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61. 发明申请

WO2009022994A1 MICROFLUIDIC SEPARATION SYSTEM 审中-公开
标题翻译：微流体分离系统
公开(公告)号：WO2009022994A1
公开(公告)日：2009-02-19
申请号：PCT/SG2008/000300
申请日：2008-08-13
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie Y. , XU, Guolin , LEE, Yoke San Daniel
发明人： YING, Jackie Y. , XU, Guolin , LEE, Yoke San Daniel
IPC分类号： B03C1/035 , G01N27/00 , B81B1/00 , G01N33/50
CPC分类号： B03C1/32 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/035 , B03C1/288 , B03C2201/18 , B03C2201/22 , B03C2201/26 , G01N35/0098
摘要： A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.
摘要翻译：微流体分离系统，其包括磁分离器，其本身包括磁能源; 第一和第二导电构件，其从磁能源引出并且具有由由于磁能源而施加磁场的间隙分开的相应末端。分离系统还包括用于插入到间隙中的微流体芯片，其包括在主体的相应面上限定通道的主体; 以及密封多个通道以允许单独的测试样品体积在至少两个通道中循环的外部衬里。当将芯片插入到间隙中时，第一测试样本体积被限制为更靠近第一构件的终端循环，并且第二测试样本体积被限制为更靠近第二构件的终端循环。

62. 发明申请

WO2009020435A1 INTEGRATED MICROFLUIDIC DEVICE FOR GENE SYNTHESIS 审中-公开
标题翻译：用于基因合成的集成微流体装置
公开(公告)号：WO2009020435A1
公开(公告)日：2009-02-12
申请号：PCT/SG2008/000282
申请日：2008-07-31
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LI, Mo-Huang , YING, Jackie Y. , HUANG, Mo-Chao , NG, Sean Pin
发明人： LI, Mo-Huang , YING, Jackie Y. , HUANG, Mo-Chao , NG, Sean Pin
IPC分类号： C12N15/10 , B81B7/00 , C12Q1/68
CPC分类号： C12N15/1093 , C12N15/1031
摘要： We report making an integrated micro-fluidic device for synthesizing double stranded DNA from short oligo-nucleotides. We demonstrate successful synthesis of a 760 bp gene segment from a pool of 39 oligonucleotides on a micro-fluidic device using both the one-step and two-step synthesis processes. We also describe purifying the double stranded DNA PCR product and filtering out sequence errors in the double stranded DNA product, all on the same device.
摘要翻译：我们报告制备用于从短寡核苷酸合成双链DNA的整合微流体装置。我们证明使用一步法和两步合成法在微流体装置上从39个寡核苷酸库中成功地合成了一个760bp的基因区段。我们还描述了纯化双链DNA PCR产物并滤出双链DNA产物中的序列错误，全部在同一器件上。

63. 发明申请

WO2009014500A1 DEVICE AND METHOD FOR FOCUSING A BEAM OF LIGHT WITH REDUCED FOCAL PLANE DISTORTION 审中-公开
标题翻译：用减轻焦点平面失真聚焦光束的装置和方法
公开(公告)号：WO2009014500A1
公开(公告)日：2009-01-29
申请号：PCT/SG2008/000262
申请日：2008-07-21
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KAN, Shyi-Herng , HSIEH, Tseng-Ming , YING, Jackie Y.
发明人： KAN, Shyi-Herng , HSIEH, Tseng-Ming , YING, Jackie Y.
IPC分类号： G02B27/30 , G02B27/09
CPC分类号： B29C64/135
摘要： A system for focusing a light beam may be used for multi-photon stereolithography. It comprises a collimator or expander for adjusting the beam divergence and a scanner for directing the beam onto a focusing device to focus the beam to a focal point or beam waist and to scan the focused beam. A controller controls adjustment of the beam divergence so that the focal point or beam waist is scanned substantially in a plane. A light source may be provided to generate the light beam. The expander may comprise a diverging lens and a converging lens for expanding the beam to produce a collimated beam. The divergence of the collimated beam is dependent on the distance between the diverging lens and the converging lens, which may be adjusted to adjust the beam divergence. The focusing device may comprise a dry objective lens to focus the collimated beam onto the target material to induce multi-photon absorption in the target material at the beam waist of the focused beam.
摘要翻译：用于聚焦光束的系统可以用于多光子立体光刻。它包括用于调整光束发散的准直器或扩展器和用于将光束引导到聚焦装置上以将光束聚焦到焦点或光束腰部并扫描聚焦光束的扫描器。控制器控制光束发散的调节，使得焦点或光束腰部基本上在平面中扫描。可以提供光源以产生光束。扩展器可以包括发散透镜和用于展开光束以产生准直光束的会聚透镜。准直光束的发散度取决于发散透镜和会聚透镜之间的距离，其可以被调整以调节光束发散。聚焦装置可以包括干物镜，以将准直光束聚焦到目标材料上，以在聚焦光束的束腰处的目标材料中引起多光子吸收。

64. 发明申请

WO2008136773A8 FUNCTIONALIZATION OF NANOPARTICLES BY GLUCOSAMINE DERIVATIVES 审中-公开
标题翻译：通过葡萄糖胺衍生物对纳米颗粒的功能化
公开(公告)号：WO2008136773A8
公开(公告)日：2009-01-29
申请号：PCT/SG2008000160
申请日：2008-05-02
申请人： AGENCY SCIENCE TECH & RES , YING JACKIE Y , JANA NIKHIL R , ERATHODIYIL NANDANAN
发明人： YING JACKIE Y , JANA NIKHIL R , ERATHODIYIL NANDANAN
IPC分类号： C08B37/08 , A61K47/36 , A61K49/00 , C08L5/08
CPC分类号： A61K9/5161 , A61K47/36 , A61K47/61 , A61K47/6923 , A61K47/6929 , B22F1/0018 , B22F1/0062 , B22F2998/00 , B82Y30/00 , C08B37/003 , C08L5/08 , B22F1/0025
摘要： The present invention relates to oligomeric or polymeric saccharide derivatives comprising glucosamine moieties, e.g. derivatives of oligomeric or polymeric glucosamines such as chitosan oligomers or polymers, in which one or more amine groups are substituted by anchoring groups that chemisorb to the surface of a nanoparticle or form an interdigitated bilayer with a surfactant layer surrounding the nanoparticle. The invention also relates to functionalized nanoparticles comprising such derivatives, a method for forming the functionalized particles and to uses thereof as molecular imaging agents, biosensing agents or drug delivery agents, or in the preparation of such agents.
摘要翻译：本发明涉及包含葡糖胺部分的低聚或聚合糖衍生物，例如低分子或聚合葡糖胺的衍生物，例如壳聚糖低聚物或聚合物，其中一个或多个胺基被化学吸附到纳米颗粒表面的锚定基团或与周围纳米颗粒的表面活性剂层形成叉指双层而被取代。本发明还涉及包含这种衍生物的官能化纳米颗粒，形成官能化颗粒的方法及其用作分子显像剂，生物传感剂或药物递送剂，或在制备这些试剂中。

65. 发明申请

WO2009002276A1 PROCESS FOR ALDOL CONDENSATION FOR PREPARATION OF α,β-UNSATURATED ALDEHYDE OR KETONE AND APPLICATION THEREOF IN SYNTHESIS OF SUBSTITUTED PYRROLE OR ARYLATION OF α,β-UNSATURATED ENAL 审中-公开
标题翻译：用于制备不饱和二醛或酮的ALDOL浓缩方法及其应用于合成取代的β-不饱和脂肪酸的阳离子或芳构化
公开(公告)号：WO2009002276A1
公开(公告)日：2008-12-31
申请号：PCT/SG2008/000230
申请日：2008-06-27
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZHANG, Yugen , YING, Jackie Y.
发明人： ZHANG, Yugen , YING, Jackie Y.
IPC分类号： C07C45/74
CPC分类号： C07C45/74
摘要： A process for aldol condensation is provided. The process involves mixing of an α-unsubstituted aldehyde or ketone with another aldehyde or ketone under dry reaction conditions in the presence of an organocatalyst. The process for aldol condensation may be used for domino reactions, including the preparation of substituted pyrroles and the arylation of α,β-unsaturated enals.
摘要翻译：提供醛醇缩合方法。该方法包括在有机催化剂存在下，在干燥条件下将α-未取代的醛或酮与另一种醛或酮混合。醛醇缩合的方法可用于多米诺骨牌反应，包括制备取代的吡咯和α，β-不饱和烯的芳基化。

66. 发明申请

WO2008115149A8 N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF ß -AMINO ACID ESTER DERIVATIVE 审中-公开
标题翻译： N-苯基卡宾催化合成N-苯基恶唑啉-5-酮衍生物和β-氨基酸酯衍生物的合成
公开(公告)号：WO2008115149A8
公开(公告)日：2008-12-31
申请号：PCT/SG2008000079
申请日：2008-03-14
申请人： AGENCY SCIENCE TECH & RES , ZHANG YUGEN , YING JACKIE Y , SEAYAD JAYASREE , PATRA PRANAB K
发明人： ZHANG YUGEN , YING JACKIE Y , SEAYAD JAYASREE , PATRA PRANAB K
IPC分类号： C07D261/04 , C07C227/18 , C07C229/18
CPC分类号： C07C227/18 , C07D261/04 , C07C229/18
摘要： A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting an a, ß-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst. A process for preparing an N-alkoxyphenyl protected ß-amino acid ester derivative is further provided. The process for preparing the N-alkoxyphenyl protected ß-amino acid ester derivative comprises reacting an a, ß-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst to form a N-phenylisoxazolidin-5-one derivative, and then treating the N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst. A process for preparing an N-alkoxyphenyl protected ß-amino acid ester derivative, comprising treating a N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst, is also provided.
摘要翻译：提供了制备N-苯基异恶唑烷-5-酮衍生物的方法。制备N-苯基异恶唑烷-5-酮衍生物的方法包括在N-杂环卡宾（NHC）催化剂存在下使α，β-不饱和醛与亚硝基苯反应。还提供了制备N-烷氧基苯基保护的β-氨基酸酯衍生物的方法。制备N-烷氧基苯基保护的β-氨基酸酯衍生物的方法包括在N-杂环卡宾（NHC）催化剂存在下使α，β-不饱和醛与亚硝基苯反应，形成N-苯基异恶唑烷-5-酮衍生物，然后在酸催化剂存在下用醇处理N-苯基异恶唑烷-5-酮衍生物。还提供了一种制备N-烷氧基苯基保护的β-氨基酸酯衍生物的方法，包括在酸催化剂存在下用醇处理N-苯基异恶唑烷-5-酮衍生物。

67. 发明申请

WO2008136773A1 FUNCTIONALIZATION OF NANOPARTICLES BY GLUCOSAMINE DERIVATIVES 审中-公开
标题翻译：通过葡萄糖胺衍生物对纳米颗粒的功能化
公开(公告)号：WO2008136773A1
公开(公告)日：2008-11-13
申请号：PCT/SG2008/000160
申请日：2008-05-02
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie Y. , JANA, Nikhil R. , ERATHODIYIL, Nandanan
发明人： YING, Jackie Y. , JANA, Nikhil R. , ERATHODIYIL, Nandanan
IPC分类号： C08B37/08 , A61K47/36 , C08L5/08 , A61K49/00
CPC分类号： A61K9/5161 , A61K47/36 , A61K47/61 , A61K47/6923 , A61K47/6929 , B22F1/0018 , B22F1/0062 , B22F2998/00 , B82Y30/00 , C08B37/003 , C08L5/08 , B22F1/0025
摘要： The present invention relates to oligomeric or polymeric saccharide derivatives comprising glucosamine moieties, e.g. derivatives of oligomeric or polymeric glucosamines such as chitosan oligomers or polymers, in which one or more amine groups are substituted by anchoring groups that chemisorb to the surface of a nanoparticle or form an interdigitated bilayer with a surfactant layer surrounding the nanoparticle. The invention also relates to functionalized nanoparticles comprising such derivatives, a method for forming the functionalized particles and to uses thereof as molecular imaging agents, biosensing agents or drug delivery agents, or in the preparation of such agents.
摘要翻译：本发明涉及包含葡糖胺部分的低聚或聚合糖衍生物，例如低分子或聚合葡糖胺的衍生物，例如壳聚糖低聚物或聚合物，其中一个或多个胺基被化学吸附到纳米颗粒表面的锚定基团或与周围纳米颗粒的表面活性剂层形成叉指双层而被取代。本发明还涉及包含这种衍生物的官能化纳米颗粒，形成官能化颗粒的方法及其用作分子显像剂，生物传感剂或药物递送剂，或在制备这些试剂中。

68. 发明申请

WO2008100226A1 METHOD FOR FORMATION OF TUBULES 审中-公开
标题翻译：管形成方法
公开(公告)号：WO2008100226A1
公开(公告)日：2008-08-21
申请号：PCT/SG2007/000051
申请日：2007-02-16
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SCHUMACHER, KARL M. , YING, JACKIE Y.
发明人： SCHUMACHER, KARL M. , YING, JACKIE Y.
IPC分类号： C12N5/08
CPC分类号： C12N5/0697 , C12N5/0686 , C12N2502/256 , C12N2502/28 , C12N2533/50 , C12N2533/54
摘要： There is provided a method for forming tubules. The method involves providing a gel body enclosing one or more channels with each channel enclosed entirely within the gel body, the gel body comprising basement membrane components and growth medium. A suspension of cells, for example endothelial cells or epithelial cells, is introduced to one or more of the channels and the gel body containing the introduced cells is incubated under conditions sufficient to permit formation of a tubule, the tubule having an interior lumen.
摘要翻译：提供了形成小管的方法。该方法包括提供包围一个或多个通道的凝胶体，每个通道完全封闭在凝胶体内，凝胶体包含基底膜组分和生长介质。将细胞例如内皮细胞或上皮细胞的悬浮液引入一个或多个通道，并且将含有引入的细胞的凝胶体在足以允许形成小管的条件下孵育，所述小管具有内腔。

69. 发明申请

WO2007106497A3 THREE-DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸的生物化学结构的三维制造
公开(公告)号：WO2007106497A3
公开(公告)日：2008-07-17
申请号：PCT/US2007006346
申请日：2007-03-13
申请人： AGENCY SCIENCE TECH & RES , YING JACKIE Y , KAN SHYI-HERNG , LOH JEREMY MING HOCK , SCHUMACHER KARL , HSIEH JAMES TSENG-MING
发明人： YING JACKIE Y , KAN SHYI-HERNG , LOH JEREMY MING HOCK , SCHUMACHER KARL , HSIEH JAMES TSENG-MING
IPC分类号： A61L27/38 , A61L27/56 , C12N5/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three- dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
摘要翻译：本发明涉及包括用于组织工程和器官置换的生物相容结构的方法和装置，更具体地涉及涉及通过用于组织工程和器官置换的三维制造形成的生物相容性结构的方法和装置。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。在一些情况下，通过三维制造形成的结构包括在壁的至少一部分中限定空腔和多个孔的壁。孔可以渗透到壁上并且使得能够在空腔内部的部分和腔外部的部分（例如，分子和/或细胞）之间进行交换。例如，孔可以允许在结构和其宿主环境之间传递分子，细胞迁移和/或结缔组织的产生。本发明的结构可以植入哺乳动物，或者另外地和/或另外可以作为生物人造辅助装置离体使用。

70. 发明申请

WO2008060249A1 POROUS POLYMERIC MATERIAL WITH CROSS-LINKABLE WETTING AGENT 审中-公开
标题翻译：具有交联湿润剂的多孔聚合物材料
公开(公告)号：WO2008060249A1
公开(公告)日：2008-05-22
申请号：PCT/SG2007/000398
申请日：2007-11-17
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , CHOW, Edwin Pei Yong , YING, Jackie Y.
发明人： CHOW, Edwin Pei Yong , YING, Jackie Y.
IPC分类号： C08F251/00 , A61F9/00 , G02C7/04
CPC分类号： C08J9/283 , A61F9/0008 , A61L27/16 , A61L27/50 , A61L27/56 , C08B37/0021 , C08B37/0072 , C08F290/10 , C08J2207/10 , C08J2333/06 , C08L51/02 , G02B1/043 , C08L2666/02
摘要： A porous material is provided which comprises a transparent polymer matrix defining interconnected pores and a wetting agent. At least a portion of the wetting agent is cross-linked with the polymer matrix. A process for forming a porous polymeric material is also provided. A bicontinuous microemulsion comprising water, a wetting agent, a monomer, and a surfactant copolymerizable with the monomer is polymerized, to form a polymer defining interconnected pores. The wetting agent comprises a cross-linkable wetting agent such that after polymerization, at least a portion of the cross-linkable wetting agent is cross-linked with the polymer. The wetting agent may comprise acrylated hyaluronic acid (AHA) such as methacrylated hyaluronic acid (MeHA). The wetting agent may also comprise a hyaluronic acid (HA). The wetting agent may include an unbonded portion that this releasable from the material. A contact lens may be made from the porous material.
摘要翻译：提供了一种多孔材料，其包括限定相互连接的孔的透明聚合物基质和润湿剂。至少一部分润湿剂与聚合物基质交联。还提供了形成多孔聚合物材料的方法。包含水，润湿剂，单体和可与该单体共聚的表面活性剂的双连续微乳液聚合，形成限定互连孔的聚合物。润湿剂包含可交联的润湿剂，使得在聚合之后，至少一部分可交联的润湿剂与聚合物交联。润湿剂可以包含丙烯酸化的透明质酸（AHA），例如甲基丙烯酸化的透明质酸（MeHA）。润湿剂还可以包含透明质酸（HA）。润湿剂可包括可从材料中释放的未粘合部分。隐形眼镜可以由多孔材料制成。

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