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61. 发明申请

WO2009105387A1 ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE 审中-公开
标题翻译：离子色谱系统与流延迟回收
公开(公告)号：WO2009105387A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/034015
申请日：2009-02-13
申请人： DIONEX CORPORATION , LIU, Yan , SRINIVASAN, Kannan , POHL, Christopher, A. , BHARDWAJ, Sheetal , LU, Zhongqing
发明人： LIU, Yan , SRINIVASAN, Kannan , POHL, Christopher, A. , BHARDWAJ, Sheetal , LU, Zhongqing
IPC分类号： G01N30/96
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber (31), and recycling the effluent stream from the catalytic gas elimination chamber to the chromatography separation column (10). The residence time between the detector (14) and said chamber (31) is at least one minute to facilitate decomposition of unstable oxidative compounds. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor (28). Also, applying heat or UV energy between the detector (14) and the chamber (31). Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
摘要翻译：一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室（31）中的过氧化氢，以及将来自催化剂的流出物流气体消除室至色谱分离柱（10）。检测器（14）和所述室（31）之间的停留时间为至少一分钟，以促进不稳定的氧化化合物的分解。此外，使循环物依次流过电解膜抑制器（28）的两个检测器流出物流动通道。而且，在检测器（14）和腔室（31）之间施加热或UV能量。另外，在室后检测气泡。此外，铂族金属催化剂和离子交换介质在室内。用于执行方法的装置。

62. 发明申请

WO2009042711A1 POLO-LIKE KINASE INHIBITORS 审中-公开
标题翻译： POLO-like激酶抑制剂
公开(公告)号：WO2009042711A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/077558
申请日：2008-09-24
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , CAO, Sheldon X. , FEHER, Victoria , ICHIKAWA, Takashi , JONES, Benjamin , KALDOR, Stephen W. , KIRYANOV, Andre A. , LIU, Yan , MCBRIDE, Christopher , NATALA, Srinivasa Reddy , NIE, Zhe , STAFFORD, Jeffrey A. , LAM, Betty
发明人： CAO, Sheldon X. , FEHER, Victoria , ICHIKAWA, Takashi , JONES, Benjamin , KALDOR, Stephen W. , KIRYANOV, Andre A. , LIU, Yan , MCBRIDE, Christopher , NATALA, Srinivasa Reddy , NIE, Zhe , STAFFORD, Jeffrey A. , LAM, Betty
IPC分类号： A61K31/4545 , C07D487/04 , C07D487/14 , A61P37/08 , A61P11/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供下式的化合物与激酶一起使用：（I）其中变量如本文所定义。还提供了包含此类化合物的药物组合物，试剂盒和制品; 用于制备该化合物的方法和中间体; 和使用所述化合物的方法。

63. 发明申请

WO2008033804A2 QUANTUM DOT BARCODE STRUCTURES AND USES THEREOF 审中-公开
标题翻译：量子点条码结构及其应用
公开(公告)号：WO2008033804A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078114
申请日：2007-09-11
申请人： THE ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , WANG, Qiangbin , LIU, Yan
发明人： YAN, Hao , WANG, Qiangbin , LIU, Yan
IPC分类号： F24D13/02
CPC分类号： C09C1/24 , A61K9/14 , B82Y10/00 , B82Y15/00 , C01P2004/03 , C01P2004/04 , C01P2006/42 , G01N33/54366 , G01N33/588 , H01L29/127 , Y10T428/2991
摘要： The present invention provides novel barcode microstructures and methods for making and using the microstructures for molecular recognition, and/or delivery of therapeutic, diagnostic, contrast, and imaging agents.
摘要翻译：本发明提供了用于制造和使用用于分子识别的微结构和/或递送治疗剂，诊断剂，造影剂和显像剂的新型条形码微结构和方法。

64. 发明申请

WO2006124089A1 SELF-ASSEMBLED NUCLEIC ACID NANOARRAYS AND USES THEREFOR 审中-公开
标题翻译：自组装的核酸纳豆糖及其用途
公开(公告)号：WO2006124089A1
公开(公告)日：2006-11-23
申请号：PCT/US2006/005682
申请日：2006-02-15
申请人： THE ARIZONA BOARD OF REGENTS, A BODY CORPORATE ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY , LINDSAY, Stuart , YAN, Hao , CHAPUT, John , LIU, Yan , ZHANG, Peiming
发明人： LINDSAY, Stuart , YAN, Hao , CHAPUT, John , LIU, Yan , ZHANG, Peiming
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , C12N15/10 , C12Q1/6837 , C12Q2565/601 , C12Q2525/185
摘要： The present invention provides self-assembling, finite nucleic acid tiling arrays, and methods for their synthesis and use, which overcome a major hurdle in self-assembled DNA nanostructures, and therefore have numerous potential applications for nanofabrication of complex structures and useful devices, as further disclosed herein.
摘要翻译：本发明提供自组装的有限核酸贴片阵列及其合成和使用的方法，其克服了自组装DNA纳米结构中的主要障碍，因此具有许多用于复合结构和有用器件纳米制造的潜在应用，如本文进一步公开。

65. 发明申请

WO2006067638A2 AMPHIPHILIC BLOCK COPOLYMERS AND THEIR USE 审中-公开
标题翻译：丙烯酸嵌段共聚物及其用途
公开(公告)号：WO2006067638A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005/004116
申请日：2005-12-20
申请人： AMO GRONINGEN B.V. , LIU, Yan , HILBORN, Jons, Gunnar , HAITJEMA, Hendrick, Jan , NORRBY, Sverker , TERWEE, Thom
发明人： LIU, Yan , HILBORN, Jons, Gunnar , HAITJEMA, Hendrick, Jan , NORRBY, Sverker , TERWEE, Thom
CPC分类号： C08G18/61 , A61L24/046 , A61L27/34 , C08G18/72 , C08G71/04 , C08G77/452 , C08G77/458 , C08G77/46 , C09J183/12 , G02B1/043 , C08L83/04
摘要： The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.
摘要翻译：本发明涉及包含至少一个亲水单元嵌段和至少一个疏水单元嵌段的两亲嵌段共聚物，其中至少一个疏水嵌段含有硅氧烷单元。本发明可以特别用作组织粘合剂或用作眼内透镜（IOL）的涂层。作为IOL涂层，根据本发明的共聚物可用于例如促进组织粘连以防止后囊混浊。

66. 发明申请

WO2006019716A1 INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS 审中-公开
标题翻译：细胞内受体调节剂化合物和方法
公开(公告)号：WO2006019716A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/024625
申请日：2005-07-12
申请人： LIGAND PHARMACEUTICALS, INC. , HIGUCHI, Robert I. , ROACH, Steven L. , ZHI, Lin , ADAMS, Mark E. , LIU, Yan , KARANEWSKY, Donald S. , HUDSON, Andrew
发明人： HIGUCHI, Robert I. , ROACH, Steven L. , ZHI, Lin , ADAMS, Mark E. , LIU, Yan , KARANEWSKY, Donald S. , HUDSON, Andrew
IPC分类号： A61K31/4709
CPC分类号： C07D215/18 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： This invention relates to compounds of Formula I, II or III with the definitions of R1-R10 according to claim 1 that bind to intracellular receptors and/or modulate activity of intracellular receptors, and to methods for making and using such compounds.
摘要翻译：本发明涉及结合细胞内受体和/或调节细胞内受体活性的根据权利要求1的R1-R10定义的式I，II或III的化合物，以及制备和使用这些化合物的方法。

67. 发明申请

WO2004024302A1 ELECTROLYTIC ELUENT GENERATOR AND METHOD OF USE 审中-公开
标题翻译：电解电容发生器及其使用方法
公开(公告)号：WO2004024302A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/028511
申请日：2003-09-09
申请人： DIONEX CORPORATION , LIU, Yan , AVDALOVIC, Nebojsa
发明人： LIU, Yan , AVDALOVIC, Nebojsa
IPC分类号： B01D61/44
CPC分类号： B01D69/02 , B01D15/16 , B01D15/166 , B01D61/44 , B01D61/48 , B01D69/141 , G01N30/34 , G01N30/96 , G01N2030/965 , Y10T436/25
摘要： An acid or base is generated in an aqueous solution by the steps of: (a) providing a source of first ions (40) adjacent an aqueous liquid in a first acid or base generation zone (50), separated by a first barrier (46) (e.g., anion exchange membrane) substantially preventing liquid flow and transporting ions only of the same charge as said first ions, (b) providing a source of second ions of opposite charge (40) adjacent an aqueous liquid in a second acid or base generation zone (48), separated by a second barrier (44) transporting ions only of the same charge as the second ions, and (c) transporting ions across the first barrier by applying an electrical potential (52, 54) through said first and second zones and a base-containing aqueous solution in the other one which may be combined to form a salt (62). Also electrolytic apparatus for performing the above method. The product solutions can be used as an element for a chromato graphic separation medium (70). The element can be regenerated in order to reuse the ions by means of a membrane suppressor (74).
摘要翻译：通过以下步骤在水溶液中产生酸或碱：（a）在第一酸或碱生成区（50）中提供邻近含水液体的第一离子源（40）（46）（例如，阴离子交换膜）隔开，所述第一屏障基本上防止液体流动并且仅传输与所述第一离子相同电荷的离子，（b）提供相邻电荷（40）的第二离子源（48）分离，所述第二屏障（44）仅传输与所述第二离子相同电荷的离子，以及（c）通过施加电势将所述离子传输穿过所述第一屏障（通过所述第一和第二区以及另一区中的含碱基水溶液，其可以结合形成盐（62）。用于执行上述方法的电解装置也是如此。产品溶液可用作色谱图分离介质（70）的元素。该元件可以再生以通过膜抑制器（74）重新使用离子。

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