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61. 发明申请

WO2012109112A3 POLYMER-CARBOHYDRATE-LIPID CONJUGATES 审中-公开
标题翻译：聚合物 - 碳酸酯 - 脂质混合物
公开(公告)号：WO2012109112A3
公开(公告)日：2013-01-17
申请号：PCT/US2012023844
申请日：2012-02-03
申请人： WU NIAN
发明人： WU NIAN
IPC分类号： C08G65/329
CPC分类号： C07H1/00 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0095 , A61K9/2013 , A61K31/05 , A61K31/223 , A61K31/231 , A61K31/25 , A61K31/325 , A61K31/4188 , A61K31/575 , A61K31/7032 , A61K47/26 , C07H15/04 , C07J41/0061 , C08G65/329 , C08L2203/02
摘要： The invention comprises compounds, methods of making, and methods of using. The compounds may have a backbone and three appended functional groups: one lipid, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. A variety of linkers between the backbone and functional groups may also be selected to optimize performance.
摘要翻译：本发明包括化合物，制备方法和使用方法。化合物可以具有主链和三个附加的官能团：一种脂质，一种亲水聚合物和一种碳水化合物。可以在配制药物，化妆品，营养品等中的具体应用中选择特定的官能团。骨架和功能组之间的各种接头也可以被选择以优化性能。

62. 发明申请

WO2009096985A1 SUSTAINED RELEASE PARTICULATE ORAL DOSAGE FORMS OF (R)-BACLOFEN PRODRUGS AND METHODS OF TREATMENT 审中-公开
标题翻译：持续释放（R）-BACLOFEN PRODRUGS的颗粒剂量形式和治疗方法
公开(公告)号：WO2009096985A1
公开(公告)日：2009-08-06
申请号：PCT/US2008/052808
申请日：2008-02-01
申请人： XENOPORT, INC. , SASTRY, Srikonda , CUNDY, Kenneth, C. , LEUNG, Manshiu
发明人： SASTRY, Srikonda , CUNDY, Kenneth, C. , LEUNG, Manshiu
IPC分类号： A61K9/16
CPC分类号： A61K9/1635 , A61K9/1676 , A61K9/5078 , A61K31/197 , A61K31/25
摘要： Sustained release particulate oral dosage forms of ( R )-baclofen prodrugs and methods of treating a disease comprising orally administering such dosage forms are disclosed.
摘要翻译：公开了（R） - 巴氯芬前药的持续释放微粒口服剂型和治疗包括口服该剂型的疾病的方法。

63. 发明申请

WO2008008513A3 COMBINATION TREATMENTS 审中-公开
标题翻译：组合治疗
公开(公告)号：WO2008008513A3
公开(公告)日：2008-03-06
申请号：PCT/US2007016032
申请日：2007-07-12
申请人： BETH ISRAEL HOSPITAL , BACH FRITZ H , HASCHEMI ARVAND , OTTERBEIN LEO E
发明人： BACH FRITZ H , HASCHEMI ARVAND , OTTERBEIN LEO E
IPC分类号： A61K31/409 , A61K31/25 , A61K31/295 , A61K33/26 , A61K45/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/25 , A61K31/295 , A61K31/409 , A61K31/52 , A61K33/26 , A61K2300/00
摘要： The present invention relates to the treatment of disorders using pharmaceutical agents in combination with heme oxygenase- 1 and/or heme degradation products, such as biliverdin or carbon monoxide.
摘要翻译：本发明涉及使用药剂与血红素加氧酶-1和/或血红素降解产物如胆红素或一氧化碳联合治疗病症。

64. 发明申请

WO2006115712A2 CELLULOSIC FILMS INCORPORATING A PHARMACEUTICALLY ACCEPTABLE PLASTICIZER WITH ENHANCED WETTABILITY 审中-公开
标题翻译：包含具有增强湿度的药物接受性增塑剂的细胞膜
公开(公告)号：WO2006115712A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/012475
申请日：2006-04-04
申请人： EASTMAN CHEMICAL COMPANY
发明人： BERNARD, Bobby, Lynn
IPC分类号： A61K9/28 , A61K9/48
CPC分类号： A61K9/2866 , A61K9/2853 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K31/25 , A61K31/355 , A61K31/717
摘要： An enteric coating for a solid pharmaceutical carrier or substrate wherein the enteric coating includes a cellulosic polymeric material selected from selected from the group consisting of hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, ethyl cellulose, cellulose acetate, cellulose acetate butyrate, cellulose acetate phthalate, cellulose acetate succinate, cellulose acetate propionate, cellulose acetate trimellitate, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose succinate, hydroxypropylmethyl cellulose acetate succinate, cellulose acetate succinate butyrate, cellulose acetate succinate propionate, carboxymethylcellulose sodium, cellulose butyrate, and mixtures thereof and a plasticizer selected from a water-soluble preparation of a fat-soluble vitamin. A preferred plasticizer is Vitamin E polyethylene glycol 1000 succinate.
摘要翻译：用于固体药物载体或基质的肠溶衣，其中所述肠溶衣包含选自羟丙基纤维素，羟乙基纤维素，羟丙基甲基纤维素，甲基纤维素，乙基纤维素，乙酸纤维素，乙酸丁酸纤维素的纤维素聚合物，乙酸琥珀酸纤维素，乙酸琥珀酸纤维素，乙酸丙酸纤维素，醋酸偏苯三酸纤维素，邻苯二甲酸羟丙基甲基纤维素，琥珀酸羟丙基甲基纤维素，琥珀酸羟丙基甲基纤维素，琥珀酸乙酸琥珀酸纤维素，丙酸纤维素乙酸琥珀酸酯，羧甲基纤维素钠，丁酸纤维素及其混合物增塑剂选自脂溶性维生素的水溶性制剂。优选的增塑剂是维生素E聚乙二醇1000琥珀酸酯。

65. 发明申请

WO0182928A9 USE OF MEDIUM CHAIN TRIGLYCERIDES FOR THE TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE AND OTHER DISEASES RESULTING FROM REDUCED NEURONAL METABOLISM 审中-公开
标题翻译：用于治疗和预防由减少的神经元代谢引起的阿尔茨海默病和其他疾病的中链链抗体的使用
公开(公告)号：WO0182928A9
公开(公告)日：2006-06-15
申请号：PCT/US0113955
申请日：2001-05-01
申请人： ACCERA INC , HENDERSON SAMUEL T
发明人： HENDERSON SAMUEL T
IPC分类号： A61K31/12 , A61K45/00 , A61K31/20 , A61K31/205 , A61K31/215 , A61K31/22 , A61K31/221 , A61K31/23 , A61K31/25 , A61K45/06 , A61P3/10 , A61P25/28 , A61P43/00
CPC分类号： A61K45/06 , A61K31/12 , A61K31/20 , A61K31/205 , A61K31/215 , A61K31/22 , A61K31/221 , A61K31/23 , A61K31/25 , A61K2300/00
摘要： Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of triglicerides or fatty acids with chain lengths between 5 and 12, to said patient at a level produce an improvement in cognitive ability.
摘要翻译：描述了用于治疗或预防阿尔茨海默氏型老年性痴呆的发生或由减少的神经元代谢引起的导致认知功能降低的其它病症的方法和组合物。在优选的实施方案中，将链长度在5至12之间的三联体或脂肪酸以一定水平给予所述患者的认知能力的改善。

66. 发明申请

WO03008457A3 POLYSACCHARIDIC ESTERS OF RETINOIC ACID 审中-公开
标题翻译：多糖酸多糖
公开(公告)号：WO03008457A3
公开(公告)日：2003-04-17
申请号：PCT/EP0207895
申请日：2002-07-16
申请人： EURAND PHARMACEUTICALS LTD , RASTRELLI ALESSANDRO , MIGLIERINI GIULIANA , PERBELLINI ALBERTO , STUCCHI LUCA
发明人： RASTRELLI ALESSANDRO , MIGLIERINI GIULIANA , PERBELLINI ALBERTO , STUCCHI LUCA
IPC分类号： A61K47/36 , A61K8/67 , A61K8/72 , A61K8/73 , A61K31/203 , A61K31/25 , A61K31/715 , A61K31/716 , A61K31/728 , A61P9/00 , A61P11/00 , A61P17/06 , A61P17/16 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/04 , A61Q19/00 , C08B37/00 , C08B37/08 , C08B37/18
CPC分类号： A61K8/671 , A61K8/73 , A61K31/25 , A61K2800/57 , A61Q19/00 , C08B37/00 , C08B37/0024 , C08B37/0036 , C08B37/006 , C08B37/0069 , C08B37/0072 , C08B37/0075
摘要： The present invention relates to polysaccharidic esters of retinoic acid, wherein the hydroxyl groups of the monosaccharidic units of the polysaccharide are partially or totally esterified with retinoic acid. A process to obtain these esters is also described. The products according to the present invention can be used in the pharmaceutical and cosmetic field.
摘要翻译：本发明涉及视黄酸多糖酯，其中多糖的单糖单元的羟基用视黄酸部分或全部酯化。还描述了获得这些酯的方法。根据本发明的产品可用于药物和化妆品领域。

67. 发明申请

WO2003008457A2 POLYSACCHARIDIC ESTERS OF RETINOIC ACID 审中-公开
标题翻译：维甲酸的多糖酸酯
公开(公告)号：WO2003008457A2
公开(公告)日：2003-01-30
申请号：PCT/EP2002/007895
申请日：2002-07-16
申请人： EURAND PHARMACEUTICALS LTD , RASTRELLI, Alessandro , MIGLIERINI, Giuliana , PERBELLINI, Alberto , STUCCHI, Luca
发明人： RASTRELLI, Alessandro , MIGLIERINI, Giuliana , PERBELLINI, Alberto , STUCCHI, Luca
IPC分类号： C08B37/00
CPC分类号： A61K8/671 , A61K8/73 , A61K31/25 , A61K2800/57 , A61Q19/00 , C08B37/00 , C08B37/0024 , C08B37/0036 , C08B37/006 , C08B37/0069 , C08B37/0072 , C08B37/0075
摘要： The present invention relates to polysaccharidic esters of retinoic acid, wherein the hydroxyl groups of the monosaccharidic units of the polysaccharide are partially or totally esterified with retinoic acid. A process to obtain these esters is also described. The products according to the present invention can be used in the pharmaceutical and cosmetic field.
摘要翻译：本发明涉及视黄酸的多糖酯，其中多糖的单糖单元的羟基部分或完全被视黄酸酯化。还描述了获得这些酯的方法。根据本发明的产品可以用于制药和化妆品领域。

68. 发明申请

WO02024195A1 METHOD OF TREATING GASTROINTESTINAL DISORDERS, PARTICULARLY COLITIS 审中-公开
标题翻译：治疗胃肠疾病的方法，特别是患者
公开(公告)号：WO02024195A1
公开(公告)日：2002-03-28
申请号：PCT/US2001/029006
申请日：2001-09-18
IPC分类号： A61K31/23 , A61K31/25 , C07C69/30 , C07C69/52 , A61K31/22
CPC分类号： C07C69/52 , A61K31/23 , A61K31/25 , C07C69/30
摘要： Administration of alkoxylated acyl glycerine (AAG) containing lower carboxylic acid acyl moieties to mammalian subjects results in increase of lower carboxylate concentration, particularly in the colon, and may be used to treat such disorders as simple colitis, ulcerative colitis, divertive colitis, colorectal cancer, and other diseases of the gastrointestinal tract where lower carboxylates are implicated. The AAG encourage patient compliance due to substantially no odor, even when butyric acid acyl groups are employed.
摘要翻译：向哺乳动物受试者施用含有低级羧酸酰基部分的烷氧基化酰基甘油（AAG）导致较低羧酸盐浓度的增加，特别是在结肠中，可用于治疗诸如简单结肠炎，溃疡性结肠炎，憩室结肠炎，结肠直肠癌，以及涉及较低羧化物的胃肠道的其它疾病。即使使用丁酸酰基，AAG基本上不会产生气味，从而鼓励患者依从性。

69. 发明申请

WO00010558A1 NATURAL PHYSIOLOGICALLY ACTIVE SUBSTANCES EFFICACIOUS AGAINST FISH DISEASES AND FISH FEEDS CONTAINING THE SAME 审中-公开
标题翻译：自然生理活性物质对鱼类疾病的有效性和含有其的鱼类饲料
公开(公告)号：WO00010558A1
公开(公告)日：2000-03-02
申请号：PCT/JP1999/004427
申请日：1999-08-18
IPC分类号： A23K1/16 , A23K1/18 , A61K31/16 , A61K31/20 , A61K31/23 , A61K31/25 , A61K31/375
CPC分类号： A61K31/25 , A23K20/158 , A23K20/174 , A23K50/80 , A61K31/16 , A61K31/20 , A61K31/23 , A61K31/375 , A61K2300/00
摘要： Natural physiologically active substances capable of achieving oral effects on fish diseases such as viral diseases, bacterial diseases and parasitic diseases. The above substances comprise C6-12 fatty acids optionally together with a substance having a vitamin C activity and exert effects on fish diseases such as viral diseases, bacterial diseases and parasitic diseases. The C6-12 fatty acids include capric acid, caprylic acid and pelargonic acid. Fish feeds or feed additives containing the above substances in an amount of about 25 % by weight corresponding to the optimum concentration efficacious against parasitic disease.
摘要翻译：能够对病毒性疾病，细菌性疾病，寄生虫病等鱼类疾病产生口服效果的天然生理活性物质。上述物质可以任选地与具有维生素C活性的物质一起包含C6-12脂肪酸，并对鱼病例如病毒性疾病，细菌性疾病和寄生虫病产生影响。 C6-12脂肪酸包括癸酸，辛酸和壬酸。含有上述物质的鱼饲料或饲料添加剂的量为约25重量％，相当于对抗寄生虫病有效的最佳浓度。

70. 发明申请

WO98044915A1 IN VIVO POLYMERIZABLE OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：体内可聚合的眼用组合物
公开(公告)号：WO98044915A1
公开(公告)日：1998-10-15
申请号：PCT/US1998/007280
申请日：1998-04-07
IPC分类号： A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , A61P27/02 , C08F20/04 , C08F20/22 , C08F22/10
CPC分类号： C08F20/04 , A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/22 , C08F22/105 , Y10S514/839 , Y10S514/912 , Y10S514/915 , Y10T428/3154
摘要： Ophthalmic compositions containing biocompatible, bioadhesive polymerizable amphipathic mesophase materials useful for repairing retinal tissue tears or retinal detachments are disclosed. In one embodiment, the polymerizable materials, which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends, are polymerized in vivo to provide effective, long-lasting repair of torn, ruptured or detached retinal tissue. Ophthalmic applications of these materials are not limited to retinal repair.
摘要翻译：公开了含有用于修复视网膜组织撕裂或视网膜脱离的生物相容性，生物粘附性可聚合两亲中间相材料的眼用组合物。在一个实施方案中，包含在不饱和氟疏离末端具有阴离子，阳离子和/或非离子表面活性官能团的取代的氟代烷基或全氟烷基单体的可聚合材料在体内聚合，以提供有效的，持久的修复撕裂，破裂或分离的视网膜组织。这些材料的眼科应用不限于视网膜修复。

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