜，密封膜构造成可移动地密封微反应器阵列。微反应器阵列平台还包括用于经由阵列和密封膜的第二表面之间的流体路径将试剂输送到微反应器阵列中的注射器，以及用于将密封液引导到密封膜的第一表面上的施加器。微反应器阵列平台还包括用于在喷射器中的试剂和微反应器阵列与密封膜的第二表面之间的空间之间产生压力差的系统。

65. 发明申请

WO2015069726A1 SELECTION APPARATUS AND METHODS 审中-公开
标题翻译：选择装置和方法
公开(公告)号：WO2015069726A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064069
申请日：2014-11-05
申请人： X-MACHINE RX, INC.
发明人： SCHULZ, Stephen
IPC分类号： C40B20/04 , C40B30/04 , G01N33/48 , C12M1/34
CPC分类号： G01N35/1097 , B01J2219/00394 , B01J2219/00418 , B01J2219/00576 , B01J2219/00689 , B01J2219/00704 , C40B20/04 , C40B60/04 , G01N2035/0436
摘要： Embodiments of the present invention are directed to apparatus, conduit assembly devices, containment vessel assembly devices, methods and control systems that feature substantially automated, closed environmentally contained systems and methods for identifying a library molecule of interest from a library of tagged molecule through selective binding processes. The apparatus, devices control systems and methods permit parallel processing and high through-put.
摘要翻译：本发明的实施例涉及装置，导管组装装置，容纳容器装配装置，方法和控制系统，其特征在于基本上自动化的，封闭的环境包含的系统和用于通过选择性结合从标记分子文库鉴定感兴趣的文库分子的方法流程。设备，设备控制系统和方法允许并行处理和高吞吐量。

66. 发明申请

WO2009100922A1 MEHRZONENOFEN 审中-公开
标题翻译： MORE区加热炉
公开(公告)号：WO2009100922A1
公开(公告)日：2009-08-20
申请号：PCT/EP2009/001021
申请日：2009-02-13
申请人： HTE AKTIENGESELLSCHAFT , DEJMEK, Michael , MAZZONCINI, Luca , HAAS, Andreas , FRIESS, Markus , KOECHEL, Oliver , VASSILIADIS, Georg
发明人： DEJMEK, Michael , MAZZONCINI, Luca , HAAS, Andreas , FRIESS, Markus , KOECHEL, Oliver , VASSILIADIS, Georg
IPC分类号： F27B17/02
CPC分类号： F27B17/02 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00337 , B01J2219/00389 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00698 , B01J2219/00747 , B01L7/00 , B01L2300/1827 , B01L2300/1844 , B01L2300/185 , B01L2300/1883
摘要： Die vorliegende Erfindung betrifft einen Mehrzonenofen zur Beheizung und Temperierung von Reaktoren und Leitungen in Apparaturen. Der erfindungsgemäße Mehrzonenofen ist modular aufgebaut, wodurch es möglich ist, den Ofen beziehungsweise auch einzelne Zonen des Ofens in effizienter Weise zu beheizen und/oder zu kühlen. Darüber hinaus bieten austauschbare Heizkassetten den Vorteil, dass die Reaktoren und die mit den Reaktoren verbundenen Bauteile besonders gut zugänglich sind, wodurch Umbauarbeiten erleichtert werden.
摘要翻译：本发明涉及一种多区炉中的装置的反应器和管线的加热和温度控制。根据本发明的多区炉具有模块化结构，从而可以以加热烘箱或烘箱的各个区以有效的方式和/或冷却。此外，更换的加热磁带具有的优点是反应器的反应器和相关部件都特别接近，使转换工作变得更加容易。

67. 发明申请

WO2008002502A3 DEVICES AND SYSTEMS FOR CREATION OF DNA CLUSTER ARRAYS 审中-公开
标题翻译：用于创建DNA集群阵列的设备和系统
公开(公告)号：WO2008002502A3
公开(公告)日：2008-07-31
申请号：PCT/US2007014649
申请日：2007-06-22
申请人： SOLEXA INC , REED MARK , SABOT ANDREA
发明人： REED MARK , SABOT ANDREA
IPC分类号： C12M1/36 , C12M1/38 , C12M3/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00333 , B01J2219/00353 , B01J2219/00355 , B01J2219/00391 , B01J2219/00418 , B01J2219/00495 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C12Q1/6837 , C12Q2565/543 , C12Q2565/629
摘要： The present invention comprises systems and devices for isothermal amplification of polynucleotide sequences to produce DNA cluster arrays.
摘要翻译：本发明包括用于等位扩增多核苷酸序列以产生DNA簇阵列的系统和装置。

68. 发明申请

WO2006024167A1 METHOD AND APPARATUS FOR PERFORMING MICRO-SCALE CHEMICAL REACTIONS 审中-公开
标题翻译：用于实施微尺度化学反应的方法和装置
公开(公告)号：WO2006024167A1
公开(公告)日：2006-03-09
申请号：PCT/CA2005/001333
申请日：2005-08-31
申请人： TOTAL SYNTHESIS LTD. , ORGAN, Michael , COMER, Eamon
发明人： ORGAN, Michael , COMER, Eamon
IPC分类号： B01J19/24
CPC分类号： B01J19/0046 , B01J19/0093 , B01J19/126 , B01J23/44 , B01J31/0237 , B01J31/0239 , B01J31/04 , B01J31/2239 , B01J31/2265 , B01J31/2404 , B01J37/0215 , B01J37/031 , B01J2219/00286 , B01J2219/00333 , B01J2219/00344 , B01J2219/00367 , B01J2219/00369 , B01J2219/00389 , B01J2219/00418 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/0072 , B01J2219/00747 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00835 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00891 , B01J2219/00941 , B01J2219/1227 , B01J2231/4211 , B01J2231/4261 , B01J2231/543 , B01J2531/821 , B01J2531/824 , B01J2531/96 , C07C1/321 , C07C41/30 , C07C45/65 , C07C45/68 , C07C51/353 , C07C67/343 , C07C201/12 , C07C209/02 , C07C213/08 , C07C253/30 , H05B6/806 , C07C15/14 , C07C47/54 , C07C49/794 , C07C49/86 , C07C47/546 , C07C47/575 , C07C63/04 , C07C69/618 , C07C69/65 , C07C69/734 , C07C211/52 , C07C217/58 , C07C217/60 , C07C255/34 , C07C205/06 , C07C205/56 , C07C43/215 , C07C43/23 , C07C43/205
摘要： A reactor apparatus includes at least one reaction capillary having a lumen for receiving a reactant to undergo a reaction, and a magnetron for irradiating reactant contained in at least a portion of the capillary with microwaves. A method of micro-reacting a reactant includes providing a capillary, and irradiating the reactant in the capillary with microwaves to facilitate a chemical reaction in the capillary by which the reactant is converted into a desired product.
摘要翻译：反应器装置包括具有用于接收反应物进行反应的内腔的至少一个反应毛细管，以及用于用包含在毛细管的至少一部分中的反应物照射微波的磁控管。使反应物微反应的方法包括提供毛细管，并用微波照射毛细管中的反应物以促进毛细管中的化学反应，通过该化学反应将反应物转化成所需产物。

69. 发明申请

WO2005120710A2 DISPENSING SYSTEMS, SOFTWARE, AND RELATED METHODS 审中-公开
标题翻译：分配系统，软件和相关方法
公开(公告)号：WO2005120710A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/020049
申请日：2005-06-06
申请人： IRM LLC , CHANG, Jim, Yuchen , MICKLASH, Kenneth, J., II , DOWNS, Robert, Charles , MAINQUIST, James, Kevin , SHAW, Christopher, M.
发明人： CHANG, Jim, Yuchen , MICKLASH, Kenneth, J., II , DOWNS, Robert, Charles , MAINQUIST, James, Kevin , SHAW, Christopher, M.
IPC分类号： B01L3/02
CPC分类号： B01L3/0293 , B01J2219/00315 , B01J2219/00353 , B01J2219/00355 , B01J2219/0036 , B01J2219/00364 , B01J2219/00389 , B01J2219/004 , B01J2219/00418 , B01J2219/00466 , B01J2219/005 , B01J2219/00527 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/0074 , B01J2219/00743 , B01L3/021 , B01L3/0241 , B01L9/52 , B01L9/523 , B01L2200/025 , B01L2200/0605 , B01L2300/0829 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , G01N35/08 , G01N35/1002 , G01N35/1016 , G01N35/1065
摘要： The present invention provides dispensing systems that include peristaltic pumps and other pressure sources for the efficient delivery of accurate volumes of fluidic materials into the wells of multi-well containers or onto substrate surfaces. These systems are typically configured to dispense volumes of fluid having substantially uniform densities. Related computer program products and methods of dispensing fluidic materials are also provided.
摘要翻译：本发明提供了分配系统，其包括蠕动泵和其它压力源，用于将精确体积的流体材料有效地输送到多孔容器的孔中或衬底表面上。这些系统通常被配置成分配具有基本均匀密度的体积的流体。还提供了相关的计算机程序产品和分配流体材料的方法。

70. 发明申请

WO2004099435A2 APPARATUS FOR THE AUTOMATED SYNTHESIS OF POLYNUCLEOTIDES 审中-公开
标题翻译：用于自动合成多核苷酸的装置
公开(公告)号：WO2004099435A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/014271
申请日：2004-05-06
申请人： EGEA BIOSCIENCES, INC. , KEEN, Randy , KODER, Alan , EVANS, David
IPC分类号： C12Q
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00353 , B01J2219/00364 , B01J2219/00416 , B01J2219/00418 , B01J2219/00459 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00675 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： The invention provides an apparatus for maintaining a closed continuous anhydrous system for automated polynucleotide synthesis, having a) a plurality of moisture resistant reagent containers, b) a dry box capable of forming a seal over a synthesis platform of an automated polynucleotide synthesizer, c) moisture-resistant tubing connecting the reagent containers to the dry box, d) a reagent gas feed connecting the reagent containers to a gas, where the gas pressurizes the reagent containers, and e) a digital gas regulator connected to the reagent gas feed, where the gas regulator maintains constant pressure in the reagent containers.
摘要翻译：本发明提供一种用于维持用于自动多核苷酸合成的封闭的连续无水系统的装置，其具有a）多个防潮试剂容器，b）能够在自动多核苷酸合成仪的合成平台上形成密封的干燥箱，c）将试剂容器连接到干燥箱的防湿管，d）将试剂容器连接到气体的反应气进料，其中气体对试剂容器进行加压，以及e）连接到反应气进料的数字气体调节器，其中气体调节器在试剂容器中保持恒定的压力。

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