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61. 发明申请

WO2012047679A3 CONSENSUS ANTIGEN CONSTRUCTS AND VACCINES MADE THERE FORM, AND METHODS OF USING SAME TO TREAT MALARIA 审中-公开
标题翻译：共同抗原构建物及其形式的疫苗，以及使用它们治疗疟疾的方法
公开(公告)号：WO2012047679A3
公开(公告)日：2012-06-14
申请号：PCT/US2011053541
申请日：2011-09-27
申请人： UNIV PENNSYLVANIA , INOVIO PHARMACEUTICALS INC , WEINER DAVID B , YAN JIAN , SARDESAI NIRANJAN Y , FERRARO BERNADETTE
发明人： WEINER DAVID B , SARDESAI NIRANJAN Y
IPC分类号： A61K48/00 , C12N15/00
CPC分类号： A61K39/015 , A61K38/195 , A61K38/20 , A61K38/208 , A61K38/2086 , A61K2039/53 , A61K2039/54 , A61K2039/55527 , A61K2039/70 , C07K14/445
摘要： Provided herein is consensus amino acid sequences of P. falciparum (P.f.) proteins and their encoding sequences, as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against P. falciparum using the expression constructs provided herein.
摘要翻译：本文提供恶性疟原虫（P.f.）蛋白及其编码序列的共有氨基酸序列，以及表达序列的表达构建体。本文还提供了使用本文提供的表达构建体来产生针对恶性疟原虫的免疫应答的方法。

62. 发明申请

WO2009124312A2 CONSENSUS SEQUENCES OF CHIKUNGUNYA VIRAL PROTEINS, NUCLEIC ACID MOLECULES ENCODING THE SAME, AND COMPOSITIONS AND METHODS FOR USING THE SAME 审中-公开
标题翻译： CHIKUNGUNYA病毒蛋白的同源性序列，编码其的核酸分子及其组合物及其使用方法
公开(公告)号：WO2009124312A2
公开(公告)日：2009-10-08
申请号：PCT/US2009/039656
申请日：2009-04-06
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , MUTHUMANI, Karuppiah
发明人： WEINER, David, B. , MUTHUMANI, Karuppiah
IPC分类号： A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/55522 , A61K2039/55588 , A61K2039/575 , C07H21/04 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , Y02A50/383
摘要： Consensus CHIKV El protein, consensus CHIKV E2 protein, consensus CHIKV capsid protein, or fragments and homologues thereof, and nucleic acid molecules that encode the same are disclosed. A consensus CHIKV Env protein which includes CHIKV El consensus protein, CHIKV E2 consensus protein, CHIKV E3 consensus protein, or fragments and homologues thereof and nucleic acid molecules that encode the same are also disclosed. Compositions and recombinant vaccines comprising CHIKV consensus proteins, and methods of using them are disclosed.
摘要翻译：共识CHIKV E1蛋白，共有CHIKV E2蛋白，共有CHIKV衣壳蛋白或其片段和同系物，以及编码该基因的核酸分子。还公开了包括CHIKV E1共有蛋白，CHIKV E2共有蛋白，CHIKV E3共有蛋白或其片段和同系物以及编码它们的核酸分子的共识CHIKV Env蛋白。公开了包含CHIKV共有蛋白质的组合物和重组疫苗及其使用方法。

63. 发明申请

WO2009073330A3 NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF INFLUENZA VIRUS 审中-公开
公开(公告)号：WO2009073330A3
公开(公告)日：2009-06-11
申请号：PCT/US2008/083281
申请日：2008-11-12
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , VGX PHARMACEUTICALS, INC , DRAGHIA-AKLI, Ruxandra , WEINER, David, B. , YAN, Jian , LADDY, Dominick
发明人： DRAGHIA-AKLI, Ruxandra , WEINER, David, B. , YAN, Jian , LADDY, Dominick
IPC分类号： A01N43/04 , A61K31/70
摘要： An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing an influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-proteiπ (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e -NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.

64. 发明申请

WO2008014521A2 IMPROVED VACCINES AND METHODS FOR USING THE SAME 审中-公开
标题翻译：改进的疫苗和使用该疫苗的方法
公开(公告)号：WO2008014521A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074769
申请日：2007-07-30
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , YAN, Jian
发明人： WEINER, David, B. , YAN, Jian
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HlV immυnogens and nucleic acid molecules that encode them are disclosed, lmmunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HlV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译：公开了改进的抗-HIV免疫原和编码它们的核酸分子，公开的免疫原包括那些具有针对HIV亚型A包膜蛋白的共有序列的那些，具有针对H1V亚型B包膜蛋白的共有序列的那些， HIV亚型C包膜蛋白的共有序列，具有HIV亚型D包膜蛋白的共有序列的那些序列，具有HIV亚型B共有Nef-Rev蛋白的共有序列的序列，以及具有共有序列的那些序列形成HIV Gag蛋白亚型A，B，C和 D.改进的抗HPV免疫原和编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 并公开了改进的抗流感免疫原和编码它们的核酸分子。公开了药物组合物，包含和减毒活病原体的重组疫苗以及在个体中诱导针对HIV，HPV，HCV，hTERT和流感的免疫应答的方法。

65. 发明申请

WO2007087178A2 VACCINES AND IMMUNOTHERAPEUTICS USING CODON OPTIMIZED IL-15 AND METHODS FOR USING THE SAME 审中-公开
标题翻译：使用优化的IL-15的疫苗和免疫球蛋白及其使用方法
公开(公告)号：WO2007087178A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/000886
申请日：2007-01-12
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , KUTZLER, Michele
发明人： WEINER, David, B. , KUTZLER, Michele
IPC分类号： A61K48/00
CPC分类号： C07K14/5443 , A61K2039/55522 , Y02A50/394
摘要： Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of coding sequences for IL-15 signal sequences and/or the absence of IL-15 untranslated sequences and/or inclusion of non-IL-15 signal sequences are also disclosed. Vectors, including plasmids and viral vectors, comprising such nucleic acid molecules; and to host cells comprising such nucleic acid molecules are disclosed as well as methods of using such nucleic acid molecules alone or in combination with nucleic acid sequences encoding immunogens which are part of the nucleic acid molecules and/or part of a different nucleic acid molecule. Recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed.
摘要翻译：公开了编码IL-15或其片段的核酸分子，其表达比具有IL-15的天然编码序列的核酸分子更高水平的蛋白质。还公开了具有附加修饰的核酸分子，例如不存在IL-15信号序列的编码序列和/或不存在IL-15非翻译序列和/或包含非IL-15信号序列。包括这种核酸分子的载体，包括质粒和病毒载体; 以及包含这种核酸分子的宿主细胞以及使用这些核酸分子单独或与编码作为核酸分子和/或不同核酸分子的一部分的免疫原的核酸序列组合的方法。公开了重组疫苗和编码融合蛋白的活减毒病原体及其使用方法。

66. 发明申请

WO2007050095A2 IMPROVED VACCINES AND METHODS FOR USING THE SAME 审中-公开
标题翻译：改进的疫苗及其使用方法
公开(公告)号：WO2007050095A2
公开(公告)日：2007-05-03
申请号：PCT/US2005/042231
申请日：2005-11-18
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , KUTZLER, Michele
发明人： WEINER, David, B. , KUTZLER, Michele
IPC分类号： A61K48/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/541 , A61K2039/55516 , C07K14/005 , C12N2740/16222 , C12N2740/16234 , Y02A50/394
摘要： Compositions comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with one or more of CTACK protein, TECK protein, MEC protein and functional fragments thereof and/or an isolated nucleic acid molecule that encodes an protein selected from the group consisting of: CTACK, TECK, MEC and functional fragments thereof are disclosed. Methods of inducing an immune response, including methods of inducing mucosal immune responses, in an individual against an immunogen, using such compositions are disclosed.
摘要翻译：包含一个或多个分离的核酸分子的组合物，其编码与CTACK蛋白质，TECK蛋白质，MEC蛋白质及其功能片段中的一种或多种的免疫原，和/或分离的核酸分子，其编码选自以下的蛋白质：公开了CTACK，TECK，MEC及其功能片段。公开了使用这种组合物诱导免疫应答的方法，包括诱导个体对免疫原的粘膜免疫应答的方法。

67. 发明申请

WO2006091661A1 COMPOSITIONS FOR AND METHODS OF MODULATING PLATELET LEVELS 审中-公开
标题翻译：组合物和调节电极水平的方法
公开(公告)号：WO2006091661A1
公开(公告)日：2006-08-31
申请号：PCT/US2006/006261
申请日：2006-02-22
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B.
发明人： WEINER, David, B.
IPC分类号： A01N63/00 , A01N65/00 , A01N43/04 , A61K31/711
CPC分类号： A61K38/162 , A61K31/56 , A61K31/7088 , A61K31/711 , A61K2300/00
摘要： Compositions for and methods of treating individuals who have elevated platelet levels are disclosed. The methods comprise the step of administering to the individual a therapeutically effective amount Vpr protein; a function fragment of Vpr protein; a nucleic acid encoding Vpr protein operably linked to regulatory elements; or a nucleic acid encoding a functional fragment of Vpr protein operably linked to regulatory elements. Compositions for and methods of treating individuals who have insufficient platelet levels are disclosed. The methods comprising the step of administering to the individual an amount of one or more glucocorticoid receptor antagonist compounds effective to increase platelet number.
摘要翻译：公开了治疗血小板水平升高的个体的组合物和方法。所述方法包括向个体施用治疗有效量的Vpr蛋白的步骤; Vpr蛋白的功能片段; 编码与调节元件可操作地连接的Vpr蛋白的核酸; 或编码与调节元件可操作地连接的Vpr蛋白的功能性片段的核酸。公开了治疗血小板水平不足的个体的组合物和方法。所述方法包括向个体施用一定量的一种或多种有效增加血小板数的糖皮质激素受体拮抗剂化合物的步骤。

68. 发明申请

WO2004000217A3 VACCINES FOR SUPPRESSING IGE-MEDIATED ALLERGIC DISEASE AND METHODS FOR USING THE SAME 审中-公开
标题翻译：用于抑制神经介导的过敏性疾病的疫苗及其使用方法
公开(公告)号：WO2004000217A3
公开(公告)日：2005-05-06
申请号：PCT/US0319383
申请日：2003-06-20
申请人： UNIV PENNSYLVANIA , LEVINSON ARNOLD I , CALAROTA SANDRA , WEINER DAVID B , OTERO MIGUEL
发明人： LEVINSON ARNOLD I , CALAROTA SANDRA , WEINER DAVID B , OTERO MIGUEL
IPC分类号： C07K16/00 , C12N5/02 , C07H21/04 , A01N37/18 , A01N43/04 , A01N65/00 , A61K31/70 , A61K38/00 , A61K38/16 , A61K39/395
CPC分类号： A61K39/0005 , A61K39/00 , A61K39/08 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K2317/52 , C07K2318/10 , C07K2319/55
摘要： Nucleic acid molecules that encode a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines, vectors and host cells that comprise such nucleic acid molecules are disclosed. Isolated proteins, including haptenized proteins, comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise and methods of making such proteins and antibodies that specifically bind to such proteins are disclosed. Killed or inactivated cells or particles, including haptenized killed or inactivated cells or particles, that comprise a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise such killed or inactivated cells or particles are disclosed. Methods of treating and preventing IgE mediated allergic disease or condition are disclosed.
摘要翻译：公开了编码包含血清IgE上存在的表位的膜IgE的至少一个表位的蛋白质的核酸分子，包括进一步包含非IgE T细胞辅助因子表位的蛋白质。公开了包含这种核酸分子的疫苗，载体和宿主细胞。公开了包含至少一个不含存在于血清IgE上的表位的膜IgE表位的半抗原蛋白，包括进一步包含非IgE T细胞辅助表位的蛋白质的分离的蛋白质。公开了包含制备这种蛋白质和特异性结合这些蛋白质的抗体的方法的疫苗。杀伤或灭活的细胞或颗粒，包括半抗原的灭活或灭活的细胞或颗粒，其包含含有血清IgE上存在的表位的膜IgE的至少一个表位的蛋白质，包括进一步包含非IgE T细胞辅助表位的蛋白质，披露。公开了包含这种杀死或灭活的细胞或颗粒的疫苗。公开了治疗和预防IgE介导的过敏性疾病或病症的方法。

69. 发明申请

WO2004045548A3 GENETIC CONSTRUCTS AND COMPOSITIONS COMPRISING RRE AND CTE AND USES THEREOF 审中-公开
公开(公告)号：WO2004045548A3
公开(公告)日：2004-06-03
申请号：PCT/US2003/036924
申请日：2003-11-19
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , MUTHUMANI, Karuppiah
发明人： WEINER, David, B. , MUTHUMANI, Karuppiah
IPC分类号： C12N5/00
摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.

70. 发明申请

WO2003099851A3 METHODS AND COMPOSITIONS FOR INHIBITING HIV REPLICATION 审中-公开
公开(公告)号：WO2003099851A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/016524
申请日：2003-05-23
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B.
发明人： WEINER, David, B.
IPC分类号： A61K39/00
摘要： Pharmaceutial composition comprising compounds and/or compositions useful to inhibit HIV replication are disclosed. Methods of treating individuals infected with HIV are disclosed. Methods of preventing HIV infection in high-risk individuals are disclosed.

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