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61. 发明申请

WO1992015668A1 CELL CULTURE TANK 审中-公开
标题翻译：细胞培养罐
公开(公告)号：WO1992015668A1
公开(公告)日：1992-09-17
申请号：PCT/JP1992000222
申请日：1992-02-28
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , NAKAKARUMAI, Tadashi , MANO, Takashi , KAWAHARA, Hiroyuki , MATSUDA, Yoshiaki , MITSUDA, Shinjiro , KUMAZAWA, Eitaro , BABA, Atsushi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C12M01/06
CPC分类号： B01F3/04609 , B01F2003/04673 , B01F2003/0468 , B01F2003/04872 , B01F2003/04879 , C12M27/02 , C12M41/02
摘要： A cell culture tank (A) having in the cell culture zone (A') thereof a partial zone (B) partitioned with a filter (8) permitting permeation of a culture medium and protein produced by cells under culture but intercepting permeation of cell or cohesive carrier of cells. A jet nozzle (6) of a conduit for feeding oxygen or air is provided on the bottom of the zone (B), stirring vanes (3) rotating at high speed are provided immediately above said jet nozzle, and a space corresponding to 30 to 50 % of the height of the filter (8) is exposed to a gaseous phase part in the cell culture tank. A conduit nozzle (7) for recovering the culture medium is provided just below the medium level in the zone (B). Another stirring vane (1) rotating at low speed is provided in the culture zone (A'). By providing an exhaust pipe (20) and a sterile air ventilation pipe (21) to the gaseous phase part of the culture zone (A') as well as valves to the conduit pipe of jet nozzle (6), exhaust pipe (20), and sterile ventilation pipe (21), respectively, the level of the medium in the zone (B) having been lowered by bubbles developing in the zone (B) is raised and said bubbles are squeezed out to the culture tank (A) through the filter, whereby the bubbles are broken. When an opening is provided in the upper part of the zone (B) and a bubble breaking vane rotating at high speed is provided above the level of medium in said zone (B), bubbles having developed in said zone can be broken.

62. 发明申请

WO1992013632A1 COMPLEX MIXER FOR DISPERSION OF GASES IN LIQUID 审中-公开
标题翻译：用于液体气体分散的复合混合器
公开(公告)号：WO1992013632A1
公开(公告)日：1992-08-20
申请号：PCT/HU1992000005
申请日：1992-01-31
申请人： BIOGAL GYOGYSZERGYAR RT. , RICHTER GEDEON VEGYÉSZETI GYAR RT. , KOZMA, László , KOVATS, Sándor , MAKADI, Béla , CSÉKE, László , PUSZTAI, Sándor , KASZAS, Mihály , SANTHA, György , BARTHO, Itsván , ZALAI, Károly , BESZEDICS, Gyula , KORDIK, Gabriella , GERGELY, Károly , FÉDER, Miklós
发明人： BIOGAL GYOGYSZERGYAR RT. , RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： B01F03/04
CPC分类号： B01F3/04836 , B01F3/04531 , B01F7/00341 , B01F7/00366 , B01F7/00633 , B01F2003/04673
摘要： Complex mixing system with stages consisting of propeller mixers with open channels (5) opposite to the direction of rotation are on the blades (4) of the dispersing stage (2a) of the propeller mixers (2) fixed to a common shaft, where the channels (5) are interconnected with gas inlet (7). The angle of incidence of a certain part of the blades (4) of mixing stages (2b, 2d) used for homogenization and suspension is of opposite direction and the length is shorter and/or the angle of incidence is smaller than those of the other blades. Baffle bars (8) are on the trailing end of the blades on a certain part (2c) of the propeller mixers used similarly for homogenization and suspension, and/or auxiliary blades (12) at an angle of max. 20° to the blade wings are arranged above or below the trailing end of the blades.

63. 发明申请

WO1989012496A1 MIXING APPARATUS 审中-公开
标题翻译：混合装置
公开(公告)号：WO1989012496A1
公开(公告)日：1989-12-28
申请号：PCT/US1989002832
申请日：1989-06-20
申请人： GENERAL SIGNAL CORPORATION
发明人： GENERAL SIGNAL CORPORATION , WEETMAN, Ronald, J.
IPC分类号： B01F03/04
CPC分类号： B01F3/04531 , B01F7/00291 , B01F2003/04546 , B01F2003/04567 , B01F2003/04673 , B01F2003/04709
摘要： A mixing system for dispersing gas or other fluids in liquid which may have a solid suspension so as to improve mass transfer to the liquid or its solids suspension while maintaining a flow pattern which is substantially axial (up and down) in the tank containing the liquid thereby also facilitating mixing (blending) utilizes an (unshrouded) axial flow impeller which provides the desired single stage axial flow downwardly to the bottom of the tank and upwardly along the sidewalls of the tank with radial flow confined principally to the bottom region of the tank. A sparge system which releases the gas or other fluid in the region at the bottom of the tank where the flow is predominantly radial allows attainment of gas rates with complete dispersion of gas throughout the tank, which rates are much higher (about four times as great) as when conventional sparge systems are used with axial flow impellers. The gas rate is maximum when the impeller has a plurality of blades which are located at an elevation of fifteen to twenty-five percent of the impeller diameter from the bottom of the tank and the outlet ports of the sparge which delivers the gas are located at a radius greater than the radius of the impeller and at about the same elevation from the bottom of the tank as the elevation of the lower edges of the impeller's blades. The condition known as flooding where the escaping gas, rather than the impeller, controls the flow pattern in the tank (the escaping gas then not flowing with the liquid as it is pumped by the impeller but rather rising due to its own energy and geysering out of the liquid) does not occur, even though an axial flow pattern is maintained by an impeller of the axial flow type which pumps by virtue of the pressure differential across the impeller blades, rather than by direct impact with the liquid as in a radial flow impeller.

64. 发明申请

WO1989000450A1 APPARATUS FOR INTRODUCING A GAS INTO A LIQUID 审中-公开
标题翻译：将气体引入液体的装置
公开(公告)号：WO1989000450A1
公开(公告)日：1989-01-26
申请号：PCT/US1987001603
申请日：1987-07-10
申请人： FRANKLIN, Grover, C., Jr.
IPC分类号： B01F03/04
CPC分类号： B01F3/04503 , B01F3/04531 , B01F5/0057 , B01F5/0609 , B01F15/005 , B01F15/00525 , B01F2003/04673
摘要： An apparatus for introducing a gas into a liquid comprising a container (10), at least one vertical conduit (16) in fluid communication with the container, the conduit having therein at least one mixer assembly (26) for breaking up gas bubbles into bubbles having small diameters, and a means (60) for introducing a gas into the conduit at a point below the mixer assembly, the mixer assembly comprising at least two freely rotating turbines (30, 32, 34) which are spaced apart axially and have different direction or speed of rotation.

65. 发明申请

WO2019143476A1 SYSTEM AND METHOD FOR CELL CULTURE SCALING 审中-公开
公开(公告)号：WO2019143476A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/012120
申请日：2019-01-03
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： BRAU, Christopher , JONES, Nephi , SMITH, Mark
IPC分类号： C12M1/00 , C12M1/06 , C12M1/34
CPC分类号： B01F7/00391 , B01F3/04531 , B01F7/0005 , B01F7/00725 , B01F7/18 , B01F7/24 , B01F15/00538 , B01F15/00707 , B01F15/00772 , B01F15/0085 , B01F2003/04673 , B01F2015/0011 , B01F2015/00603 , B01F2215/0073 , C12M23/50 , C12M23/58 , C12M27/02 , C12M27/06 , C12M35/04 , C12M41/48 , C12N5/0602 , C12N2527/00
摘要： The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

66. 发明申请

WO2016107788A1 SHAFT-MOUNTED FLUID TRANSFER ASSEMBLY FOR A DISPOSABLE BIOREACTOR 审中-公开
标题翻译：用于可替代生物反应器的轴安装流体传输组件
公开(公告)号：WO2016107788A1
公开(公告)日：2016-07-07
申请号：PCT/EP2015/080957
申请日：2015-12-22
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： DAMREN, Richard, Lee , TUOHEY, Colin, R.
IPC分类号： C12M1/00 , C12M1/04 , B01F7/00 , B01F3/04
CPC分类号： C12M23/14 , B01F3/04539 , B01F7/00341 , B01F7/00383 , B01F7/00633 , B01F7/00641 , B01F15/00707 , B01F15/0085 , B01F2003/04553 , B01F2003/04673 , C12M1/04 , C12M23/28 , C12M27/04 , C12M29/06
摘要： A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.
摘要翻译：用于单次生物反应器的流体转移组件包括流体传送壳体，其可以使用将流体传递组件直接放置在最低叶轮下方但允许叶轮轴独立于流体传递组件旋转的轴承安装到叶轮轴。流体导管将流体转移壳体连接到单用袋壁中的端口，其允许流体被引入到分布器中，并且还有助于防止流体转移组件与叶轮轴一起旋转。

67. 发明申请

WO2015101239A1 一种卫生泡沫发生器审中-公开
公开(公告)号：WO2015101239A1
公开(公告)日：2015-07-09
申请号：PCT/CN2014/095225
申请日：2014-12-27
申请人：田中洲
发明人：田中洲
IPC分类号： B01F3/04 , E03D9/00
CPC分类号： B01F3/04531 , B01F3/04262 , B01F3/04453 , B01F7/00558 , B01F7/00733 , B01F15/0072 , B01F2003/04297 , B01F2003/04673
摘要：一种卫生泡沫发生器，包括箱体（5）、导管（2）、发泡装置（4）。箱体（5）内设有供液泵（6）、供液储瓶（8）及空气压缩机（7）；发泡装置（4）包括竖直放置的柱状壳体（9），该壳体（9）内腔设有隔离界面（30），隔离界面（30）设有进液口（21），进液口（21）通过供液管（19）与供液泵（6）连接，该供液泵（6）与供液储瓶（8）连接，隔离界面（30）分布有多个气孔，起泡发生室（28）顶端设有泡沫出口（3），该导管（2）出口端伸入至马桶（1）内，导管（2）进口端与泡沫出口（3）连接。

68. 发明申请

WO2015068989A1 초미세기포 발생장치 및 이를 갖는 수처리설비 审中-公开
标题翻译：微型发泡机和水处理设备
公开(公告)号：WO2015068989A1
公开(公告)日：2015-05-14
申请号：PCT/KR2014/010428
申请日：2014-11-03
申请人： 대웅이엔에스(주) , 우광재
发明人： 우광재 , 김연길 , 강줄기 , 김동욱 , 강석환 , 김진호 , 김효식
IPC分类号： B01F3/04 , B01F5/00 , C02F1/74
CPC分类号： C02F9/00 , B01F3/04531 , B01F3/0876 , B01F5/0268 , B01F7/00733 , B01F2003/04673 , B01F2003/04858 , C02F1/24 , C02F1/52 , C02F1/66 , C02F3/00
摘要： 본 발명은 상압에서 초미세기포를 발생하여 수중으로 공급함으로써 오염수를 정화할 수 있는 초미세기포 발생장치 및 이를 이용한 수처리설비에 관한 것이다. 본 발명에 의한 초미세기포 발생장치는, 유입공간과 흡입구멍이 형성된 케이스와, 유입공간으로 공기를 공급하기 위한 공기 공급관과, 물과 공기를 혼합하여 만든 물-공기 혼합유체를 펌핑하기 위해 케이스 내부에 설치되는 물 펌프와, 분산장치를 포함한다. 분상장치는, 케이스 내부의 연결유로를 따라 유동하는 물-공기 혼합유체를 케이스 외부로 분사하기 위해 연결유로와 연결되는 토출구를 갖는 분사 헤드와, 분사 헤드의 토출구 전방에 토출구로부터 이격되도록 설치되는 충돌판과, 물-공기 혼합유체가 토출구로부터 토출된 후 충돌판에 충돌하면서 생성되는 초미세기포와 물을 분사 헤드 외부로 분사하기 위해 분사 헤드와 충돌판 사이에 구비되는 분사구를 갖는다.
摘要翻译：本发明涉及一种微气泡发生器，其能够通过在大气压下产生微气泡并在水中提供微气泡来净化污染的水，以及使用该气泡发生器的水处理设备。根据本发明的微气泡发生器包括：具有形成在其中的入口室和吸入孔的壳体; 用于向所述入口室供给空气的供气管; 安装在壳体内部的水泵，用于泵送通过混合水和空气制成的水 - 空气混合流体; 和分散机。分散器包括：喷头，其具有出口，该出口连接到壳体内部的连接流路，以便向外部喷射沿着连接流动路径流动的水 - 空气混合流体; 撞击板，其安装在喷头的出口前面以便与出口分离; 设置在喷头和冲击板之间的喷嘴，以便在水 - 空气混合流体从出口排出之后喷射到喷头外部的水和与撞击板碰撞产生的微气泡。

69. 发明申请

WO2013082132A1 GAS INJECTION METHOD AND APPARATUS 审中-公开
标题翻译：气体注入方法和装置
公开(公告)号：WO2013082132A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/066823
申请日：2012-11-28
申请人： PRAXAIR TECHNOLOGY, INC.
发明人： FABIYI, Malcolm, E. , WATTANAPANOM, Witawat , NOVAK, Richard, A. , CONNERY, Karen
IPC分类号： C02F3/12 , C02F3/20 , C02F3/16 , C02F3/26 , B01F7/00 , B01F13/00 , C02F101/30
CPC分类号： B01F3/04539 , B01F3/04106 , B01F3/04262 , B01F3/04609 , B01F7/00358 , B01F7/00733 , B01F13/0049 , B01F2003/04553 , B01F2003/04666 , B01F2003/04673 , B01F2003/0468 , B01F2003/04709 , B01F2215/0431 , C02F3/1284 , C02F3/16 , C02F3/206 , C02F3/26 , C02F2101/301 , Y02W10/15
摘要： A method and apparatus for injecting a gas into a liquid in which a rotating helical impeller (30) within a draft tube (20) submerged in the liquid creates a liquid flow within the draft tube. Gas bubbles are injected into the draft tube either above or below or alongside the helical impeller or in all three locations. The liquid is drawn into the draft tube with a superficial velocity greater than a substantially uniform terminal ascent velocity of the gas bubbles to allow entrainment ofundissolved gas bubbles in the bulk liquid into the liquid being drawn into the draft tube. The gas bubbles are injected with a uniform diameter of between about 10.0 microns and about 1.0 millimeters. The small bubble size enhances the dissolution of the gas into the liquid and also allow the entrainment of the gas into the liquid being drawn into the draft tube. The gas can be oxygen, ozone or carbon dioxide.
摘要翻译：一种用于将气体注入液体中的方法和装置，其中浸没在液体中的引流管（20）内的旋转螺旋叶轮（30）在引流管内产生液体流。在螺旋叶轮的上方或下方或旁边，或者在所有三个位置，将气泡注入引流管。将液体以大于气泡的基本均匀的终点上升速度的表观速度吸入引流管，以允许将本体液体中的不溶性气泡夹带入被引入引流管的液体中。气泡以约10.0微米至约1.0毫米的均匀直径喷射。小的气泡尺寸增加了气体溶解到液体中并且还允许将气体夹带到被吸入引流管的液体中。气体可以是氧气，臭氧或二氧化碳。

70. 发明申请

WO2012163511A4 ROTATING SPRAY APPARATUS 审中-公开
标题翻译：旋转喷雾器
公开(公告)号：WO2012163511A4
公开(公告)日：2013-03-28
申请号：PCT/EP2012002253
申请日：2012-05-25
申请人： EKATO RUEHR MISCHTECHNIK , HIMMELSBACH WERNER
发明人： HIMMELSBACH WERNER
IPC分类号： B08B3/02 , B01F5/22
CPC分类号： B08B3/02 , B01F3/04531 , B01F2003/04673
摘要： The invention provides a rotating spray apparatus (8) for cleaning walls and a lid of a space at the top (5) of a large stirred container (1), wherein the rotating spray apparatus is designed in the form of a cup, with tubes fitted thereon, which is fastened on a stirring shaft (2) in the space at the top (5) of the container (1) and which rotates along therewith and into which, by means of a rinsing-liquid-supply tube (7) guided into the vicinity of the stirring shaft (2) at the space at the top (5) of the container (1), rinsing liquid is supplied, and therefore the rinsing liquid supplied, as a result of centrifugal forces, is sprayed from the cup, in the vicinity of the stirring shaft (2), at least onto the wall and the lid of the container (1). In particular the peripheral region of the cup is covered by an annular lid (14), or the periphery of the cup is of serrated configuration.
摘要翻译：提供了一种用于壁的清洁的旋转喷雾装置（8）和一个顶部空间的盖（5）大的搅拌罐（1）是可用的，其中所述旋转喷射装置处于杯的形式附接管上的搅拌轴（2）被固定在所述容器（1）的顶部空间（5），并通过在容器的顶部空间（5）的手段与其并且其中旋转（1）在搅拌轴的附近（2）内而外Spülflüssigkeitszufuhrrohrs（7）冲洗液体被供给，使得所供给的清洗液喷洒作为离心力出杯在搅拌轴的附近（2）至少到所述容器（1）的壁和盖的结果。特别地，杯子的边缘区域覆盖有环形盖子（14）或者杯子的边缘是锯齿状的。

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